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Chinese Journal of Electronics 2024年第2期33卷 423-435页

作者： Juncai he Zhenxue he Jia LIU yan ZHANG Fan ZHANG Fangfang LIANG Tao WANG Limin xiao Xiang WANG hebei Agricultural University Beijing Information Science and Technology University School of Computer Science and Engineering Beihang University School of Electronic and Information Engineering Beihang University

Power is an issue that must be considered in the design of logic circuits. Power optimization is a combinatorial optimization problem, since it is necessary to search for a logical expression that consumes the least amount of power from a large number of Reed-Muller(RM) logical expressions. The existing approach for optimizing the power of multi-output mixed polarity RM(MPRM) logic circuits suffer from poor optimization results. To solve this problem, a whale optimization algorithm with two-populations strategy and mutation strategy(TMWOA) is proposed in this paper. The two-populations strategy speeds up the convergence of the algorithm by exchanging information about the two-populations. The mutation strategy enhances the ability of the algorithm to jump out of the local optimal solutions by using the information of the current optimal solution. Based on the TMWOA, we propose a multi-output MPRM logic circuits power optimization approach(TMMPOA). Experiments based on the benchmark circuits of the Microelectronics Center of North Carolina(MCNC) validate the effectiveness and superiority of the proposed TMMPOA.

关键词： Logic circuits Benchmark testing Search problems Whale optimization algorithms Microelectronics Optimization Convergence

SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

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Signal Transduction and Targeted Therapy 2022年第1期7卷 295-309页

作者： Meng-Li Wu Feng-Liang Liu Jing Sun Xin Li xiao-yan he Hong-Yi Zheng yan-heng Zhou Qihong yan Ling Chen Guo-Ying Yu Junbiao Chang Xia Jin Jincun Zhao Xin-Wen Chen Yong-Tang Zheng Jian-Hua Wang College of Life Science Henan Normal UniversityXinxiang 453007China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510182China Guangzhou Institutes of Biomedicine and health Chinese Academy of SciencesGuangzhou 510530China Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China Shanghai Public health Clinical Center Affiliated to Fudan University Shanghai 201508China University of Chinese Academy of Sciences Beijing 100039China

SARS-CoV-2 infection-induced hyper-inflammation links to the acute lung injury and COVID-19 *** the primary mediators that initiate the uncontrolled hypercytokinemia is essential for *** cells(MCs)are strategically located at the mucosa and beneficially or detrimentally regulate immune *** this study,we showed that SARS-CoV-2-triggered MC degranulation initiated alveolar epithelial inflammation and lung ***-CoV-2 challenge induced MC degranulation in ACE-2 humanized mice and rhesus macaques,and a rapid MC degranulation could be recapitulated with Spike-RBD binding to ACE2 in cells;MC degranulation altered various signaling pathways in alveolar epithelial cells,particularly,the induction of pro-inflammatory factors and consequential disruption of tight ***,the administration of clinical MC stabilizers for blocking degranulation dampened SARS-CoV-2-induced production of pro-inflammatory factors and prevented lung *** findings uncover a novel mechanism for SARS-CoV-2 initiating lung inflammation,and suggest an off-label use of MC stabilizer as immunomodulators for COVID-19 treatments.

关键词： inflammation lung alveolar

An Overview on the Composition and Age of Upper Crust of Proto-Tethyan Lajishan Intra-oceanic Arc,NE Tibet Plateau

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 285-302页

作者： FU Changlei he xiaohu yan Zhen Jonathan CAITCHISON xiao Wenjiao WANG Bingzhang LI Wufu LI Yusen SinoProbe Laboratory Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China Key Laboratory of the Northern Qinghai–Tibet Plateau Geological Processes and Mineral Resources Qinghai Geological Survey InstituteXining 810012China Department of Geology School of Earth SciencesYunnan UniversityKunming 650091China School of Earth and Environmental Sciences University of QueenslandBrisbane 4072Australia Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830011China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Earth Science and Resources China University of GeosciencesBeijing 100083China

Identification and anatomy of oceanic arcs within ancient orogenic belt are significant for better understanding the tectonic framework and closure process of paleo-ocean *** article summarizes the geological,geochemical,and geochronological characteristics of upper crust of Proto-Tethyan Lajishan intra-oceanic arc and provides new data to constrain the subduction evolution of the South Qilian *** intra-oceanic arc volcanic rocks,including intermediate-mafic lava,breccia,tuff,and minor felsic rocks,are distributed along southern part of the Lajishan ophiolite *** and isotopic compositions indicate that the intermediate-mafic lava were originated from depleted mantle contaminated by sediment melts or hydrous fluids,whereas the felsic rocks were likely generated by partial melting of juvenile mafic crust in intra-oceanic arc *** from felsic rocks yield consistent and concordant ages ranging from 506 to 523 Ma,suggesting these volcanic rocks represent the relicts of upper crust of the Cambrian intra-oceanic *** with the Cambrian forearc ophiolite and accretionary complex,we suggest that the Cambrian intra-oceanic arc in the Lajishan ophiolite belt is belonging to the intra-oceanic arc system which was generated by south-directed subduction in the South Qilian Ocean at a relatively short interval between approximately 530 and 480 Ma.

关键词： volcanic rocks intra-oceanic arc U-Pb age Lajishan ophiolite belt South Qilian Ocean Proto-Tethyan realm

High-throughput screening of single-atom catalysts confined in monolayer black phosphorus for efficient nitrogen reduction reaction

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Nano Research 2024年第4期17卷 2360-2367页

作者： xiao-yan Li Manyi Duan Pengfei Ou Department of Electrical and Computer Engineering University of TorontoTorontoOntario M5S 1A4Canada School of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610101China Department of Chemistry Northwestern UniversityEvanstonIL 60208USA

The discovery of metal-nitrogen centers as the active sites for electrolysis has aroused significant interest in utilizing single-atom catalysts for nitrogen reduction reaction(NRR).Properly designed nanostructured catalysts that strongly interact with nitrogen molecules(N_(2))can promote adsorption and activation,thereby resulting in efficient catalysts with high stability,activity,and *** this study,using density functional theory calculations,we selected monolayer black phosphorus(BP)as the substrate and screened a series of single-atom transition metals confined in tri-coordinated and tetra-coordinated active centers(without and with N dopants)to electro-catalyze *** a result,we have identified two promising candidates(Hf_(1)-N_(1)P_(2)-1 and Tc_(1)-N_(4)),which exhibit not only low overpotentials of 0.56 and 0.49 V but also high thermodynamic and electrochemical stability,as well as good selectivity towards NRR over the competing hydrogen evolution *** also demonstrate the ability of Hf_(1)-N_(1)P_(2)-1 and Tc_(1)-N_(4) to activate and hydrogenate N_(2) by donating electrons and regulating charge *** study not only predicts new BP-based promising catalysts but also provides guidance for the rational design of high-performance NRR electrocatalysts under ambient conditions.

关键词： N_(2) electroreduction reaction single-atom catalysts black phosphorus density functional theory high-throughput calculations

Review of data security within energy blockchain:A comprehensive analysis of storage,management,and utilization

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High-Confidence Computing

High-Confidence Computing 2024年第3期4卷 82-102页

作者： Yunhua he Zhihao Zhou yan Pan Fahui Chong Bin Wu Ke xiao Hong Li School of Information Science and Technology North China University of TechnologyBeijing 100144China China Industrial Control Systems Cyber Emergency Response Team Beijing 100040China Key Laboratory in Blockchain and Data Security by Ministry of Industry and Information Technology Beijing 100040China Institute of Information Engineering Chinese Academy of Sciences Beijing 100195China

Energy systems are currently undergoing a transformation towards new paradigms characterized by decarbonization,decentralization,democratization,and *** this evolving context,energy blockchain,aiming to enhance efficiency,transparency,and security,emerges as an integrated technological solution designed to address the diverse challenges in this *** security is essential for the reliable and efficient functioning of energy *** pressing need to address challenges related to secure data storage,effective data management,and efficient data utilization is increasingly *** paper offers a comprehensive survey of academic discourse on energy blockchain data security over the past five years,adopting an all-encompassing perspective that spans data storage,management,and *** work systematically evaluates and contrasts the strengths and weaknesses of various research ***,this paper proposes an integrated hierarchical on-chain and off-chain security energy blockchain architecture,specifically designed to meet the complex security requirements of multi-blockchain business ***,this paper identifies key directions for future research,particularly in advancing the integration of storage,management,and utilization of energy blockchain data security.

关键词： Energy blockchain Data security Storage Management Utilization

Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer

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World Journal of Gastroenterology 2024年第16期30卷 2195-2208页

作者： xiao-Jun Zhang yan Yu he-Ping Zhao Lei Guo Kun Dai Jing Lv Department of Clinical Laboratory Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Department of Spinal Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Department of Clinical Laboratory Yanliang Railway Hospital of Xi’anXi’an 710089Shaanxi ProvinceChina

As a highly invasive malignancy,esophageal cancer(EC)is a global health issue,and was the eighth most prevalent cancer and the sixth leading cause of cancerrelated death worldwide in *** to its highly immunogenic nature,emerging immunotherapy approaches,such as immune checkpoint blockade,have demonstrated promising efficacy in treating EC;however,certain limitations and challenges still *** addition,tumors may exhibit primary or acquired resistance to immunotherapy in the tumor immune microenvironment(TIME);thus,understanding the TIME is urgent and crucial,especially given the importance of an immunosuppressive microenvironment in tumor *** aim of this review was to better elucidate the mechanisms of the suppressive TIME,including cell infiltration,immune cell subsets,cytokines and signaling pathways in the tumor microenvironment of EC patients,as well as the downregulated expression of major histocompatibility complex molecules in tumor cells,to obtain a better understanding of the differences in EC patient responses to immunotherapeutic strategies and accurately predict the efficacy of ***,personalized treatments could be developed to maximize the advantages of immunotherapy.

关键词： Esophageal cancer Esophageal squamous cell carcinoma Esophageal adenocarcinoma Tumor immune microenvironment Immunosuppression Immunotherapy

Psychological Status and Warfarin Therapy in Patients after Valve Replacement during the COVID-19 Pandemic:A Cross-sectional Study

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Current Medical Science 2024年第4期44卷 686-691页

作者： xiao-yan CheN Sheng he Zhen TAN Feng GAO Hui JIANG Lu CheN Li yanG Yu-shan LIU Si-yi he Department of Cardiovascular Surgery The General Hospital of Western Theater CommandChengdu610083China Department of Digestive Medicine The General Hospital of Western Theater CommandChengdu610083China Department of General Surgery The General Hospital of Western Theater CommandChengdu610083China

Objective The standardization of warfarin anticoagulant therapy is the key to lifelong treatment for patients after heart valve *** present study explored the possible risk factors for anxiety and depression during the coronavirus disease 2019(COVID-19)pandemic and analyzed the influence of psychological state on medication *** Eligible patients received a web-based questionnaire survey via the Wenjuanxing platform during outpatient *** was evaluated by the Self-Rating Depression Scale(SDS).Anxiety was evaluated by the Self-Rating Anxiety Scale(SAS).Medication adherence was evaluated by the Morisky *** A total of 309 patients(aged 52.2±11.4 years)were included in the present *** SDS score of all included patients was 36.9±9.4 points,of which 11(3.6%)patients were diagnosed as having *** SAS score of all included patients was 43.1±9.3 points,of which 71(23%)patients were diagnosed as having *** patients(2.3%)had both anxiety and *** regression analysis revealed that only monthly income was an independent influencing factor for *** anxiety,patients who underwent repeated operations had a 2.264-fold greater risk,and patients who received combination medication had a 2.140-fold greater *** bleeding events and coagulation disorders could be observed in patients with anxiety,depression or *** anxiety occurred,patients showed worse medication ***,depression had no significant effect on medication *** During the COVID-19 pandemic,the detection rate of mental illnesses such as anxiety and depression was high,which seriously affected the medication safety of *** of its influencing factors will provide a reference for further standardized regulation of warfarin anticoagulant therapy after valve replacement.

关键词： Warfarin COVID-19 valve replacement depression anxiety

Computed tomography-based radiomics combined with machine learning allows differentiation between primary intestinal lymphoma and Crohn's disease

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World Journal of Gastroenterology 2024年第25期30卷 3155-3165页

作者： Meng-Jun xiao Yu-Teng Pan Jia-he Tan Hai-Ou Li Hai-yan Wang Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250000Shandong ProvinceChina University of California DavisCA 95616United States Qilu Hospital Cheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Due to similar clinical manifestations and imaging signs,differential diagnosis of primary intestinal lymphoma(PIL)and Crohn's disease(CD)is a challenge in clinical *** To investigate the ability of radiomics combined with machine learning methods to differentiate PIL from *** We collected contrast-enhanced computed tomography(CECT)and clinical data from 120 patients form center 1.A total of 944 features were extracted singlephase images of CECT *** the last absolute shrinkage and selection operator model,the best predictive radiographic features and clinical indications were *** from 54 patients were collected at center 2 as an external validation set to verify the robustness of the *** area under the receiver operating characteristic curve,accuracy,sensitivity and specificity were used for *** A total of five machine learning models were built to distinguish PIL from *** on the results from the test group,most models performed well with a large area under the curve(AUC)(>0.850)and high accuracy(>0.900).The combined clinical and radiomics model(AUC=1.000,accuracy=1.000)was the best model among all *** Based on machine learning,a model combining clinical data with radiologic features was constructed that can effectively differentiate PIL from CD.

关键词： Primary intestinal lymphoma Crohn's disease Radiomics Machine learning Diagnosis

Fluorographene with Narrow Lateral Size and Thickness Distributions Prepared for Enhancing Lubrication Performance of Bentonite Grease

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1294-1302页

作者： XIANG Shuo LU Peng ZHANG Qinhui xiao Bowen yanG Xin ZHANG Peili MA Pengfei he yan LI Xuebin Army Logistics Academy of PLA Chongqing 401311China Naval Aeronautical University Yantai 2640003China Unit 32568 Shaoguan 512131China

Fluorographene(FG)with narrow lateral size and thickness distributions was prepared by a liquid-phase exfoliation method,based on liquid cascade *** Rtec MFT-5000 tribo-meter was used to investigate the lubricating performance of bentonite grease enhanced by the as-prepared *** results showed that the coefficient of friction and the wear volume of bentonite grease with 0.3 wt%FG were decreased by 20.4%and 44.9%,respectively,as compared to those of the base *** main reason is that FG can promote the formation of the tribo-chemical reaction film consisting of complex carbon oxide,Fe_(2)O_(3)and FeF_(3)on the friction surface,which can remarkably improve the performance of friction reduction and prevent the appearance of severe wear.

关键词： fluorographene liquid-phase exfoliation bentonite grease lubrication performance

Pro-inflammatory microenvironment and systemic accumulation of CXCR3+cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3033-3044页

作者： Hong-Yi Zheng xiao-yan he Wei Li Tian-Zhang Song Jian-Bao Han Xiang yang Feng-Liang Liu Rong-Hua Luo Ren-Rong Tian xiao-Li Feng Yu-Hua Ma Chao Liu Ming-Hua Li Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnanChina Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnanChina Kunming National High-Level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnanChina National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnanChina Bioland Laboratory(Guangzhou Regenerative Medicine and health Guangdong Laboratory) GuangzhouChina

Understanding the pathological features of severe acute respiratory syn drome coronavirus 2(SARS-CoV-2)infect io n in an animal model is crucial for the treatment of coronavirus disease 2019(COVID-19).here,we compared imnnunopathological changes in young and old rhesus macaques(RMs)before and after SARS-CoV-2 infection at the tissue *** analysis of multiplex immunofluoresce nee staining images of formali n-fixed paraffi n-embedded(FFPE)sections showed that SARS-CoV-2 infectio n specifically induced elevated levels of apoptosis,autophagy,and nuclear factor kappa-B(NF-kB)activation of angiotensirv convert!ng enzyme 2(ACE2)+cells,and increased interferon a(IFN-a)-and interleukin 6(IL-6)-secreting cells and C-X-C motif chemokine receptor 3(CXCR3)+cells in lung tissue of old *** pathological pattern,which may be related to the age-related pro-inflammatory microenvironment in both lungs and spleens,was significantly correlated with the systemic accumulation of CXCR3+cells in lungs,spleens,and peripheral ***,the ratio of CXCR3+to T-box protein expression in T cell(T-bet)+(CXCR3+/T-bet+ratio)in CD8+cells may be used as a predictor of severe *** findings uncovered the impact of aging on the immunopathology of early SARS-CoV-2 infection and demonstrated the potential application of CXCR3+cells in predicting severe COVID-19.

关键词： CXCR3 spleen lung