检索结果-南通市图书馆

Journal of Geriatric Cardiology 2024年第1期21卷 90-103页

作者： Cheng-yan HU yan-ling wang Zhen-Xing FAN Xi-Peng SUN Shuai wang Zhi LIU Department of Geriatrics Fu Xing HospitalCapital Medical UniversityBeijingChina Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Emergency Department of Xuanwu Hospital Capital Medical UniversityBeijingChina

Objective To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with longterm clinical outcome in patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods In total,675 patients were *** on the platelet inhibition rate,patients were categorized into two groups:clopidogrel low responsiveness(CLR)and normal clopidogrel responsiveness(NCR).The CLR group was divided into ticagrelor and clopidogrel group based on the antiplatelet drugs used in the follow-up *** were classified into three groups(normal metabolizer,intermediate metabolizer,and poor metabolizer)based on the CYP2C19 *** aimed to evaluate the impact of CYP2C19 gene polymorphism on clopidogrel *** cumulative rates of 12-month all-cause deaths,major adverse cardiovascular events(MACCEs),and bleeding events were *** CLR was observed in 44.4%of the overall *** differences were observed in the platelet inhibition rate of clopidogrel among the three metabolic genotypes(P0.05).Conclusions Low response to clopidogrel in CHD patients is correlated with CYP2C19 gene ***2C19 genotyping combined with platelet reactivity is an independent predictor of 12-months MACCEs in patients with clopidogrel treatment after PCI,which is better than either test alone.

关键词： CYP2C19 drugs PCI

Electroencephalogram findings in 10 patients with post-stroke epilepsy:A retrospective study

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第2期12卷 249-255页

作者： Li-Min Wen Ran Li yan-ling wang Qing-Xia Kong Min Xia Clinical Medicine College Jining Medical UniversityJining 272067Shandong ProvinceChina School of Basic Medical Sciences Shandong UniversityJinan 250012Shandong ProvinceChina Department of Neurology The Affiliated Hospital of Jining Medical UniversityJining 272007Shandong ProvinceChina

BACKGROUND Post-stroke epilepsy is a common and easily overlooked complication of acute cerebrovascular ***-term seizures can seriously affect the prognosis and quality of life of ***(EEG)is the simplest way to diagnose epilepsy,and plays an important role in predicting seizures and guiding *** To explore the EEG characteristics of patients with post-stroke epilepsy and improve the detection rate of inter-seizure epileptiform *** From January 2017 to June 2020,10 patients with post-stroke epilepsy in our hospital were *** clinical,imaging,and EEG characteristics were *** stroke location,seizure type,and ictal and interictal EEG manifestations of the patients with post-stroke epilepsy were then retrospectively *** In all 10 patients,epileptiform waves occurred in the side opposite to the stroke lesion during the interictal stage;these manifested as sharp wave,sharp-wave complex,or spike discharges in the anterior head lead of the side opposite to the *** In EEG,epileptiform waves can occur in the side opposite to the stroke lesion in patients with post-stroke epilepsy.

关键词： Post-stroke epilepsy Electroencephalogram Seizure Stroke Slow wave

Human CD56+CD39+ dNK cells support fetal survival through controlling trophoblastic cell fate:immune mechanisms of recurrent early pregnancy loss

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第06期 129-145页

作者： Wentong Jia Liyang Ma Xin Yu Feiyang wang Qian yang Xiaoye wang Mengjie Fan yan Gu Ran Meng Jian wang Yuxia Li Rong Li Xuan Shao yan-ling wang State Key Laboratory of Stem cell and Reproductive Biology Key Laboratory of Organ Regeneration and ReconstructionInstitute of ZoologyChinese Academy of Sciences Beijing Institute for Stem Cell and Regenerative Medicine University of the Chinese Academy of Sciences NHC Key Lab of Reproduction Regulation Shanghai Engineering Research Center of Reproductive Health Drug and Devices Shanghai Institute for Biomedical and Pharmaceutical Technologies National Clinical Center for Obstetrics and Gynecology Peking University Third Hospital Department of Family Planning The Second Hospital of Tianjin Medical University Department of Prenatal Screening Haidian Maternal and Child Health Hospital

Decidual natural killer（dNK） cells are the most abundant immune cells at the maternal-fetal interface during early pregnancy in both mice and humans, and emerging single-cell transcriptomic studies have uncovered various human dNK subsets that are disrupted in patients experiencing recurrent early pregnancy loss（RPL） at early gestational stage, suggesting a connection between abnormal proportions or characteristics of dNK subsets and RPL pathogenesis. However, the functional mechanisms underlying this association remain unclear. Here, we established a mouse model by adoptively transferring human dNK cells into pregnant NOG（NOD/Shi-scid/IL-2Rγnull） mice, where human dNK cells predominantly homed into the uteri of recipients. Using this model, we observed a strong correlation between the properties of human dNK cells and pregnancy outcome. The transfer of dNK cells from RPL patients（dNK-RPL）remarkably worsened early pregnancy loss and impaired placental trophoblast cell differentiation in the recipients. These adverse effects were effectively reversed by transferring CD56+CD39+dNK *** studies revealed that CD56+CD39+dNK subset facilitates early differentiation of mouse trophoblast stem cells（m TSCs） towards both invasive and syncytial pathways through secreting macrophage colony-stimulating factor（M-CSF）. Administration of recombinant M-CSF to NOG mice transferred with dNK-RPL efficiently rescued the exacerbated pregnancy outcomes and fetal/placental development. Collectively, this study established a novel humanized mouse model featuring functional human dNK cells homing into the uteri of recipients and uncovered the pivotal role of M-CSF in fetal-supporting function of CD56+CD39+dNK cells during early pregnancy, highlighting that M-CSF may be a previously unappreciated therapeutic target for intervening RPL.

关键词：

Impact of clay stabilizer on the methane desorption kinetics and isotherms of Longmaxi Shale,China

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2022年第1期19卷 234-244页

作者： Zhong-Hua Liu Jia-Chun wang Bao-Jun Bai yan-ling wang School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Exploration and Development Research Institute of Daqing Oilfield Co Ltd. Daqing163712HeilongjiangChina Geosciences and Geological and Petroleum Engineering Missouri University of Science and TechnologyRollaMO65409USA School of Petroleum and Natural Gas Engineering Chongqing University of Science and TechnologyChongqing401332China

Knowing methane desorption characteristics is essential to define the contribution of adsorbed gas to gas well *** evaluate the synthetic effect of a clay stabilizer solution on methane desorption kinetics and isotherms pertaining to Longmaxi shale,an experimental setup was designed based on the volumetric *** objective was to conduct experiments on methane adsorption and desorption kinetics and isotherms before and after clay stabilizer *** experimental data were a good fit for both the intraparticle diffusion model and the Freundlich isotherm *** analyzed the effect of the clay stabilizer on desorption kinetics and *** show that clay stabilizer can obviously improve the diffusion rate constant and reduce the methane adsorption ***,we analyzed the desorption efficiency before and after treatment as well as the adsorbed methane *** results show that a higher desorption efficiency after treatment can be observed when the pressure is higher than 6.84 ***,the adsorbed methane content before and after treatment all increase when the pressure decreases,and clay stabilizer can obviously promote the adsorbed methane to free gas when the pressure is lower than 19 *** can also be applied to the optimization formulation of slickwater and the design of gas well production.

关键词： Shale gas Clay stabilizer Kinetics Isotherms Adsorption Desorption efficiency

Subfoveal choroidal thickness and volume in severe internal carotid artery stenosis patients

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2017年第12期10卷 1870-1876页

作者： Hui wang yan-ling wang Hong-yang Li Department of Ophthalmology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

AIM：To demonstrate the differences of retinal and choroidal structure changes in internal carotid artery（ICA） patients of China by enhanced-depth imaging optical coherence tomography（EDI-OCT）.METHODS：A retrospective review was conducted of 46 patients with a diagnosis of ICA stenosis greater than 65% on only one side（the opposite ICA Stenosis had less than 40% stenosis） from June 2015 through June *** of the patients were combined with amaurosis fugax,but without any abnormality with other ocular *** and volume of choroid and retina were manually measured by *** were compared between ICA stenosis eyes and fellow ***：There were no significant differences in the retinal thickness,macular retinal nerve fiber layer（m RNFL） thickness,inner thickness,or outer retinal thickness between the ICA Stenosis group and the control group（P=0.834,0.187,0.552,and 0.903,respectively）.The mean central choroidal thickness of the ICA Stenosis group was significantly lower than that of the control group（239.70±23.76 μm vs 257.46±22.13 μm,P〈0.001）.The percentage of ICA stenosis was significantly associated with the central choroidal thickness,central retinal thickness,foveal center choroidal volume,and foveal center retinal volume（r=0.854,0.678,0.729,and 0.785,respectively;P〈0.001）.There were no significant differences in the retinal and choroidal volume values in the 4 inner and 4 outer sectors between the two ***：The choroidal thickness in severe ICA stenosis eyes is lower than in fellow *** choroidal thinning may occur before the retinal changes in patients with ocular ischemic *** of choroidal thickness may be useful to choose the optimal therapeutic schedule for ICA patients.

关键词： ophthalmic artery internal carotid artery ocular ischemic syndrome optical coherence tomography

Twist-teleportation-based local discrimination of maximally entangled states

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2020年第8期63卷 46-52页

作者： Mao-Sheng Li Shao-Ming Fei Zong-Xing Xiong yan-ling wang Department of Physics Southern University of Science and TechnologyShenzhen 518055China Department of Physics University of Science and Technology of ChinaHefei 230026China School of Mathematical Sciences Capital Normal UniversityBeijing 100048China Max-Planck-Institute for Mathematics in the Sciences Leipzig 04103Germany Department of Mathematics South China University of TechnologyGuangzhou 510640China School of Computer Science and Network Security Dongguan University of TechnologyDongguan 523808China

In this work,we study the local distinguishability of maximally entangled states(MESs).In particular,we are concerned with whether any fixed number of MESs can be locally distinguishable for sufficiently large *** and Tian et *** already obtained two satisfactory results for the generalized Bell states(GBSs)and the qudit lattice states when applied to prime or prime power *** construct a general twist-teleportation scheme for any orthonormal basis with MESs that is inspired by the method used in[***.A 70,022304(2004)].Using this teleportation scheme,we obtain a sufficient and necessary condition for one-way distinguishable sets of MESs,which include the GBSs and the qudit lattice states as special ***,we present a generalized version of the results in[***.A 92,042320(2015)]for the arbitrary dimensional case.

关键词： teleportation local discrimination maximally entangled states

Efficacy of comprehensive remote ischemic conditioning in elderly patients with acute ST-segment elevation myocardial infarction underwent primary percutaneous coronary intervention

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2022年第6期19卷 435-444页

作者： yan-ling wang Qi yanG Cheng-yan HU yan-yan CHU Zheng SUN Huan ZHAO Zhi LIU Department of Cardiology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijingChina

BACKGROUND Remote ischemic conditioning(RIC)is used to protect against myocardial ***,there is no adequate evidence for comprehensive RIC in elderly patients with ST-segment elevation myocardial infarction(STEMI).This study aimed to test whether comprehensive RIC,started pre-primary percutaneous coronary intervention(PPCI)and repeated daily on 1-30 days post-PPCI,can improve myocardial salvage index(SI),left ventricular ejection fraction(LVEF),Kansas City Cardiomyopathy Questionnaire Clinical Summary Score(KCCQ-CSS)and 6-min walk test distance(6MWD)in elderly patients with acute STEMI during 12 months *** 328 consenting elderly patients were randomized to receive standard PPCI plus comprehensive RIC(the treatment group)or standard PPCI(the control group).SI at 5-7 days after PPCI,LVEF,left ventricular end-diastolic volume index(LVEDVI),left ventricular end-systolic volume index(LVESVI),KCCQ-CSS,6MWD and adverse events rates were measured and *** SI was significantly higher in the treatment group[interquartile range(IQR):0.38-0.66,P=0.037].There were no significant differences in major adverse events at 12 *** the differences of LVEDVI,LVESVI and LVEF between the treatment group and the control group did not reach statistical significance at 6 months and 12 months,LVEF tended to be higher,LVEDVI tended to be lower in the treatment *** KCCQ-CSS was significantly higher in the treatment group at 1 month(IQR:46.5-87,P=0.001)and 12 months(IQR:55-93,P=0.008).There was significant difference in 6MWD between the treatment group and the control group(IQR:258-360 ***:250-345,P=0.002)at 1 month and(IQR:360-445 ***:345-432,P=0.035)at 12 months.A modest correlation was found between SI and LVEF(r=0.452,P<0.01),KCCQ-CSS(r=0.440,P<0.01)and 6MWD(r=0.384,P<0.01)respectively at 12 *** The comprehensive RIC can improve SI,KCCQ-CSS and *** may be an adjunctive therapy to PPCI in elderly patients with STEMI

关键词： patients infarction coronary

Imageology of internal carotid artery siphon in nonarteritic anterior ischaemic optic neuropathy

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2020年第12期13卷 1941-1947页

作者： Zhi-Yong Fu Hong-yang Li yan-ling wang Department of Ophthalmology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

AIM:To evaluate whether narrowing of internal carotid artery siphon(ICAS)may increase the risk of developing non-arteritic anterior ischaemic optic neuropathy(NAION).METHODS:Totally 30 consecutive patients who had unilateral NAION and 30 gender-matched control subjects were recruited in the present *** diameter of ICAS of all the participants were measured using head-and-neck computed tomographic angiography(CTA).Color doppler flow imaging(CDI)was used to measure the haemodynamics parameters of ICAS and short posterior ciliary arteries(SPCAs)in all *** of parameters between the NAION patients and controls as well as between the two sides within the patients were *** correlation between the diameter of ICAS and NAION was ***:A comparison of parameters between the affected side of the NAION patients and the controls,including the diameter of ICAS,the resistance index(RI)of ICAS,the blood flow velocities of SPCAs and RI of SPCAs,showed significantly difference(P<0.01),while there was no significant difference in terms of the mean blood flow velocity(Vm)of ICAS;Similar results were found while comparing all the measurements of the affected and unaffected side of patients(P for RI of SPCAs<0.05).No marked difference was detected in nearly all parameters except for RI of ICAS and SPCAs between the unaffected side of the NAION patients and the controls(P<0.05).The diameter of ICAS were significantly positive correlated with both peak systolic velocity(PSV)of SPCAs and end diastolic velocity(EDV)of SPCAs in patients with NAION(r=0.514,P<0.01 and r=0.418,P<0.05,respectively).CONCLUSION:Narrowing of ICAS may increase the risk of developing NAION.

关键词： internal carotid artery siphon imageology haemodynamics parameter non-arteritic anterior ischaemic optic neuropathy

Results of cataract surgery in renal transplantation and hemodialysis patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2015年第5期8卷 971-974页

作者： Li-Hua Luo Shi-Hong Xiong yan-ling wang Department of Ophthalmology Beijing Friendship HospitalCapital Medical University

AIMTo compare the effect of cataract surgery in renal transplantation and hemodialysis *** evaluated 51 eyes of 31 renal transplantation patients, 41 eyes of 29 hemodialysis patients and 45 eyes of 32 normal control patients who received phacoemulsification and intraocular lens (IOL) implantation from January, 2000 to August, 2014 in the Beijing Friendship Hospital. Each individual underwent a blood routine and a kidney function examination. Routine ophthalmologic examination included best-corrected visual acuity (BCVA), a slit-lamp examination to detect cataract type, determination of intraocular pressure, a corneal endothelial count, and fundus examination. All patients received phacoemulsification and an IOL *** the types of cataract in the three groups, transplantation group was significantly different from normal control group (P=0.04), the most kind is posterior subcapsular cataract (PSC) in transplantation group 33 (64.7%), hemodialysis group had no significantly difference from normal control group (P=0.43), and the difference between transplantation group and hemodialysis group also had significantly difference (P=0.02). For postoperative BCVA in the three groups, transplantation group had significantly difference from normal control group (P=0.03), hemodialysis group was significantly different from normal control group (P=0.00), and the difference between transplantation group and hemodialysis group also had significantly difference (P=0.00). The multiple linear regression equation is Y=0.007 hemoglobin (Hb)-0.000233 serum creatinine (Cr), R2=0.898. Postoperative fundus examination showed that hemorrhage, exudation, and macular degeneration were greater in the hemodialysis *** study showed that the PSC was more in the renal transplantation patients. BCVA was better and fundus lesions were less frequent in the renal transplantation group than in the hemodialysis group after cataract surgery. Th

关键词： hemodialysis renal transplantation cataract phacoemulsification intraocular lens

Dynamic response and plastic deformation behavior of Ti–5Al–2.5Sn ELI and Ti–8Al–1Mo–1V alloys under high-strain rate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2014年第2期33卷 127-133页

作者： yan-ling wang Song-Xiao Hui Rui Liu Wen-Jun Ye yang Yu Ravil Kayumov State Key Laboratory for Fabrication & Processing of Nonferrous Metals General Research Institute for Nonferrous Metals Department of Mechanical Engineering Sun Moon University

Split Hopkinson pressure bar test system was used to investigate the plastic deformation behavior and dynamic response character of a-type Ti–5Al–2.5Sn ELI and near a-type Ti–8Al–1Mo–1V titanium alloy when subjected to dynamic loading. In the present work, stress–strain curves at strain rate from 1.5 9 103to 5.0 9 103s-1were analyzed, and optical microscope（OM） was used to reveal adiabatic shearing behavior of recovered samples. Results show that both the two alloys manifest significant strain hardening effects. Critical damage strain rate of the two alloys is about 4.3 9 103s-1, under which the impact absorbs energy of Ti–5Al–2.5Sn ELI and Ti–8Al–1Mo–1V are 560 and 470 MJ m-3, respectively. Both of them fracture along the maximum shearing strength orientation, an angle of 45° to the compression axis. No adiabatic shear band（ASB） is found in Ti–5Al–2.5Sn ELI alloy, whereas several ASBs with different widths exist without regular direction in Ti–8Al–1Mo–1V alloy.

关键词： Titanium alloy Ti–5Al–2.5Sn ELI Ti–8Al– 1Mo–1V High-strain rate Adiabatic shear band