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Banxia Xiexin Decoction Alleviated Cerebral Glucose Metabolism Disorder by Regulating Intestinal Microbiota in APP/PS1 Mice

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Chinese Journal of Integrative Medicine 2024年第8期30卷 701-712页

作者： GAO Chen-yan QIN Gao-feng zheng Ming-cui TIAN Mei-jing HE yan-nan WANG peng-wen Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Neurology Department Binzhou Medical University HospitalBinzhouShandong Province256603China

Objective To identify whether Banxia Xiexin Decoction(BXD)alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in APP/PS1 *** Forty-five 3-month-old male APP/PS1 mice were divided into 3 groups using a random number table(n=15 per group),including a model group(MG),a liraglutide group(LG)and a BXD group(BG).Fifteen 3-month-old male C57BL/6J wild-type mice were used as the control group(CG).Mice in the BG were administered BXD granules by gavage at a dose of 6 g/(kg·d)for 3 months,while mice in the LG were injected intraperitoneally once daily with Liraglutide Injection(25 nmol/kg)for 3 ***,liquid chromatography with tandem-mass spectrometry was used to analyze the active components of BXD granules and the medicated serum of ***,the cognitive deficits,Aβpathological change and synaptic plasticity markers,including synaptophysin(SYP)and postsynaptic density protein 95(PSD95),were measured in APP/PS1 *** glucose uptake was detected by micropositron emission *** microbial constituents were detected by 16S rRNA *** levels of intestinal glucagon-like peptide 1(GLP-1)and cerebral GLP-1 receptor(GLP-1R),as well as the phosphoinositide-3-kinase/protein kinase B/glycogen synthase kinase-3β(PI3K/Akt/GSK3β)insulin signaling pathway were determined by immunohistochemical(IHC)staining and Western blot analysis,*** BXD ameliorated cognitive deficits and Aβpathological features(P<0.01).The expressions of SYP and PSD95 in the BG were higher than those in the MG(P<0.01).Brain glucose uptake in the BG was higher than that in the MG(P<0.01).The intestinal microbial composition in the BG was partially *** levels of intestinal GLP-1 in the BG were higher than those in the MG(P<0.01).Compared with the MG,the expression levels of hippocampal GLP-1R,Akt,PI3K and p-PI3K in the BG were significantly increased(P<0.01),while the levels of GSK3βwere reduced(P<0.01).Conclusion BXD

关键词： Banxia Xiexin Decoction Alzheimer's disease intestinal microbiota glucagon-like peptide 1 cerebral insulin resistance phosphoinositide-3-kinase/proteinkinase B/glycogen synthase kinase-3β Chinese medicine

Impacts of changed litter inputs on soil CO2 efflux in three forest types in central south China

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Science Bulletin 2013年第7期58卷 750-757页

作者： yan WenDe CHEN XiaoYong TIAN DaLun peng YuanYing WANG GuangJun zheng Wei National Engineering Laboratory for Applied Forest Ecological Technology in Southern China Natural Sciences Division College of DuPage College of Arts and Sciences Governors State UniversityUniversity Park College of Life Science and Technology Central South University of Forestry and Technology

Climate change is expected to cause the alteration of litter production in forests,which may result in substantial changes in soil CO2 efflux (FCO2) process as litter represents a major pathway of carbon from vegetation to the *** this study,we conducted an aboveground litter manipulation experiment to examine the influence of litter addition and exclusion on soil FCO2 in Camphor tree,Masson pine,and mixed Camphor tree and Masson pine forests in central south *** input manipulation included three treatments:non-litter input (litter exclusion),double litter input (litter addition),and natural litter input (control).On average,litter exclusion significantly reduced soil FCO2 rate by approximately 39%,24% and 22% in Camphor tree forests,the Mixed forests,and Masson pine forests,*** a yearly basis,double litter addition significantly increased soil CO2 by 12% in the Mixed forests (P=0.02) but not in both Camphor tree and Masson pine forests (P>0.05),when compared with their corresponding control ***,litter addition increased soil FCO2 rates in the months of June-August in Camphor tree and Masson pine forests,coinciding with high soil temperature of summer *** exclusion reduced soil FCO2 more than litter addition increased it in the study *** of soil respiration to litter input treatments varied with forest *** input treatments did not alter the seasonal patterns of soil temperature and soil water *** results indicated that changes in aboveground litter as a result of global climate change and/or forest management have a great potential to alter soil respiration and soil carbon balance in forest ecosystems.

关键词： soil respiration litter exclusion litter addition subtropical forests soil environmental factors

Monitoring nearest neighbor queries with cache strategies

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 529-537页

作者： PAN peng LU yan-sheng College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

The problem of continuously monitoring multiple K-nearest neighbor (K-NN) queries with dynamic object and query dataset is valuable for many location-based applications. A practical method is to partition the data space into grid cells, with both object and query table being indexed by this grid structure, while solving the problem by periodically joining cells of objects with queries having their influence regions intersecting the cells. In the worst case, all cells of objects will be accessed once. Object and query cache strategies are proposed to further reduce the I/O cost. With object cache strategy, queries remaining static in current processing cycle seldom need I/O cost, they can be returned quickly. The main I/O cost comes from moving queries, the query cache strategy is used to restrict their search-regions, which uses current results of queries in the main memory buffer. The queries can share not only the accessing of object pages, but also their influence regions. Theoretical analysis of the expected I/O cost is presented, with the I/O cost being about 40% that of the SEA-CNN method in the experiment results.

关键词： K-nearest neighbors (K-NNs) Continuous query Object cache Query cache

A beam flexure-based nanopositioning stage supporting laser direct-write nanofabrication

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Science China(Physics,Mechanics & Astronomy) 2016年第8期59卷 50-55页

作者： Zhen Zhang peng Wang peng yan YingChun Guan State Key Laboratory of Tribology and Institute of Manufacturing Engineering Department of Mechanical EngineeringTsinghua University Beijing Key Lab of Precision/Ultra-precision Manufacturing Equipments and Control Tsinghua University State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University Key Laboratory of High-efficiency and Clean Mechanical Manufacture Ministry of Education School of Mechanical EngineeringShandong University School of Automation Science and Electrical Engineering Beihang University School of Mechanical Engineering and Automation Beihang University

A nanopositioning system of both millimetric stroke and nanometric tracking accuracy is a key component for nanofabrication in many applications. In this paper, a novel bi-axial beam-flexure nano servo stage is proposed to support a direct writing system for femtosecond laser nanofabrication. The important features of the stage lie in: a mirror symmetric instead of rotational symmetric configuration is adopted to restrict cross axis coupling, and a novel Z-shaped guidance module is proposed to achieve relative large linear stiffness range, in addition a redundant constraints module is introduced to increase off-axis stiffness of the stage. Mechanical analysis and system identification are provided, with which a feedback control algorithm demonstrates the tracking capability for laser fabrication purposes. Based on the fabricated XY nano-stage, real time control and measurements are deployed, demonstrating the millimetric operating workspace and 77.8 nm(RMS) error of tracking a circular trajectory.

关键词： laser nanofabrication direct writing servo and control system

Regulation of the Arabidopsis GSK3-like Kinase BRASSINOSTEROID-INSENSITIVE 2 through Proteasome-Mediated Protein Degradation

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Molecular Plant 2008年第2期1卷 338-346页

作者： peng peng Zhenyan yan Yongyou Zhu Jianming Li Department of Molecular Cellular and Development Biology University of Michigan Ann Arbor MI 48109-1048 USA Present address: Howard Hughes Medical Institute Department of Molecular Cell and Developmental Biology University of California-Los AngelesLos Angeles CA g0095 USA

Glycogen synthase kinase 3 （GSK3） is a unique serine/threonine kinase that is implicated in a variety of cellular processes and is regulated by phosphorylation or protein-protein interaction in animal cells. BIN2 is an Arabidopsis GSK3- like kinase that negatively regulates brassinosteroid （BR） signaling. Genetic studies suggested that BIN2 is inhibited in response to BR perception at the cell surface to relieve its inhibitory effects on downstream targets; however, little is known about biochemical mechanisms of its inhibition. Here, we show that BIN2 is regulated by proteasome-mediated protein degradation. Exogenous application of a BR biosynthesis inhibitor and an active BR increased and decreased the amount of BIN2 proteins, respectively. Interestingly, the gain-of-function bin2-1 mutation significantly stabilizes BIN2, making it unresponsive to BR-induced BIN2 depletion. Exogenous application of different plant growth hormones revealed that BIN2 depletion is specifically induced by BR through a functional BR receptor, while treatment of a protea- some inhibitor, MG132, not only prevented the BR-induced BIN2 depletion but also nullified the inhibitory effect of BR on the BIN2 kinase activity. Taken together, our results strongly suggest that proteasome-mediated protein degradation constitutes an important regulatory mechanism for restricting the BIN2 activity.

关键词： .Regulates brassinosteroid BR signaling Arabidopsis GSK BR receptor

Biomimetic Method Synthesis of HgS/Polyurethane Composite Film and Its Sensing Properties to Ba2＋

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Chinese Journal of Chemical Physics 2015年第3期28卷 370-374,I0002页

作者： Shan Wang Min-yan zheng School of Chemistry and Chemical Engineering of Xianyang Normal University XianyanE 712000 China

Polyurethane-conjugated HgS nanocrystals with tunable sizes prepared by using biomimetic method. The obtained HgS nanoparticles with good dispersibility were characterized by Fourier transform infrared. Scanning electron microscopy are used to envisage the binding of nanoparticles with functional groups. The polyurethane molecules can control nucleation and growth of HgS crystals by binding on the surface of nanocrystals to stabilize nanoparticles. Quantum confinement effect of polyurethane-conjugated HgS nanocrystals was confirmed by UV-Vis spectra. The nanoparticles exhibit a well-defined emission feature at about 291 nm. The fluorescence results reveal that the PU/HgS nanoparticles film is sensitive to Ba2＋, and a small amount of Ba2＋ makes the emissions increase rapidly. The emission is hardly affected by other common ions in water. The nanocomposite film is possible to become a special sensor material for Ba2＋.

关键词： Polyurethane HgS nanoparticals Fluorescence sensor

Sensor management of LEO constellation based on covariance control

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Journal of Systems Engineering and Electronics 2019年第2期30卷 393-401页

作者： QIN zheng LIANG yan'gang College of Aerospace Science and Engineering National University of Defense Technology

This paper studies the multi-sensor management problem for low earth orbit(LEO) infrared warning constellation used to track a midcourse missile. A covariance control approach, which selects sensor combinations or subset based on the difference between the desired covariance matrix and the actual covariance of each target, is used for sensor management, including some matrix metrics to measure the differentia between two covariance matrices. Besides, to meet the requirements of the space based warning system, the original covariance control approach is improved. Simulation results demonstrate that the covariance control approach is able to provide a better tracking performance by providing a well-designed desired covariance and balance tracking performance goals with system demands.

关键词： sensor management covariance control target tracking accuracy LEO constellation

Aerodynamic interaction between forewing and hindwing of a hovering dragonfly

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Acta Mechanica Sinica 2014年第6期30卷 787-799页

作者： zheng Hu Xin-yan Deng School of Mechanical Engineering Purdue University 585 Purdue MallWest Lafayette IN 47906 USA

The phase change between the forewing and hindwing is a distinct feature that sets dragonfly apart from other *** this paper,we investigated the aerodynamic effects of varying forewing-hindwing phase di ff erence with a60 inclined stroke plane during hovering *** measurements on a pair of mechanical wing models showed that in-phase flight enhanced the forewing lift by 17%and the hindwing lift was reduced at most phase *** total lift of both wings was also reduced at most phase di ff erences and only increased at a phase range around *** results may explain the commonly observed behavior of the dragonfly where 0 is employed in *** further investigated the wing-wing interaction mechanism using the digital particle image velocimetry（PIV）system,and found that the forewing generated a downwash flow which is responsible for the lift reduction on the *** the other hand,an upwash flow resulted from the leading edge vortex of the hindwing helps to enhance lift on the *** results suggest that the dragonflies alter the phase di ff erences to control timing of the occurrence of flow interactions to achieve certain aerodynamic effects.

关键词： Dragonfly aerodynamics Forewing-hindwing interaction Phase di ff erence Interactive flow

A decision support system for satellite layout integrating multi-objective optimization and multi-attribute decision making

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Journal of Systems Engineering and Electronics 2019年第3期30卷 535-544页

作者： LIANG yan’gang QIN zheng College of Aerospace Science and Engineering National University of Defense Technology

A decision support system, including a multi-objective optimization framework and a multi-attribute decision making approach is proposed for satellite equipment layout. Firstly, given three objectives (to minimize the C.G. offset, the cross moments of inertia and the space debris impact risk), we develop a threedimensional layout optimization model. Unlike most of the previous works just focusing on mass characteristics of the system, a space debris impact risk index is developed. Secondly, we develop an efficient optimization framework for the integration of computer-aided design (CAD) software as well as the optimization algorithm to obtain the Pareto front of the layout optimization problem. Thirdly, after obtaining the candidate solutions, we present a multi-attribute decision making approach, which integrates the smart Pareto filter and the correlation coefficient and standard deviation (CCSD) method to select the best tradeoff solutions on the optimal Pareto fronts. Finally, the framework and the decision making approach are applied to a case study of a satellite platform.

关键词： layout optimization satellite multi-objective optimization Pareto front multi-attribute decision making