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Propofol induces apoptosis and increases gemcitabine sensitivity in pancreatic cancer cells in vitro by inhibition of nuclear factor-κ B activity

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World Journal of Gastroenterology 2013年第33期19卷 5485-5492页

作者： Qi-Hang Du yan-bing xu Meng-Yuan Zhang Peng Yun Chang-Yao He Department of Anesthesiology Shandong Provincial Hospital Affiliated to Shandong University

AIM:To investigate the effect of propofol on human pancreatic cells and the molecular mechanism of propofol ***:We used the human pancreatic cancer cell line MIAPaCa-2 for in vitro studies measuring growth inhibition and degree of apoptotic cell death induced by propofol alone,gemcitabine alone,or propofol followed by *** experiments were conducted in triplicate and carried out on three or more separate *** were means of the three or more independent experiments±*** significant differences were determined by two-tailed unpaired Student’s t test and defined as P<***:Pretreatment of cells with propofol for 24 h followed by gemcitabine resulted in 24%-75% growth inhibition compared with 6%-18%when gemcitabine was used *** growth inhibition was directly correlated with apoptotic cell *** also showed that propofol potentiated gemcitabine-induced killing by downregulation of nuclear factor-κB(NF-κB).In contrast,NF-κB was upregulated when pancreatic cancer cells were exposed to gemcitabine alone,suggesting a potential mechanism of acquired ***:Inactivation of the NF-κB signaling pathway by propofol might abrogate gemcitabineinduced activation of NF-κB,resulting in chemosensitization of pancreatic tumors to gemcitabine.

关键词： Pancreatic cancer Propofol Gemcitabine Nuclear factor-κB Apoptosis

Expression of Peptidylarginine Deiminase 4 and Protein Tyrosine Phosphatase Nonreceptor Type 22 in the Synovium of Collagen-Induced Arthritis Rats

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Chinese Medical Sciences Journal 2014年第2期29卷 85-90页

作者： yan-bing xu Nai-zhi Wang Li-li yang Hua-dong Cui Hong-xia xue Ning Zhang Department of Rheumatology Shengjing Hospital of China Medical University

Objective To study the expression level of peptidylarginine deiminase 4(PADI4) and protein tyrosine phosphatase nonreceptor type 22(PTPN22) in the synovium of rat model of collagen-induced arthritis, and to explore their possible therapeutic role in rheumatoid arthritis. Methods Thirty-two female Wistar rats weighing 100±20 g were randomly assigned into 3-week collagen-induced arthritis(CIA) model group(n=8), 4-week CIA model group(n=8), 6-week CIA model group(n=8), and the control group(n=8). The body weight changes of each group were recorded. The expression levels of PADI4 and PTPN22 were detected and compared by the methods of immunohistochemical staining and Western blot. Results Arthritis of rat began to form 14 days after sensitization and the joint swelling reached peak at 28 days. The weights of the rats slowly grew both in CIA model groups and the control group. Immunohistochemical staining results showed that the positive expression of PADI4 and PTPN22 was mainly located in cartilage peripheral mononuclear cells, the cytoplasm of infiltrated cells, and bone marrow cavity. There were significant differences in the optical density of PADI4 and PTPN22 among CIA model groups and the control group(PADI4, 0.2898±0.012, 0.2982±0.022, 0.2974±0.031, 0.2530±0.013 in 3-week CIA model, 4-week CIA model, 6-week CIA model and control groups; PTPN22, 0.2723±0.004, 0.2781±0.010, 0.2767±0.008, 0.2422±0.019; all P <0.05). The expression bands of PADI4 were observed in Western blot 3 weeks after initial immunization, the thickest in the 4th week, and decreased in the 6th week. The expression bands of PTPN2 were observed at all the time points, with no obvious time-dependent trend. Conclusions PADI4 and PTPN22 are obviously correlated with CIA in rat model. PADI4 is expressed at early stage of the disease, while the expression of PTPN22 sustains throughout the course.

关键词： peptidylarginine deiminase 4 protein tyrosine phosphatase nonreceptor type 22 rheumatoid arthritis rat model

EFFECTS OF VASCULAR ZERO STRESS STATE ON PULSATILE BLOOD FOLW

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Journal of Hydrodynamics 2001年第2期13卷 40-49页

作者： Liu Zhao rong,Chen Yong,yan Yu bing,xu Gang Biomechanics Laboratory,Fudan University,Shanghai 200433,China

In this paper,blood flow in artery was treated as the flow under equilibrium state (the steady flow under mean pressure) combined with the periodically small sulsatile *** on vascular zero stress state ,the pulsatile strains according to the radial and axial displacements of blood vessel were *** the use of Hooke's law,the pulsatile strains and the corresponding Cauchy stresses were connected,so the corresponding wall motion equations could be established *** solving the linearized Navier Stokes equations,the analytic expressions of the blood flow velocities and the vascular displacements could be obtained,and the in fluence of the circumferential and axial stretch ratio on pulsatile blood flow and vascular motion was discussed in details.

关键词： pulse wave pulsatile blood flow,vessel wall,zero stress state

带有量测数据丢失的虚观测鲁棒卡尔曼滤波算法

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华中科技大学学报（自然科学版） 2016年第9期44卷 55-58页

作者：黄珏颜冰徐朋豪海军工程大学兵器工程系湖北武汉430033

针对传感器量测数据丢失的卡尔曼(Kalman)滤波问题进行了研究,提出了一种基于虚观测值的鲁棒卡尔曼滤波算法,针对伯努利(Bernoulli)分布描述的量测数据丢失的模型,充分利用当前时刻的先验信息,应用趋势移动平均法来预估构造丢失数据时... 详细信息

针对传感器量测数据丢失的卡尔曼(Kalman)滤波问题进行了研究,提出了一种基于虚观测值的鲁棒卡尔曼滤波算法,针对伯努利(Bernoulli)分布描述的量测数据丢失的模型,充分利用当前时刻的先验信息,应用趋势移动平均法来预估构造丢失数据时刻的虚观测值,建立了等效的传感器量测模型.利用鲁棒卡尔曼滤波方法来消除预测偏差较大的虚观测值对目标跟踪的影响,从而达到对目标的稳健跟踪.仿真实例说明了该算法能在量测数据丢失的情况下对目标进行有效的跟踪,跟踪精度高于跳变线性系统的卡尔曼滤波算法.

关键词：量测数据丢失卡尔曼(Kalman)滤波虚观测值伯努利分布跳变线性系统

Design and performance study of the HEPP-H calorimeter onboard the CSES satellite

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Research in Astronomy and Astrophysics 2018年第12期18卷 105-110页

作者： Yu-Fei Nan Zheng-Hua An Hang-xu Li Xiao-Yun Zhao Xiang-yang Wen Da-Li Zhang Shu-Guang Cheng Xin-Qiao Li Hui Wang Xiao-Hua Liang Feng Shi yan-bing xu Xiao-Xia Yu Ping Wang Hong Lu Huan-Yu Wang Yu-Qian Ma School of Physics Northwest UniversityXi'an 710069China Key Laboratory of Particle Astrophysics(LPA) Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

The China Seismo-Electromagnetic Satellite(CSES) will investigate iono-magnetospheric disturbance and will monitor the temporal stability of the inner Van Allen radiation *** particular,the mission aims at confirming the existences of a temporal correlation between the occurrence of earthquakes and the observation of electromagnetic disturbances, plasma fluctuations and anomalous fluxes of high-energy particles precipitating from the inner Van Allen belt in *** high energy detector of the High Energy Particle Package(HEPP-H) is a payload onboard CSES and is designed for detecting electrons(2–50 MeV) and protons(20–200 MeV) in its 500 km orbit above *** was launched in February *** this paper, the instrumentation and development of the HEPP-H calorimeter are *** calibration with beam particles(electrons and protons) is discussed in detail.

关键词： telescopes instrumentation:detectors site testing

Synthesis for New Azasugars from Ketosugar

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有机化学 2004年第Z1期24卷 353-页

作者： ZHANG,Hong-Yu ZHANG,yan-bing xu,Wei-Chao LIU,Hong-Min Department of Chemistry New Drug Research & Development Center of Zhengzhou University Zhengzhou 450052 Department of Chemistry New Drug Research & Development Center of Zhengzhou University Zhengzhou 450052 Department of Chemistry New Drug Research & Development Center of Zhengzhou University Zhengzhou 450052 Department of Chemistry New Drug Research & Development Center of Zhengzhou University Zhengzhou 450052

　　Imino sugars, sometimes called azasugars, are an important class of natural and unnatural compounds that have activity to selectively inhibit glycohydrolases responsible for the cleavage of glycosidic bonds.[1,2] In azasugars, the ring oxygen is replaced by nitrogen, which can be protonated under physiological pH, thus mimicking the glycopyranosyl cation. Because of the potential chemotherapeutic applications of such compounds, lots of chemists have continuing interests in the synthesis of imino sugars, such as deoxynojirimycin (DNJ, 1,5-dideoxy-1,5-imino-D-glucitol) and miglitol derivatives.……

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The energy response of LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals for GECAM

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Nuclear Science and Techniques 2024年第2期35卷 110-122页

作者： Pei-Yi Feng Xi-Lei Sun Zheng-Hua An Yong Deng Cheng-Er Wang Huang Jiang Jun-Jie Li Da-Li Zhang Xin-Qiao Li Shao-Lin Xiong Chao Zheng Ke Gong Sheng yang Xiao-Jing Liu Min Gao Xiang-yang Wen Ya-Qing liu yan-bing xu Xiao-Yun Zhao Jia-Cong Liu Fan Zhang Hong Lu Particle and Astrophysics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Experimental Physics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of South ChinaHengyang 421001China National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.and General Research Institute for Nonferrous MetalsBeijing 100088China

The GECAM series of satellites utilizes LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals as sensitive materials for gamma-ray detectors(GRDs).To investigate the nonlinearity in the detection of low-energy gamma rays and address the errors in the calibration of the E-C relationship,comprehensive tests and comparative studies of the three aforementioned crystals were conducted using Compton electrons,radioactive sources,and mono-energetic *** nonlinearity test results of the Compton electrons and X-rays demonstrated substantial differences,with all three crystals presenting a higher nonlinearity for X/-rays than for Compton *** the LaBr_(3)(Ce)and LaBr_(3)(Ce,Sr)crystals having higher absolute light yields,they exhibited a noticeable nonlinear decrease in the light yield,especially at energies below 400 *** NaI(Tl)crystal demonstrated an"excess"light output in the 6-200 keV range,reaching a maximum"excess"of 9.2%at 30 keV in the X-ray testing and up to 15.5%at 14 keV during Compton electron testing,indicating a significant advantage in the detection of low-energy gamma ***,we explored the underlying causes of the observed nonlinearity in these *** study not only elucidates the detector responses of GECAM,but also initiates a comprehensive investigation of the nonlinearity of domestically produced lanthanum bromide and sodium iodide crystals.

关键词： LaBr_(3)(Ce)detector LaBr_(3)(Ce,Sr)detector NaI(Tl)detector GECAM Energy response Light yield nonlinearity

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基于组合零样本学习的接触网吊弦线缺陷识别

浙江大学学报（工学版） 2023年第11期57卷 2285-2293页

作者：顾桂梅贾耀华赵岩浩张文辉闫炳旭兰州交通大学自动化与电气工程学院甘肃兰州730070 中国铁路兰州局集团有限公司甘肃兰州730030 中国铁路郑州局集团有限公司河南郑州450015

目前现场接触网吊弦缺陷图像严重不足,导致模型特征学习不充分,识别准确率难以得到有效提高,为此提出基于组合零样本学习的接触网吊弦线缺陷识别方法.采用以ResNet-50作为主干网络的视觉特征提取模块提取图像视觉特征;使用预训练的Word2... 详细信息

目前现场接触网吊弦缺陷图像严重不足,导致模型特征学习不充分,识别准确率难以得到有效提高,为此提出基于组合零样本学习的接触网吊弦线缺陷识别方法.采用以ResNet-50作为主干网络的视觉特征提取模块提取图像视觉特征;使用预训练的Word2Vec词向量对标签组合图中的节点特征进行初始化,并通过2层图卷积网络学习标签组合图中各节点之间的依赖关系,从而优化组合标签节点的语义特征,改善最终的识别效果;将提取到的视觉特征和优化后的组合标签节点的语义特征相对齐,构建相似度函数计算图像视觉特征与组合标签语义特征之间的相似度得分,并通过交叉熵损失完成图像组合标签的预测.仿真实验结果表明:所提方法对可见类样本的类平均检测准确率为93.5%,对不可见类样本的类平均检测准确率为86.5%.

关键词：接触网吊弦缺陷识别组合零样本学习 ResNet-50网络图卷积网络词向量

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Aggregation-induced Emission of Lanthanide（Ⅲ） Complexes

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Aggregation-induced Emission of Lanthanide（Ⅲ） Complexes