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Ileal collision tumor associated with gastrointestinal bleeding: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 628-634页

作者： Yu-Qi Wu hong-yan wang Mu-Min Shao Lin Xu Xiao-yan Jiang Shao-Ju Guo Department of Gastroenterology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina Department of Pathology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina

BACKGROUND Collision tumors involving the small intestine,specifically the combination of a hamartomatous tumor and a lipoma,are extremely *** our knowledge,no previous case report has described a collision tumor composed of two benign tumors of different origins in the small *** SUMMARY Here,we present the case of an 82-year-old woman who presented with hemorrhagic shock and was found to have a mass measuring approximately 50 mm×32 mm×30 mm in the terminal *** on computed tomography scan findings,the mass was initially suspected to be a lipoma.A subsequent colonoscopy revealed a pedunculated submucosal elevation consisting of two distinct parts with a visible demarcation line.A biopsy of the upper portion suggested a juvenile polyp(JP).Owing to the patient’s advanced age,multiple comorbidities,and poor surgical tolerance,a modified endoscopic submucosal dissection was *** examination of the excised mucosal mass revealed a lipoma at the base and a JP at the top,demonstrating evidence of rupture and associated *** patient’s overall health remained satisfactory,with no recurrence of hematochezia during the six-month follow-up *** This case report provides new evidence for the understanding of gastrointestinal collision tumors,emphasizing their diverse clinical presentations and histopathological *** also offers diagnostic and therapeutic insights as well as an approach for managing benign collision tumors.

关键词： Collision tumor Gastrointestinal bleeding Hamartomatous tumor Lipoma Modified endoscopic submucosal dissection Case report

Msx2 plays a critical role in lens epithelium cell cycle control

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 276-279页

作者： Jiang-Yue Zhao Feng-Feng Zhuang hong-yan wang Di Wu Jin-Song Zhang Eye Hospital of China Medical University Department of Ophthalmology the 4~(th) Affiliated Hospital of China Medical University Provincial Key Laboratory of Lens Research Department of Ophthalmology and Doheny Eye Institute Keck School of Medicine University of Southern California Department of General Surgery People's Hospital of Liaoning Province

AIM: To investigate the effects of Msx2 on lens epithelium cell cycle, and evaluate the changes of the proliferation, apoptosis of lens epithelium cells. METHODS: Mice lens epithelium cells were cultured and transfected with pEGFP-Msx2 and control. Msx2-deficient mice (Msx2(-/-)) lens tissue were isolated. Lens tissue and transfected cells were prepared for mRNA extraction using Trizol reagent. CyclinD1 and Prox1 expression were evaluated by real-time RT-PCR. BrdU incorporation and apoptosis rate were investigated by immunofluorescence and flow cytometry analysis. RESULTS: After transfected with pEGFP-Msx2, lens epithelium cells failed to incorporate BrdU and anti - phospho-histone-3 immunofluorescence failed to detect cell nuclei which GFP were positive. Msx2 over expression resulted in increasing apoptosis rate in lens epithelium cells. CyclinD1 and Prox1 expression increased significantly in Msx2 knockout mice by real time RT-PCR quantization and CyclinD1 expression decreased significantly in Msx2overexpressed cell. CONCLUSION: Msx2 has the effect of inhibiting proliferation and differentiation, triggering apoptosis on mice lens epithelium cells.

关键词： Msx2 lens epithelium cell cell cycle

Metastatic infection caused by hypervirulent Klebsiella pneumonia and co-infection with Cryptococcus meningitis: A case report

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World Journal of Clinical Cases 2019年第22期7卷 3812-3820页

作者： Yun-Feng Shi Yu-Kai wang yan-hong wang Hui Liu Xiao-Han Shi Xiao-Jie Li Ben-Quan Wu Medical Intensive Care Unit Department of Respiratory and Critical Care MedicineThird Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Institute of Respiratory Diseases Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Laboratory Medicine Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Klebsiella pneumoniae(***)used to affect mainly people with compromised immunity or weakened by other infections,but recent emergence of hypervirulent strains has increased infections even in healthy *** infections include liver abscess,pneumonia,bacteremia,meningitis,necrotizing fasciitis,and *** metastatic infection by hypervirulent ***(hvKP)is increasingly recognized,co-infection with Cryptococcus neoformans(***)meningitis in immunocompetent hosts is rare but ***,it is necessary to determine the risk factors,complications,and comorbidity of this *** SUMMARY This report describes a 58-year-old man with hvKP pulmonary abscess,bacteremia,and meningitis,accompanied by fatal Cryptococcus *** patient presented with fever for 1 wk and drowsiness for 3 *** findings revealed pulmonary abscess and bacteremia of *** was given intravenous antibiotic therapy,and the infection was under control for about 1 ***,his condition deteriorated rapidly because of metastatic purulent *** hvKP and *** were isolated and confirmed,the patient died of spontaneous respiratory and cardiac arrest caused by cerebral *** HvKP has emerged as a cause of metastatic infections in immunocompetent *** co-infections should be taken into consideration when metastatic infection is present.

关键词： Hypervirulent Klebsiella pneumoniae Metastatic infection Cryptococcusneoformans meningitis Comorbidity Case report

Retraction note to:Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole:A randomized controlled trial

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World Journal of Gastroenterology 2023年第1期29卷 221-222页

作者： Qing-Hua Sun hong-yan wang Shi-Dong Sun Xin Zhang Han Zhang Department of Gastroenterology Peking University Third HospitalBeijing 100191China Department of Gastroenterology PKUCare Luzhong HospitalZibo 255400Shandong ProvinceChina

We have decided to retract the above article for further consideration due to a data labelling error.

关键词： Retraction note

Two New Sesquiterpenes from Celastrus ***

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Chinese Chemical Letters 1997年第11期8卷 961-964页

作者： Kun ZHANG yan hong wang Yao Zu CHEN (The State Key Laboratory of Applied Organic Chemistry, Lanzhou University,Lanzhou. 730000)(Institute of Organic Chemistry, Zhejiang University, Hangzhou,310027)(Guangdong University of Technology,Guangzhau,510090) State Key Lab. of Appl. Organ. Chem. Lanzhou University Lanzhou 730000 China Institute of Organic Chemistry Zhejiang University Hangzhou 310027 China Guangdong University of Technology Guangzhau 510090 China

Two new beta-dihydroagarofuran sesquiterpene polyol esters were isolated from Celastrus ***. Their Structures were deduced on the basis of spectral analyses including 2D NMR. CO2 supercritical fluid was used in separa... 详细信息

关键词： CDC Two New Sesquiterpenes from Celastrus Paniculatus.Subsp.Paniculatus

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Metal-organic framework IRMOFs coated with a temperaturesensitive gel delivering norcantharidin to treat liver cancer

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World Journal of Gastroenterology 2021年第26期27卷 4208-4220页

作者： Xiu-yan Li Qing-Xia Guan Yu-Zhou Shang yan-hong wang Shao-Wa Lv Zhi-Xin yang Rui wang Yu-Fei Feng Wei-Nan Li Yong-Ji Li College of Pharmacy Heilongjiang University of Chinese MedicineHarbin 150040Heilongjiang ProvinceChina

BACKGROUND Norcantharidin(NCTD)is suitable for the treatment of primary liver cancer,especially early and middle primary liver *** compound can reduce tumors and improve immune ***,the side effects of NCTD have limited its *** is a marked need to reduce the side effects and increase the efficacy of *** To develop a nanomaterial carrier,NCTD-loaded metal-organic framework IRMOF-3 coated with a temperature-sensitive gel(NCTD-IRMOF-3-Gel),aiming to improve the anticancer activity of NCTD and reduce the drug *** NCTD-IRMOF-3-Gel was obtained by a coordination *** apparent characteristics and in vitro release of NCTD-IRMOF-3-Gel were *** cytotoxicity assays,flow cytometry,and apoptosis experiments in mouse hepatoma(Hepa1-6)cells were used to determine the anti-liver cancer activity of NCTD-IRMOF-3-Gel in in vitro *** The particle size of NCTD-IRMOF-3-Gel was 50-100 nm,and the particle size distribution was *** release curve showed that NCTD-IRMOF-3-Gel had an obvious sustained-release *** cytotoxicity assays showed that the free drug NCTD and NCTD-IRMOF-3-Gel treatments markedly inhibited Hepa1-6 cell proliferation,and the inhibition rate increased with increasing drug *** flow cytometry,NCTD-IRMOF-3-Gel was observed to block the Hepa1-6 cell cycle in the S and G2/M phases,and the thermosensitive gel nanoparticles may inhibit cell proliferation by inducing cell cycle *** experiments showed that NCTD-IRMOF-3-Gel induced the apoptosis of Hepa1-6 *** Our results indicated that the NCTD-IRMOF-3-Gel may be beneficial for liver cancer disease treatment.

关键词： Norcantharidin Metal-organic frameworks IRMOF-3 Temperature-sensitive gel Drug delivery Liver cancer

Out-of-pocket payments and economic consequences from tuberculosis care in eastern China:income inequality

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Infectious Diseases of Poverty 2020年第1期9卷 26-35页

作者： yan Liu Cai-hong Xu Xiao-Mo wang Zhen-Yu wang yan-hong wang Hui Zhang Li wang Department of Epidemiology and Biostatistics Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Critical Care Medicine The Second People’s Hospital of Shenzhen&First Affiliated Hospital of Shenzhen UniversityHealth Science CenterShenzhen 518035China National Center for Tuberculosis Control and Prevention China Center for Disease ControlBeijing 100226China

Background:Despite the availability of free tuberculosis(TB)diagnosis and treatment,TB care still generates substantial costs that push people into *** investigated out-of-pocket(OOP)payments for TB care and assessed the resulting economic burden and economic consequences for those with varying levels of household income in eastern ***:A cross-sectional study was conducted among TB patients in the national TB programme networks in eastern ***-related direct OOP costs,time loss,and coping strategies were investigated across households in different economic *** of Variance was used to examine the differences in various costs,and Kruskal-Wallis tests were used to compare the difference in total costs as a percentage of annual household ***:Among 435 patients,the mean OOP total costs of TB care were USD *** the lower-income quartile,OOP payments were lower,but costs as a percentage of reported annual household income were *** costs and costs prior to treatment accounted for 66.4 and 48.9%of the total costs,*** lower the household income was,the higher the proportion of medical costs to total costs before TB treatment,but the lower the proportion of medical costs patients spent in the intensive *** care caused 25.8%of TB-affected households to fall below the poverty line and caused the poverty gap(PG)to increase by United States Dollar(USD)*** in the poorest households had the highest poverty headcount ratio(70.2%)and PG(USD 236.1),but those in moderately poor households had the largest increase in the poverty headcount ratio(36.2%)and PG(USD 177.8)due to TB *** from poor households were more likely to borrow money to cope with the costs of TB care;however,there were fewer social consequences,except for food insecurity,in poor ***:Medical and pretreatment costs lead to high costs of TB care,especially among patients from the poorest *** is nec

关键词： Out-of-pocket payment Tuberculosis Impoverishment Coping strategy Eastern China

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Cardiac involvement in light chain amyloidosis: a case report

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Journal of Geriatric Cardiology 2020年第6期17卷 373-378页

作者： Jing LI hong-yan wang Ning BIAN Ru-Yi XU Can HUA Shao-Li NIU Zhuo-Kun GAN Qing wang Hai-Tao TIAN VIP Cardiovascular Department the Sixth Medical Center of Chinese PLA General Hospital

Amyloidosis refers to a group of heterogeneous diseases in which amyloid fibers deposited in organ and extracellular tissue comprise misfolded precursor proteins.[1] According to the variety of misfolded proteins, the site of production and the type of tissue infiltrated, amyloidosis of the myocardium is divided into five subtypes: immunoglobulin light chain(AL), secondary amyloidosis(or reactive amyloido-

关键词： Arrhythmias Cardiac amyloidosis Diagnosis Immunoglobulin light chains Thromboembolism

The effects of biodiversity gradient on plant mass and metabolism of individual submerged macrophytes

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Ecological Processes 2021年第1期10卷 500-509页

作者： Liang-Yu Qi hong-Yuan Zeng Zhong-Xi Bai yan-hong wang Li Liu Wen Zhong Shi-Yun Ye Hui Fu Feng Li Chang-Liang Shao Ai-Ping Wu Ecology Department College of Resources&EnvironmentHunan Provincial Key Laboratory of Rural Ecosystem Health in Dongting Lake AreaHunan Agricultural UniversityChangsha 410128China. School of Forestry and Bio-technology Zhejiang Agriculture and Forestry UniversityHangzhou 311300China. CAS Key Laboratory of Agro-ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChangsha 410128China. National Hulunber Grassland Ecosystem Observation and Research Station&Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesBeijing 100081China.

Background:The effects of biodiversity on community function and services are frequently studied in the history of ecology,while the response of individual species to biodiversity remains great *** this study,we determined the biodiversity effects on community productivity as well as species level plant mass and carbon(C)and nitrogen(N)metabolism of eight submerged *** macrophytes in Lake Erhai were selected and planted in a water depth of one meter along a diversity gradient of 1,2,4 or 8 ***,the community productivity or species level plant mass,soluble protein,free amino acid and soluble carbohydrate were correlated to species richness to determine the biodiversity effects on community and single ***:The results showed that the community level biomass was positively correlated to plant species richness although the species level plant mass of individual species responded differently to the overall plant species ***,only one plant mass positively correlated to species richness and the others decreased or showed no significant correlation with the increase of species *** soluble proteins of most macrophytes were positively correlated to species richness;however,both the free amino acid and soluble carbohydrate of the plants were negatively or not significantly correlated to species ***:These results indicated that the selection effects might dominate in our aquatic communities and the negative impacts of biodiversity on C and N metabolism of the macrophytes increased with the increase of species richness,which might result from the strong competition among the studied *** biodiversity effects on the plant mass,and C and N metabolism of individual submerged species were first reported in this study,while more such field and control experiments deserve further research.

关键词： Species richness Productivity Competition Submerged macrophyte Metabolism Biodiversity