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Overcoming the biofilm barrier by cell-like microbubbles for the treatment of biofilm-associated implant infections

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Biomedical Engineering Communications 2024年第2期3卷 1-3页

作者： yan-ling hu Jin-Gai Jiang hui-Juan Cheng Wei Shi yan-Ni Song Min Zhang Dong-Liang yang College of Life and Health Nanjing Polytechnic InstituteNanjing 210048China Hangzhou huasu Industry Co. Ltd.Hangzhou 310012China Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China

Although the advent of antibiotics has significantly improved the quality of life of infected patients,bacterial infections continue to pose a serious threat to public health[1,2].According to a recent report,within the next 30 years,bacterial infections are projected to surpass cancer in terms of lethality rates,resulting in an alarming 10 million deaths annually by 2050 due to the development of bacterial resistance[3].Moreover,the formation of bacterial biofilms hampers the penetration of antibacterial agents and inhibits the host immune response,making biofilm infections extremely challenging to treat[4-7].Hence,the development of innovative antimicrobial biofilm therapeutics is imperative.

关键词： infections annually treatment

Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

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Science China(Life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia Xue-Feng Wang Xiao-Ming Cui Yi-Ming Zhang Zhen-Fei Wang En-Tao Li Chang-Fa Fan Ke Song Yuan-Guo Li Run-Ze Ye Fang-Xu Li Dai-Yun Zhu Jie Zhang Zhuang-Zhuang Shi Ming-Zhu Zhang Liang-Jing Li Shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu Lin Zhao Wen-Hao Wang Tie-Cheng Wang You-Chun Wang Jia-Fu Jiang yan-ling hu Na Jia Yu-Wei Gao Wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China Life Sciences Institute Guangxi Medical UniversityNanning 530020China College of Life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

Single-doped charged gold cluster with highly selective catalytic activity for the reduction of SO2 by CO: First-principles study

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Chinese Physics B 2019年第11期28卷 140-149页

作者： yan-ling hu Hao-Ran Zhu Shi-Hao Wei Department of Microelectronic Science and Engineering School of Physical Science and TechnologyNingbo UniversityNingbo 315211China

It is important for environmental protection to search for catalysts with excellent performance and cost-effective to reduce SO2 by CO. In this work, using first-principles calculation, we have studied the catalytic performance of Au5Mn（M = Ni, Pd, Pt, Cu, Ag, Au; n = 1, 0,-1） clusters, and showed that, by giving a negative charge to the Au5M（M = Cu,Ag, Au, Pd） clusters, we could improve the selectivity of SO2 and avoid effectively catalyst CO poisoning *** the same time, the catalytic reaction rate for the reduction of SO2 by CO with Au5M-（M = Cu, Ag, Au, Pd） clusters is greatly improved when the Au5M clusters are charged. These advantages can be well explained by the charge transfer between the clusters and adsorbed molecules, which means that we can effectively control the performance of the *** equilibrium structures of Au5Mn（M = Ni, Pd, Pt, Cu, Ag, Au; n = 1, 0,-1） clusters without or with adsorbed SO2 or CO molecule are also discussed, and the most stable geometrical structures of Aun5 M-ML（ML = SO2, CO, SO, and COS）can be explained very well by the match of orbitals symmetry and density of electron cloud through their frontier molecular orbitals. Considering the catalyst cost（Cu is much cheaper than Ag and Au）, selectivity of SO2, and effectively avoiding the catalyst CO poisoning, we propose that Au5Cu-is an ideal catalyst for getting rid of SO2 and CO simultaneously.

关键词： bimetallic clusters catalyst first-principles electronic structure

Peripherally inserted central catheter placement in neonates with persistent left superior vena cava: Report of eight cases

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World Journal of Clinical Cases 2021年第26期9卷 7944-7953页

作者： Qiong Chen yan-ling hu Ying-Xin Li Xi huang Department of Neonatal Nursing West China Second University HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041Sichuan ProvinceChina

BACKGROUND Reports on peripherally inserted central catheter(PICC)placement in neonates with persistent left superior vena cava(PLSVC)are *** majority of PLSVC patients have no clinical symptoms or hemodynamic changes,which are usually detected during cardiac catheterization,cardiac pacemaker implantation,or PICC ***,in neonates with PLSVC,PICC placement can be ***,we report PICC placement in eight neonates with *** SUMMARY This article introduces the concept of the“TIMB”*** PICC implantation,we found PLSVC in all eight *** key points of care regarding PICC placement in neonates with PLSVC included“TIMB”,where“T”indicates a reasonable choice of the catheterization time,“I”refers to a retrospective analysis of imaging data before catheterization,“M”refers to correct measurement of the body surface length,and“B”indicates that the tip of the PICC is placed in the middle and lower 1/3 of the left superior vena cava under the guidance of ***“TIMB”is a bundle for PICC placement in neonates,especially for those with *** this new approach can improve the first-attempt success rate of PICC placement,reveal cardiovascular abnormalities in advance,allow the selection of different measurement methods reasonably according to the puncture site,and finally,improve the accuracy of catheter positioning through the use of B-ultrasound guidance.

关键词： Neonate Persistent left superior vena cava Peripherally inserted central catheter Complications “TIMB”bundle Case report

Neonatal necrotizing enterocolitis caused by umbilical arterial catheter-associated abdominal aortic embolism:A case report

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World Journal of Clinical Cases 2021年第22期9卷 6557-6565页

作者： Xi huang yan-ling hu Yuan Zhao Qiong Chen Ying-Xin Li Department of Neonatal Nursing West China Second University HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan UniversityMinistry of EducationChengdu 610041Sichuan ProvinceChina

BACKGROUND Reports of necrotizing enterocolitis(NEC)caused by umbilical arterial catheter(UAC)-associated abdominal aortic embolism in neonates are ***,we report the case of an extremely low birth weight(ELBW)infant with NEC caused by UAC-associated abdominal aortic *** SUMMARY A female infant,aged 21 min and weighing 830 g at 28+6 wk of gestational age,was referred to our hospital because of premature birth and shallow *** patient was diagnosed with ELBW,neonatal respiratory distress syndrome,neonatal intrauterine infection,and neonatal *** arterial and venous catheters were inserted on the day after birth and were removed 9 d later,according to the doctor’s *** 48 h after extubation,the patient’s manifestations included poor responsiveness,heart rate range of 175-185/min,and currant jelly ***,we considered a diagnosis of *** determine the cause,we used B-mode ultrasound,which revealed a partial abdominal aortic embolism(2 cm×0.3 cm)and abdominal *** patient was treated with nil per os,gastrointestinal decompression,anti-infective therapy,blood transfusion,and low-molecular-weight heparin sodium q12h for anticoagulant therapy(from May 20 to June 1,the dosage of low-molecular-weight heparin sodium was adjusted according to the anti-Xa activity during treatment).On the 67th day after admission,the patient fully recovered and was *** The abdominal aortic thrombosis in this patient was considered to be catheter related,which requires immediate treatment once *** choice of treatment should be determined according to the location of the thrombus and the patient’s condition.

关键词： Umbilical arterial catheter Abdominal aortic thrombosis Necrotizing enterocolitis Neonate Case report

“AFGP” bundles for an extremely preterm infant who underwent difficult removal of a peripherally inserted central catheter:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4253-4261页

作者： Qiong Chen yan-ling hu Shao-Yu Su Xi huang Ying-Xin Li Department of Neonatal Nursing West China Second University HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041Sichuan ProvinceChina

BACKGROUND There have been few reports on level 3 difficult removal of peripherally inserted central catheter(PICC)in ***,we reported a case of an extremely preterm infant who underwent level 3 difficult removal of a *** SUMMARY Female baby A,weighing 1070 g at 27^(+1) wk of gestational age,was diagnosed with extremely preterm infant and neonatal respiratory distress *** underwent PICC insertion *** first PICC insertion went well;the second PICC was inserted in the right lower extremity,however,phlebitis occurred on the second day after the *** the third day of catheterization,phlebitis was aggravated,while the right leg circumference increased by 2.5 *** the fourth day of catheterization,more red swelling was found in the popliteal part,covering an area of about 1.5 cm×4 cm,which was diagnosed as phlebitis level 3;thus,we decided to remove the *** tube removal,the catheter rebounded and could not be pulled out(several conventional methods were performed).Finally,we successfully removed the PICC using a new approach termed“AFGP”.On the 36th day of admission,the baby fully recovered and was *** The“AFGP”bundle approach was effective for an extremely preterm infant,who underwent level 3 difficult removal of a PICC.

关键词： Infant,Newborn Extremely preterm infant Catheterization,Peripheral Nursing Complications Case report

Arterial embolism caused by a peripherally inserted central catheter in a very premature infant:A case report and literature review

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World Journal of Clinical Cases 2020年第18期8卷 4259-4265页

作者： Yi-Fei huang yan-ling hu Xing-Li Wan Hong Cheng Yao-hua Wu Xiao-yan yang Jing Shi Department of Neonatal Nursing West China Second University HospitalSichuan UniversityChengdu 610066Sichuan ProvinceChina Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan UniversityChengdu 610066Sichuan ProvinceChina Ministry of Education West China Nursing SchoolSichuan UniversityChengdu 610066Sichuan ProvinceChina

BACKGROUND Extremely premature infants have poor vascular *** often choose deep veins such as the femoral vein and axillary vein to peripherally insert central catheters,and these vessels are often accompanied by arteries;thus,it is easy to mistakenly enter the *** SUMMARY The case of an extremely premature infant(born at gestational age 28+3)in whom the left upper extremity artery was accidentally entered during peripheral puncture of the central venous catheter is *** the 19th day of hospitalization,the index finger,middle finger and ring finger of the left hand were rosy,the left radial artery and brachial artery pulse were palpable,the recovery was 95%,and the improvement was *** discharge 42 d after admission,there was no abnormality in fingertip activity during the follow-up *** Arterial embolization in preterm infants requires an individualized treatment strategy combined with local anticoagulation and 2%nitroglycerin ointment for local tissue damage caused by arterial embolism in the upper *** visualization of disease changes using image visualization increases the likelihood of a good outcome.

关键词： Arterial thrombosis Anticoagulation Nitroglycerin Peripherally inserted central catheters Case report

Combined Detection of Serum Matrix Metalloproteinase 9,Acetyl Heparinase and Cathepsin L in Diagnosis of Ovarian Cancer

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Chinese Journal of Cancer Research 2012年第1期24卷 67-71页

作者： Wei Zhang Xiao-xia hu Xing-zhi yang Qi Wang Hong Cheng Shu-mei Wang yan-ling hu Zhi-jun yang Li Li Department of Gynecologic Oncology Cancer Institute and HospitalGuangxi Medical UniversityNanning 530021China Department of Gynecology and Obstetrics the People's Hospital of Guangxi ProvinceNanning 530022China

Objective： To investigate the clinic values of combining test of serum matrix metalloproteinase 9 （MMP-9）, acetyl heparinase （Hpa） and Cathepsin L （CL） in diagnosis of ovarian cancer. Methods： Serum levels of MMP-9, Hpa and CL were detected in a total of 418 cases, including 217 cases with ovarian malignant tumor, 100 cases with ovarian benign tumor and 101 healthy controls, by using enzyme-linked immunosorbent assay （ELISA）. Their correlation with clinicopathologic feature of ovarian malignant tumor was analyzed and their diagnosis performance was evaluated by receiver operating characteristic （ROC）. The combined diagnosis model was established by logistic regression analysis. Results： The serum levels of MMP-9, Hpa and CL were significantly higher in patients with ovarian malignant tumor than in benign tumor and healthy control, the serum levels of CL and Hpa were higher in epithelial cancer than in non-epithelial tumor, and MMP-9, Hpa and CL were elevated in low grade and advanced stage compared to high grade and early stage. The sensitivity for diagnosis of ovarian malignant tumor from high to low was CL, Hpa and MMP-9, and the specificity was MMP-9, CL and Hpa. The united diagnosis model was established and showed the sensitivity and specificity of combined detection were 84.6% and 82.1%, respectively, which were significantly higher than a single tumor marker. Conclusion： Serum MMP-9, Hpa and CL were correlated with ovarian malignant tumor and the combined detection of which may be valuable for clinical diagnosis of ovarian malignant tumor.

关键词： Ovarian cancer Matrix metalloproteinase 9 Acetyl heparinase Cathepsin Diagnosis

Impact of next-generation sequencing on antimicrobial treatment in immunocompromised adults with suspected infections

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World Journal of Emergency Medicine 2024年第2期15卷 105-110页

作者： Jia Li Jiazhen Luo Tao hu ling Cheng Weiwei Shang Li yan Department of Intensive Care Unit Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Emergency Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

BACKGROUND:Prompt pathogen identification can have a substantial impact on the optimization of antimicrobial *** objective of the study was to assess the diagnostic value of next-generation sequencing(NGS)for identifying pathogen and its clinical impact on antimicrobial intervention in immunocompromised patients with suspected ***:This was a retrospective *** January and August 2020,47 adult immunocompromised patients underwent NGS testing under the following clinical conditions:1)prolonged fever and negative conventional cultures;2)new-onset fever despite empiric antimicrobial treatment;and 3)afebrile with suspected infections on *** data,including conventional microbial test results and antimicrobial treatment before and after NGS,were *** were analyzed according to documented changes in antimicrobial treatment(escalated,no change,or deescalated)after the NGS ***:The median time from hospitalization to NGS sampling was 19 *** relevant pathogens were detected via NGS in 61.7% of patients(29/47),more than half of whom suffered from fungemia(n=17),resulting in an antimicrobial escalation in 53.2% of patients(25/47)and antimicrobial de-escalation in 0.2% of patients(1/47).Antimicrobial changes were mostly due to the identification of fastidious organisms such as Legionella,Pneumocystis jirovecii,and *** the remaining three cases,NGS detected clinically relevant pathogens also detected by conventional cultures a few days *** antimicrobial treatment was subsequently adjusted according to the susceptibility test ***,NGS changed antimicrobial management in 55.3%(26/47)of patients,and conventional culture detected clinically relevant pathogens in 14.9% of the patients(7/47).CONCLUSION:With its rapid identification and high sensitivity,NGS could be a promising tool for identifying relevant pathogens and enabling rapid appropriate treatment in immunocompromised patients w

关键词： Immunocompromised patients Next-generation sequencing Antimicrobial management