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Clinical treatment considerationsin the intensity-modulated radiotherapy era for patients with NO-category nasopharyngeal carcinoma and enlarged neck lymph nodes

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Chinese Journal of Cancer 2017年第7期36卷 306-314页

作者： Hao Peng Lei Chen Rui Guo Yuan Zhang Wen.Fei Li yan.ping Mao Ying Sun Fan Zhang Li.Zhi Liu Li Tian Jun Ma State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Department of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China State Key Laboratory of Oncology in South China Department of Radiation OncologySun Yat-sen University Cancer Center 651 Dongfeng Road East Guangzhou 510060 P. R. China

Background:Nasopharyngeal carcinoma(NPC) shows a high proportion of lymph node metastasis,and treatment guidelines have been developed for positive ***,no irradiation guidelines have been proposed for patients with enlarged neck lymph nodes(ENLNs) that do not meet the radiological criteria of 10 mm in diameter for positive lymph *** study aimed to determine the prognostic value and radiation dose for ENLNs in NO-category NPC patients treated with intensity-modulated radiotherapy(IMRT).Methods:We reviewed the medical data of 251 patients with non-metastatic,NO-category NPC treated with *** operating characteristic curves were used to calculate the cut-off value of the ENLN diameter for the prediction of disease *** biological equivalent dose(BED) for ENLNs was *** survival was compared between the small and large ENLN *** prognostic factors were identified using the Cox proportional hazards ***:The estimated 4-year regional relapse-free survival rate was higher in patients with ENLNs ≥5.5 mm than in those with ENLNs 0.05 for all survival rates).In the subgroup analysis,patients receiving BED ≥72 Gy had a similar prognosis as patients receiving BED <72 Gy in both the small and large ENLN *** multivariate analysis also confirmed that BED≥72 Gy was not associated with significantly improved prognosis in patients with NO-category ***:A BED of 72 Gy to ENLNs is considerably sufficient to provide a clinical benefit to patients with NO-category *** studies are warranted to validate the findings in the present study.

关键词： Nasopharyngeal carcinoma N0-category Enlarged neck lymph node Biological equivalent dose Intensity-modulated radiotherapy Prognosis

Effect of saltwater intrusion on groundwater environment in Weihe River downstream, Shandong Province, China

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Journal of Groundwater Science and Engineering 2019年第3期7卷 245-252页

作者： MENG Yong-hui WANG Ji-ning YU De-Jie ZHANG Li-xia FENG Zai-min yan tang ZHOU Yong Geology and Environment Monitoring Station of Shandong Province Jinan 250014China Mineral Resources Management Center of Weifang City Weifang 262400Shandong ProvinceChina

Based on the geological and hydrogeological conditions along with dynamic changes of groundwater level,this paper analyzes the hydrodynamic characteristics of saltwater intrusion in the study *** to monitoring data of groundwater quality,the distribution characteristics of macro component are analyzed,and then fuzzy comprehensive evaluation method is adopted to evaluate the impact of saltwater intrusion on groundwater *** the influence degree of groundwater environment,the study area is divided into brine area,seriously influenced area,moderately influenced zone,slightly influenced zone and uninfluenced *** results can offer references for prevention and control of saltwater intrusion as well as the protection of water resources.

关键词： Saltwater intrusion Brine resources Hydrodynamic characteristics Groundwater macro component Groundwater environment

Clustered spikelets 4,encoding a putative cytochrome P450 protein CYP724B1,is essential for rice panicle development

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Chinese Science Bulletin 2014年第31期59卷 4050-4059页

作者： Min Guo Yi-Hao yang Min Liu Qing-Cai Meng Xiu-Hong Zeng Ling-Xia Dong Shu-Zhu tang Ming-Hong Gu Chang-Jie yan Jiangsu Key Laboratory of Crop Genetics and Physiology/ Co-Innovation Center for Modern Production Technology of Grain Crops Key Laboratory of Plant Functional Genomics of the Ministry of EducationYangzhou University

Rice(Oryza sativa L.)inflorescence(panicle)architecture is an important agronomic trait,serving as one of the determinants of rice yield.A number of genes related to panicle development have been cloned and functionally characterized so ***,more information is needed for fully understanding of the mechanism underlying the panicle *** the present study,we identified a clustered spikelets 4(cl4)mutant in the 93-11 genetic *** to its wild-type 93-11,cl4 mutant has a typical clustered spikelets phenotype with all primary branches clustered on the base of the main rachis and 2–3abnormal spikelets clustered on the primary ***,cl4 mutant also shows shorter plant height than that of the wild ***-based cloning strategy is performed to clone the CL4 *** a result,CL4 is demonstrated to encode a putative cytochrome P450 protein CYP724B1,which is involved in brassinosteroid *** confirm our mapping result,the CL4 RNAi transgenic plants are *** the transgenic plants also show similar phenotype as the cl4 *** results provide strong evidence that CL4 plays an important role in rice panicle development as well as plant height regulation.

关键词：细胞色素P450 水稻产量小穗集群蛋白编码稻穗转基因植物

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基于伪谱法的亚轨道飞行器返回轨迹优化设计

西北工业大学学报 2010年第5期28卷 748-752页

作者：闫晓东唐硕西北工业大学航天学院陕西西安710072

在亚轨道飞行器返回轨迹设计中,不仅要研究其可行轨迹的设计问题,还要研究在各种性能指标下的最优轨迹。文章采用伪谱法研究了亚轨道飞行器返回轨迹优化设计问题。为了便于应用伪谱法并加快优化速度,建立了以能量为独立积分变量的动力... 详细信息

在亚轨道飞行器返回轨迹设计中,不仅要研究其可行轨迹的设计问题,还要研究在各种性能指标下的最优轨迹。文章采用伪谱法研究了亚轨道飞行器返回轨迹优化设计问题。为了便于应用伪谱法并加快优化速度,建立了以能量为独立积分变量的动力学方程,并进行了归一化处理,将终端时间自由的优化问题转化为固定积分区间的优化问题。考虑状态约束、控制约束、过程约束以及终端约束,采用伪谱法进行了亚轨道飞行器的返回轨迹优化设计。从算例的仿真结果可以看出,伪谱法可以较好完成亚轨道飞行器的返回轨迹的优化设计任务。

关键词：轨迹,优化,亚轨道飞行器,返回轨迹伪谱法

A review of seismo-electromagnetic research in China

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Science China Earth Sciences 2022年第7期65卷 1229-1246页

作者： Guoze ZHAO Xuemin ZHANG Juntao CAI yan ZHAN Qinzhong MA Ji tang Xuebin DU Bing HAN Lifeng WANG Xiaobin CHEN Qibin XIAO Xiangyu SUN Zeyi DONG Jijun WANG Jihong ZHANG Ye FAN Tao YE State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China Institute of Earthquake Forecasting China Earthquake AdministrationBeijing 100036China National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China Shanghai Earthquake Agency Shanghai 200062China China Earthquake Administration Lanzhou Institute of Earthquake Lanzhou 730000China Shandong Earthquake Agency Jinan 250014China China Earthquake Network Center Beijing 100045China

The seismo-electromagnetic(EM)method is an important geophysical method that plays a major role in the observation of seismic anomalies related to earthquake *** is the most promising method for a breakthrough in short-term earthquake *** digital transformation and network upgrading implemented in the“Ninth five-year plan”and“Tenth five-year plan”have optimized the original observation system,improved the quality of observed data,enriched the seismicelectromagnetic information,and enhanced the analysis capability and timeliness of seismic-electromagnetic *** improvements are of major importance for the research on seismo-electromagnetics as well as for the development of new *** the beginning of the 21 st century,China has launched a satellite named CSES that was designed for the generation and study of seismo-electromagnetic data and built a high-power transmitting source and a new CSELF observation network that is used specifically for earthquake *** platform has promoted the full-time three-dimensional EM monitoring and the identification of earthquake *** on the study of anomalies related to earthquake precursors,the physical and numerical simulations,and the study on generation mechanism of anomalies in China,we summarize the characteristics of earthquake EM anomalies and discuss the advantages and disadvantages of different EM observation ***,considering the related questions of the seismo-electromagnetic prediction and implementing the recent developments both in China and abroad,we review the current status of seismo-electromagnetic research and propose strategies for future research.

关键词： Seismo-electromagnetism Seismic anomaly Electromagnetic observation Experiment and simulation Earthquake prediction Prospect

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Electropuncture influences on learning, memory, and neuropeptide expression in a rat model of vascular dementia

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Neural Regeneration Research 2008年第3期3卷 267-271页

作者： Ying Shao yanqian Fu Lihua Qiu Bing yan Xinsheng Lai Chunzhi tang College of Acupuncture and Massage Guangzhou University of Chinese Medicine Guangzhou 510405 Guangdong Province China

BACKGROUND： Studies in recent years have indicated that several neuropeptide-like substances, such as arginine vasopressin （AVP）, somatostatin （SS）, and β-endorphine （β-EP）, are involved in the process of cerebral ischemic damage to cranial nerves. OBJECTIVE： To observe the effects of electropuncture on back-shu points, as well as the influence on learning and memory, AVP, SS, and β-EP levels in plasma and brain were measured in a rat model of vascular dementia （VD）. DESIGN： Randomized controlled trial. SETTING： College of Acupuncture and Massage of Guangzhou University of Chinese Medicine. MATERIALS： This experiment was performed at the Animal Experiment Center of Guangzhou University of TCM from December 2005 to December 2006. A total of 48 healthy adult male Sprague Dawley rats of SPF-grade, 180-220 g, were provided by The Animal Experiment Center of Guangzhou University of Traditional Chinese Medicine. The following instruments were used： SDQ-30 Dipolar Radio-frequency Electrocoagulator （Shanghai Operation Instrument Factory）, Morris Water Maze （The Animal Experiment Center of Guangzhou University of Traditional Chinese Medicine）, Type G6805-1 Treating Equipment （Huasheng Equipment Factory, Qingdao, China）. METHODS： ① Eight rats were randomly selected for the control group; the remaining 40 rats underwent 4-vascular occlusion to establish a cerebral ischemia model. Due to the death of 13 rats and 2 hemiplegies during model establishment, there was a total of 25 model rats available for testing. The model rats were divided randomly into 3 groups according to their body weight： electropuncture group （n = 9）, medication group （n = 8）, and VD group （n = 8）. ② Electropuncture group： 25 mm needles （28 gauge） were used to electropuncture （150 Hz, continuous waves, 1.0-2.0 mA, duration of 20 minutes） the following acupoints： Baihui （GV20）, Geshu （BLIT）, Pishu （BL20）, and Shenshu （BL23）. The acupoints were located according to Experimental acupuncturology and were stimul

关键词： electropuncture vascular dementia neuropeptide learning and memory

一种基于FP-树的时态关联规则的分区挖掘方法

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计算机工程 2006年第17期32卷 132-134页

作者：马慧汤庸潘炎中山大学计算机科学系广州510275

随着各种形式的数据的迅速增长,业务数据中的时态信息挖掘问题受到人们普遍关注。该文提出了一种带有效时间区间的时态关联规则,给出了一种基于FP-树的挖掘方法。该方法利用分区挖掘的思想,以分区为单位表示项集的有效时间区间,并为每... 详细信息

随着各种形式的数据的迅速增长,业务数据中的时态信息挖掘问题受到人们普遍关注。该文提出了一种带有效时间区间的时态关联规则,给出了一种基于FP-树的挖掘方法。该方法利用分区挖掘的思想,以分区为单位表示项集的有效时间区间,并为每个分区构建FP-树,大大简化了对某个项集在其有效时间区间中的出现次数的计算,从而更有效地计算时态置信度。最后用一个例子对该方法的执行过程进行了阐述。

关键词：数据挖掘时念数据挖掘关联规则频繁模式树

Trends in medication use and treatment patterns in Chinese patients with inflammatory bowel disease

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World Journal of Gastroenterology 2022年第30期28卷 4102-4119页

作者： Ling-Ya Yao Bu-Le Shao Feng Tian Mei Ye Yu-Qin Li Xiao-Lei Wang Lin Wang Shao-Qi yang Xiao-ping Lv yan Jia Xue-Hong Wang Xiao-Qi Zhang yan-Ling Wei Qian Cao Department of Gastroenterology Sir Run Run Shaw HospitalCollege of Medicine Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan 430000Hubei ProvinceChina Department of Gastroenterology Bethune First Affiliated Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Gastroenterology Shanghai 10th People's HospitalTongji UniversityShanghai 200072China Department of Gastroenterology Zhongshan Hospital Affiliated to Xiamen UniversityXiamen 361000Fujian ProvinceChina Department of Gastroenterology General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology The 7th Medical Center of Chinese PLA General HospitalBeijing 100000China Department of Gastroenterology Second Xiangya HospitalChangsha 410011Hunan ProvinceChina Department of Gastroenterology Nanjing Drum Tower HospitalNanjing 210000Jiangsu ProvinceChina Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqing 400000China

BACKGROUND Medications for inflammatory bowel disease(IBD)have changed dramatically over ***,no study on long-term medication profiles has been conducted in the Chinese *** To evaluate temporal changes in medication use and treatment patterns for Chinese patients with *** A multicenter retrospective cohort study was conducted among Chinese patients newly diagnosed with Crohn’s disease(CD)and ulcerative colitis(UC)between January 1999 and December *** characteristics and drug prescriptions were *** in medication use and therapeutic patterns were *** In total,3610 patients were *** follow-up,5-aminosalicylates(5-ASA)and corticosteroids(CS)prescriptions gradually decreased,accompanied by a notable increase in immunosuppressants(IMS)and infliximab(IFX)prescriptions in patients with *** rates of 5-ASA and CS were stable,whereas IMS and IFX slightly increased since 2007 in patients with ***(n=957)analyses showed a switch from conventional medications to IFX in patients with CD,while 5-ASA and CS were still steadily prescribed in patients with *** regression analyses revealed that surgical history,disease behavior,and disease location were associated with initial therapeutic strategies in patients with ***,medications before diagnosis,disease location,and diagnostic year might affect initial strategies in patients with *** Long-term treatment strategies analyses has provided unique insight into the switch from conventional drugs to IFX in Chinese patients with CD.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Medication trends Treatment pattern Infliximab

Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3600-3623页

作者： Li-Li Yin ping-Qian Qi Yun-Fei Hu Xiao-Jun Fu Rui-Shan He Meng-Meng Wang yan-Juan Deng Su-Yi Xiong Qi-Wen Yu Jin-ping Hu Lv Zhou Zhi-Bin Zhou Ying Xiong Huan Deng The Affiliated Rehabilitation Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Fourth Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second College of Clinical Medicine Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Tumor Immunology Institute Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of General Medicine The Second College of Clinical MedicineJiangxi Medical CollegeNanchang UniversityNanchang 330031Jiangxi ProvinceChina The Ministry of Education Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors Jiangxi Medical CollegeNanchang UniversityNanchang 330031Jiangxi ProvinceChina

BACKGROUND Colorectal polyps,which are characterized by a high recurrence rate,represent preneoplastic conditions of the *** to unclear mechanisms of pathogenesis,first-line therapies for non-hereditary recurrent colorectal polyps are limited to endoscopic *** recent studies suggest a mechanistic link between intestinal dysbiosis and polyps,the exact compositions and roles of bacteria in the mucosa around the lesions,rather than feces,remain *** To clarify the composition and diversity of bacteria in the mucosa surrounding or 10 cm distal to recurrent intestinal *** Mucosal samples were collected from four patients consistently with adenomatous polyps(Ade),seven consistently with non-Ade(Pol),ten with current Pol but previous Ade,and six healthy individuals,and bacterial patterns were evaluated by 16S rDNA *** discriminant analysis and Student’s t-tests were used to identify the genus-level bacteria differences between groups with different colorectal polyp ***’s correlation coefficients were used to evaluate the correlation between intestinal bacteria at the genus level and clinical *** The results confirmed a decreased level of probiotics and an enrichment of pathogenic bacteria in patients with all types of polyps compared to healthy *** changes were not restricted to the mucosa within 0.5 cm adjacent to the polyps,but also existed in histologically normal tissue 10 cm distal from the *** differences in bacterial diversity were observed in the mucosa from individuals with normal conditions,Pol,and *** abundance of Gram-negative bacteria,including Klebsiella,Plesiomonas,and Cronobacter,was observed in Pol group and Ade group,suggesting that resistance to antibiotics may be one risk factor for bacterium-related harmful ***,age and gender were linked to bacteria changes,indicating the potential involvement of sex hormone

关键词： Dysbiosis Biopsy Polyp Bacteria Colorectum