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Chinese Medical Journal 2011年第4期124卷 622-626页

作者： JIANG Guo-qing GAO Yu-nong GAO Min ZHENG hong yan Xin wang Wen AN Na CAO Kun Department of Gynecologic Oncology Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing 100142 China

Unlike other non-gynecologic solid tumors, such as breast cancer, lung cancer, metastasis to bone from endometrial carcinoma is rare, metastasis to extremity is extremely rare. We report a 51-year-old multiparous woman with FIGO Stage IVb Grade 2 endometrial adenocarcinoma which metastasized to left lower extremity bone. She received an amputation of left lower extremity below the knees, and a total abdominal hysterectomy and bilateral salpingo-oophorectomy, and followed by systemic chemotherapy, radiation therapy to the pelvis and progestational agent. She had a complete response to above treatments, and disease-free survival for 10 months. After recurrence, she received chemotherapy, radiotherapy and progestational agent once again. She had lived 56 months and is still alive by the time of report. Metastasis of endometrial carcinoma to extremity bone can rarely occur and should be considered when the patient with endometrial carcinoma complained of unexplained pain and swelling associated with extremity bone.

关键词： endometrial carcinoma lower-extremity bone metastasis therapy clinicopathological

A guinea pig model of Ciwujia Injection-induced anaphylaxis for allergic substance screening

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Chinese Herbal Medicines 2019年第3期11卷 332-336页

作者： Yu-fei Feng Zhong-xu Jing yan-yan Zhang Shao-wa Lv Qing-xia Guan Zhi-xin yang Rui wang yan-hong wang College of Pharmacy Heilongjiang University of Chinese Medicine

Objective: Though especially efficient for cardiovascular and cerebrovascular diseases treatment, many serious anaphylactic diseases could be induced by Ciwujia Injection(CWJI). However, study of the mechanism and detection of allergies have been investigated by the unknown sources of allergenic *** this study, a guinea pig model which could mimic the symptoms of anaphylactic reactions induced by Ciwujia Injection(CWJI) was modeled and used to screen the allergenic substance of ***: Guinea pigs were sensitized three times every other day with CWJI and excitated 14 d after the last sensitization administration. Then, the histamine, trypsin, IL-4 and IFN-γ levels, and the Annexin V positive rate of peritoneal mast cells(PMC) were detected, the numbers of B lymphocyte and the pathological changes were also analyzed to verify the guinea pig allergy model, PCA test and Ig E antibody levels were determined to study the ***: The levels of total IgE, histamine, and trypsin were significantly increased after CWJI sensitization, IL-4 level was elevated, Annexin V positive of PMC cell rate, local skin reactions, and declined IFN-γwere observed after excitation. Histological examination showed that mild pathological changes in lungs were ***: This guinea pig model may provide a powerful tool to study the mechanism in CWJI induced anaphylaxis and screen the allergic source of CWJI.

关键词： anaphylaxis Ciwujia Injection guinea pig IgE

Diver CE versus Guardwire Plus for thrombectomy in patients with inferior myocardial infarction:a trial of aspiration of thrombus during primary angioplasty for inferior myocardial infarction

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Chinese Medical Journal 2007年第7期120卷 557-561页

作者： yan hong-bing wang Jian LI Nan ZHU Xiao-ling GAO Hai AI Hui LI Xiang YE Ming CHI Yun-peng ZHANG hong Emergency Center for Heart Lung and Vessel Diseases Beijing Anzhen Hospital Capital University of Medical Sciences Beijing 100029 China

Background Different feasible and safe thrombectomy and distal protection devices have been used in clinical practice. The efficiency and safety of adjunct thrombectomy using Diver CE device （Invatec, Italy） versus Guardwire Plus device （Medtronic, USA） before percutaneous coronary intervention （PCI） were compared in patients with acute inferior ST-segment-elevation myocardial infarction （STEMI） for less than 12 hours, thrombolysis in myocardial infarction （TIMI） flow grade 0 to 1, and total occlusion of the proximal right coronary artery （≥3 mm in diameter） in a prospective randomized single-center study. Methods The primary end point was the magnitude of ST-segment resolution （STR）（〉70%） measured immediately, 90 minutes and 6 hours after PCI, myocardial blush grade and slow flow or no-reflow. Secondary end points were left ventricular end-diastolic volume （LVEDV）, left ventricle ejection fraction （LVEF） and major adverse cardiac events （MACEs） including death, myocardial infarction, target vessel revascularization and stroke at 30 days. Results A total of 122 patients were equally divided into Diver CE group and Guardwire Plus group, which were comparable by age （（60±14） years vs （60±13） years）, male （82% vs 84%）, diabetes （31% vs 28%）, previous coronary artery disease （25% vs 23%）, onset-to-angiogram （（350±185） min vs （345±180） min）, and use of glycoprotein lib/llia inhibitor （11% vs 13%）. The magnitude of ST-segment resolution was similar in the two groups as ST-segment resolution 〉70% （57% vs 59%; P〉0.05）. Similar slow flow/no-reflow rates were observed in the Diver CE group （8%） and the Guardwire Plus group （7%）. TIMI flow grade 3 was obtained in 95% vs 97% patients, respectively （P〉0.05）. Myocardial blush grade 3 was similar （70% vs 72%; P〉0.05）. Thirty-day clinical outcome was comparable （LVEF, 0.54±0.12 vs 0.53 ±0.11; death, 3% vs 3%; myocardial infarction, 2% vs 0%; and target vessel revascularization, 2% vs 2%; P〉0.05, respectively）. Conclusions Re

关键词： acute myocardial infarction stenting thrombectomy devices

Oxaliplatin and 5-fluorouracil hepatic infusion with lipiodolized chemoembolization in large hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第13期21卷 3970-3977页

作者： Jing-Huan Li Xiao-Ying Xie Lan Zhang Fan Le Ning-Ling Ge Li-Xin Li Yu-hong Gan Yi Chen Ju-Bo Zhang Tong-Chun Xue Rong-Xin Chen Jing-Lin Xia Bo-Heng Zhang Sheng-Long Ye yan-hong wang Zheng-Gang Ren Key Laboratory of Carcinogenesis and Cancer Invasion Liver Cancer InstituteZhongshan HospitalFudan UniversityMinistry of Education

AIM: To investigate transarterial chemoembolization(TACE) with hepatic infusion of oxaliplatin and 5-fluorouracil and Lipiodol chemoembolization in large hepatocellular carcinoma(HCC).METHODS: In this retrospective study, 132 patients with unresectable HCCs larger than 10 cm were treated with hepatic infusion of oxaliplatin and 5-fluorouracil followed by Lipiodol chemoembolization. The primary endpoint was overall survival(OS). Sixteen-week disease-control rate, time to progression(TTP), and major complications were also studied. Univariate and multivariate analyses were performed to identify prognostic factors affecting OS and ***: A total of 319 procedures were performed in the 132 patients. Eleven(8.3%) patients received radical resection following TACE treatment(median time to initial TACE 4.3 ± 2.3 mo). The median OS and TTP were 10.3 and 3.0 mo respectively, with a 50.0% 16-wk disease-control rate. Major complications were encountered in 6.0%(8/132) of patients following TACE and included serious jaundice in 1.5%(2/132) patients, aleukia in 1.5%(2/132), and hepatic failure in 3.0%(4/132). One patient died within one month due to serious hepatic failure and severe sepsis after receiving the second TACE. The risk factor associated with TTP was baseline alpha-fetoprotein level, and vascular invasion was an independent factor related to ***: Hepatic infusion of oxaliplatin and 5-fluorouracil followed by lipiodolized-chemoembolization is a safe and promising treatment for patients with HCCs larger than 10 cm in diameter.

关键词： Hepatic infusion Large hepatocellular carcinoma Ox

Functional analysis of missense mutations in GLI2 and GLI3 involved in congenital heart disease

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Reproductive and Developmental Medicine 2023年第2期7卷 83-87页

作者： Rui Peng Lei Lu Bing-Kun Lei hong-yan wang Xiao-Ying Yao Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Institute of Metabolism and Integrative Biology Fudan UniversityShanghai 200438China

Objective:In this study,we aimed to explore the biological functions of 10 rare case-specific missense mutations in GLI2 and 4 in GLI3,which were previously screened in a cohort of 412 patients with congenital heart disease(CHD)and 213 normal controls from Shandong Province,***:A dual-luciferase reporter assay was used to assess the effects of these mutations in GLI2 and GLI3 on the activity of the sonic Hedgehog signaling pathway in HEK293T *** in protein levels between mutant and wild-type GLI2 and GLI3 were detected in HEK293T cells using Western ***:The dual-luciferase reporter assay showed that compared to the wild-type GLI2 protein,p.A1113V significantly increased activation of the sonic Hedgehog signaling pathway,whereas p.H78P and p.I1451S did not have a significant *** other mutations largely reduced the activation *** with the wild-type GLI3 protein,only p.A286V,among the four mutations,significantly reduced the activation effect on the SHH signaling *** blotting data showed reduced expression of GLI2 p.G716V,GLI2 p.K736N,GLI2 p.I1451S,and GLI3 p.A286V,whereas the remaining mutations had no significant ***:The mutations GLI2 c.2147G>T(p.G716V),GLI2 c.2208G>C(p.K736N),and GLI3 c.857C>T(p.A286V)involved in CHD affect the regulation of the sonic Hedgehog signaling pathway;thus,these rare missense mutations in GLI2 and GLI3 might increase the risk of CHD.

关键词： Congenital heart disease Missense mutations

Valsartan Decreases Platelet Activity and Arterial Thrombotic Events in Elderly Patients with Hypertension

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Chinese Medical Journal 2015年第2期128卷 153-158页

作者： Fang Wu hong-yan wang Fan Cai Ling-Jie wang Feng-Ru Zhang Xiao-Nan Chen Qian yang Meng-Hui Jiang Xue-Feng wang Wei-Feng Shen Department of Geriatrics Ruijin Hospital Jiao Tong University School of Medicine Shanghai 200025 China Department of Cardiology Ruijin Hospital Jiao Tong University School of Medicine Shanghai 200025 China Institute of Health Sciences Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200025 China Department of Laboratory Medicine Ruijin Hospital Jiao Tong University School of Medicine Shanghai 200025 China

Background：Angiotensin type 1 receptor （AT1R） antagonists are extensively used for blood pressure control in elderly patients with *** study aimed to investigate the inhibitory effects of AT1R antagonist valsartan on platelet aggregation and the occurrence of cardio-cerebral thrombotic events in elderly patients with ***：Two-hundred and ten patients with hypertension and aged 〉 60 years were randomized to valsartan （n =140） or amlodipine （n =70） on *** primary endpoint was platelet aggregation rate （PAR） induced by arachidonic acid at discharge,and the secondary endpoint was the rate of thrombotic events including brain infarction and myocardial infarction during *** aortic endothelial cells （HAECs） were stimulated by angiotensin Ⅱ （Ang Ⅱ,100 nmol/L） with or without pretreatment of valsartan （100 nmol/L）,and relative expression of cyclooxygenase-2 （COX-2） and thromboxane B2 （TXB2） and both p38 mitogen-activated protein kinase （p38MAPK） and nuclear factor-kB （NF-kB） activities were *** analyses were performed by GraphPad Prism 5.0 software （GraphPad Software,Inc.,California,USA）.Results：PAR was lower after treatment with valsartan （1 1.49 ± 0.69% vs.18.71 ± 2.47%,P 〈 0.001）,associated with more reduced plasmalevels of COX-2 （76.94 ± 7.07 U/L vs.116.4 ± 15.89 U/L,P 〈 0.001） and TXB2 （1667 ± 56.50 pg/ml vs.2207 ± 180.20 pg/ml）（all P 〈 0.001）.Plasma COX-2 and TXB2 levels correlated significantly with PAR in overall patients （r =0.109,P 〈 0.001）.During follow-up （median,18 months）,there was a significantly lower thrombotic event rate in patients treated with valsartan （14.3% vs.32.8%,P =0.002）.Relative expression of COX-2 and secretion of TXB2 with concordant phosphorylation ofp38MAPK and NF-kB were increased in HAECs when stimulated by Ang Ⅱ （100 nmol/L） but were significantly decreased by valsartan pretreatment （100 nmol/L）.Conclusions：AT1R antagonist valsartan decreases platelet activity by attenua

关键词： Angiotensin Type 1 Receptor Antagonist Elderly Hypertension Platelet Activity Thrombosis

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胰腺分裂症的内镜微创治疗研究进展

世界华人消化杂志 2024年第3期32卷 199-202页

作者：王艳红邢台市人民医院内镜中心河北省邢台市054000

胰腺分裂症是胰腺的一种先天性解剖变异性疾病,内镜微创治疗疗效好、恢复快、并发症少.本文就胰腺分裂症的发病机制、诊断及治疗方法做一综述.

关键词：胰腺分裂症内镜微创治疗内镜逆行性胰胆管造影术超声内镜

Deficiency of Antisense lncRNA Gm48853 Resulted in Embryonic Lethality and Impaired Placental Development in Mice

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Reproductive and Developmental Medicine 2019年第1期3卷 5-10页

作者： Qi-Yun Qin Wei-Jia Zeng Chu-Yue Peng Yu-Fang Zheng hong-yan wang The Institute of Reproduction and Developmental Biology Obstetrics and Gynecology HospitalFudan UniversityShanghai 200438China Institute of Developmental Biology and Molecular Medicine Fudan UniversityShanghai 200438China The State Key Laboratory of Genetic Engineering MOE Key Laboratory of Contemporary AnthropologySchool of Life ScienceFudan UniversityShanghai 200438China Children’s Hospital and Institutes of Biomedical Sciences Fudan UniversityShanghai 200438China

Objective:Long noncoding RNAs(lncRNAs)play important roles in embryonic development and in various ***48853 is a predicted natural antisense lncRNA gene of unknown *** present study aimed to investigate its expression and ***:Quantitative reverse transcription-polymerase chain reaction and sequencing were used to detect the expression of Gm48853 antisense *** and eosin staining and pathological analysis were applied to evaluate the effects of Gm48853 mutations on embryonic/placental development.5-Ethynyl-2’-deoxyuridine(EdU)and terminal deoxynucleotidyl transferase deoxy-UTP-nick-end labeling assays were used to analyze the status of cell proliferation and apoptosis in Gm48853-deficient embryos and ***:PiggyBac(PB)transposon insertion into the intron of Gm48853 resulted in a significant decrease in Gm48853 expression and embryonic lethality at *** Gm48853 mutations led to severe growth retardation of embryos and impaired the morphogenesis of the placental *** addition,cell proliferation was dramatically decreased in Gm48853^(PB/PB) embryos and placentas,and apoptosis was radically increased in the mutant embryos but not in the mutant ***:Antisense lncRNA Gm48853 may regulate embryonic/placental development by enhancing cell proliferation and/or inhibiting apoptosis.

关键词： Antisense lncRNA Embryonic Development Gm48853 Placental Development

Investigation on Pd（Ⅱ/Ⅳ）-Catalyzed Reaction of Allyl 3-Phenylpropiolate

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Investigation on Pd（Ⅱ/Ⅳ）-Catalyzed Reaction of Allyl 3-P...

A novel angiographic technique, StentBoost, in comparison with intravascular ultrasound to assess stent expansion

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作者： yan-hong An and Zhi-hong wang~* The State Key Laboratory and Institute of Elemento-Organic Chemistry,Nankai University,Tianjin 300071

＜正＞In recent years,Pd（Ⅱ/Ⅳ）-catalyzed reactions of enynes have been widely and deeply ***,the mechanism of these reactions is *** paper studies the mechanism of the known but controversial reaction（Scheme 1） t...

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Chinese Medical Journal 2011年第6期124卷 939-942页

作者： yanG Fei-fei ZHANG Li-wei HUANG Dang-sheng SHEN Dong SUN hong-yan ZHANG Chun-hong wang Yu-mei ZHANG Xu-wen BAI Jing MA Yong-jiang Department of Cardiology First Affiliated Hospital of General Hospital of Chinese People's Liberation Army Beijing 100048China

Background StentBoost （SB） is a novel angiographic technique which can enhance stent visualization and improve detection of inadequate stent expansion. Studies of SB that compare it with intravascular ultrasound （IVUS）, which is the current gold standard for detection of stent underexpansion, remain inadequate. This study aimed to test the correlation of IVUS and SB, and to evaluate the effect of SB guiding the stent *** From March 2009 to June 2010, 52 patients were analyzed using quantitative coronary angiography （QCA）,IVUS, and SB. They included 37 patients （54 stents） with postdilatation and 15 patients （21 stents） without *** of stent diameter between the three modalities were *** The minimum diameter, maximum diameter and average diameter of postdilatation obtained by QCA, IVUS,SB were significantly larger than that of poststenting, and the ratio （maximum stent diameter （MaxLD）-minimum stent diameter （MinLD））/MaxLD of postdilatation was smaller. Correlations of MinLD were the highest between IVUS and SB （r=0.979, P 〈0.0001） when compared with QCA and SB （r=0.973, P 〈0.0001）, and QCA and IVUS （r=0.964, P 〈0.0001）.Conclusions SB has superior correlations for stent expansion measured by IVUS when compared with QCA. In addition, there is an important advantage for SB in guiding the stent postdilatation.

关键词： angiography coronary disease imaging stents postdilatation