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Transcription factor Foxp1 is essential for the induction of choroidal neovascularization

Eye and Vision 2024年第3期10卷 1-12页

作者： Meifang yan Junjian Li Li yan xue Li jie-Guang Chen School of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical UniversityState Key Laboratory of OptometryOphthalmology and Vision Scienceand Zhejiang Provincial Key Laboratory of Optometry and Ophthalmology270 Xueyuan RoadWenzhouZhejiang325027People’s Republic of China Joint Shantou International Eye Center(JSIEC)of Shantou University and the Chinese University of Hong Kong ShantouGuangdong515000People’s Republic of China

Background The exudative form of age-related macular degeneration(AMD)is characterized by abnormal blood vessel growth,which is stimulated by vascular endothelial growth factor(VEGF)released from retinal pigment epithelium(RPE).The angiogenic behaviors of vascular endothelial cells in vitro depend on forkhead box protein P1(Foxp1),a transcription repressor widely expressed in human and murine tissues during *** this study,we aimed to determine whether loss of Foxp1 affects laser-induced choroidal neovascularization(CNV)in *** Eye-selective deletion of Foxp1 was obtained by crossing Foxp1flox/flox with Six3-Cre *** photocoagulation was delivered to six-to eight-week-old mice to induce *** expression of Foxp1 and Cre was determined by immunofluorescence in cryostat sections of the *** fluorescein angiography(FFA),optical coherence tomography(OCT),and B4 isolectin staining were applied to analyze the leakage,bulge height,and area of CNV lesions,***-choroid tissues were isolated for the determination of VEGF and pigment epithelium derived factor(PEDF)by Western *** Foxp1 was expressed in retinal ganglion cells,RPE,and the choroidal endothelial *** photocoagulation increased the number of Foxp1+-endothelial cells and induced ***3-Cre reduced Foxp1 expression in RPE but not the endothelium,leading to a lower level of VEGF in the ***1 knockout inhibited pathological angiogenesis and vascular leakage of the laser-induced CNV *** Foxp1 regulates the expression of VEGF in the RPE,and inhibition of Foxp1 could potentially be a novel strategy for the prevention and therapy of neovascularization related to AMD.

关键词： Foxp1 Choroidal neovascularization Angiogenesis Laser photocoagulation Age-related macular degeneration

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Effect of pre-annealing treatment on the microstructure and mechanical properties of extruded Al–Zn–Mg–Cu alloy bars

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International Journal of Minerals,Metallurgy and Materials 2017年第11期24卷 1284-1292页

作者： Zhi-hao Zhang jie xue yan-bin Jiang Feng Jin Institute for Advanced Materials and Technology University of Science and Technology Beijing Beijing Hangxing Machine Manufacture Co. Ltd

Taking extruded Al–Zn–Mg–Cu alloy(7A04 alloy) bars as the research object, the effect and mechanism of pre-annealing treatments on the microstructure and mechanical properties of the aged alloy bars were investigated. The results show that a pre-annealing treatment at 350°C for 15 h before a T6 treatment substantially reduced the sensitivity of the microstructure and mechanical properties of the extruded 7A04 aluminum alloy specimens toward the extrusion temperature. The average grain sizes of the specimens extruded at 390 and 430°C after T6 treatment were 3.4 and 8.1 μm, respectively, and their elongations to failure were 7.0% and 9.2%, respectively. However, after pre-annealing + T6 treatment, the differences in both the grain sizes and the elongations of the specimens became small, i.e., their average grain sizes were 3.2 and 3.8 μm and their elongations were 12.0% and 13.3%, respectively. For the specimens extruded at the same temperature, pre-annealing treatment obviously improved the plasticity of the alloy, which is attributed to an increase in soft texture or to grain refinement in the specimens as a result of the pre-annealing + T6 treatment.

关键词： aluminum alloy hot extrusion pre-annealing treatment microstructure mechanical properties

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-yan Huang Yi-De Zhang jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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EV71 infection correlates with viral IgG preexisting at pharyngolaryngeal mucosa in children

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Virologica Sinica 2015年第2期30卷 146-152页

作者： Jingchang xue Yaoming Li Xiaoyi Xu jie Yu Hu yan Huimin yan Changzhou Center for Disease Control and Prevention Mucosal Immunity Research Group State Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of Sciences

Enterovirus 71(EV71) infection causes severe central nervous system damage, particularly for children under the age of 5 years old, which remains a major public health burden worldwide. Clinical data released that children may be repeatedly infected by different members in enterovirus and get even worsen. Mucosa, especially epithelium of alimentary canal, was considered the primary site of EV71 infection. It has been elusive whether the preexsiting viral antibody in mucosa plays a role in EV71 infection. To answer this question, we respectively measured viral antibody response and EV71 RNA copy number of one hundred throat swab specimens from clinically confirmed EV71-infected children. The results released that low-level of mucosal Ig G antibody against EV71 broadly existed in young population. More importantly, it further elucidated that the children with mucosal preexsiting EV71 Ig G were prone to be infected, which suggested a former viral Ig G mediated enhancement of viral infection in vivo.

关键词： EV71 clinical infection mucosal Ig G VP1 VP2 3D

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Characteristics of seismic activity before Chile M_W8.8 earthquake in 2010

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Earthquake Science 2010年第4期23卷 333-341页

作者： yan xue jie Liu Gang Li Institute of Geophysics China Earthquake Administration Beijing 100081 China China Earthquake Networks Center Beijing 100045 China

The tempo-spatial variation of seismic activity before great Chile Mw8.8 earthquake on February 27, 2010 is studied. Some results are as follows： ①Two types of seismic gaps appeared before the Chile MwS.8 shock. One is background gap of Mw≥8.0 earthquakes with 360 km length since 1900, the other is seismogenic gap formed by M≥5.5 earth- quakes with 780km length five years before the Chile earthquake; ②There was only one Mw7.1 earthquake in the middle and southern part of Chile from 1986 to 2010. The obvious quiescence of Mw≥7.0 earthquake is the long-term background anomaly for the Chile earthquake; ③ The quiescence of M≥6.5 earthquakes appeared in South American block and its vicinity during the period from 2007 to 2009, and the quietude state has been disappeared three months before the Chile Mw8.8 earthquake; ④ The deep and intermediate-depth earthquake activity has been noticeablely strengthened in the subduction zone of South American block since 1993; ⑤The great Chile earthquake shows that global seismicity is still in the active period of Mw≥8.5 earthquakes since 2004. Based on the characteristics of the former two active periods, several great earthquakes with Mw≥8.5 would take place in a few years. In addition, the circum-Pacific seismic belt would be the main region for Mw≥8.0 earthquakes.

关键词： Chile earthquake two types of seismic gaps deep and intermediate-depth earthquake South Americanblock circum-Pacific seismic belt

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Seismicity characteristics of the 2011 M9.0 Tohoku earthquake near the East Coast of Honshu in Japan

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Chinese Science Bulletin 2012年第8期57卷 886-893页

作者： xue yan LIU jie YU HuaiZhong LIU ShuangQing Institute of Geophysics China Earthquake AdministrationBeijing 100081China China Earthquake Networks Center Beijing 100045China Earthquake Administration of Tianjin Municipality Tianjin 300201China

The spatiotemporal evolution of the M9.0 Tohoku earthquake sequence off the East Coast of Honshu in Japan on March 11,2011 and precursive seismic activity near the Japan Trench show that the earthquake sequence has foreshock-main shock-aftershock *** foreshock sequence is characterized by a concentrated spatial distribution,low b value and the same focal *** an hour after the main shock,the two greatest aftershocks,with magnitudes of M7.9 and M7.7,occurred,followed by a rapid reduction in the strength of *** aftershock activity was enhanced roughly two weeks and one month after the main *** great earthquake ruptured *** hours after the main shock,the aftershock zone extended over a range that was 500 km in length and 300 km in width.A day later,the long axis of the aftershock area had expanded to about 600 *** years prior to the 2011 earthquake,the seismicity in the location of the seismic source for this event enhanced significantly,with the extent of this area of enhanced seismicity being roughly equivalent to the aftershock zone.

关键词：地震活动特征日本海沟东海岸东北地震序列余震活动时空演化空间分布

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The Effect of Trifluoroacetic Acid on Molecular Weight Determination of Polyesters:An in Situ NMR Investigation

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Chinese Journal of Polymer Science 2021年第12期39卷 1590-1596页

作者： yan-yan Tu xue-Ting Wan jie Huan Xiang Zhu Xiao-Hong Li Ying-Feng Tu State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Due to the poor solubility of aromatic polyesters in comm on orga nic solve nts,trifluoroacetic acid is usually used as a co-solve nt to increase their solubility for ***,only few studies have reported the side reactions induced by *** present here the application of in situ 1H-NMR techniques to explore its effect on the hydroxyl end-groups,which are usually used for the molecular weight determination of polyesters by end-group estimation *** bis(2-hydroxyethyl)terephthalate(BHET)as model compound,quantitative NMR results show the peak integration of hydroxyethyl end-groups decreased with time via a pseudo-first-order kinetics in d-trifluoroacetic acid/d-chloroform mixture solvent(1:10,V:V).This is due to the esterification of hydroxyethyl groups with trifluoroacetic acid,revealed by the H-^(13)C gradient-enhanced heteronuclear multiple bond correlation(gHMBC)*** mixtures of dimethyl terephthalate and BHET with different molar ratios were used to represent poly(ethylene terephthalate)(PET)with different degrees of polymerization,and the effect of trifluoroacetic acid on the estimation of hydroxyethyl groups and subsequent molecular weight determination of polyesters was *** results show that if a relative error of 5%is allowed,the NMR measurements must be finished within 1.3 h of solution preparation at 25℃ in the mixture solve *** results were confirmed in PET sample,while in poly(ethyle ne adipate),the obtained esterifaction con stant is faster that those in aromatic *** results can be applied to other polymer systems with alcohol functionalized groups,and used as a guideline for the characterization of polyesters and polyethers by end-group estimation method.

关键词： Polyesters NMR spectroscopy Trifluoroacetic acid Molecular weight

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Solving elastic wave equations in 2D transversely isotropic media by a weighted Runge-Kutta discontinuous Galerkin method

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Petroleum Science 2023年第2期20卷 827-839页

作者： Xi-Jun He Jing-Shuang Li xue-Yuan Huang yan-jie Zhou School of Mathematics and Statistics Beijing Technology and Business University(BTBU)Beijing100048China School of Science China University of Mining and Technology(Beijing)Beijing100083China

Accurate wave propagation simulation in anisotropic media is important for forward modeling, migration and inversion. In this study, the weighted Runge-Kutta discontinuous Galerkin (RKDG) method is extended to solve the elastic wave equations in 2D transversely isotropic media. The spatial discretization is based on the numerical flux discontinuous Galerkin scheme. An explicit weighted two-step iterative Runge-Kutta method is used as time-stepping algorithm. The weighted RKDG method has good flexibility and applicability of dealing with undulating geometries and boundary conditions. To verify the correctness and effectiveness of this method, several numerical examples are presented for elastic wave propagations in vertical transversely isotropic and tilted transversely isotropic media. The results show that the weighted RKDG method is promising for solving wave propagation problems in complex anisotropic medium.

关键词： Discontinuous Galerkin method Anisotropy Transversely isotropic Modeling

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同辈心理健康病耻感量表中文版测评中学生的效度与信度

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中国心理卫生杂志 2025年第1期39卷 63-67页

作者：彭彪韩雪王慧杨棋凯罗杰长沙民政职业技术学院马克思主义学院长沙410004 贵州医科大学马克思主义学院贵阳550025 贵州师范大学附属中学贵阳550001 清镇市广大实验学校贵阳551499 岳阳市康复医院精神科湖南岳阳414022 贵州师范大学心理学院贵阳550025

目的:检验同辈心理健康病耻感量表(PMHSS-R)中文版在中学生中的效度与信度。方法:选取1 099名中学生,随机分为样本1 (n=549)和样本2(n=550),分别进行探索性因子分析和验证性因子分析;总样本(n=1 099)用于考察内部一致性信度,2周后选取其... 详细信息

目的:检验同辈心理健康病耻感量表(PMHSS-R)中文版在中学生中的效度与信度。方法:选取1 099名中学生,随机分为样本1 (n=549)和样本2(n=550),分别进行探索性因子分析和验证性因子分析;总样本(n=1 099)用于考察内部一致性信度,2周后选取其中87名中学生进行重测;另外选取259名中学生(样本3),采用抑郁症病耻感量表(DSS)、专业心理支持求助态度量表简版(ATSPPHSF)进行效标效度检验。结果:探索性因子分析共提取出2个公因子,命名为病耻感意识、病耻感认同,累计方差贡献率为66.86%;验证性因子分析表明2因子模型拟合指数较好(χ~2/df=3.70,CFI=0.97,TLI=0.96,SRMR=0.03,RMSEA=0.07);PMHSS-R中文版得分与DSS得分正相关(ICC=0.58,P<0.01),与ATSPPH-SF得分负相关(ICC=-0.40,P<0.01);总量表及2个因子的Cronbachα系数分别为0.90、0.92和0.85,重测信度(ICC)分别为0.84、0.76和0.78。结论:同辈心理健康病耻感量表(PMHSS-R)中文版评估中学生的心理健康病耻感具有良好效度与信度。

关键词：心理健康病耻感效度信度中学生

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An Overview of Anterior Repositioning Splint Therapy for Disc Displacement-related Temporomandibular Disorders

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Current Medical Science 2021年第3期41卷 626-634页

作者： yan-ning GUO Sheng-jie CUI yan-heng ZHOU xue-dong WANG Department of Orthodontics Peking University School and Hospital of StomatologyBeijing 100081China National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing 100081China Beijing Key Laboratory of Digital Stomatology Beijing 100081China

Anterior repositioning splint(ARS)therapy is considered one of the most effective therapies for treating disc displacement-related temporomandibular disorders(TMDs),which account for a large proportion of TMD *** to the wide application of this therapy,the exact mechanism of remission has increasingly drawn *** that practitioners have different views on ARS therapy,its indications are broadened,and operating methods *** review attempts to provide an overview of ARS therapy and helps practitioners establish indications and suitable operating *** views in the past 10 years were summarised,and conclusions were drawn as follows:The mechanism of ARS therapy is mainly attributed to internal derangement correction,improvement of stress distribution and recently reported joint *** has an evident effect in the short term,and the most prevalent operating methods are protruding the mandible to the edge-to-edge position and wearing the ARS for 24 hours daily for 3-6 ***,long-term stability is not optimal,and thus indications should be selected ***,most of the clinical studies in this field are case analyses with low-quality ***-designed RCTs are required to further validate relevant theories.

关键词： anterior repositioning splint disc displacement occlusal splint temporomandibular joint disorders therapeutics

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