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Impact of baseline CD4^＋ T cell counts on the efficacy of nevirapinebased highly active antiretroviral therapy in Chinese HIV/AIDS patients： a prospective, multicentric study

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Chinese Medical Journal 2009年第20期122卷 2497-2502页

作者： LIU Zheng-yin GUO Fu-ping HAN yang QIU Zhi-feng ZUO Ling-yan LI yan-ling LI Tai-sheng Department of Infectious Diseases Peking Union Medical College Hospital Beiiing 100730 China

Background CD4^＋T cell counts have been used as the indicator of human immunodeficiency virus type 1 （HIV-1） disease progression and thereby to determine when to start highly active antiretroviral therapy （HAART）. Whether and how the baseline CD4^＋T cell count affects the immunological and viral responses or adverse reactions to nevirapine （NVP）-containing HAART in Chinese HIV-1 infected adults remain to be characterized. Methods One hundred and ninety-eight HIV-seropositive antiretroviral therapy （ART）-naive subjects were enrolled into a prospective study from 2005 to 2007. Data were analyzed by groups based on baseline CD4^＋T cell counts either between 100-200 cells/μl or 201-350 cells/μl. Viral responses, immunologic responses and adverse events were monitored at baseline and at weeks 4, 12, 24, 36, 52, 68, 84, 100. Results Eighty-six and 112 subjects ranged their CD4^＋T cell counts 100-200 cells/μl and 201-350 cells/μl, respectively. The pre-HAART viral load in CD4 201-350 cells/μl group was significantly lower than that in CD4 100-200 cells/μl group （P=0.000）. After treatment, no significant differences were observed between these two groups either in the plasma viral load （pVL） or in the viral response rate calculated as the percentage of pVL less than 50 copies/ml or less than 400 copies/ml. The CD4^＋T cell counts were statistically higher in the 201-350 group during the entire follow-ups （P 〈0.01） though CD4^＋ T cell count increases were similar in these two groups. After 100-week treatment, the median of CD4^＋ T cell counts were increased to 331 cells/μl for CD4 100-200 cells/μl group and to 462 cells/μl for CD4 201-350 cells/μl group. Only a slightly higher incidence of nausea was observed in CD4 201-350 cells/μl group （P=0.05） among all adverse reactions, including rash and liver function abnormality. Conclusions The pVLs and viral response rates are unlikely to be associated with the baseline CD4^＋T cell counts. Initiating HAART in Chinese HIV-1 infected

关键词： human immunodeficiency virus acquired immunodeficiency syndrome highly active antiretroviral therapy CD4^+ T cell counts nevirapine

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水中爆炸气泡与水底边界相互作用的水射流现象

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爆炸与冲击 2011年第3期31卷 250-255页

作者：汪斌张远平王彦平中国工程物理研究院流体物理研究所冲击波物理与爆轰物理国防科技重点实验室四川绵阳621900

应用开尔文冲量原理,分析了水中爆炸产生的气泡与水底边界相互作用产生水射流的主要影响因素,开展了气泡与水平放置的钢板相互作用水射流现象的实验研究工作。通过改变炸药到钢板的距离,得到不同爆距条件下,气泡与钢板相互作用形成水射... 详细信息

应用开尔文冲量原理,分析了水中爆炸产生的气泡与水底边界相互作用产生水射流的主要影响因素,开展了气泡与水平放置的钢板相互作用水射流现象的实验研究工作。通过改变炸药到钢板的距离,得到不同爆距条件下,气泡与钢板相互作用形成水射流的动态过程图像和气泡2次脉动压力。理论分析和实验结果均表明:随着爆距的减小,Bjerknes力迅速增加,气泡与水平放置钢板相互作用产生水射流的临界条件为爆距小于气泡最大半径。水射流具有非常明显的方向性,对目标毁伤作用明显。

关键词：爆炸力学水射流气泡脉动水中爆炸 Bjerknes力

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Contrast Test Between Direct Seeding and Seedling Transplanting of Diwangcai

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Agricultural Biotechnology 2019年第1期8卷 47-48页

作者： ping LI yan yanG Zhonggang CUI Zhonghua ZHANG Dazhou Academy of Agricultural Sciences

To improve the yield of Diwangcai and explore its best cultivation way,direct seeding and seedling transplanting of Diwangcai were contrasted. The results showed that cumulative annual yield of Diwangcai by seedling t... 详细信息

关键词： Diwangcai Direct seeding Seedling transplanting Contrast

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晏殊诗“富贵气象”新论

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江淮论坛 2009年第3期 179-182页

作者：谢琰北京师范大学文学院北京100875

本文从富贵心态和审美趣味两个方面对晏殊诗的"富贵气象"进行了新阐释。认为:晏殊在心态上重气氛而轻物欲、"体富"而不"观富"、"怜贫"而不"处贫",因此其诗多流连而少失落、多体验而少虚拟、多悲悯而少讽谏。其审美趣味包含了节制物象、... 详细信息

本文从富贵心态和审美趣味两个方面对晏殊诗的"富贵气象"进行了新阐释。认为:晏殊在心态上重气氛而轻物欲、"体富"而不"观富"、"怜贫"而不"处贫",因此其诗多流连而少失落、多体验而少虚拟、多悲悯而少讽谏。其审美趣味包含了节制物象、节制描写与节制理致三大特征。

关键词：晏殊富贵气象心态趣味

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自修复微胶囊的制备及其性能研究

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高校化学工程学报 2011年第3期25卷 513-518页

作者：鄢瑛罗永平张会平华南理工大学化学与化工学院广东广州510640

采用双环戊二烯(DCPD)为芯材、脲醛树脂为壁材,利用原位聚合法制备自修复微胶囊。采用光学显微镜观察了微胶囊的形成过程,采用扫描电子显微镜考察了乳化剂种类对微胶囊的微观形貌的影响,利用傅里叶红外光谱和激光粒度仪分析了微胶囊的... 详细信息

采用双环戊二烯(DCPD)为芯材、脲醛树脂为壁材,利用原位聚合法制备自修复微胶囊。采用光学显微镜观察了微胶囊的形成过程,采用扫描电子显微镜考察了乳化剂种类对微胶囊的微观形貌的影响,利用傅里叶红外光谱和激光粒度仪分析了微胶囊的化学成分和粒径分布,考察了不同乳化剂用量和乳化速度对微胶囊的粒径分布的影响,并讨论了助剂NaCl水溶液的质量分数对微胶囊包封率的影响。实验结果表明:采用十二烷基苯磺酸钠(DBS)作为乳化剂,其用量占芯材质量的5.0%,乳化转速为6000 r·min-1,制备的微胶囊形貌质量最好,分散效果好,粒径分布较窄,加入质量分数为4.0%的NaCl水溶液能显著提高微胶囊的包封率,使得微胶囊的包封率从73.0%提高至89.2%。

关键词：微胶囊自修复原位聚合法性能

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Rapid thermal sensors with high resolution based on an adaptive dual-comb system

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Frontiers of Information Technology & Electronic Engineering 2019年第5期20卷 674-684页

作者： Yi-zheng GUO Ming yan Qiang HAO Kang-wen yanG Xu-ling SHEN He-ping ZENG Shanghai Key Laboratory of Modem Optical System Engineering Research Center of Optical Instrument and System (Ministry of Education) School of Optical-Electrical and Computer Engineering University of Shanghai for Science and Technology Shanghai 200093 China State Key Laboratory of Precision Spectroscopy East China Normal University Shanghai 200062 China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China

We report a high-resolution rapid thermal sensing based on adaptive dual comb spectroscopy interrogated with a phase-shifted fiber Bragg grating(PFBG). In comparison with traditional dual-comb systems, adaptive dual-comb spectroscopy is extremely simplified by removing the requirement of strict phase-locking feedback loops from the dual-comb configuration. Instead, two free-running fiber lasers are adopted as the light sources. Because of good compensation of fast instabilities with adaptive techniques, the optical response of the PFBG is precisely characterized through a fast Fourier transform of the interferograms in the time domain. Single-shot acquisition can be accomplished rapidly within tens of milliseconds at a spectral resolution of 0.1 pm, corresponding to a thermal measurement resolution of 0.01 ℃. The optical spectral bandwidth of the measurement also exceeds 14 nm, which indicates a large dynamic temperature range. It shows great potential for thermal sensing in practical outdoor applications with a loose self-control scheme in the adaptive dual-comb system.

关键词： Interferometers Fiber sensors Laser spectroscopy

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电感耦合等离子体质谱法测定食品级磷酸盐中杂质元素

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光谱学与光谱分析 2012年第10期32卷 2834-2837页

作者：李坦平谢华林湖南工学院材料与化学工程学院湖南衡阳421002 长江师范学院化学化工学院重庆涪陵408100

建立了电感耦合等离子体质谱(ICP-MS)法测定食品级磷酸盐中Mg,Ti,V,Cr,Fe,Co,Ni,Cu,Zn,As,Cd,Pb等12种杂质元素的分析方法。样品经硝酸消解后直接进行分析,应用碰撞/反应池(ORS)技术有效地消除了多原子离子对待测元素的干扰,选用Sc,Y,In... 详细信息

建立了电感耦合等离子体质谱(ICP-MS)法测定食品级磷酸盐中Mg,Ti,V,Cr,Fe,Co,Ni,Cu,Zn,As,Cd,Pb等12种杂质元素的分析方法。样品经硝酸消解后直接进行分析,应用碰撞/反应池(ORS)技术有效地消除了多原子离子对待测元素的干扰,选用Sc,Y,In,Bi等元素为内标混合液校正基体干扰和漂移。研究结果表明,该方法对12种待测元素的检出限在0.004～0.362μg.L-1之间。本法简便,快速,能满足食品级磷酸盐中多种杂质元素同时测定的分析需求。

关键词：电感耦合等离子体质谱法八极杆碰撞/反应池磷酸盐杂质元素

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Alterations of sleep deprivation on brain function:A coordinatebased resting-state functional magnetic resonance imaging metaanalysis

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World Journal of Psychiatry 2024年第2期14卷 315-329页

作者： Qin Zhang Yong-Zhe Hou Hui Ding yan-ping Shu Jing Li Xi-Zhao Chen Jia-Lin Li Qin Lou Dai-Xing Wang Department of Radiology The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Department of Radiology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina Department of Psychiatry of Women and Children The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Medical Humanities College Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Sleep deprivation is a prevalent issue that impacts cognitive *** numerous neuroimaging studies have explored the neural correlates of sleep loss,inconsistencies persist in the reported results,necessitating an investigation into the consistent brain functional changes resulting from sleep *** To establish the consistency of brain functional alterations associated with sleep deprivation through systematic searches of neuroimaging *** metaanalytic methods,signed differential mapping(SDM)and activation likelihood estimation(ALE),were employed to analyze functional magnetic resonance imaging(fMRI)*** A systematic search performed according to PRISMA guidelines was conducted across multiple databases through July 29,*** that met specific inclusion criteria,focused on healthy subjects with acute sleep deprivation and reported whole-brain functional data in English were considered.A total of 21 studies were selected for SDM and ALE *** Twenty-one studies,including 23 experiments and 498 subjects,were *** to pre-sleep deprivation,post-sleep deprivation brain function was associated with increased gray matter in the right corpus callosum and decreased activity in the left medial frontal gyrus and left inferior parietal *** revealed increased brain functional activity in the left striatum and right central posterior gyrus and decreased activity in the right cerebellar gyrus,left middle frontal gyrus,corpus callosum,and right *** This meta-analysis consistently identified brain regions affected by sleep deprivation,notably the left medial frontal gyrus and corpus callosum,shedding light on the neuropathology of sleep deprivation and offering insights into its neurological impact.

关键词： Sleep deprivation Resting-state-functional magnetic resonance imaging Activation likelihood estimation-meta Signed differential mapping-meta

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单原子催化剂的生物医学应用研究进展

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上海交通大学学报（医学版） 2022年第12期42卷 1751-1756页

作者：谢玉婷熊屏上海交通大学医学院附属第九人民医院超声医学科上海200011

随着纳米技术和材料科学的快速发展,许多根据疾病的微环境理化特性进行设计和改造的纳米材料,通过特定刺激触发原位催化反应,已被证实具有有效的治疗作用。然而,针对目前纳米医学应用的催化剂存在结构复杂和潜在的金属离子毒性问题,研... 详细信息

随着纳米技术和材料科学的快速发展,许多根据疾病的微环境理化特性进行设计和改造的纳米材料,通过特定刺激触发原位催化反应,已被证实具有有效的治疗作用。然而,针对目前纳米医学应用的催化剂存在结构复杂和潜在的金属离子毒性问题,研究者们致力于开发和改进合成更有效、更可控和毒性更低的纳米催化剂。近年来,单原子催化剂(single-atom catalysts,SACs)作为锚定或配位在合适载体上的原子分散的金属活性位点,具有优异催化活性和高选择性,显示出在治疗应用中的巨大潜力。该文概述了SACs在生物医学应用方面的开发进展,重点阐述了在抗菌、癌症治疗、氧化应激细胞保护和生物传感方面应用的最新进展,通过列举成功研制的一系列代表性SACs揭示其在不同疾病应用的催化触发机制,了解潜在的结构与性能关系。最后,对SACs在纳米催化医学领域面临的当前挑战和未来机遇进行了探讨和展望。

关键词：单原子催化剂生物医学应用酶样反应纳米医学生物催化机制

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Effects of oxygen plasma etching and post-annealing on Pt Schottky contact on Mg-doped InZnO

Effects of oxygen plasma etching and post-annealing on Pt Sc...

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2012 IEEE 11th International Conference on Solid-State and Integrated Circuit Technology(ICSICT-2012)

作者： yan-ping Deng Jia-Hong Wu Xin-ping Qu State key lab of ASIC and system Department of MicroelectronicsFudan University

Mg-doped InZnO（MIZO）films were prepared by sol-gel *** surface of the films was treated by oxygen *** was then deposited on O2-treated films to form MIZO/Pt Schottky *** I-V properties of this structure were studied under different oxygen plasma treatment *** experimental results show that oxygen plasma treatment can improve the Schottky properties by minimizing the surface adsorbates and subsurface defects of MIZO films.

关键词： Plasmas Films Annealing Schottky barriers Zinc oxide Etching

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