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不同官能团微塑料对斑马鱼胚胎菌群和代谢功能的胁迫效应

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环境科学 2024年第3期45卷 1859-1868页

作者：闫振华张燕包旭辉朱培元陈玉芳河海大学浅水湖泊综合治理与资源开发教育部重点实验室南京210098 河海大学环境学院南京210098 上海勘测设计研究院有限公司上海200335

为探究官能团修饰对微塑料生物效应的影响规律和机制,分析了3种聚苯乙烯微塑料(PS、PS—NH_(2)和PS—COOH)在斑马鱼(Danio rerio)胚胎内的累积特征,并利用微生物组学和代谢组学相结合的分析技术,解析了斑马鱼幼鱼体内代谢功能及微生物... 详细信息

为探究官能团修饰对微塑料生物效应的影响规律和机制,分析了3种聚苯乙烯微塑料(PS、PS—NH_(2)和PS—COOH)在斑马鱼(Danio rerio)胚胎内的累积特征,并利用微生物组学和代谢组学相结合的分析技术,解析了斑马鱼幼鱼体内代谢功能及微生物群落的响应规律.结果显示,3种微塑料都可以在斑马鱼体内产生累积,其含量范围为143~175μg·g^(-1),且不存在明显差异性.斑马鱼胚胎绒毛膜是微塑料早期暴露的主要累积场所,但不能有效阻止小粒径微塑料的穿透.未修饰的PS明显影响了斑马鱼幼鱼体内氨基糖苷类的代谢能力,PS—NH_(2)主要对氨基酸的代谢过程产生了影响,而PS—COOH则主要作用于三羧酸循环、氨基酸及糖酵解等代谢通路.3种微塑料均导致了斑马鱼幼鱼体内代谢功能的变化,从而对斑马鱼产生了毒性效应,而微塑料的官能团修饰则加强了这一影响程度.与对照组相比,PS—NH_(2)明显降低了斑马鱼幼鱼体内的微生物群落的多样性,显著增加了变形菌门(Proteobacteria)的占比,导致斑马鱼幼鱼体内的菌群失衡,从而引起鱼体代谢功能的紊乱.微塑料的官能团修饰可能会明显改变其对生物体的胁迫效应,导致难以预测的生态风险.

关键词：微塑料官能团代谢物菌群累积

Recent advances in MXene for terahertz applications

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Optoelectronics Letters 2024年第5期20卷 272-288页

作者： zhang Yongzhi JIANG Jiuxing YAO Yongtao HE Xunjun Key Laboratory of Engineering Dielectric and Applications(Ministry of Education) School of Electrical and Electronic EngineeringHarbin University of Science and TechnologyHarbin 150080China College of Science Harbin University of Science and TechnologyHarbin 150080China National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin University of Science and TechnologyHarbin 150080China

Since first synthesized in 2011, MXenes have attracted extensive attention in many scientific fields as a new two-dimensional(2D) material because of the unique physical and chemical properties. Over the past decade, in particular, MXenes have obtained numerous exciting achievements in the field of terahertz applications. In this review, we first briefly introduce the MXene materials, such as the basic structure and main fabrication processes of MXenes. Then, we summarize the recent applications of MXene materials in various terahertz research areas, including terahertz modulation, terahertz absorption, terahertz shielding, terahertz communication, terahertz detection and terahertz generation, in which the representative results are presented. Finally, we give an outlook on the future research directions of MXene materials and their potential applications.

关键词： terahertz directions absorption

Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models

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Zoological Research 2024年第4期45卷 747-766页

作者： Hong-Yi Zheng Tian-zhang Song Yong-Tang Zheng State Key Laboratory of Genetic Evolution&Animal Models KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

The distribution of the immune system throughout the body complicates in vitro assessments of coronavirus disease 2019(COVID-19)immunobiology,often resulting in a lack of reproducibility when extrapolated to the whole ***,developing animal models is imperative for a comprehensive understanding of the pathology and immunology of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** review summarizes current progress related to COVID-19 animal models,including non-human primates(NHPs),mice,and hamsters,with a focus on their roles in exploring the mechanisms of immunopathology,immune protection,and long-term effects of SARS-CoV-2 infection,as well as their application in immunoprevention and immunotherapy of SARS-CoV-2 *** among these animal models and their specific applications are also highlighted,as no single model can fully encapsulate all aspects of *** effectively address the challenges posed by COVID-19,it is essential to select appropriate animal models that can accurately replicate both fatal and non-fatal infections with varying courses and *** animal model libraries and associated research tools is key to resolving the global COVID-19 pandemic,serving as a robust resource for future emerging infectious diseases.

关键词： SARS-CoV-2 COVID-19 Animal models Infection immunology Immunotherapy

A study of novel real-time power balance strategy with virtual asynchronous machine control for regional integrated electric-thermal energy systems

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Science China(Technological Sciences) 2024年第7期67卷 2074-2086页

作者： WANG Rui LI Ming-Jia WANG YiBo SUN QiuYe zhang PinJia College of Information Science and Engineering Northeastern UniversityShenyang 110819China School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China

The development of regional integrated electric-thermal energy systems(RIETES) is considered a promising direction for modern energy supply systems. These systems provide a significant potential to enhance the comprehensive utilization and efficient management of energy resources. Therein, the real-time power balance between supply and demand has emerged as one pressing concern for system stability operation. However, current methods focus more on minute-level and hour-level power optimal scheduling methods applied in RIETES. To achieve real-time power balance, this paper proposes one virtual asynchronous machine(VAM) control using heat with large inertia and electricity with fast response speed. First, the coupling timescale model is developed that considers the dynamic response time scales of both electric and thermal energy systems. Second, a real-time power balance strategy based on VAM control can be adopted to the load power variation and enhance the dynamic frequency response. Then, an adaptive inertia control method based on temperature variation is proposed, and the unified expression is further established. In addition, the small-signal stability of the proposed control strategy is validated. Finally, the effectiveness of this control strategy is confirmed through MATLAB/Simulink and HIL(Hardware-in-the-Loop) experiments.

关键词： regional integrated electric-thermal energy systems real-time power balance virtual asynchronous machine adaptive inertia small-signal stability

A Residual Frequency Offset Estimation Method Based on Range Migration Fitting

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Journal of Beijing Institute of Technology 2024年第2期33卷 103-110页

作者： Liting zhang Hao Huan Ran Tao Xiaogang Tang School of Information and Electronics Beijing Institute of Technology School of Aerospace Information Space Engineering University

Recently, researchers have proposed an emitter localization method based on passive synthetic aperture. However, the unknown residual frequency offset(RFO) between the transmitter and the receiver causes the received Doppler signal to shift, which affects the localization accuracy. To solve this issue, this paper proposes a RFO estimation method based on range migration fitting. Due to the high frequency modulation slope of the linear frequency modulation(LFM)-modulation radar signal, it is not affected by RFO in range compression. Therefore, the azimuth time can be estimated by fitting the peak value position of the pulse compression in range ***, the matched filters are designed under different RFOs. When the zero-Doppler time obtained by the matched filters is consistent with the estimated azimuth time, the given RFO is the real RFO between the transceivers. The simulation results show that the estimation error of azimuth distance does not exceed 20 m when the received signal duration is not less than 3 s, the pulse repetition frequency(PRF) of the transmitter radar signal is not less than 1 k Hz, the range detection is not larger than 1 000 km, and the signal noise ratio(SNR) is not less than –5 d B.

关键词： range migration fitting (RMF) passive localization residual frequency offset (RFO)

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新质生产力背景下劳动者的精神特质探究

经济问题 2024年第8期 19-26页

作者：朱晓妍张惠元山西大学马克思主义学院山西太原030006 太原师范学院马克思主义学院山西晋中030619

劳动者的精神特质既是新质生产力背景下劳动者精神世界的集中体现,又是推动新质生产力加快发展的精神力量。劳动者的精神特质是全面理解和把握新质生产力的一个重要视角。从价值维度看,探究新质生产力背景下劳动者的精神特质,对于全面... 详细信息

劳动者的精神特质既是新质生产力背景下劳动者精神世界的集中体现,又是推动新质生产力加快发展的精神力量。劳动者的精神特质是全面理解和把握新质生产力的一个重要视角。从价值维度看,探究新质生产力背景下劳动者的精神特质,对于全面把握马克思生产力理论中的劳动者要素,促进人的自由全面发展,推动精神生活共同富裕具有重要意义。从内涵维度看,新质生产力背景下劳动者的精神特质具有深厚的文化基础和鲜明的时代特色,可以凝练为:胸怀祖国、一心为民的爱国精神,追求卓越、勇攀高峰的科学精神,精益求精、技艺高超的工匠精神,集智攻关、团结合作的协同精神,脚踏实地、真抓实干的奋斗精神。从实践维度看,需要从政策引导、现实需求、人才培养、社会熏陶这四个方面形成合力,探寻新质生产力背景下涵养劳动者精神特质的实践路径,为加快发展新质生产力注入强大的精神动力,加快推进中国式现代化。

关键词：新质生产力劳动者精神特质

Associations of Perchlorate,Nitrate,and Thiocyanate with Sex Hormones among Children:A Nationally Representative Cross-sectional Study in U.S.

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Biomedical and Environmental Sciences 2024年第6期37卷 666-671页

作者： Yiwen Wang Guodong Ding Peipei Hu Yongjun zhang Department of Pediatrics Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China MOE-Shanghai Key Laboratory of Children’s Environmental Health Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China

Nitrates,thiocyanates,and perchlorates are ubiquitous in the environment and can be introduced to the public through various dietary and environmental ***,thiocyanates,and perchlorates mainly affect health via the sam... 详细信息

关键词： mechanism sectional perchlorate

Robust Correlation Clustering Problem with Locally Bounded Disagreements

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Tsinghua Science and Technology 2024年第1期29卷 66-75页

作者： Sai Ji Min Li Mei Liang Zhenning zhang Institute of Mathematics Hebei University of TechnologyTianjin 300401China School of Mathematics and Statistics Shandong Normal UniversityJinan 250358China College of Statistics and Data Science Beijing University of TechnologyBeijing 100124China Department of Operations Research and Information Engineering Beijing University of TechnologyBeijing 100124China

Min-max disagreements are an important generalization of the correlation clustering problem(CorCP).It can be defined as *** a marked complete graph G=(V,E),each edge in the graph is marked by a positive label"+"or a negative label"_"based on the similarity of the connected *** goal is to find a clustering C of vertices V,so as to minimize the number of disagreements at the vertex with the most ***,the disagreements are the positive cut edges and the negative non-cut edges produced by clustering *** paper considers two robust min-max disagreements:min-max disagreements with outliers and min-max disagreements with *** parameter δ∈(0,1/14),we first provide a threshold-based iterative clustering algorithm based on LP-rounding technique,which is a(1/δ,7/(1-14δ))-bi-criteria approximation algorithm for both the min-max disagreements with outliers and the min-max disagreements with outliers on one-sided complete bipartite ***,we verify that the above algorithm can achieve an approximation ratio of 21 for min-max disagreements with penalties when we set parameter δ=1/21.

关键词： min-max disagreements outliers penalties approximation algorithm LP-rounding

Ultrasound-assisted isolation:A new method to isolate stromal vascular fraction

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第1期6卷 8-15页

作者： Yiming Gao Xiaojie zhang Poh-Ching Tan Yun Xie Peiqi zhang Tianyu zhang Qingfeng Li Shuangbai Zhou Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Department of Burns and Plastic Surgery Shanghai Changzheng HospitalShanghai200003China College of Life Sciences Shanghai Normal UniversityShanghai200233China

Background:The stromal vascular fraction(SVF),a cluster of stem and progenitor cells isolated from adipose tissue,holds significant promise for application in regenerative ***,the existing methods for SVF isolation are time-consuming and ***,in this study,we explored a new method of SVF extrac-tion-ultrasound-assisted SVF isolation(USASI)-and compared the viability and characteristics of SVF isolated using different ***:SVF extraction methods using different combinations of ultrasound power,ultrasound time,collagenase dosage,and collagenase digestion time were compared with those of the control group(collagenase digestion method).The cell yield and vitality of the SVF were evaluated via cell counting and trypan blue *** cell components and immunophenotypes of freshly isolated SVF were analyzed using flow *** prolifer-ative capacity and differentiation potential of the SVF were also ***:Ultrasonication at 95 W-20 kHz for 30 s followed by digestion with 0.15%collagenase for 30 min was identified as the most suitable parameter for the USASI method in isolating SVF,as recommended based on the evaluation of various tested *** USASI method significantly reduced the collagenase dosage and shortened the digestion *** to the collagenase digestion method,the USASI method had a higher cell yield and cell viability,with no adverse effects on cell components,proliferative capacity,or multipotential differentiation ***:With reduced processing time,lower collagenase dosage,and increased cell yield without impairing the viability and characteristics of SVF,USASI holds the potential to emerge as a time-saving and cost-effective method for future clinical applications.

关键词： Stromal vascular fractions SVF isolation Mechanical force Ultrasound