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Effect of cytochrome P4502C19(CYP2C19)gene polymorphism and clopidogrel reactivity on long term prognosis of patients with coronary heart disease after PCI

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Journal of Geriatric Cardiology 2024年第1期21卷 90-103页

作者： cheng-yan hu yan-Ling WANG Zhen-Xing FAN Xi-Peng SUN Shuai WANG Zhi LIU Department of Geriatrics Fu Xing HospitalCapital Medical UniversityBeijingChina Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Emergency Department of Xuanwu Hospital Capital Medical UniversityBeijingChina

Objective To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with longterm clinical outcome in patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods In total,675 patients were *** on the platelet inhibition rate,patients were categorized into two groups:clopidogrel low responsiveness(CLR)and normal clopidogrel responsiveness(NCR).The CLR group was divided into ticagrelor and clopidogrel group based on the antiplatelet drugs used in the follow-up *** were classified into three groups(normal metabolizer,intermediate metabolizer,and poor metabolizer)based on the CYP2C19 *** aimed to evaluate the impact of CYP2C19 gene polymorphism on clopidogrel *** cumulative rates of 12-month all-cause deaths,major adverse cardiovascular events(MACCEs),and bleeding events were *** CLR was observed in 44.4%of the overall *** differences were observed in the platelet inhibition rate of clopidogrel among the three metabolic genotypes(P0.05).Conclusions Low response to clopidogrel in CHD patients is correlated with CYP2C19 gene ***2C19 genotyping combined with platelet reactivity is an independent predictor of 12-months MACCEs in patients with clopidogrel treatment after PCI,which is better than either test alone.

关键词： CYP2C19 drugs PCI

Efficacy of comprehensive remote ischemic conditioning in elderly patients with acute ST-segment elevation myocardial infarction underwent primary percutaneous coronary intervention

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Journal of Geriatric Cardiology 2022年第6期19卷 435-444页

作者： yan-Ling WANG Qi yanG cheng-yan hu yan-yan Chu Zheng SUN huan ZHAO Zhi LIU Department of Cardiology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijingChina

BACKGROUND Remote ischemic conditioning(RIC)is used to protect against myocardial ***,there is no adequate evidence for comprehensive RIC in elderly patients with ST-segment elevation myocardial infarction(STEMI).This study aimed to test whether comprehensive RIC,started pre-primary percutaneous coronary intervention(PPCI)and repeated daily on 1-30 days post-PPCI,can improve myocardial salvage index(SI),left ventricular ejection fraction(LVEF),Kansas City Cardiomyopathy Questionnaire Clinical Summary Score(KCCQ-CSS)and 6-min walk test distance(6MWD)in elderly patients with acute STEMI during 12 months *** 328 consenting elderly patients were randomized to receive standard PPCI plus comprehensive RIC(the treatment group)or standard PPCI(the control group).SI at 5-7 days after PPCI,LVEF,left ventricular end-diastolic volume index(LVEDVI),left ventricular end-systolic volume index(LVESVI),KCCQ-CSS,6MWD and adverse events rates were measured and *** SI was significantly higher in the treatment group[interquartile range(IQR):0.38-0.66,P=0.037].There were no significant differences in major adverse events at 12 *** the differences of LVEDVI,LVESVI and LVEF between the treatment group and the control group did not reach statistical significance at 6 months and 12 months,LVEF tended to be higher,LVEDVI tended to be lower in the treatment *** KCCQ-CSS was significantly higher in the treatment group at 1 month(IQR:46.5-87,P=0.001)and 12 months(IQR:55-93,P=0.008).There was significant difference in 6MWD between the treatment group and the control group(IQR:258-360 ***:250-345,P=0.002)at 1 month and(IQR:360-445 ***:345-432,P=0.035)at 12 months.A modest correlation was found between SI and LVEF(r=0.452,P<0.01),KCCQ-CSS(r=0.440,P<0.01)and 6MWD(r=0.384,P<0.01)respectively at 12 *** The comprehensive RIC can improve SI,KCCQ-CSS and *** may be an adjunctive therapy to PPCI in elderly patients with STEMI

关键词： patients infarction coronary

Acid-catalyzed chemoselective C-and O-prenylation of cyclic 1,3-diketones

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Chinese Journal of Catalysis 2020年第9期41卷 1401-1409页

作者： Ying Li yan-cheng hu Ding-Wei Ji Wei-Song Zhang Gu-cheng He Yu-Feng Cong Qing-An Chen Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023LiaoningChina College of Chemistry Chemical Engineering and Environmental EngineeringLiaoning Shihua UniversityFushun 113001LiaoningChina

The chemoselective C-and O-prenylation of cyclic 1,3-diketones was achieved by tuning the prenyl source and *** the presence of the solid acid Nafion,the coupling of 1,3-cyclohexanediones with isoprene gave C-prenylated ***,using prenol as the substrate with the Lewis acid Al Cl3 as the catalyst resulted in the exclusive O-prenylation of 1,***,the resulting products could easily undergo aromatization to deliver prenylated resorcinols that are otherwise difficult to *** methodology is highly selective,atom-economical,operationally simple,easily scalable,and has potential applications throughout organic synthesis.

关键词： 5-Chromenones 1 3-Cyclohexanediones O-Prenylation [3+3]Annulation Isoprene Prenol

A Novel Disturbance Observer Based Fixed-Time Sliding Mode Control for Robotic Manipulators With Global Fast Convergence

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 661-672页

作者： Dan Zhang Jiabin hu Jun cheng Zheng-Guang Wu huaicheng yan IEEE Zhejiang University of Technology Guangxi Normal University Zhejiang University the East China University of Science and Technology

This paper proposes a new global fixed-time sliding mode control strategy for the trajectory tracking control of uncertain robotic ***,a fixed-time disturbance observer(FTDO) is designed to deal with the adverse effects of model uncertainties and external disturbances in the manipulator *** an adaptive scheme is used and the adaptive FTDO(AFTDO) is developed,so that the priori knowledge of the lumped disturbance is not ***,a new non-singular fast terminal sliding mode(NFTSM) surface is designed by using an arctan function,which helps to overcome the singularity problem and enhance the robustness of the *** on the estimation of the lumped disturbance by the AFTDO,a fixed-time non-singular fast terminal sliding mode controller(FTNFTSMC)is developed to guarantee the trajectory tracking errors converge to zero within a fixed *** settling time is independent of the initial state of the *** addition,the stability of the AFTDO and FTNFTSMC is strictly proved by using Lyapunov ***,the fixed-time NFESM(FTNFTSM) algorithm is validated on a 2-link manipulator and comparisons with other existing sliding mode controllers(SMCs) are *** comparative results confirm that the FTNFTSMC has superior control performance.

关键词： Disturbance observer(DO) fixed-time non-singular sliding mode control robotic manipulator trajectory tracking

Microstructure,wear and friction behavior of CoCrAITaY-xCNTs composite coatings deposited by laser-induction hybrid cladding

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Rare Metals 2024年第4期43卷 1815-1827页

作者： Sheng-Feng Zhou Yu Long yan-Liang Yi cheng Deng Lian-Xi hu Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou510632China Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and TechnologyWuhan430074China MOE Key Laboratory of New Processing Technology for Non-Ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsGuangxi UniversityNanning530004China School of Mechatronics Engineering Guangdong Polytechnic Normal UniversityGuangzhou510635China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China

To improve the wear performance of CoCrAlYTa coating,part of the carbon nanotubes(CNTs)chemically reacted with Ta to form reinforcement phase(TaC),while the other CNTs were retained as lubrication ***,the CoCrAlYTa-xCNTs(x=0,1,2,and 4;wt%)composite coatings were prepared by laserinduction hybrid cladding(LIHC),and the microstructure and wear resistance of coatings were systematically *** show that the coatings are mainly composed of TaC,y-(Co,Cr)andβ-(Co,Cr)*** the CNTs content increases from 0 wt%to 4 wt%,the volume fraction of TaC increases from 13.11 vol%to 16.12 vol%.Meanwhile,the nano-hardness ofγ-(Co,Cr)andβ-(Co,Cr)Al are improved from 7.49 and 9.72 to 9.36 and 11.19 GPa,*** a result,the microhardness of coating increases from HV536.25 to HV 738.16,the wear rate decreases from32.4×10^(-3)to 6.1×10^(-3)mg·m^(-1),and the average friction coefficient decreases from 0.55 to *** good wear performance of the coating is attributed to the formation of TaC and the existence of remained CNTs lubricant film.

关键词： Carbon nanotube MCrAlY coating Friction and wear performance Laser-induction hybrid cladding

Catalytic C2 prenylation of unprotected indoles:Late‐stage diversification of peptides and two‐step total synthesis of tryprostatin B

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Chinese Journal of Catalysis 2021年第9期42卷 1593-1607页

作者： yan‐cheng hu Ying Li Ding‐Wei Ji Heng Liu Hao Zheng Gong Zhang Qing‐An Chen Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

C2 prenylated indoles are widespread in a variety of bioactive natural ***,theselective installation of prenyl group at C2 position of NH indoles is of great ***,the known protocols generally require a multi‐step procedure and stoichiometric *** develop a one‐step C2 prenylation of NH indole with cheap tert‐prenyl alcohol enabled by *** features include good regioselectivity,step‐and atom‐economy,broad substratescope,and simple catalytic *** mechanistic investigations demonstrate that both C2prenylation and C3 prenylation/migration pathways are engaged in the ***,this practicalstrategy can be applied to the late‐stage diversification of tryptophan‐based peptides and concisesynthesis of tryprostatin B.

关键词： Indole prenylation Step economy Atom economy Tryptophan Peptide diversification Total synthesis

Impact of next-generation sequencing on antimicrobial treatment in immunocompromised adults with suspected infections

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World Journal of Emergency Medicine 2024年第2期15卷 105-110页

作者： Jia Li Jiazhen Luo Tao hu Ling cheng Weiwei Shang Li yan Department of Intensive Care Unit Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Emergency Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

BACKGROUND:Prompt pathogen identification can have a substantial impact on the optimization of antimicrobial *** objective of the study was to assess the diagnostic value of next-generation sequencing(NGS)for identifying pathogen and its clinical impact on antimicrobial intervention in immunocompromised patients with suspected ***:This was a retrospective *** January and August 2020,47 adult immunocompromised patients underwent NGS testing under the following clinical conditions:1)prolonged fever and negative conventional cultures;2)new-onset fever despite empiric antimicrobial treatment;and 3)afebrile with suspected infections on *** data,including conventional microbial test results and antimicrobial treatment before and after NGS,were *** were analyzed according to documented changes in antimicrobial treatment(escalated,no change,or deescalated)after the NGS ***:The median time from hospitalization to NGS sampling was 19 *** relevant pathogens were detected via NGS in 61.7% of patients(29/47),more than half of whom suffered from fungemia(n=17),resulting in an antimicrobial escalation in 53.2% of patients(25/47)and antimicrobial de-escalation in 0.2% of patients(1/47).Antimicrobial changes were mostly due to the identification of fastidious organisms such as Legionella,Pneumocystis jirovecii,and *** the remaining three cases,NGS detected clinically relevant pathogens also detected by conventional cultures a few days *** antimicrobial treatment was subsequently adjusted according to the susceptibility test ***,NGS changed antimicrobial management in 55.3%(26/47)of patients,and conventional culture detected clinically relevant pathogens in 14.9% of the patients(7/47).CONCLUSION:With its rapid identification and high sensitivity,NGS could be a promising tool for identifying relevant pathogens and enabling rapid appropriate treatment in immunocompromised patients w

关键词： Immunocompromised patients Next-generation sequencing Antimicrobial management

Utilizing interpretable stacking ensemble learning and NSGA-Ⅲ for the prediction and optimisation of building photo-thermal environment and energy consumption

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Building Simulation 2024年第5期17卷 819-838页

作者： Yeqin Shen Yubing hu Kai cheng Hainan yan Kaixiang Cai Jianye hua Xuemin Fei Qinyu Wang School of Arts Jiangsu UniversityZhenjiang212013China School of Architecture and Urban Planning Nanjing UniversityNanjing210093China School of Computer Science and Communication Engineering Jiangsu UniversityZhenjiang212013China

This study develops an approach consisting of a stacking model integrated with a multi-objective optimisation algorithm aimed at predicting and optimising the ecological performance of *** integrated model consists of five base models and a meta-model,which significantly improves the prediction ***,the R2 value was improved by 9.19% and the error metrics MAE,MSE,MAPE,and CVRMSE were reduced by 69.47%,79.88%,67.32%,and 57.02%,respectively,compared to the single prediction *** to the research on interpretable machine learning,adding the SHAP value gives us a deeper understanding of the impact of each architectural design parameter on the *** the multi-objective optimisation part,we used the NSGA-Ⅲ algorithm to successfully improve the energy efficiency,daylight utilisation and thermal comfort of the ***,the optimal design solution reduces the energy use intensity by 31.6 kWh/m^(2),improves the useful daylight index by 39%,and modulated the thermal comfort index,resulting in a decrement of 0.69℃ for the summer season and an enhancement of 0.64℃ for the winter season,***,this study provides building designers and decision makers with a tool to make better design decisions at an early stage to achieve a better combination of energy efficiency,daylight utilisation and thermal comfort optimisation in an integrated manner,providing an important support for achieving sustainable building design.

关键词： building ecological performance ensemble learning multi-objective optimisation sustainable design explainable machine learning

Research on construction management innovation system of metro in China

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Engineering Sciences 2009年第3期7卷 66-71页

作者： Lu yan Dong Jianjun cheng hu Project Management Research Institute Southeast University Nanjing 210096 China

Construction management innovation system of metro in China is put forward in this paper. Guidelines,objective system,new management ideas and contents of this construction management innovation system are set forth particularly. The construction management innovation system of metro can meet needs of building harmonious and economized society and realizing sustainable development in China,it is also an important part of science & technology innovation system.

关键词： metro construction management innovation system China