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Contributions of aversive environmental stress to migraine chronification:Research update of migraine pathophysiology

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World Journal of Clinical Cases 2021年第9期9卷 2136-2145页

作者： Tang-Hua liu Zhen Wang Fang Xie yan-qing liu qing Lin Department of Algology The Third People's Hospital of YibinYibin 644000Sichuan ProvinceChina Department of Psychology University of Texas at ArlingtonArlingtonTX 76019United States Department of Algology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

Clinical studies have suggested that internal and/or external aversive cues may produce a negative affective-motivational component whereby maladaptive responses(plasticity)of dural afferent neurons are initiated contributing to migraine ***,pathophysiological processes and neural circuitry involved in aversion(unpleasantness)-producing migraine chronification are still *** interdisciplinary team conducted this narrative review aimed at reviewing neuronal plasticity for developing migraine chronicity and its relevant neurocircuits and providing the most cutting-edge information on neuronal mechanisms involved in the processing of affective aspects of pain and the role of unpleasantness evoked by internal and/or external cues in facilitating the chronification process of migraine ***,information presented in this review promotes the understanding of the pathophysiology of chronic migraine and contribution of unpleasantness(aversion)to migraine *** hope that it will bring clinicians’attention to how the maladaptive neuroplasticity of the emotion brain in the aversive environment produces a significant impact on the chronification of migraine headache,which will in turn lead to new therapeutic strategies for this type of pain.

关键词： Migraine chronification Aversive environmental stress Migraine pathophysiology Migraine headache Roles of unpleasantness Emotion brain

Template-directed synthesis of pyridazine-containing tetracationic cyclophane for construction of[2]rotaxane

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Chinese Chemical Letters 2017年第5期28卷 1013-1017页

作者： Qiu-Sheng Fang Ling Chen qing-yan liu Department College of Chemistry and Chemical Engineering Key Laboratory of Functional Small Organic MoleculesMinistry of EducationInstitution Jiangxi Normal UniversityNanchang 330022China

Benefiting from its bent molecular structure,3,6-pyridazinyl contained tetracationic cyclophane（1） is synthesized by template-directed method with high isolated yield up to 92%.This template-directed strategy is fur... 详细信息

关键词： Tetracationic cyclophane Template effect Inclusion complex π-Stacking Rotaxane

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Cervical intervertebral disc degeneration and dizziness

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World Journal of Clinical Cases 2021年第9期9卷 2146-2152页

作者： Tang-Hua liu yan-qing liu Bao-Gan Peng Department of Algology The Third People's Hospital of YibinYibin 644000Sichuan ProvinceChina Department of Algology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Orthopedics The Third Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China

Clinical studies have found that patients withcervical degenerative disease are usually accompanied by *** cervical surgery can eliminate not only chronic neck pain,cervical radiculopathy or myelopathy,but also *** studies show that a large number of mechanoreceptors,especially Ruffini corpuscles,are present in degenerated cervical *** available evidence suggests a key role of Ruffini corpuscles in the pathogenesis of dizziness caused by cervical degenerative disease(*** discogenic dizziness).Disc degeneration is characterized by an elevation of inflammatory cytokines,which stimulates the mechanoreceptors in degenerated discs and results in peripheral *** cervical proprioceptive inputs from the mechanoreceptors are transmitted to the central nervous system,resulting in sensory mismatches with vestibular and visual information and leads to *** addition,neck pain caused by cervical disc degeneration can play a key role in cervical discogenic dizziness by increasing the sensitivity of muscle *** cervical discogenic pain,the diagnosis of cervical discogenic dizziness can be challenging and can be made only after other potential causes of dizziness have been ruled *** treatment is effective for the majority of *** basic and clinical studies have shown that cervical intervertebral disc degeneration can lead to dizziness.

关键词： Cervical intervertebral disc degeneration Cervicogenic dizziness Cervical discogenic dizziness Cervical spondylosis Neck pain Mechanoreceptors

Editorial for the special issue of the Chinese Association for the Study of Pain

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World Journal of Clinical Cases 2021年第9期9卷 2022-2026页

作者： Bao-Gan Peng yan-qing liu Ke Ma Department of Orthopedics The Third Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Algology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Algology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

The Ministry of Health of China officially issued a document,adding the first level diagnosis and treatment discipline“Algology”in the list of diagnosis and treatment subjects of medical institutions on July 16,*** the most important pain academic organization in China,the Chinese Association for the Study of Pain has made outstanding contributions in promoting the development of pain discipline and in establishing pain standards and disease diagnosis and treatment *** this special issue,under the leadership of yan-qing liu,Chairman of the 7th Committee of the Chinese Association for the Study of Pain,nine consensus and one guideline were included.

关键词： Chinese Association for the Study of Pain Algology Pain Consensus Guidelines Recommendations

Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's disease

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Neuroscience Bulletin 2014年第2期30卷 317-330页

作者： Evan Dorey Nina Chang qing yan liu Ze yang Wandong Zhang Faculty of Medicine University of Ottawa Human Health Therapeutics National Research Council of Canada Institute of Geriatrics/Beijing Hospital Ministry of Health of China

Alzheimer＇s disease （AD） is characterized by the accumulation and deposition of amyloid-beta （Aβ） peptides in the brain. Neuroinflammation occurs in the AD brain and plays a critical role in the neurodegenerative pathology. Particularly, Aβ evokes an inflammatory response that leads to synaptic dysfunction, neuronal death, and neurodegeneration. Apolipoprotein E （ApoE） proteins are involved in cholesterol transport, Aβ binding and clearance, and synaptic functions in the brain. The ApoE4 isoform is a key risk factor for AD, while the ApoE2 isoform has a neuroprotective effect. However, studies have reached different conclusions about the roles of the isoforms; some show that both ApoE3 and ApoE4 have anti-inflammatory effects, while others show that ApoE4 causes a predisposition to inflammation or promotes an inflammatory response following lipopolysaccharide treatment. These discrepancies may result from the differences in models, cell types, experimental conditions, and inflammatory stimuli used. Further, little was known about the role of ApoE isoforms in the Aβ-induced inflammatory response and in the neuroinflammation of AD. Our recent work showed that ApoE isoforms differentially regulate and modify the Aβ-induced inflammatory response in neural cells, with ApoE2 suppressing and ApoE4 promoting the response. In this article, we review the roles, mechanisms, and interrelations among Aβ, ApoE, and neuroinflammation in AD.

关键词： ApoE Alzheimer's disease Aβ neuroinflammation

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Chinese Association for the Study of Pain:Expert consensus on chronic postsurgical pain

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World Journal of Clinical Cases 2021年第9期9卷 2090-2099页

作者： Yi-Ming liu Yi Feng yan-qing liu yan Lv Yuan-Chang Xiong Ke Ma Xian-Wei Zhang Jin-Feng liu Yi Jin Hong-Guang Bao Min yan Tao Song qing liu Department of Algology Peking University People’s HospitalBeijing 100044China Department of Algology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Department of Algology Air Force Medical University of PLAXi’an 710032Shaanxi ProvinceChina Department of Anesthesiology Changhai HospitalNaval Military Medical UniversityShanghai 200433China Department of Algology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Algology The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Algology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Anesthesiology Nanjing First HospitalNanjing Medical UniversityNanjing 210006Jiangsu ProvinceChina Department of Anesthesiology The Second Affiliated Hospital of Zhejiang University school of MedicineHangzhou 310058Zhejiang ProvinceChina Department of Algology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Algology The Affiliated T.C.M Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

Chronic postsurgical pain is a common surgical complication that severely reduces a patient’s quality of *** perioperative interventions and management strategies have been developed for reducing and managing chronic postsurgical *** the leadership of the Chinese Association for the Study of Pain,an editorial committee was formed for chronic postsurgical pain diagnosis and treatment by experts in relevant *** editorial committee composed the main content and framework of this consensus and established a working *** working group conducted literature review(1989-2020)using key words such as“surgery”,“post-surgical”,“post-operative”,“pain”,“chronic”,and“persistent”in different databases including MEDLINE,EMBASE,PubMed,Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic *** publications in the English language were *** types of literature included systematic reviews,randomized controlled studies,cohort studies and case *** consensus was written based on clinical practice combined with literature *** first draft of the consensus was rigorously reviewed and edited by all the editorial committee experts before being *** level of evidence was assessed by methodological experts based on the Oxford Centre for Evidence-Based Medicine Levels of *** strength of recommendation was evaluated by all editorial committee experts,and the opinions of most experts were adopted as the final *** recommendation level“strong”generally refers to recommendations based on high-level evidence and consistency between clinical behavior and expected *** recommendation level“weak”generally refers to the uncertainty between clinical behavior and expected results based on low-level evidence.

关键词： Chronic postsurgical pain Treatment Interventional Prevention

A 65-year-old man with infratentorial diffuse encephalopathy and hydrocephalus

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Chinese Medical Journal 2011年第11期124卷 1758-1760页

作者： FENG yan-qing GUO Ning liu Jun-xiu LAI Rong CHEN Xi HUANG Fan Department of Neurology First Affiliated Hospital of Sun Yat-senUniversity Guangzhou Guangdong 510080 China

Tuberculous encephalopathy （TBE） is an important diagnosis in countries with a high prevalence of tuberculosis. TBE is a life-threatening condition but rarely reported in the modern literature. We reported a case of a man with extensive parenchymal lesions involving the brainstem and right cerebellar hemisphere that resolved after treatment. The clinical, laboratory and pathological features of this case are highlighted and the pathogenesis is discussed.

关键词： tuberculous encephalopathy hydrocephalus

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Clinical application of multidisciplinary team-and evidence-based practice project in gynecological patients with perioperative hypothermia

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World Journal of Psychiatry 2023年第11期13卷 848-861页

作者： qing-yan liu Tong-yang You Dai-Ying Zhang Juan Wang The Operating Room The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Perioperative hypothermia(PH)negatively affects the physical and mental health of patients to varying ***,there is no effective multidisciplinary team(MDT)intervention for gynecological patients with *** To apply the best evidence on the prevention and management of PH in gynecological patients,improve the quality of perioperative evidence-based care based on treatment by an MDT for gynecological patients and analyze the effect of MDT-and evidence-based practice(EBP)projects on the psychological status and cognitive function of gynecological patients with *** Under the guidance of knowledge translation and combined with the opinions of involved stakeholders and clinical experts,the best evidence for PH prevention and management in gynecological patients was selected and adjusted to suit the practice *** on the evidence,the practice plan was developed,and the MDT intervention was carried out in the preoperative ward,the preoperative preparation room,the intraoperative operating room,the postanesthesia care unit,and the 24-hour postoperative gynecological ward through the EBP *** incidence of hypothermia,the nurses’awareness,the implementation rate of examination indicators,and the thermal comfort level,psychological status and cognitive function of patients were compared before and after the implementation of the *** The incidence of PH in gynecological patients decreased from 43.33%to 13.33%after the implementation of the *** implementation rate of examination indicators 6-10,12,14,16-18,21,and 22 reached 100%,and that of other indicators was above 90%,except for examination indicators 5 and 13,which was 66.67%;the indices were significantly improved compared with the baseline(before evidence application)(P<0.05).The score of nurses'awareness of PH prevention and management in gynecological patients increased from 60.96±9.70 to 88.08±8.96,and the difference was statistically significant(P<0.001)

关键词： Hypothermia Gynecology Evidence-based care Knowledge translation Multidisciplinary team

Expert consensus of Chinese Association for the Study of Pain on the radiofrequency therapy technology in the Department of Pain

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World Journal of Clinical Cases 2021年第9期9卷 2123-2135页

作者： Jin-Feng liu Wen Shen Dong Huang Tao Song Wei Tao qing liu You-qing Huang Xiao-Mei Zhang Ling-Jie Xia Da-Sheng Wu Hui liu Fu-Yong Chen Tang-Hua liu Bao-Gan Peng yan-qing liu Department of Algology The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086Heilongjiang ProvinceChina Department of Algology Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Algology The Third Xiangya Hospital of Central South UniversityChangsha 410000Hunan ProvinceChina Department of Algology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Neurosurgery Shenzhen University General HospitalShenzhen 518000Guangdong ProvinceChina Department of Algology The Affiliated T.C.M Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Algology The Second Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina Department of Algology The First Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina Department of Algology Henan Provincial HospitalZhengzhou 450000Henan ProvinceChina Department of Algology Jilin Province People's HospitalChangchun 130000Jilin ProvinceChina Department of Algology West China Hospital of Sichuan UniversityChengdu 610000Sichuan ProvinceChina Department of Algology The Third People's Hospital of YibinYibin 644000Sichuan ProvinceChina Department of Orthopedics The Third Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Algology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

On the basis of continuous improvement in recent years,radiofrequency therapy technology has been widely developed,and has become an effective method for the treatment of various intractable *** therapy is a technique that uses special equipment and puncture needles to output ultra-high frequency radio waves and accurately act on local *** order to standardize the application of radiofrequency technology in the treatment of painful diseases,Chinese Association for the Study of Pain(CASP)has developed a consensus proposed by many domestic experts and scholars.

关键词： Radiofrequency therapy Standard radiofrequency therapy Pulsed radiofrequency Bipolar radiofrequency therapy Expert consensus Pain