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Triclosan-conjugated,Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms

Chinese Journal of Polymer Science 2024年第6期42卷 718-728页

作者： yan-qiang huang Yuan-Feng Li Yong Liu Lin-Qi Shi Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise533000China Translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325035China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of Educationand Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China

Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative *** this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery *** micelles were created using an amphiphilic block polymer synthesized via ring-opening polymerization ofε-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial *** important advantage of our micelles lies in their interaction with local bacterial lipases within *** lipases triggered rapid micelle degradation,releasing triclosan in a controlled *** liberated triclosan effectively eliminated bacteria embedded in the ***,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and *** finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial *** triclosan-conjugated,lipase-responsive polymeric micelles exhibit promising characteristics for addressing drug resistance in bacterial *** harnessing biofilm properties and implementing a responsive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.

关键词： Self-assembly Polymer prodrug Ring-opening polymerization Biofilm eradication Cytotoxicity

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Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： Chun Qin Gan-Rong huang Ai-Xing Guan Wen-Ting Zhou Hao Chen Pei-Pei Luo Xian-Ke Luo yan-qiang huang Zan-Song huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BACKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(CagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PCR and Western *** was used to analyze CagA,CagM,CagE,Cag1,Cag3,and CagT.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** CagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as CagA,CagM,CagE,Cag1,Cag3,and *** these factors,CagM and CagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,CagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and Cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

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Preparation and hypoglycemic effects of chromium-and zinc-rich Acetobacter aceti

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World Journal of Diabetes 2022年第6期13卷 442-453页

作者： Yong-Yi huang Xiang-Kun Qin Yuan-Yuan Dai Liang huang Gan-Rong huang yan-Chun Qin Xian Wei yan-qiang huang Research Center for the Prevention and Treatment of Drug Resistant Microbial Infection Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND At present,there is no ideal method to cure diabetes,and there are few reports on the treatment of diabetes with *** To propose a method for preparing a new type of chromium-and zinc-rich Acetobacter aceti(***)and explore its ability to enhance the hypoglycemic effects of probiotics in the treatment of *** *** was cultured in a liquid medium that contained chromium trichloride and zinc chloride,both at a concentration of 64 mg/mL,with the initial concentration of the bacterial solution 1×10^(4) CFU/*** the bacterial solution had been inducted for 48 h,the culture media was changed and the induction was repeated *** levels of chromium and zinc in the bacteria were detected by inductively coupled plasma mass spectrometry,and the contents of NADH and glucose dehydrogenase were determined using an NAD/NADH kit and glucose dehydrogenase kit,*** was used to establish a mouse model to evaluate the hypoglycemic effects of the proposed chromium-and zincrich ***-times the therapeutic dose was administered to evaluate its biological *** effect on MIN6 islet cells was also assessed in *** The levels of chromium metal,metallic zinc,NADH coenzyme,and glucose dehydrogenase in *** prepared by this method were 28.58-34.34 mg/kg,5.35-7.52 mg/kg,5.13-7.26μM,and 446.812-567.138 U/g,*** use of these bacteria resulted in a better hypoglycemic effect than metformin,promoting the repair of tissues and cells of pancreatic islets in vivo and facilitating the growth of MIN6 pancreatic islet cells and increasing insulin secretion in ***-times the therapeutic dose of treatment was non-toxic to *** Chromium trichloride and zinc chloride can be employed to induce the preparation of chromiumand zinc-rich ***,which can then promote the hypoglycemic effect found in normal *** bacteria biotransforms the chromium and zinc in a way that could increase thei

关键词： Acetobacter aceti Chromium Zinc Enrichment Blood sugar decrease

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BanXiaXieXin decoction treating gastritis mice with drug-resistant Helicobacter pylori and its mechanism

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World Journal of Gastroenterology 2023年第18期29卷 2818-2835页

作者： Xiao-Hua Li Jia-Yin Xu Xue Wang Li-Juan Liao Liang huang yan-qiang huang Zeng-Feng Zhang Duate School Guangxi Medical UniversityNanning 5330021Guangxi Zhuang Autonomous RegionChina Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Microbiology Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Helicobacter pylori(***)is the main pathogen that causes a variety of upper digestive *** drug resistance rate of *** is increasingly higher,and the eradication rate is increasingly *** antimicrobial resistance of *** is an urgent global *** has been confirmed that Banxia Xiexin decoction(BXXXT)demonstrates the effects of treating gastrointestinal diseases,inhibiting *** and protecting gastric *** purpose of the present study is to further explore the therapeutic effects of BXXXT on drug-resistant *** To confirm that BXXXT demonstrates therapeutical effects in vivo and in vitro on gastritis mice with drug-resistant *** and explain its mechanism to provide an experimental basis for promoting the application of *** The aqueous extract of BXXXT was gained by water decocting *** inhibitory effect of the aqueous extract on *** was detected by dilution in vitro;drug-resistant *** cells were used to build an acute gastritis model in ***,the model mice were treated with the aqueous extract of *** amount of *** colonization,the repair of gastric mucosal damage,changes of inflammatory factors,apoptosis,etc.,were *** terms of mechanism exploration,the main medicinal compositions of BXXXT aqueous extract and the synergistic bacteriostatic effects they had demonstrated were analyzed using mass spectrometry;the immune function of peripheral blood cells such as CD3+T and CD4+T of mice with gastritis before and after treatment with BXXXT aqueous extract was detected using a flow cytometry;the *** transcriptome and proteome after treatment with BXXXT aqueous extract were *** expressed genes were screened and verification was performed thereon with knockout *** The minimum inhibitory concentration of BXXXT aqueous extract against *** was 256-512μg/mL.A dose of 28 mg/kg BXXXT aqueous extract treatment produced bet

关键词： Banxia Xiexin decoction Helicobacter pylori Drug resistance Therapeutic effects Mechanism

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Linolenic acid-metronidazole inhibits the growth of Helicobacter pylori through oxidation

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世界胃肠病学杂志:英文版 2023年第32期29卷 4860-4872页

作者： Wen-Ting Zhou Yuan-Yuan Dai Li-Juan Liao Shi-Xian yang Hao Chen Liang huang Juan-Li Zhao yan-qiang huang School of Basic Medicine Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina School of Basic Medicine Youjiang Medical University for NationalitiesAffiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Laboratory Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina School of Basic Medicine Department of PathologyWannan Medical CollegeWuhu 533000Anhui ProvinceChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina School of Basic Sciences Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Resistance to antibiotics is one the main factors constraining the treatment and control of Helicobacter pylori(***)***,there is an urgent need to develop new antimicrobial agents to replace *** previous study found that linolenic acid-metronidazole(Lla-Met)has a good antibacterial effect against ***,both antibiotic-resistant and sensitive ***,*** does not develop resistance to ***,it could be used for preparing broad-spectrum antibacterial ***,since the antibacterial mechanism of Lla-Met is not well understood,we explored this phenomenon in the present *** To understand the antimicrobial effect of Lla-Met and how this could be applied in treating corresponding *** *** cells were treated with the Lla-Met compound,and the effect of the compound on the cell morphology,cell membrane permeability,and oxidation of the bacteria cell was ***,the differently expressed genes in *** in response to Lla-Met treatment were *** Lla-Met treatment induced several changes in *** cells,including roughening and *** vivo experiments revealed that Lla-Met induced oxidation,DNA fragmentation,and phosphatidylserine ectropionation in *** *** Lla-Met with L-cysteine abrogated the above *** analysis revealed that Lla-Met treatment up-regulated the expression of superoxide dismutase SodB and MdaB genes,both anti-oxidation-related *** Lla-Met kills *** mainly by inducing oxidative stress,DNA damage,phosphatidylserine ectropionation,and changes on cell morphology.

关键词： Helicobacter pylori Oxidation Superoxide dismutase SodB genes MdaB genes

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Research on the quasi-isentropic driving model of aluminized explosives in the detonation wave propagation direction

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Defence Technology（防务技术） 2024年第2期32卷 596-618页

作者： Hongfu Wang yan Liu Fan Bai Chao He Yingliang Xu qiang Zhou Chuan Xiao Fenglei huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China China Research and Development Academy of Machinery Equipment Beijing100089China Beijing Institute of Technology Chongqing Innovation Center Chongqing401120China

Taking CL-20(Hexanitrohexaazaisowurtzitane)-based aluminized explosives with high gurney energy as the research object, this research experimentally investigates the work capability of different aluminized explosive formulations when driving metal flyer plates in the denotation wave propagation *** research results showed that the formulations with 43 μm aluminum(Al) powder particles(The particle sizes of Al powder were in the range of 2~43 μm) exhibited the optimal performance in driving flyer plates along the denotation wave propagation direction. Compared to the formulations with Al powder 13 μm, the formulations with Al powder 2 μm delivered better performance in accelerating metal flyer plates in the early stage, which, however, turned to be poor in the later stage. The CL-20-based explosives containing 25% Al far under-performed those containing 15% Al. Based on the proposed quasi-isentropic hypothesis, relevant isentropy theories, and the functional relationship between detonation parameters and entropy as well as Al reaction degree, the characteristic lines of aluminized explosives in accelerating flyer plates were theoretically studied, a quasi-isentropic theoretical model for the aluminized explosive driving the flyer plate was built and the calculation methods for the variations of flyer plate velocity, Al reaction degree, and detonation product parameters with time and axial positions were developed. The theoretical model built is verified by the experimental results of the CL-20-based aluminized explosive driving flyer plate. It was found that the model built could accurately calculate the variations of flyer plate velocity and Al reaction degree over time. In addition, how physical parameters including detonation product pressure and temperature varied with time and axial positions was identified. The action time of the positive pressure after the detonation of aluminized explosives was found prolonged and the downtrend of the temperature was

关键词： Aluminized explosive Flyer plate experiment Quasi-isentropic theoretical model Al reaction Driving characteristics

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High-resolution mid-infrared single-photon upconversion ranging

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Photonics Research 2024年第6期12卷 1294-1302页

作者： SHUHONG JIANG KUN huang TINGTING YU JIANAN FANG BEN SUN yan LIANG qiang HAO E.WU MING yan HEPING ZENG State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing 401121China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China School of Optical Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Research Center for Quantum Sciences Shanghai 201315China Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqing 400064China

Single-photon laser ranging has widespread applications in remote sensing and target ***,highly sensitive light detection and ranging(lidar)has long been restricted in the visible or near-infrared *** appealing quest is to extend the operation wavelength into the mid-infrared(MIR)region,which calls for an infrared photon-counting system at high detection sensitivity and precise temporal ***,we devise and demonstrate an MIR upconversion lidar based on nonlinear asynchronous optical ***,the infrared probe is interrogated in a nonlinear crystal by a train of pump pulses at a slightly different repetition rate,which favors temporal optical scanning at a picosecond timing resolution and a kilohertz refreshing rate ***,the cross-correlation upconversion trace is temporally stretched by a factor of 2×10^(4),which can thus be recorded by a low-bandwidth silicon *** combination with the time-correlated photon-counting technique,the achieved effective resolution is about two orders of magnitude better than the timing jitter of the detector itself,which facilitates a ranging precision of 4μm under a low detected flux of 8×10^(−5) photons per *** presented MIR time-of-flight range finder is featured with single-photon sensitivity and high positioning resolution,which would be particularly useful in infrared sensing and imaging in photon-starved scenarios.

关键词： resolution lidar repetition

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Mismatch analysis of all-fiber coherent beam combiners based on the self-imaging effect

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High Power Laser Science and Engineering 2024年第2期12卷 1-15页

作者： Yuefang yan Yu Liu Haoyu Zhang Yuwei Li Chao Guo qiang Shu Wenhui huang Feng Jing Rumao Tao Laser Fusion Research Center China Academy of Engineering PhysicsMianyangChina Key Laboratory of Particle&Radiation Imaging(Tsinghua University) Ministry of EducationBeijingChina

All-fiber coherent beam combiners based on the self-imaging effect can achieve a near-perfect single laser beam,which can provide a promising way to overcome the power limitation of a single-fiber *** of the key points is combining efficiency,which is determined by various mismatches during fabrication.A theoretical model has been built,and the mismatch error is analyzed numerically for the first *** mismatch errors have been numerically studied with the beam quality and combining efficiency being chosen as the evaluation *** tolerance of each mismatch error for causing 1%loss is calculated to guide the design of the beam *** simulation results are consistent with the experimental results,which show that the mismatch error of the square-core fiber is the main cause of the efficiency *** results can provide useful guidance for the fabrication of all-fiber coherent beam combiners.

关键词： all-fiber coherent beam combination mismatch analysis self-imaging

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Object Helps U-Net Based Change Detectors

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 548-550页

作者： Lan yan qiang Li Kenli Li College of Computer Science and Electronic Engineering Hunan UniversityChangsha 410082China State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

Dear Editor,This letter focuses on leveraging the object information in images to improve the performance of the U-Net based change *** detection is fundamental to many computer vision *** existing solutions based on ... 详细信息

关键词： Net computer networks

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A wide-linear-range and low-hysteresis resistive strain sensor made of double-threaded conductive yarn for human movement detection

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Journal of Materials Science & Technology 2024年第5期172卷 202-212页

作者： Fei huang Jiyong Hu Xiong yan Shanghai Frontier Science Research Center for Modern Textiles Donghua UniversityShanghai 201620China

Yarn-based flexible strain sensors with advantages in wearability and integrability have attracted wide ***,it is still a big challenge to achieve yarn-based strain sensors with a wide linear strain range,low hysteresis,and durability synchronously that can be used for full range detection of human body ***,a new structure,double-threaded conductive yarn with rhythmic strain distribu-tion,is reported to markedly widen the linear strain range of microcrack-based stretchable strain sensors.A new method of winding and thermally adhering hot-melt filaments on the surface of the elastic fiber is used to achieve double-threaded yarn(DTY)with rhythmic strain *** proposed strategy,the integration of heterogeneous materials,is reported to significantly reduce the mechanical hysteresis of composite *** strain distribution of the DTY during stretching causes multi-level micro-cracks in different regions of the carbon nanotube(CNT)conductive layer deposited on the surface of the ***,the sensing performance of DTY-based strain sensor can be adjusted by designing the structural *** final prepared flexible strain sensor has the advantages of a wide linear strain range(100%),great sensitivity(GF=12.43),low hysteresis,rapid response(158 ms),high repeatability(>2000 cycles at 50%strain),and hydrophobicity,*** sensor can monitor human motion repeatedly and stably well,and shows great advantages in flexible wearable devices.

关键词： Double-threaded yarn Strain redistribution Hysteresis Human motion monitoring

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