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Research progress on natural products against hepatocellular carcinoma

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BIOCELL 2024年第6期48卷 905-922页

作者： liNGli zhang yan li JINGXIN MAO Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System Chongqing Medical and Pharmaceutical CollegeChongqing400030China Provincial Key Laboratory of Pharmaceutical Bioactive Substances School of Life Sciences and BiopharmaceuticalsGuangdong Pharmaceutical UniversityGuangzhou510006China

Hepatocellular carcinoma(HCC)remains a prevalent and challenging malignancy globally,characterized by its numerous causal factors and generally unfavorable *** the relentless pursuit of effective treatment modalities,natural products have emerged as a promising and relatively non-toxic alternative,garnering signiﬁcant *** integration of natural products with contemporary medical research has yielded encouraging therapeutic outcomes in the management of *** review offers a comprehensive overview of the causal factors underlying HCC,and the diverse treatment options available,and highlights the advancements made by natural products in anti-HCC ***,we provide an outline of the various types of natural products,their corresponding nomenclature,target molecules,and mechanisms of action that exhibit anti-HCC *** products are anticipated to play a pivotal role in future comprehensive treatment plans for liver cancer,potentially offering patients improved survival rates and an enhanced quality of life.

关键词： Hepatocellular carcinoma Natural products Targets Research progress Drug

Vasospastic angina with J waves formation in patients with sudden loss of consciousness

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Journal of Geriatric Cardiology 2015年第3期12卷 313-318页

作者： Dan ZHU Yi-Ming LUO Ke-Hu A ling-Yun ZU yan-Hui zhang li-Jun GUO Wei GAO Yuan zhang Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Department of Cardiology Peking University Third Hospital Beijing China

Vasospastic angina is caused by sudden occlusive vasoconstriction of a segment of an epicardial artery, which can present with a wide spectrum of clinical scenario. We report the cases of two patients diagnosed with vasospastic angina, with one of which presenting with sudden cardiac arrest, while the other presenting with a relatively benign syncope. But both of them have J waves formation on ECG during active ischemia. The diagnosis and management of vasospastic angina, as well as the proposed clinical significance of J waves during coro- nary soasm are discussed.

关键词： Angina Consciousness loss J wave Osbom wave

DYT1 MUTATIONS AMONGST EARLY ONSET PRIMARY DYSTONIA PATIENTS IN CHINA

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Chinese Medical Sciences Journal 2008年第1期23卷 38-43页

作者： Jing-fang yang Jian-yu li Yong-jie li Tao Wu yan-li zhang Biao Chen Department of Neurobiology Beijing 100053 Department of Functional Neurosurgery Key Laboratory for Neurodegenerative Disease of Ministry of Education Xuanwu Hospital of Capital Medical University Beijing 100053

Objective To investigate the frequency of GAG deletion in the DYT1 gene among early onset primary dystonia patients in China. Methods Thirteen patients with early onset primary torsion dystonia were screened for mutation in exon 5 of the DYT1 gene using denaturing high-performance liquid chromatography （DHPLC） and DNA sequencing, and the results were confirmed with polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Results The GAG deletion mutation which results in Glu302del in exon 5 of the DYT1 gene was found in 5 patients. The detecting results were consistent between with DHPLC and PCR-RFLP. We did not find any other mutations in the DYT1 gene. Conel^iotm The GAG deletion in the DYT1 gene is common amongst early onset primary torsion dystonia patients in Chin＆ The frequency of DYT1 mutation is not significantly different between European and Asian patients with early onset primary dystonia.

关键词： primary torsion dystonia DYT1 gene denaturing high-performance liquid chromatography

Aerodynamic Analysis and Optimization of Pantograph Streamline Fairing for High-Speed Trains

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Fluid Dynamics & Materials Processing 2024年第5期20卷 1075-1091页

作者： Xiang Kan yan li Tian li Jiye zhang State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu610031China Technical Center Southwest Jiaotong University Chengdu Design Institute Co.Ltd.Chengdu610031China

A pantograph serves as a vital device for the collection of electricity in ***,its aerodynamic resistance can limit the train’s running *** installing fairings around the pantograph is known to effectively reduce the resistance,in this study,different fairing lengths are considered and the related aerodynamic performances of pantograph are *** particular,this is accomplished through numerical simulations based on the k-ωShear Stress Transport(SST)two-equation turbulence *** results indicate that the fairing diminishes the direct impact of high-speed airflow on the pantograph,thereby reducing its aerodynamic ***,it also induces interferences in the flow field around the train,leading to variations in the aerodynamic resistance and lift of train *** is shown that a maximum reduction of 56.52%in pantograph aerodynamic resistance and a peak decrease of 3.38%in total train aerodynamic resistance can be achieved.

关键词： Pantograph fairing train aerodynamic numerical simulation

Adhesion strength of tetrahydrofuran hydrates is dictated by substrate stiffness

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Petroleum Science 2024年第1期21卷 667-673页

作者： yan-Wen lin Tong li Yi zhang Wei-Wei yan Xiao-Ming Chen Zhi-Sen zhang Jian-yang Wu Department of Physics Research Institute for Biomimetics and Soft MatterJiujiang Research Institute and Fujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen361005FujianChina Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201ZhejiangChina Key Laboratory of Icing and Anti/De-icing China Aerodynamics Research and Development CenterMianyang621000SichuanChina Micro-and Nano-technology Research Center State Key Laboratory for Manufacturing Systems EngineeringXi’an Jiaotong UniversityXi’an710049ShaanxiChina Electronic Materials Research Lab Key Laboratory of the Ministry of EducationXi’an Jiaotong UniversityXi’an710049ShaanxiChina NTNU Nanomechanical Lab Norwegian University of Science and Technology(NTNU)Trondheim7491Norway

Understanding the hydrate adhesion is important to tackling hydrate accretion in ***,the relationship between the Tetrahydrofuran(THF)hydrate adhesion strength(AS)and surface stiffness on elastic coatings is systemically examined by experimental shear force measurements and theoretical *** mechanical factor-elastic modulus of the coatings greatly dictates the hydrate AS,which is explained by the adhesion mechanics theory,beyond the usual factors such as wettability and structural ***,the hydrate AS increases with reducing the thickness of the elastic coatings,resulted from the decrease of the apparent surface elastic *** effect of critical thickness for the elastic materials with variable elastic modulus on the hydrate AS is also *** study provides deep perspectives on the regulation of the hydrate AS by the elastic modulus of elastic materials,which is of significance to design anti-hydrate surfaces for mitigation of hydrate accretion in petro-pipelines.

关键词： Hydrate Adhesion strength Elastic modulus Coatings

Duality theorem for weak L-R smash products

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Applied Mathematics(A Journal of Chinese Universities) 2010年第4期25卷 481-488页

作者： ZHOU Xiao-yan li Qiang zhang liang-yun Department of Mathematics, Nanjing Agricultural University, Nanjing 210095, China Department of Mathematics Nanjing Agricultural University Nanjing China

This paper gives a duality theorem for weak L-R smash products, which extends the duality theorem for weak smash products given by Nikshych.

关键词： Weak Hopf algebras weak L-R smash products duality theorem.

Fusion of a rice endogenous N-methylpurine DNA glycosylase to a plant adenine base transition editor ABE8e enables A-toK base editing in rice plants

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aBIOTECH 2024年第2期5卷 127-139页

作者： Yucai li Shaoya li Chenfei li Chen zhang Lei yan Jingying li Yubing He yan Guo Lanqin Xia Institute of Crop Sciences(ICS) Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Hainan Yazhou Bay Seed Laboratory/National Nanfan Research Institute(Sanya) CAASSanya 572024China

Engineering of a new type of plant base editor for simultaneous adenine transition and transversion within the editing window will greatly expand the scope and potential of base editing in directed evolution and crop ***,we isolated a rice endogenous hypoxanthine excision protein,N-methylpurine DNA glycosylase(OsMPG),and engineered two plant A-to-K(K=G or T)base editors,rAKBE01 and rAKBE02,for simultaneous adenine transition and transversion base editing in rice by fusing OsMPG or its mutant mOsMPG to a plant adenine transition base editor,*** further coupled either OsMPG or mOsMPG with a transactivation factor VP64 to generate rAKBE03 and rAKBE04,*** these four rAKBEs,at five endogenous loci in rice protoplasts,indicated that rAKBE03 and rAKBE04 enabled higher levels of A-to-G base transitions when compared to ABE8e and ***,whereas rAKBE01 only enabled A-to-C/T editing at one endogenous locus,in comparison with rAKBE02 and rAKBE03,rAKBE04 could significantly improve the A-to-C/T base transversion efficiencies by up to 6.57-and 1.75-fold in the rice protoplasts,***,although no stable lines with A-to-C transversion were induced by rAKBE01 and rAKBE04,rAKBE04 could enable simultaneous A-to-G and A-to-T transition and transversion base editing,at all the five target loci,with the efficiencies of A-to-G transition and A-to-T transversion editing ranging from 70.97 to 92.31%and 1.67 to 4.84%in rice stable lines,***,these rAKBEs enable different portfolios of editing products and,thus,now expands the potential of base editing in diverse application scenario for crop improvement.

关键词： Rice(Oryza sativa L) Rice N-methylpurine DNA glycosylase(OsMPG) A-to-K base editor(AKBE) Transactivation module VP64

Emergence, Development, and Future of Cardio-Oncology in China

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Chinese Medical Journal 2018年第21期131卷 2640-2644页

作者： Ying liu yan-li zhang Ji-Wei lio Feng-Qi Fang Jian-Ming li Yon-Long Xia Department of Cardiology The First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Oncology The First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Cardiovascular Division University of Minnesota Minneapolis MN 55417 USA

As the development of early detection and therapies advances in cancer patients, mortality rates attributed to cancer have declined. In the United States, there are approximately 15,5 million cancer survivors, and the number will grow to more than 20 million by 2026 （http：//***/cancer/news/news/ report-number-of-cancer-survivors-contint, es-to-grow）.

关键词： INTERNATIONAL CARDIONCOLOGY SOCIETY SHARED RISK-FACTORS CARDIOVASCULAR-DISEASE ATRIAL-FIBRILLATION CANCER DYSFUNCTION MANAGEMENT STATISTICS GUIDEliNES MORTAliTY

Zeolites for the separation of ethylene, ethane, and ethyne

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FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING 2024年第9期18卷 108-0页

作者： Wang, Binyu li, Qiang zhang, Haoyang zhang, Jia-Nan Pan, Qinhe yan, Wenfu Jilin Univ Coll Chem State Key Lab Inorgan Synth & Preparat Chem Changchun 130012 Peoples R China Zhengzhou Univ Coll Mat Sci & Engn Key Lab Adv Energy Catalyt & Funct Mat Preparat Zhengzhou 450012 Peoples R China Hainan Univ Sch Chem & Chem Engn Key Lab Adv Mat Trop Isl Resources Minist Educ Haikou 570228 Peoples R China

The cost-effective separation of ethylene (C2H4), ethyne (C2H2), and ethane (C2H6) poses a significant challenge in the contemporary chemical industry. In contrast to the energy-intensive high-pressure cryogenic distillation process, zeolite-based adsorptive separation offers a low-energy alternative. This review provides a concise overview of recent advancements in the adsorptive separation of C2H4, C2H2, and C2H6 using zeolites or zeolite-based adsorbents. It commences with an examination of the industrial significance of these compounds and the associated separation challenges. Subsequently, it systematically examines the utilization of various types of zeolites with diverse cationic species in such separation processes. And then it explores how different zeolitic structures impact adsorption and separation capabilities, considering principles such as cation-pi interaction, pi-complexation, and steric separation concerning C2H4, C2H2, and C2H6 molecules. Furthermore, it discusses methods to enhance the separation performance of zeolites and zeolite-based adsorbents, encompassing structural design, modifications, and ion exchange processes. Finally, it summarizes current research trends and future directions, highlighting the potential application value of zeolitic materials in the field of C2H4, C2H2, and C2H6 separation and offering recommendations for further investigation.

关键词： zeolite ethylene ethane cation-pi interaction pi-complexation ADSORPTIVE SEPARATION CARBON-DIOXIDE C2H4 PURIFICATION FRAMEWORKS SORBENTS REMOVAL