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Pegylated interferon α-2b up-regulates specific CD8+ T cells in patients with chronic hepatitis B

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World Journal of Gastroenterology 2010年第48期16卷 6145-6150页

作者： Ji Chen,yan Wang,xue-jie Wu,Jun Li,Feng-Qin Hou,Gui-Qiang Wang,Department of Infectious Diseases,Center for Liver Diseases,Peking University First Hospital,Beijing 100034,China Department of Infectious Diseases Center for Liver Diseases Peking University First Hospital No. 8 Xishiku Street Xicheng District Beijing 10034 China. wanggq@***

AIM:To investigate the effect of pegylated interferon (IFN) α-2b on specific CD8+ T lymphocytes in patients with chronic hepatitis B (CHB). METHODS:Twenty-one patients with CHB were treated with pegylated IFN α-2b. Periphery blood mononuclear cells were isolated from fresh heparinized blood by Ficoll-Hypaque density gradient centrifugation (density:1.077 g/L,Pharmingen) at weeks 0,4,8,12,and 24,respectively. Frequency of circulating hepatitis B virus (HBV) epitope-specific CD8 T cells was detected by flow cytometry. Cytokines were detected by cytometric bead assay. RESULTS:The frequency of circulating HBV core or env-specific CD8 T cells was higher (P < 0.05),the number of HBV core specific CD8 T cells was greater at week 24 (P < 0.05),the level of Th1-type cytokines [interleukin (IL)-12,tumor necrosis factor-α,and IFN-γ] was higher,while that of Th2-type cytokines (IL-4,IL-6,and IL-10) was lower in responders than in nonresponders (P < 0.05) after pegylated IFN α-2b treatment. The IL-6 level was correlated with HBV DNA (r = 0.597,P = 0.04),while the inducible protein-10 (IP-10) level was correlated with serum alanine aminotransferase (ALT) (r = 0.545,P = 0.005). The IP-10 level at week 8 after pegylated IFN α-2b treatment could predict the normalization of ALT in CHB patients (positive predict value = 56%,negative predict value = 92%). CONCLUSION:Pegylated IFN α-2b can enhance the immune response of CHB patients by increasing the frequency of HBV specific CD8+ T cells and regulating the Th1/Th2 cytokines.

关键词： Chronic hepatitis B Pegylated interferon α-2b therapy Immune response Cytokine

Site-testing at Muztagh-ata site Ⅲ:temperature inversion in surface-layer atmosphere

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Research in Astronomy and Astrophysics 2020年第6期20卷 185-192页

作者： Jing Xu Ali Esamdin Guo-jie Feng Guang-Xin Pu Yi Hu Ke-Liang Hu Xu yang Jin-Xin Hao yan-jie xue Xu Zhou Shu-Guo Ma Abudusaimaitijiang Yisikandee Le-Tian Wang Xuan Zhang Chun-Hai Bai Peng Wei Liang Ming Lu Ma Jin-Zhong Liu Yun-Ying Jiang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China

In this article,we present detailed seasonal,monthly and daily statistics of temperature difference in the surface layer at the Muztagh-ata site based on the temperature measurements at two heights of 2 m and6 *** find that temperature inversion occurs frequently at our site during nighttime,especially during the cold *** temperature inversion always represents stable atmospheric turbulence,which is crucial for an optical *** analyzing the behavior of temperature inversion and its correlation with wind and cloud amount,one conclusion can be made that radiation inversion is the main reason for the existence of temperature inversion in the surface-layer at the Muztagh-ata site.

关键词： site testing atmospheric turbulence temperature inversion

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煤矿皮带输送机的故障处理探析

装备制造技术 2011年第10期 113-115页

作者：闫学杰中平能化集团八矿设备管理中心河南平顶山467000

针对煤矿皮带输送机常见的故障,分析了皮带输送机发生故障的原因,指出了处理故障的办法。

关键词：煤矿皮带输送机故障处理

反抗与服从——从姚乃强《红字》译本看海丝特性格及成因

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菏泽学院学报 2015年第1期37卷 31-33页

作者：颜雪洁安徽师范大学外国语学院安徽芜湖241000

在清教殖民统治的社会大背景下,海丝特虽具有一定程度的反抗,但又不得不做出妥协和牺牲,海丝特的反抗具有不彻底性。这种不彻底的反抗有很深的社会原因,并且受到作者本人的情感经历的影响。

关键词：海丝特反抗与服从不彻底性

Site-testing at Muztagh-ata site Ⅰ:ground meteorology and sky brightness

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Research in Astronomy and Astrophysics 2020年第6期20卷 162-174页

作者： Jing Xu Ali Esamdin Jin-Xin Hao Jin-Min Bai Ji yang Xu Zhou Yong-Qiang Yao Jin-Liang Hou Guang-Xin Pu Guo-jie Feng Chun-Hai Bai Peng Wei Shu-Guo Ma Abudusaimaitijiang Yisikandee Le-Tian Wang Xuan Zhang Liang Ming Lu Ma Jin-Zhong Liu Zi-Huang Cao Yong-Heng Zhao Lu Feng Jian-Rong Shi Hua-Lin Chen Chong Pei Xiao-Jun Jiang Jian-Feng Wang Jian-Feng Tian yan-jie xue Jing-Yao Hu Yun-Ying Jiang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Yunnan Observatories Chinese Academy of SciencesKunming 650000China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008 China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210008China

Site-testing is crucial for achieving the goal of scientific research and analysis of meteorological and optical observing conditions,one of the associated basic *** one of three potential sites to host the 12-meter Large Optical/infrared Telescope(LOT),the Muztagh-ata site,which is located on the Pamir Plateau in Xinjiang,in west China,began its site-testing task in the spring of *** this paper,we firstly start with an introduction to the site and then present a statistical analysis of the ground-level meteorological properties such as air temperature,barometric pressure,relative humidity,and wind speed and direction,recorded by an automatic weather station with standard meteorological sensors for a two-year *** also show the monitoring results of sky brightness during this period.

关键词： site testing meteorological condition optical observing

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin Yuan Yi-Juan Zheng Bing-Rong Zhang Yi-jie Lin You Li yan-yan Qiu xue-Ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

Site testing at Muztagh-ata site Ⅱ:seeing statistics

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Research in Astronomy and Astrophysics 2020年第6期20卷 175-184页

作者： Jing Xu Ali Esamdin Jin-Xin Hao Jin-Min Bai Ji yang Xu Zhou Yong-Qiang Yao Jin-Liang Hou Guang-Xin Pu Guo-jie Feng Chun-Hai Bai Peng Wei Shu-Guo Ma Abudusaimaitijiang Yisikandee Le-Tian Wang Xuan Zhang Liang Ming Lu Ma Jin-Zhong Liu Zi-Huang Cao Yong-Heng Zhao Lu Feng Jian-Rong Shi Hua-Lin Chen Chong Pei Xiao-Jun Jiang Jian-Feng Wang Jian-Feng Tian yan-jie xue Jing-Yao Hu Yun-Ying Jiang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Yun nan Observatories Chin ese Academy of Scie ncesKun ming 650000China Purple Mountain Observatory Chinese Academy of SciencesNanjing 21000&China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210008China

In this article,we present a detailed analysis of the statistical properties of seeing for the Muztaghata site which is a candidate site for hosting the future Chinese Large Optical/infrared Telescope(LOT)*** measurements were obtained with differential image motion monitors(DIMMs)from April2017 to November 2018 at different heights during different *** median seeings at 11 m and6 m are very close but significantly different from that on the *** mainly analyzed the seeing at11 m monthly and hourly,having found that the best season for observing was from late autumn to early winter and seeing tended to improve during the night only in *** analysis of the dependence on temperature inversion,wind speed and direction also was made and the best meteorological conditions for seeing are given.

关键词： site testing seeing

基于Boosting的代价敏感软件缺陷预测方法

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计算机科学 2017年第8期44卷 176-180,206页

作者：杨杰燕雪峰张德平南京航空航天大学计算机科学与技术学院南京211106

Boosting重抽样是常用的扩充小样本数据集的方法,首先针对抽样过程中存在的维数灾难现象,提出随机属性子集选择方法以进行降维处理;进而针对软件缺陷预测对于漏报与误报的惩罚因子不同的特点,在属性选择过程中添加代价敏感算法。以多个... 详细信息

Boosting重抽样是常用的扩充小样本数据集的方法,首先针对抽样过程中存在的维数灾难现象,提出随机属性子集选择方法以进行降维处理;进而针对软件缺陷预测对于漏报与误报的惩罚因子不同的特点,在属性选择过程中添加代价敏感算法。以多个基本k-NN预测器为弱学习器,以代价最小为属性删除原则,得到当前抽样集的k值与属性子集的预测器集合,采用代价敏感的权重更新机制对抽样过程中的不同数据实例赋予相应权值,由所有预测器集合构成自适应的集成k-NN强学习器并建立软件缺陷预测模型。基于NASA数据集的实验结果表明,在小样本情况下,基于Boosting的代价敏感软件缺陷预测方法预测的漏报率有较大程度降低,误报率有一定程度增加,整体性能优于原来的Boosting集成预测方法。

关键词：软件缺陷预测 Boosting 代价敏感随机属性选择集成k-NN

Long-term analysis of clear nights using satellite data considering astronomical sites in western China

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Research in Astronomy and Astrophysics 2020年第6期20卷 96-108页

作者： Zi-Huang Cao Li-Yong Liu Yong-Heng Zhao Lu Feng Hugh RAJones Huang Shen Jin-Xin Hao yan-jie xue Yong-Qiang Yao Jing Xu Ali Esamdin Zhao-Xiang Qi Jian-Rong Shi Jian Li Yuan Tian Zheng Wang Tai-Sheng yan Xia Wang Jian-Ping Xiong Si-Cheng Yu Jun-Bo Zhang Zhi-Xia Shen Yun-Ying Jiang Jia Yin Guang-Xin Pu Peng Wei Chun-Hai Bai Guo-jie Feng Lu Ma Teng-Fei Song Jian-Feng Wang Jian-Feng Tian Xian-Qun Zeng Zhi-Gang Hou Shi-Long Liao Zhi-Song Cao Dong-Wei Fan Yun-Fei Xu Chang-Hua Li Yi-Han Tao National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism.Communication University of China Beijing 100024China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China

A large ground-based optical/infrared telescope is being planned for a world-class astronomical site in *** cloud-free night percentage is the primary meteorological consideration for evaluating candidate *** data from GMS and NOAA satellites and the MODIS instrument were utilized in this research,covering the period from 1996 to *** data analysis benefits from overlapping results from different independent teams as well as a uniform analysis of selected sites using GMS+NOAA *** significant ground-based monitoring is needed to validate these findings,we identify three different geographical regions with a high percentage of cloud-free conditions(~83%on average),which is slightly lower than at Mauna Kea and Cerro Armazones(~85%on average)and were chosen for the large international projects TMT and ELT *** study finds evidence that cloud distributions and the seasonal changes affected by the prevailing westerly winds and summer monsoons reduce the cloud cover in areas influenced by the *** is consistent with the expectations from climate change models and is suggestive that most of the identified sites will have reduced cloud cover in the future.

关键词： methods statistical-site testing-atmospheric effects-MODIS