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Effect of negative remodeling of the side branch ostium on the efficacy of a two-stent strategy for distal left main bifurcation lesions:an intravascular ultrasound study

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Journal of Geriatric Cardiology 2024年第5期21卷 506-522页

作者： Yi XU Tian XU Jia-Cong NONG Xiao-Han KONG Meng-Yao ZHAO Zhi-Jing GAO Yi-Fei wang Wei YOU Pei-Na MENG Yu-He ZHOU Xiang-Qi WU Zhi-Ming WU Mei-En ZHAN yan-qing wang De-Feng PAN Fei YE Department of Cardiology Nanjing First HospitalNanjing Hospital Affiliated to Nanjing Medical UniversityNanjing Medical UniversityNanjingChina Department of Cardiology Clinical Medicine School of Nanjing UniversityNanjingChina Department of Cardiology Tianchang People’s HospitalTianchangChina Department of Cardiology the Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina

OBJECTIVES To investigate whether negative remodeling(NR) detected by intravascular ultrasound(IVUS) of the side branch ostium(SBO) would affect in-stent neointimal hyperplasia(NIH) at the one-year follow-up and the clinical outcome of target lesion failure(TLF) at the long-term follow-up for patients with left main bifurcation(LMb) lesions treated with a two-stent *** A total of 328 patients with de novo true complex LMb lesions who underwent a 2-stent strategy of percutaneous coronary intervention(PCI) treatment guided by IVUS were enrolled in this study. We divided the study into two phases. Of all the patients, 48 patients who had complete IVUS detection pre-and post-PCI and at the 1-year follow-up were enrolled in phase Ⅰ analysis, which aimed to analyze the correlation between NR and in-stent NIH at SBO at the 1-year follow-up. If the correlation was confirmed, the cutoff value of the remodeling index(RI) for predicting NIH ≥ 50% was analyzed next. The phase Ⅱ analysis focused on the incidence of TLF as the primary endpoint at the 1-to 5-year follow-up for all 328 patients by grouping based on the cutoff value of *** In phase I: according to the results of a binary logistic regression analysis and receiver operating characteristic(ROC) analysis, the RI cutoff value predicting percent NIH ≥ 50% was 0.85 based on the ROC curve analysis, with a sensitivity of 85.7%, a specificity of 88.3%, and an AUC of 0.893(0.778, 1.000), P = 0.002. In phase Ⅱ: the TLR rate(35.8% vs. 5.3%, P < 0.0001)was significantly higher in the several NR(s NR, defined as RI ≤ 0.85) group than in the non-s NR *** The NR of LCx O is associated with more in-stent NIH post-PCI for distal LMb lesions with a 2-stent strategy,and NR with RI ≤ 0.85 is linked to percent NIH area ≥ 50% at the 1-year follow-up and more TLF at the 5-year follow-up.

关键词： lesions remodeling intravascular

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Laws of the Iterated Logarithm for High-Dimensional Wiener Sausage

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Acta Mathematica Sinica,English Series 2011年第8期27卷 1599-1610页

作者： yan qing wang Fu qing GAO School of Mathematics and Statistics Wuhan University Wuhan 430072 P. R. China

Let {β（s）,s ≥ O} be the standard Brownian motion in R^d with d ≥ 4 and let ｜Wr（t）｜ be the volume of the Wiener sausage associated with {β（s）, s ≥ O} observed until time t. Prom the central limit theorem of Wiener sausage, we know that when d ≥ 4 the limit distribution is normal. In this paper, we study the laws of the iterated logarithm for ｜Wr（t）｜ - e｜Wr（t）｜ in this case.

关键词： Wiener sausage Kolmogorov's law of the iterated logarithm Chung's law of the iterated logarithm

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Synthesis and Crystal Structure of a Coordination Polymer {[Co(phth)(phen)(H_2O)]·(C_2H_5OH)}_n

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Chinese Journal of Structural Chemistry 2006年第10期25卷 1193-1196页

作者： GAO Ling CHENG qing-yan wang yan-Ji Hebei University of Technology Tianjin 300130 China

The coordination polymer {[Co（phth）（phen）（H2O）]·（C2H5OH）}n （phth = phthalate, phen = 1,10-phenanthroline） with formula C22H2OCoN2O6 （Mr = 467.33） was synthesized by the solvothermal method under low temperature, and its crystal structure was determined by singlecrystal X-ray diffraction. The complex belongs to monoclinic system, space group P21/n with a = 12.7352（16）, b = 8.8125（11）, c = 18.677（2） °A, β= 102.633（2）°, V = 2045.3（4）°A^3 Z = 4, Dc= 1.518 g/cm^3,μ = 0.882 mm^-1, F（000） = 964, S = 1.053, the final R = 0.0401 and wR = 0.0984 for 3135 observed reflections （I〉 2σ（I））. Single-crystal X-ray analysis revealed that the Co（Ⅱ） ion is six-coordinated. The cobalt complex forms a one-dimensional chain structure via phthalate bridging ligand. In the cobalt complex, a 3D network structure is formed by π-π stacking interaction of 1,10-phenanthroline as well as intermolecular hydrogen bonding interactions.

关键词： cobalt complex solvothermal method π-π stacking hydrogen bond

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Silicon-carbide fiber-reinforced polymer electrolyte for all-solid-state lithium-metal batteries

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Rare Metals 2022年第11期41卷 3774-3782页

作者： Wen-qing Wei Bing-Qiang Liu yan-qing wang Kai yan Hao Zhang Yu-Song Qi School of Mechanical and Automation Weifang UniversityWeifang261061China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo315201China College of Mechanical and Electronic Engineering Shandong University of Science and TechnologyQingdao266590China School of Mechanical and Electrical Weifang University of Science and TechnologyShouguang262700China

Silicon carbide(SiC) with various morphologies was employed as reinforcing fillers for poly(ethylene oxide)(PEO)-based solid polymer electrolytes(SPEs).Specific ally,the SiC nanoparticles with an average size of 5-10 μm endow a significant enhancement of the interaction between carbon atoms for the fillers and the oxygen atoms from the PEO-lithium bis(trifluoromethanesulfonyl)imide(LiTFSI) matrix,which provides rapid transport channels for mobile Li+and enhances the mechanical strength of *** SPEs reinforced with one-dimensional SiC nanoparticles exhibit superior Li^(+)conduction,good mechanical property,and uniform Li ***,a dendrite-free plating of lithium for 0.58 mAh at 0.1 mA·cm^(-2) and excellent cycle stability at various current densities for 250 h are achieved in Li/Li symmetric cells using SPEs electrolytes with 5.0 wt% SiC ***,the LiFePO_(4)/Li full cells assembled using SPEs electrolytes with 5.0 wt% SiC nanoparticles provide a capacity of 151.5 mAh·g^(-1) at 0.1 mA·cm^(-2)(55℃),and maintained a Coulombic efficiency of 99% for 120 cycles.

关键词： All-solid-state batteries Polymer electrolyte Ionic conductivity Mechanical property Lithium dendrites

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Meta analysis about the efficacy and safety of anti-ocular hypertension eye drops without benzalkonium chloride

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Asian Pacific Journal of Tropical Medicine 2013年第12期6卷 1004-1008页

作者： yan-qing wang Xin wang Ping Liu Department of Ophthalmology People's Hospital of Zhengzhou

Objective:To explore the safety and efficacy of eye drops without benzalkonium chloride(BAK)in treating glaucoma and ocular ***:The clinical case-control literatures about eye drops without BAK treating glaucoma and ocular hypertension were retrieved in PubMed,EMBASE,Cochrane and Chinese Biological and Medical *** 5.0 software was used to analyze the ***:Five clinical control studies were *** results indicated both eye drops could lower the intraocular pressure,and the intraocular pressurelowering difference between two eye drops was 0.07 mmHg(95%CI:0.04,0.19)(P>0.05).Two adverse reactions occurred more were conjunctival injection(10.78%)and allergic conjunctivitis(4.78%).The odd ratio of two eye drops occurring conjunctival injection and allergic conjunctivitis was 0.67(95%CI,0.25,1.10)and 0.82(95%CI,0.09,1.54),respectively(P<0.05)in fixed effect ***:There is no difference between the eye drops with or without BAK in lowering intraocular *** the latter is of higher *** consideration of the relatively small sample size of this research,more high-quality clinical research contrasts are needed as evidence.

关键词： Benzalkonium chloride Meta analysis Eye drops Glaucoma

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Research progress on the NLRP3 inflammasome and its role in the central nervous system

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Neuroscience Bulletin 2013年第6期29卷 779-787页

作者： Shen-Bin Liu Wen-Li Mi yan-qing wang Department of Integrative Medicine and Neurobiology Institute of Acupuncture ResearchState Key Laboratory of Medical NeurobiologyInstitutes of Brain ScienceShanghai Medical CollegeFudan University

The NLRP3 inflammasome,which consists of the NLRP3（nucleotide-binding oligomerization domain（Nod）–like receptor 3） scaffold,the ASC（apoptosis-associated speck-like protein containing a CARD） adaptor and procaspase-1,is assembled after the cytoplasmic LRRs（leucine-rich repeats） of NLRP3 sense pathogens or danger *** NLRP3 inflammasome controls the activation of the proteolytic enzyme ***-1 in turn regulates the maturation of the proinflammasome cytokines IL-1β and IL-18,which leads to an inflammatory *** inflammasome plays an important role in the development of Alzheimer’s disease and bacterial meningitis,and the NLRP3 inflammasome may become a new target for the prevention and treatment of central nervous system diseases.

关键词： NLRP3 inflammasome central nervous system

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Mg-doped CaCO_(3)nanoarchitectures assembled by(441)high-index facets for efficient trace removal of Pb(Ⅱ)

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稀有金属：英文版 2023年第2期42卷 525-535页

作者： Yu yan Yu-Bo Cui qing-yan wang Zhong-Xuan Che Tong Liu An-Ran Li Wei Zhou School of Chemistry Beijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing100191China

Removal of trace heavy metal ions puts high demands on designing adsorbents with favorable ***-plane engineering can provide controllable adsorption energy between surficial planes and ***,we have creatively synthesized Mg-doped CaCO_(3)nanoarchitectures assembled by layered sheets(Mg-CaCO_(3)LSs)with high-index facets of(441)through a facile wet chemical *** tests reveal that the layer-bylayer assembled sample exhibits a maximum Pb(II)adsorption capacity of 1961.9 mg·g^(-1),agreeing with the monolayer-adsorption Langmuir *** an initial Pb(II)ion concentration of 20 mg·L^(-1),the adsorption can achieve a high removal rate near 99.0%within 1 min,and the adsorption kinetics follows a chemisorption pseudo-second-order ***,the Mg-CaCO_(3)LSs show much-improved adsorption properties towards low-concentration Pb(II)ions,which could reduce the concentration from 1 mg·L^(-1)to~2.9μg·L^(-1)in 3 h(within 30 min decrease to less than 10μg·L^(-1),meeting drinking water standard from WHO).For comparison,the commercial CaCO_(3)and collected CaCO_(3)scale show much lower adsorption values with Pb(Ⅱ)ion residual concentration of~935.0 and~944.9μg·L^(-1)in 3 h,*** diffraction(XRD),energy dispersive spectroscopy(EDS),and inductively coupled plasma(ICP)characterizations on the Mg-CaCO_(3)LSs before and after adsorbing Pb(Ⅱ)confirm that the high removal performance could be ascribed to fast metal ion exchange and excellent physical adsorption contributed by high-index *** density functional theory(DFT)calculations also confirm that the much-enhanced adsorption kinetics benefits from the optimal adsorption of the(441)*** work will provide a feasible route to design highefficient low-cost adsorbents through crystal-plane engineering.

关键词： High-index plane Calcium carbonate High adsorption energy Trace Pb(Ⅱ)removal

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Partial Regularity of Suitable Weak Solutions of the Model Arising in Amorphous Molecular Beam Epitaxy

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Acta Mathematica Sinica,English Series 2023年第11期39卷 2219-2246页

作者： yan qing wang Yi Ke HUANG Gang WU Dao Guo ZHOU College of Mathematics and Information Science Zhengzhou University of Light IndustryZhengzhou 450002P.R.China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China School of Mathematics Hangzhou Normal UniversityHangzhou 311121P.R.China

In this paper,we are concerned with the precise relationship between the Hausdorff dimension of possible singular point set S of suitable weak solutions and the parameterαin the nonlinear term in the following parabolic equationh_(t)+h_(xxxx)+∂_(xx)|h_(x)|^(α)=*** is shown that when 5/3≤α<7/3,the 3α-5/α−1-dimensional parabolic Hausdorff measure of S is zero,which generalizes the recent corresponding work of Ozánski and Robinson in[SIAM ***.,51,228–255(2019)]forα=2 and f=*** same result is valid for a 3D modified Navier–Stokes system.

关键词： Surface growth model modified Navier–Stokes equations partial regularity Hausdorff dimension

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An improved procedure for the synthesis of 4-methylimidazol-2-one

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Chinese Chemical Letters 2007年第7期18卷 777-778页

作者： Hong Shu yan qing wang Pu Qin Cai Chun Guo School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China

A novel one-pot synthetic method of 4-methylimidazol-2-one is described. The target compound is conveniently synthesized from sodium diformylamide, a modified Gabriel reagent prepared, through condensation, hydrolyzat... 详细信息

关键词： 4-Methylimidazol-2-one Synthesis Sodium diformylamide

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miR-124/VAMP3 is a novel therapeutic target for mitigation of surgical trauma-induced microglial activation

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Signal Transduction and Targeted Therapy 2019年第1期4卷 434-444页

作者： yan Chen Jing-xian Sun Wan-kun Chen Gen-cheng Wu yan-qing wang Ke-ying Zhu Jun wang Department of Integrative Medicine and Neurobiology State Key Laboratory of Medical NeurobiologySchool of Basic Medical ScienceFudan University200032 ShanghaiChina Institutes of Brain Science Collaborative Innovation Center for Brain ScienceFudan University200032 ShanghaiChina Institute of Acupuncture and Moxibustion Fudan Institutes of Integrative MedicineFudan University200032 ShanghaiChina Department of Anesthesiology Fudan University Shanghai Cancer Center200032 ShanghaiChina Department of Oncology Shanghai Medical CollegeFudan University200032 ShanghaiChina Department of Clinical Neuroscience Center for Molecular MedicineKarolinska Institutet17176 StockholmSweden

Activation of microglia and the subsequently elevated inflammatory cytokine release in the brain during surgery predispose individuals to cognitive dysfunction,also known as postoperative cognitive dysfunction(POCD).miR-124 is one of the most abundant microRNAs in the brain that regulates microglial *** the role of miR-124 in microglial activation in the context of surgery may therefore promote understanding of as well as therapeutic development for post-surgical disorders involving microglial *** downstream targets of miR-124 were investigated using bioinformatic screening and dual-luciferase reporter assay validation,and vesicle-associated membrane protein 3(VAMP3)was identified as a potential *** kinetics of miR-124/VAMP3 expression was first examined in vitro in microglial cells(primary microglia and BV2 microglial cells)following lipopolysaccharide(LPS)*** induced a time-dependent decrease of miR-124 and upregulated the expression of *** miR-124/VAMP3 expression by using miR-124 mimics or VAMP3-specific siRNA in LPS-stimulated BV2 microglial cells inhibited BV2 microglial activation-associated inflammatory cytokine *** further examine the role of miR-124/VAMP3 in a surgical setting,we employed a rat surgical trauma *** microglial activation and altered miR-124/VAMP3 expression were observed following surgical *** also altered miR-124/VAMP3 expression in the rat surgical trauma model by administration of exogenous miR-124 and by using electroacupuncture,which is a clinically applicable treatment that modulates microglial function and minimizes postoperative *** determined that electroacupuncture treatment specifically increases the expression of miR-124 in the hypothalamus and *** miR-124 expression with a concomitant decrease in VAMP3 expression resulted in decreased inflammatory cytokine release related to microglial activation *** s

关键词： miR surgical therapeutic

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