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Transformation Sequence Rule of Martensite Plates and Temperature Memory Effect in Shape Memory Alloys

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Acta Metallurgica Sinica(English Letters) 2015年第10期28卷 1286-1290页

作者： Tian-Wei Liu yan-jun zheng Li-Shan Cui Department of Materials Science and Engineering China University of Petroleum

In thermoelastic martensitic transformation, it is well established that the first martensite plate appearing upon cooling becomes the final one during reverse transformation to austenite upon heating. The results obtained from this work show that the transformation sequence of the martensite appears to be random. Newly formed martensite plates can modify the elastic strain energy level stored in the already existing martensite. Additionally, the elastic strain energy stored in newly formed martensite is not necessarily to be higher than the remaining martensite. The obtained results may assist in understanding phenomena related to partial transformation of shape memory alloys, such as temperature memory effect.

关键词： Phase transformation Shape memory alloys TEM Transformation sequence

Therapeutic effects of ghrelin and growth hormone releasing peptide 6 on gastroparesis in streptozotocin-induced diabetic guinea pigs in vivo and in vitro

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Chinese Medical Journal 2008年第13期121卷 1183-1188页

作者： QIU Wen-cai WANG Zhi-gang WANG Wei-gang yan jun zheng Qi Department of General Surgery Sixth Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200233 China

Background Diabetic gastroparesis is a disabling condition with no consistently effective treatment. In normal animals, both ghrelin and its synthetic peptide, growth hormone releasing peptide 6 （GHRP-6）, increase gastric emptying. Thus, we investigated the potential therapeutic significance of ghrelin and GHRP-6 in diabetic guinea pigs with gastric motility disorders. Methods A diabetic guinea pig model was produced by intraperitoneal （i.p.） injection of streptozotocin （STZ, 280 mg/kg）. Diabetic guinea pigs were injected i.p. with ghrelin or GHRP-6 （10-100 μg/kg）, and the effects on gastric emptying were measured after intragastric application of phenol red. The effect of atropine or a growth hormone secretagogue receptor （GHS-R） antagonist, D-Lys^3-GHRP-6, on the gastroprokinetic effects of ghrelin or GHRP-6 （100 μg/kg） was also investigated. Further, the in vitro effects of ghrelin or GHRP-6 （0.01-10 μmol/L） on spontaneous or carbachol-induced contractile amplitude in gastric fundic circular strips taken from diabetic guinea pigs were examined. Growth hormone secretagogue receptor transcripts in the fundic strips of diabetic guinea pigs were detected by reverse transcriptase polymerase chain reaction （RT-PCR）. Results We established a guinea pig model of delayed gastric emptying. Ghrelin （20, 50, or 100 μg/kg） and GHRP-6 （20, 50, or 100 μg/kg） accelerated gastric emptying in diabetic guinea pigs with gastroparesis （n=6, P 〈0.05）. In the presence of atropine, which delayed gastric emptying, ghrelin and GHRP-6 （100 μg/kg） failed to accelerate gastric emptying （n=6, P 〈0.05）. D-Lys^3-GHRP-6 also delayed gastric emptying induced by the GHS-R agonist （n=6, P 〈0.05）. Ghrelin and GHRP-6 increased the carbachol-induced contractile amplitude in gastric fundic strips taken from diabetic guinea pigs （n=6, P〈0.05）. RT-PCR confirmed the presence of GHS-R mRNA in the strip preparations. Conclusions Ghrelin and GHRP-6 increased gastric emptying in diabetic guinea pigs wit

关键词： gastric emptying smooth muscle strips ghrelin growth hormone releasing peptide 6 growth hormone secretagogue receptor

Gastric motor effects of ghrelin and growth hormone releasing peptide 6 in diabetic mice with gastroparesis

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World Journal of Gastroenterology 2008年第9期14卷 1419-1424页

作者： Wen-Cai Qiu Zhi-Gang Wang Wei-Gang Wang jun yan Qi zheng The Affiliated Sixth Hospital of Medical School Shanghai Jiaotong University Shanghai 200233 China

AIM:To investigate the potential therapeutic significance of ghrelin and growth hormone releasing peptide 6 (GHRP-6) in diabetic mice with gastric motility disorders. METHODS: A diabetic mouse model was established by intraperitoneal (ip) injection of alloxan. Diabetic mice were injected ip with ghrelin or GHRP-6 (20-200 μg/kg), and the effects on gastric emptying were measured after intragastric application of phenol red. The effect of atropine, NG-nitro-L-arginine methyl ester hydrochloride (L-NAME) or D-Lys3-GHRP-6 (a growth hormone secretagogue receptor (GHS-R) antagonist) on the gastroprokinetic effect of ghrelin or GHRP-6 (100 μg/kg) was also investigated. The effects of ghrelin or GHRP-6 (0.01-10 μmol/L) on spontaneous or carbachol-induced contractile amplitude were also investigated in vitro, in gastric fundic circular strips taken from diabetic mice. The presence of growth hormone secretagogue receptor 1a transcripts in the fundic strips of diabetic mice was detected by reverse transcriptase polymerase chain reaction (RT-PCR). RESULTS: We established a diabetic mouse model with delayed gastric emptying. Ghrelin and GHRP-6 accelerated gastric emptying in diabetic mice with gastroparesis. In the presence of atropine or L-NAME, which delayed gastric emptying, ghrelin and GHRP-6 (100 μg/kg) failed to accelerate gastric emptying. D-Lys3-GHRP-6 also delayed gastric emptying induced by the GHS-R agonist. Ghrelin and GHRP-6 increased the carbachol-induced contractile amplitude in gastric fundicstrips taken from diabetic mice. RT-PCR confirmed the presence of GHS-R mRNA in the strip preparations. CONCLUSION: Ghrelin and GHRP-6 increase gastric emptying in diabetic mice with gastroparesis, perhaps by activating peripheral cholinergic pathways in the enteric nervous system.

关键词： Gastric emptying Ghrelin Growth hormone releasing peptide 6 Growth hormone secretagogue receptor Diabetic mice

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan zheng Qingming Lin yan You zheng Gong yangping Zhuang Jiali Wu Yu Wang Hanlin Huang jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Fabrication of thick BOX SOI by Smart-cut technology

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Nuclear Science and Techniques 2003年第2期14卷 115-118页

作者： WU yan-jun, ZHANG Miao, AN zheng-Hua, LIN Cheng-Lu(State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology,the Chinese Academy of Sciences, Shanghai 200050) Shanghai Institute of Microsystem and Information Technology the Chinese Academy of Sciences State Key Laboratory of Functional Materials for Informatics 上海 200050

A SOI material with thick BOX (2.2 μm) was successfully fabricated using the Smart-cut technology. The thick BOX SOI microstructures were investigated by high resolution cross-sectional transmission electron microscopy (XTEM), while the electrical properties were studied by the spreading resistance profile (SRP). Experimental results demonstrate that both structural and electrical properties of the SOI structure are very good.

关键词：灵活切割技术微观结构截面透射电子显微镜 XTEM 电学特性绝缘硅片 SOI

Effects of fluid balance on prognosis of acute respiratory distress syndrome patients secondary to sepsis

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World Journal of Emergency Medicine 2020年第4期11卷 216-222页

作者： Yu-ming Wang yan-jun zheng Ying Chen Yun-chuan Huang Wei-wei Chen Ran Ji Li-li Xu Zhi-tao yang Hui-qiu Sheng Hong-ping Qu En-qiang Mao Er-zhen Chen Department of Emergency Ruijin Hospital Affi liated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Critical Care Medicine Ruijin Hospital Affi liated to Shanghai Jiao Tong University School of MedicineShanghaiChina

BACKGROUND:Fluid management is crucial to acute respiratory distress syndrome(ARDS)secondary to ***,choices of fluid resuscitation strategies and fluid input volumes remain a thorny *** study aimed to elucidate the relationship between fluid balance and prognosis of ARDS patients secondary to ***:Our study included 322 sepsis patients from Ruijin Hospital between 2014 and 2018,and 84 patients were diagnosed as ARDS within 72 hours after onset of sepsis according to Berlin ARDS Defi ***:Among the 322 sepsis patients,84(26.1%)were complicated with ARDS within 72 *** patients had a lower oxygenation index(PaO2/FiO2166.4±71.0 vs.255.0±91.2,P<0.05),longer duration of mechanical ventilation(11[6-24]days vs.0[0-0]days,P<0.05)than those without *** patients with ARDS showed daily positive net fl uid balance during seven days compared with those without ARDS who showed daily negative net fluid balance since the second day with signifi cant statistical *** the 84 sepsis patients with ARDS,58(69.0%)*** daily fl uid input volumes were much lower in survivors than in non-survivors(43.2±16.7 mL/kg vs.51.0±25.2 mL/kg,P<0.05)while output volumes were much higher in survivors(45.2±19.8 mL/kg vs.40.2±22.7 mL/kg,P<0.05).Using binary logistic regression analysis,we found that the mean daily fl uid balance was independently associated with mortality of sepsis patients complicating with ARDS(P<0.05).CONCLUSIONS:Early negative fluid balance is independently associated with a better prognosis of sepsis patients complicated with ARDS.

关键词： Sepsis Acute respiratory distress syndrome Fluid balance Prognosis

In Vivo Kinetics and Biodistribution of a Hantaan Virus DNA Vaccine after Intramuscular Injection in Mice

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Virologica Sinica 2010年第3期25卷 177-182页

作者： Si WANG Qing NIE Lan-yan zheng jun HU En-jie LUO Department of Medical microbiology and parasitology Preclinical Medical College China Medical University Shenyang 110001 China

To study the kinetics in vivo of a Hantaan virus DNA vaccine, we constructed a fusion DNA vaccine, pEGFP/S, by cloning the S segment of Hantavirus into the vector, pEGFP-C1, which encodes Green fluorescent protein EGFP. In this report, we provide evidence that pEGFP/S was distributed and persistently expressed for more than 60 days in several organs after inoculation. Our findings suggest that the persistent immune responses induced by a Hantaan virus DNA vaccine are likely due to the plasmid pEGFP/S deposited in vivo, which acts as a booster immunization.

关键词： Hantaan virus DNA vaccine Intramuscular injection Immunologic memory Nucleocapsid protein

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基于异构网络面向多标签系统的推荐模型研究

软件学报 2017年第10期28卷 2611-2624页

作者：王瑜武延军吴敬征刘晓燕中国科学院软件研究所北京100190 中国科学院大学北京100049

标签成为信息组织的重要方式之一,随着推荐系统的蓬勃发展,标签推荐成为学者们研究的重要问题之一.目前存在各种各样的标签系统,其功能千差万别,标签数据信息越来越复杂.目前研究往往针对特定类型标签数据,缺乏既综合考虑标签数据中不... 详细信息

标签成为信息组织的重要方式之一,随着推荐系统的蓬勃发展,标签推荐成为学者们研究的重要问题之一.目前存在各种各样的标签系统,其功能千差万别,标签数据信息越来越复杂.目前研究往往针对特定类型标签数据,缺乏既综合考虑标签数据中不同类型对象的复杂信息又能适用于多种标签系统数据的标签推荐模型.构建了标签推荐模型Hn MTR,该模型首先针对标签数据中不同类型对象构建异构网络模型,其次对异构网络模型中不同类型顶点进行同空间映射,使不同类型的顶点和边可在同一空间进行量化比较;最后基于同空间映射后网络,引入多参数马尔可夫模型进行标签评分和推荐.通过基于豆瓣、Delicious和Meetup这3个标签系统数据实验,其结果表明,Hn MTR模型平均准确率比目前主流算法提高10%以上,取得了较好的推荐结果.

关键词：异构网络网络嵌入标签推荐标签系统周模型

西双版纳热带森林空心树形成概率及其影响因素

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生态学杂志 2016年第10期35卷 2621-2626页

作者：刘俊雁郑征牛燕芬董廷发西南野生动植物资源保护教育部重点实验室西华师范大学生命科学学院四川南充637009 中国科学院西双版纳热带植物园热带森林生态学重点实验室云南勐腊666303 昆明学院农学院昆明650214

空心树是森林生态系统的重要结构组分,它在维持森林动物群落的物种多样性方面起着重要作用。选取西双版纳20 hm^2热带森林动态监测样地为研究对象,采用地面观测法调查了样地内所有胸径≥5 cm的活体乔木,研究热带森林主要空心树形成概率... 详细信息

空心树是森林生态系统的重要结构组分,它在维持森林动物群落的物种多样性方面起着重要作用。选取西双版纳20 hm^2热带森林动态监测样地为研究对象,采用地面观测法调查了样地内所有胸径≥5 cm的活体乔木,研究热带森林主要空心树形成概率及其影响因素。运用逻辑斯蒂回归模型探讨空心树形成概率与胸径的关系;再结合地形数据,拟合空心树形成概率的最优模型。结果表明:该样地森林的空心树形成概率与物种有关,空心树形成概率最高的4个种分别是红锥(Castanopsis hystrix)(21.23%)、黑毛柿(Diospyros hasseltii)(13.53%)、毛猴欢喜(Sloanea tomentosa)(12.06%)和短刺锥(***)(11.99%);空心树形成概率随着树木胸径的增加而增加,相同径阶下各树种空心树形成概率不同;根据拟合的最优模型,空心树形成概率主要受胸径、坡度、坡向的影响。这些结果表明,空心树形成概率不仅与树木本身的生长有关,还受到地形因子的影响。提出对热带森林多样性的保护与管理的建议。

关键词：空心树生物多样性保护胸径热带森林