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Neuroscience Bulletin 2024年第2期40卷 182-200页

作者： yang Zhu Hao Huang Zhi Chen Yong Tao Ling-Yi Liao Shi-Hao Gao yan-jiang wang Chang-Yue Gao Department of Rehabilitation Medicine Daping HospitalArmy Medical UniversityChongqing 400042China Department of Neurology and Center for Clinical Neuroscience Daping HospitalArmy Medical UniversityChongqing 400042China Department of Special Medicine Daping HospitalArmy Medical UniversityChongqing 400042China

Intermittent theta burst stimulation(iTBS),a time-saving and cost-effective repetitive transcranial magnetic stimulation regime,has been shown to improve cognition in patients with Alzheimer’s disease(AD).However,the specific mechanism underlying iTBS-induced cognitive enhancement remains *** studies suggested that mitochondrial functions are modulated by magnetic ***,we showed that iTBS upregulates the expression of iron-sulfur cluster assembly 1(ISCA1,an essential regulatory factor for mitochondrial respiration)in the brain of APP/PS1 *** vivo and in vitro studies revealed that iTBS modulates mitochondrial iron-sulfur cluster assembly to facilitate mitochondrial respiration and function,which is required for ***,iTBS rescues cognitive decline and attenuates AD-type pathologies in APP/PS1 *** present study uncovers a novel mechanism by which iTBS modulates mitochondrial respiration and function via ISCA1-mediated iron-sulfur cluster assembly to alleviate cognitive impairments and pathologies in *** provide the mechanistic target of iTBS that warrants its therapeutic potential for AD patients.

关键词： Intermittent theta burst stimulation Alzheimer’s disease Iron-sulfur cluster assembly 1 Mitochondrial dysfunction Neurodegeneration

Rejuvenating the Immune System:Insights for Anti-Neurodegeneration Strategies

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Neuroscience Bulletin 2022年第1期38卷 107-109页

作者： Jie Liu yan-jiang wang Department of Neurology Daping HospitalThird Military Medical UniversityChongqing400042China Chongqing Key Laboratory of Ageing and Brain Diseases Chongqing400042China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai200031China

Aging is the primary risk factor for various chronic disorders,especially neurodegeneration diseases,including Alzheimer’s disease(AD)and Parkinson’s disease(PD).It has been estimated that about one in ten individuals aged>65 are affected by AD,and this prevalence continues to increase with the aging of the population[1],causing a heavy burden on the family and *** the aging population grows progressively around the globe,drug discoveries targeting the aging process have become a hot spot[2].

关键词： degeneration Immune diseases

Meningeal Lymphatic Vessels:A Drain of the Brain Involved in Neurodegeneration?

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Neuroscience Bulletin 2020年第5期36卷 557-560页

作者： Yuan Cheng yan-jiang wang Department of Neurology and Center for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing 400042China Chongqing Key Laboratory of Aging and Brain Diseases Chongqing 400042.China The Institute of Brain and Intelligence Third Military Medical UniversityChongqing 400042China

Neurodegenerative diseases include several kinds of neurological disorder that are caused by the progressive death of neurons in different regions of the *** diseases affect millions of people worldwide and impose a heavy health burden on modern ***,their pathogenesis remains elusive,and disease-modifying methods are not currently available to prevent,halt,or reverse them[1].

关键词： degeneration diseases death

Early Intervention in Alzheimer’s Disease: How Early is Early Enough?

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Neuroscience Bulletin 2020年第2期36卷 195-197页

作者： Dong-Yu Fan yan-jiang wang Department of Neurology and Center for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing 400042China Chongqing Key Laboratory of Aging and Brain Diseases Chongqing 400042China

In 1906,*** Alzheimer reported a case of dementia and thought it was a new type of ***,*** Kraepelin named it Alzheimer’s disease(AD).One hundred years later,AD has become the most common type of dementia affecting the elderly population and a heavy health ***,the pathogenesis of the disease remains unclear,and no disease-modifying therapies are available to prevent,halt,or even slow the progression of the disease[1].

关键词： Alzheimer pathogenesis Early

Biofluid Biomarkers of Alzheimer's Disease:Progress,Problems,and Perspectives

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Neuroscience Bulletin 2022年第6期38卷 677-691页

作者： Shan Huang yan-jiang wang Junhong Guo Department of Neurology First HospitalShanxi Medical UniversityTaiyuan 030000China Department of Neurology and Centre for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing 400042China

Since the establishment of the biomarker-based A-T-N(Amyloid/Tau/Neurodegeneration)framework in Alzheimer's disease(AD),the diagnosis of AD has become more precise,and cerebrospinal fluid tests and positron emission tomography examinations based on this framework have become widely ***,the A-T-N framework does not encompass the whole spectrum of AD pathologies,and problems with invasiveness and high cost limit the application of the above diagnostic methods aimed at the central nervous ***,we suggest the addition of an“X”to the A-T-N framework and a focus on peripheral biomarkers in the diagnosis of *** this review,we retrospectively describe the recent progress in biomarkers based on the A-T-N-X framework,analyze the problems,and present our perspectives on the diagnosis of AD.

关键词： Alzheimer's disease Biomarker Amyloidbeta Tau Diagnosis

Combining Multiple Factors to Predict Alzheimer’s Disease

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Neuroscience Bulletin 2022年第8期38卷 969-972页

作者： Xiao-Lin Gao Jun wang yan-jiang wang Xian-Le Bu Department of Neurology and Centre for Clinical Neuroscience Daping HospitalThird Military Medical University400042ChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases 400042ChongqingChina Institute of Brain and Intelligence Third Military Medical University400042ChongqingChina State Key Laboratory of Trauma Burns and Combined InjuryThird Military Medical University400042ChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences200031ShanghaiChina

Alzheimer's disease(AD)is the most common type of dementia that imposes a high burden on caregivers and has substantial economic cost for *** there are no drugs available to reverse the progression of AD,a large number of studies have shown that intervention for the risk factors for AD or administration of disease-modifying therapy at the preclinical/prodromal stage yields better ***,early diagnosis or accurate prediction of AD in healthy populations and preclinical AD is an important prerequisite for effective intervention.

关键词： Alzheimer diagnosis drugs

Is Alzheimer’s Disease Transmissible in Humans?

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Neuroscience Bulletin 2019年第6期35卷 1113-1115页

作者： Xian-Le Bu Wei-Wei Li yan-jiang wang Department of Neurology and Centre for Clinical Neuroscience Daping Hospital Third Military Medical University

Alzheimer’s disease(AD),the most common type of dementia,has been identified as a protein misfolding disease with the accumulation of abnormally folded amyloid-β(Aβ)protein and hyperphosphorylated tau protein in the brain[1,2].Aβ is known to play a crucial role in the pathogenesis of *** of Aβ protein in the brain parenchyma causing senile plaques is the obligatory event in AD pathogenesis.Aβ protein is also deposited in the media and adventitia of small and midsized cerebral arteries leading to cerebral amyloid angiopathy(CAA),which is also present in the large majority of AD patents.

关键词： Alzheimer Aβ tau

White Matter“Matters”in Alzheimer’s Disease

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Neuroscience Bulletin 2022年第3期38卷 323-326页

作者： Man-Yu Xu Zhi-Qiang Xu yan-jiang wang Department of Neurology and Center for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing400042China Chongqing Key Laboratory of Ageing and Brain Diseases Chongqing400042China The Institute of Brain and Intelligence Third Military Medical UniversityChongqing400042China

Alzheimer's disease(AD)is a neurodegenerative disease that increasingly burdens many families *** AD is generally thought to be closely associated with gray matter,many studies have identified significant changes in white matter as well,including demyelination and function alterations in oligodendrocytes in the AD *** addition,Ap plaques,the most important pathological characteristic in AD,are deposited in late-myelinating regions such as the prefrontal and temporal lobes,where myelin is prone to damage[1].All the evidence hints that the changes in myelin are closely associated with the onset and progression of AD,prompting scientists to outline the process of changing myelin in AD and develop novel strategies for the treatment of AD.

关键词： Alzheimer alterations damage

Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives

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Translational Neurodegeneration 2020年第2期9卷 178-188页

作者： Yuan Cheng Ding-Yuan Tian yan-jiang wang Department of Neurology and Centre for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqingChina The Institute of Brain and Intelligence Third Military Medical UniversityChongqingChina Key Laboratory of Aging and Brain Diseases ChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina

Alzheimer’s disease(AD)is the most common type of dementia,and no disease-modifying treatments are available to halt or slow its ***-beta(Aβ)is suggested to play a pivotal role in the pathogenesis of AD,and clearance of Aβfrom the brain becomes a main therapeutic strategy for *** studies found that Aβclearance in the periphery contributes substantially to reducing Aβaccumulation in the ***,understanding the mechanism of how Aβis cleared in the periphery is important for the development of effective therapies for *** this review,we summarized recent findings on the mechanisms of Aβefflux from the brain to the periphery and discuss where and how the brain-derived Aβis cleared in the *** on these findings,we propose future strategies to enhance peripheral Aβclearance for the prevention and treatment of *** review provides a novel perspective to understand the pathogenesis of AD and develop interventions for this disease from a systemic approach.

关键词： Alzheimer's disease Beta-amyloid Blood-brain barrier Lymphatic vessel Venous sinus Periphery Liver Kidney Intestine Skin Blood Monocyte Enzymes

Neuroprotective effects of cromakalim on cerebral ischemia-reperfusion injury in rats Correlation with hippocampal metabotropic glutamate receptor 1 alpha and glutamate transporter 1

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Neural Regeneration Research 2010年第9期5卷 678-682页

作者： Shilei wang Junchao Liu Qingxian Chang Yu Li, yan jiang Shiduan wang Department of Anesthesiology Affiliated Hospital of Qingdao University Medical CollegeQingdao 266003Shandong ProvinceChina

BACKGROUND：Studies have reported that potassium channel openers exhibit a protective effect on cerebral ischemia-reperfusion injury and inhibit glutamate excitotoxicity in ***,the effects of the glutamate receptor 1α and glutamate transporter 1 remain poorly ***：To investigate the prophylactic use of the adenosine triphosphate-sensitive potassium channel opener cromakalim on neurological function and cerebral infarct size,as well as glutamate receptor 1α and glutamate transporter 1 expression,in rats with cerebral ischemia-reperfusion injury,and to explore action mechanisms underlying reduced glutamate excitotoxicity and neuroprotection in ***,TIME AND SETTING：Randomized,controlled,animal experiment was performed at the Brain Institute,Qingdao University Medical College,Between July 2008 and April ***：Cromakalim was purchased from Sigma,USA; rabbit anti-glutamate receptor 1α polyclonal antibody was offered by Wuhan Boster,China; rabbit anti-glutamate transporter 1 polyclonal antibody was offered by Santa Cruz Biotechnology,***：Sixty male,Wistar rats,aged 6 months,were randomly assigned to three groups （n =20）：sham-surgery,model,and *** thread methods were used to establish middle cerebral artery occlusion in rats from the model and cromakalim *** from the sham-surgery group were subjected to exposed common carotid artery,external carotid artery,and internal carotid artery,without *** （10 mg/kg） was administered 30 minutes prior to middle cerebral artery occlusion,but there was no intervention in the model and sham-surgery *** OUTCOME MEASURES：At 24 hours post-surgery,neurological behavioral functions were evaluated using Bederson＇s test,cerebral infarction volume was determined following tetrazolium chloride staining,and glutamate receptor 1a and glutamate transporter 1 expressions were detected using ***：Following cerebral ischemia-repe

关键词： cerebral ischemia-reperfusion cromakalim glutamate receptor 1α glutamate transporter 1