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PM2.5-induced Alterations of Gene Expression in HBE Cells Revealed by Gene Chip Analysis

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Biomedical and Environmental Sciences 2020年第3期33卷 213-216页

作者： WANG Bing Yu CAI ying ZHENG Kai HUANG Hai yan QIN Xiao yun XU Xin yun School of public health University of South ChinaHengyang 421001HunanChina Institute of environment and health Shenzhen center for disease control and preventionShenzhen 518055GuangdongChina

PM2.5 are fine inhalable particles with diameters that are generally 2.5 micrometers and smaller and are characterized by a small particle size,a large surface area,and a strong toxin absorption ability[1-3].PM2.5 contains heavy metals and organic pollutants that are harmful to human health and exert carcinogenic,teratogenic,and mutagenic effects[4-7].PM2.5 has been classified as a human carcinogen by the International Agency for Research on Cancer(IARC)[2].The economy has developed rapidly making air pollution a serious environmental health problem in *** purpose of this study was to explore the differentially expressed genes and pathways after a PM2.5 exposure in the human bronchial epithelial(HBE)cells via gene chip technology and bioinformatics analysis.

关键词： PM2.5 absorption ability gene chip technology

Low Calf Circumference Predicts Nutritional Risks in Hospitalized Patients Aged More Than 80 Years

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Biomedical and Environmental Sciences 2019年第8期32卷 571-577页

作者： ZHANG Xiao yan ZHANG Xing Liang ZHU yun Xia TAO Jun ZHANG Zhen ZHANG Yue WANG yan yan KE ying ying REN Chen Xi XU Jun ZHONG Yuan Department of Geriatrics Shanghai Jiaotong University Affiliated Sixth People’s Hospital

Objective The aim of this study was to determine whether low calf circumference(CC) could predict nutritional risk and the cutoff values of CC for predicting nutritional risk in hospitalized patients aged ≥ 80 *** A total of 1,234 consecutive patients aged ≥ 80 years were enrolled in this *** admission, demographic data, CC, and laboratory parameters were *** with Nutritional Risk Screening 2002(NRS-2002) total score ≥ 3 were considered as having nutritional *** CC values were significantly lower in patients with nutritional risk compared to those in patients without nutritional risk [27.00(24.50-31.00) vs.31.00(29.00-33.50], P < 0.001].CC was negatively correlated with age and nutritional risk *** regression analysis of nutritional risk revealed that body mass index, albumin level, hemoglobin level, cerebral infarction, neoplasms, and CC(OR, 0.897;95% confidence interval, 0.856-0.941;P < 0.001) were independent impact factors of nutritional *** risk scores increased with a decrease in *** men, the best CC cutoff value for predicting nutritional risk according to the NRS-2002 was 29.75 *** women, the cutoff value was 28.25 *** CC is a simple, noninvasive, and valid anthropometric measure to predict nutritional risk for hospitalized patients aged ≥ 80 years.

关键词： Calf circumference Nutritional risk NRS-2002

Relationship Between Producer Services Developing Level and Urban Hierarchy——A Case Study of Zhujiang River Delta

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Chinese Geographical Science 2008年第1期18卷 1-8页

作者： ZHONG yun yan Xiaopei Institute of Hong Kong Macao ＆ SEZs Economy Jinan University Guangzhou 510632 China Center for Urban ＆ Regional Studies SUN Yat-Sen University Guangzhou 510275 China

As the Central Place Theory indicates, the centricity of a central city can influence the extension of its ser- vice. Since the service industry in the theory is mostly consumer services, it is worth studying the relationship between the producer services and the centricity of the city in the service society with producer services becoming a more im- portant part of the service industry. The paper takes the case of the Zhujiang (Pearl) River Delta (PRD), a developed region in China, to study the relationship between the developing level of producer services and the urban hierarchy. Based on the analysis about the spatial difference of the producer services in the nine cities of the PRD, and the divi- sion of the nine cities according to some economic indices, it is shown that there is a correlation between the develop- ing level of producer services and the urban hierarchy. Furthermore, two deductions about the future status of the pro- ducer services in the city and the location of the producer services in a large region can be made from this correlation between the developing level of producer services and the urban hierarchy.

关键词： producer services urban hierarchy correlativity Zhujiang (Pearl) River Delta (PRD)

Investigation of scale efect for the computation of turbulent flow around a circular cylinder

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Acta Mechanica Sinica 2013年第5期29卷 641-648页

作者： Lin Lin yan-ying Wang State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology

In order to investigate the scale effect of turbulent flow around a circular cylinder, two similarity numbers （criteria） based on turbulent kinetic and dissipation rates associ- ated with the fluctuation characteristics of turbulence wake are deduced by analyzing the Reynolds averaged NavierStokes equations （RANS）. The RNG k-s models and finite volume method are used to solve the governing equations and the second-order implicit time and upwind space discretization algorithms are used to discrete the governing equations. A numerical computation of flow parameters around a two-dimensional circular cylinder with Reynolds numbers ranging from 102 to l07 is accomplished and the result indicates that the fluctuation of turbulence flow along the center line in the wake of circular cylinder can never be changed with increasing Reynolds numbers when Re ≥ 3 × 10^6. This conclusion is useful for controlling the scale of numerical calculations and for applying model test data to engineering practice.

关键词： Turbulent flow Flow around circular cylinder Scale effect Dynamic similarity

Body mass index effects sperm quality： a retrospective study in Northern China

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Asian Journal of Andrology 2017年第2期19卷 234-237页

作者： En-Yin Wang yan Huang Qing-yun Du Gui-Dong Yao ying-Pu Sun Reproductive Medical Center The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China

Excess weight and obesity have become a serious problem in adult men of reproductive age throughout the world. The purpose of this retrospective study was to assess the relationships between body mass index and sperm quality in subfertile couples in a Chinese Han population. Sperm analyses were performed and demographic data collected from 2384 male partners in subfertile couples who visited a reproductive medical center for treatment and preconception counseling. The subjects were classified into four groups according to their body mass index： underweight, normal, overweight, and obese. Of these subjects, 918 （38.3%） had a body mass index of 〉25.0 kg m-2. No significant differences were found between the four groups with respect to age, occupation, level of education, smoking status, alcohol use, duration of sexual abstinence, or the collection time of year for sperm. The results clearly indicated lower sperm quality （total sperm count, sperm concentration, motile sperm, relative amounts of type A motility, and progressive motility sperm [A ＋ B]） in overweight and obese participants than in those with normal body mass index. Normal sperm morphology and sperm volume showed no clear difference between the four groups. This study indicates that body mass index has a negative effect on sperm quality in men of subfertile couples in a Northern Chinese population. Further study should be performed to investigate the relationship between body mass index and sperm aualitv in a lar^er ooDulation.

关键词： body mass index male infertility obesity sperm quality

Efficacy of combination of localized closure,ethacridine lactate dressing,and phototherapy in treatment of severe extravasation injuries:A case series

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World Journal of Clinical Cases 2021年第18期9卷 4599-4606页

作者： yan-Xu Lu ying Wu Peng-Fei Liang Rong-Chan Wu Ling-yun Tian Hui-ying Mo Xiangya Stomatological Hospital&School of Stomatology Central South UniversityChangsha 410000Hunan ProvinceChina Teaching and Research Section of Clinical Nursing Department of Burn and Reconstructive SurgeryXiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina Department of Burn and Reconstructive Surgery Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina Phase 1 Clinical Trial Center Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina School of Nursing Anhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

BACKGROUND The management of severe extravasation injuries is still *** injuries can be treated in many *** To present a series of patients with severe extravasation injuries due to infusion who were managed with ethacridine lactate dressing combined with localized closure and *** In this study,we evaluated the data of eight patients,including six from the Department of Burn,one(with colorectal carcinoma)from the Veteran Cadre Department,and one(with leukemia)from the Hematology *** these,three patients were male and five were *** of the patients ranged from 10 mo to 72 years,including two children(10 and 19 mo of age).In this study,the infusion was stopped immediately when the extravasation was *** extravasation event was managed routinely using a blocking solution.A ring-shaped localized closure was performed using the blocking ***,ethacridine lactate dressing and phototherapy were applied for 3-5 *** In this study,the drugs contained in the infusates were iodixanol,norepinephrine,alprostadil,amino acids,fat emulsion,cefoselis,cefoxitin,and potassium chloride+concentrated sodium *** of the patients achieved complete healing after treatment and no obvious adverse reactions were *** The treatment of severe extravasation injuries using a combination of localized closure,ethacridine lactate dressing,and phototherapy resulted in satisfactory outcomes in patients.

关键词： Extravasation Closure Ethacridine lactate Dressing Phototherapy Treatment

Research Progress of Bobbin Tool Friction Stir Welding of Aluminum Alloys:A Review

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Acta Metallurgica Sinica(English Letters) 2020年第1期33卷 13-29页

作者： Guo-Qing Wang yan-Hua Zhao ying-ying Tang China Academy of Launch Vehicle Technology Beijing 100076China Capital Aerospace Machinery Company Beijing 100076China

Bobbin tool friction stir welding(BT-FSW)is a variant of conventional friction stir welding(FSW).It can be used to weld complex curvature structures and closed sections by adding an extra shoulder instead of a rigid backing anvil,which expands the potential application of FSW in aerospace,railway,automotive and marine ***-FSW has some signifi cant advantages over conventional FSW such as no root fl aws,full weld penetration,low stiff ness requirements for machines and fi xtures,balanced heat input,lower distortion and thus has broad prospects for *** present,there have been numerous research reports on BT-FSW,but its widespread use is still restricted due to various factors such as tool life,process stability,control complexity and implementation *** this paper,the domestic and foreign research progress of BT-FSW is reviewed from four aspects of bobbin tool design and classifi cation,temperature fi eld and fl ow fi eld during welding,microstructure and mechanical properties of welded joints as well as industrial application,and then the possible research hotspots of BT-FSW in the future are pointed *** paper mainly aims to help researchers have a comprehensive and in-depth understanding of BT-FSW.

关键词： Bobbin tool Temperature field Flow field Microstructure Mechanical properties Application

Trudinger–Moser Inequalities on a Closed Riemann Surface with a Symmetric Conical Metric

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2263-2284页

作者： Yu FANG yun yan yanG College of Teacher Education Quzhou UniversityQuzhou 324003P.R.China Department of Mathematics Renmin University of ChinaBeijing 100872P.R.China

This is a continuation of our previous work(*** ***.,20,1295–1324,2020).Let(Σ,g)be a closed Riemann surface,where the metric g has conical singularities at finite *** G is a group whose elements are isometries acting on(Σ,g).Trudinger–Moser inequalities involving G are established via the method of blow-up analysis,and the corresponding extremals are also *** extends previous results of Chen(***.,1990),Iula–Manicini(Nonlinear Anal.,2017),and the authors(2020).

关键词： Trudinger-Moser inequality blow-up analysis conical singularity

The rhizospheric microbiome becomes more diverse with maize domestication and genetic improvement

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Journal of Integrative Agriculture 2022年第4期21卷 1188-1202页

作者： HUANG Jun LI yun-feng MA Yuan-ying LI yan-sheng JIN Jian LIAN Teng-xiang Key Laboratory of Plant Molecular Breeding of Guangdong Province College of AgricultureSouth China Agricultural UniversityGuangzhou 510640P.R.China Centre for Mined Land Rehabilitation Sustainable Minerals InstituteThe University of QueenslandBrisbane Qld 4072Australia Key Laboratory of Mollisols Agroecology Northeast Institute of Geography and AgroecologyChinese Academy of SciencesHarbin 150081P.R.China Department of Animal Plant and Soil SciencesCentre for AgriBioscienceLa Trobe UniversityMelbourne CampusBundoora Vic 3086Australia

Domestication and genetic improvement of maize improve yield and stress tolerance due to changes in morphological and physiological properties, which likely alter rhizosphere microbial diversity. Understanding how the evolution of maize germplasm impacts its rhizobacterial traits during the growth stage is important for optimizing plant-microbe associations and obtaining yield gain in domesticated germplasms. In this study, a total of nine accessions representing domestication and subsequent genetic improvement were selected. We then sequenced the plant DNA and rhizobacterial DNA of teosinte, landraces and inbred lines at the seedling, flowering and maturity stages in a field trial. Moreover, the soil chemical properties were determined at the respective stages to explore the associations of soil characteristics with bacterial community structures. The results showed that domestication and genetic improvement increased the rhizobacterial diversity and substantially altered the rhizobacterial community composition. The core microbiome in the rhizosphere differed among germplasm groups. The co-occurrence network analysis demonstrated that the modularity in the bacterial network of the inbred lines was greater than those of teosinte and the landraces. In conclusion, the increased diversity of the rhizobacterial community with domestication and genetic improvement may improve maize resilience to biotic stresses and soil nutrient availability to plants.

关键词： teosinte landraces inbred lines domestication and improvement core microbiome network