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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo yan Pan Liao Zhenyu Yin Xintong ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye yan Sun Jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen ge Song Chuanbin yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Automatic interval management for aircraft based on dynamic fuzzy speed control considering uncertainty

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Chinese Journal of Aeronautics 2023年第11期36卷 354-372页

作者： Jie YUAN yang PEI yan XU Xiaochen LI Yuxue ge School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China School of Aerospace Transport and ManufacturingCranfield UniversityCranfield MK430ALUnited Kingdom

A novel real-time autonomous Interval Management System(IMS)is proposed to automate interval management,which considers the effect of wind uncertainty using the Dynamic Fuzzy Velocity Decision(DFVD)*** membership function can be generated dynamically based on the True Air Speed(TAS)limitation changes in real time and the interval criterion of the adjacent aircraft,and combined with human cognition to formulate fuzzy rules for speed adjusting *** groups of experiments were conducted during the en-route descent stage to validate the proposed IMS and DFVD performances,and to analyze the impact factors of the *** verification experimental results show that compared with actual flight status data under controllers’command,the IMS reduces the descent time by approaching 30%with favorable wind uncertainty suppression *** analysis shows that the ability improvement of DFVD is mainly affected by the boundary value of the membership ***,the dynamic generation of the velocity membership function has greater advantages than the static method in terms of safety and *** the analysis of influencing factors,we found that the interval criterion and aircraft category have no significant effect on the capability of *** a higher initial altitude scenario,the initial interval should be appropriately increased to enhance safety and efficiency during the descent *** prototype system could evolve into a realtime Flight-deck Interval Management(FIM)tool in the future.

关键词： Air traffic control Air transportation Fuzzy logic Safety interval Wind uncertainty

Metallurgical characterization of Ti-bearing 9Cr low activation martensitic steel

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Acta Metallurgica Sinica(English Letters) 2011年第1期24卷 9-17页

作者： Rong MA Yafeng yang Qingzhi yan Ying yang Xinggang LI Changchun ge Institute of Nuclear Materials University of Science and Technology Beijing Beijing 100083 China

Two heats of low activation martensitic （LAM） steels with Ti and Ta （denominated as 9Cr-Ti and 9Cr-Ta）, respectively, developed as candidate structure materials for nuclear reactor were characterized. This paper was focused on the effect of titanium on the microstructures and mechanical properties of 9Cr LAM steel in as-received condition （normalized at 950 ℃ for 30 min with water quenching plus tempered at 780 ℃ for 90 min with air cooling）. Chemical analysis and microstructure observation were conducted on 9Cr-Ti and 9Cr-Ta with optical microscopy, X-ray diffraction analysis, scanning electron microscopy and transmission electron microscopy. Impact properties and tensile strengths were measured with Charpy impact experiments and tensile tests. The results indicated that 9Cr-Ti and 9Cr-Ta were fully martensitic steels in as-received condition. MX type and M23C6 type precipitates were observed distributing along boundaries of prior austenite grains and martensite laths in *** addition of titanium accelerated the precipitation of TiC and TiN, and produced much finer grains in 9Cr-Ti than 9Cr-Ta at the same normalization temperature. Mechanical properties tests showed the ductile brittle transition temperatures of 9Cr- Ti and 9Cr-Ta were about -90℃ and -85℃, respectively. The ultimate tensile strengths at room temperature and 600℃,were 680 MPa and 365 MPa for 9Cr-Ti, and 660 MPa and 335 MPa for 9Cr-Ta, respectively. The favorite impact toughness and tensile properties of 9Cr-Ti could be attributed to the fine grains in as-received condition.

关键词： 9Cr low activation martensitic steel Alloying effect Microstructure Mechanical properties

Facile access to C-N bonds via unexpected side reactions of Knoevenagel condensation and their application in high-efficiency organic solar cells

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Science China Chemistry 2024年第1期67卷 323-329页

作者： Daobin yang Shuncheng yang Hongqian Wang Lin Xie Pengyu yan Ziyi ge Zhejiang Engineering Research Center for Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The construction of C-N bonds is of great importance in the fields of biology,medicine,chemistry and materials ***,the replacement of organic base from pyridine to piperidine in the Knoevenagel condensation process unexpectedly yields a series of novel organic molecules containing C-N ***,the synthesis method does not require any external transition-metals catalysis,and photo-/***,when the new compound 1b is added as a third component to a well-known binary system of PM6:Y6,the efficiency of the organic solar cell is significantly improved,resulting in an outstanding efficiency of 18.0%,which is one of the highest values reported to date for PM6:Y6-based ternary organic solar cells.

关键词： C-N bonds Knoevenagel condensation cross-coupling reaction third component organic solar cells

Effect of alloying on the properties of 9Cr low activation martensitic steels

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Acta Metallurgica Sinica(English Letters) 2010年第6期23卷 451-460页

作者： Rong MA Yafeng yang Qingzhi yan Ying yang Xinggang LI Changchun ge Institute of Nuclear Materials University of Science and Technology Beijing Beijing 100083 China

Two types of 9Cr low activation martensitic steels （named 9Cr-1 and 9Cr-2） were developed in University of Science and Technology Beijing. 9Cr-1 and 9Cr-2 were produced by vacuum induction melting method, and examinations of the microstruc- tures were carried out with X-ray diffraction analysis, optical microscopy, scanning electron microscopy and transmission electron microscopy. The ultimate tensile strength and yield tensile strength were evaluated with tensile tests. The impact properties were characterized with Charpy impact experiments. The results indi- cated that 9Cr-1 and 9Cr-2 on as-received condition （95 ~C/30 min/water quenching plus 780 ~C/90 min/air cooling） were flflly martensitic steels free of ^-ferrite. The ul- timate tensile strength of 9Cr-1 and 9Cr-2 were 695 MPa and 680 MPa, respectively. However, 9Cr-2 showed a fine grain size of 4.8 pm, and its value of ductile-brittle transition temperature （DBTT） was -90 ~C under as-received condition. The additions of vanadium, titanium and boron accelerated the formation of MX precipitates and resulted in fine grains and precipitates. The fine grains effectively reduced the value of DBTT from -60 ℃ to -90 ℃ with identical upper shelf energy （USE）. The decrease in silicon concentration of 9Cr-2 induced a slight reduction in ultimate tensile strength from 695 MPa to 680 MPa.

关键词： 9Cr low activation martensitie steel Grain size Mechanical properties

Hot Deformation Behavior of Modified CNS-Ⅱ F/M Steel

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Journal of Iron and Steel Research International 2012年第1期19卷 60-65页

作者： yang Ying yan Qing-zhi ge Chang-chun School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

Modified CNS-Ⅱ F/M steel was designed for in-core components of supercritical water cooled reactor. Study on the hot deformation behavior of modified CNS- Ⅱ F/M steel is of great importance for processing parameter planning and microstructure controlling during hot deformation. The hot deformation behavior of modified CNS-Ⅱ F/M steel was investigated through isothermal hot compression test at temperature ranging from 1 223 to 1 373 K and strain rate 0.01 to 10 s^-1. The true stress true strain data gained from compression tests were used to built constitu- tive equation of modified CNS-Ⅱ F/M steel. The influence of strain on the accuracy of constitutive analysis was in corporated, assuming strain has a influence on material constants. A 5th order polynominal equation with very good accuracy was used to represent the influence of strain on material constant. The flow stresses calculated from the constitutive equation were compared with test values in the whole experiment range and the absolute average error for the constitutive equation in predicting *** stress is 4. 728 %. At last, the recrystallization behavior of modified CNS-Ⅱ F/M steel was investigated. The relationship of critical strain and peak strain with Zener-Hollomon parameter were given by an experimental equation.

关键词： F/M steel constitutive equation dynamic recrystallization

Radical cascade reactions of unsaturated C–C bonds involving migration

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Science China Chemistry 2019年第11期62卷 1476-1491页

作者： ge Zhang yang Liu Jinbo Zhao yan Li Qian Zhang Jilin Province Key Laboratory of Organic Functional Molecular Design&Synthesis Department of ChemistryNortheast Normal UniversityJilin 130024China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

During the past few years, with the rapid development of mild methods for the generation of radical species, great progress in radical cascade reactions of unsaturated C–C bonds has been made. Many radical cascade reactions involve functional groups migration, which leads structurally much more diverse, complex and valuable compounds not easily obtained through other methods. In this review, the recent achievements in unsaturated C–C bonds radical cascade reactions involving migration are summarized.

关键词： radical cascade reaction functional group migration unsaturated C–C bonds C-centered radicals N-centered radicals

Electrochemical synthesis of FeN_(x) doped carbon quantum dots for sensitive detection of Cu^(2+) ion

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Green Energy & Environment 2023年第1期8卷 141-150页

作者： Siyuan Sun Weijie Bao Fan yang Xingru yan yang Sun ge Zhang Wang yang Yongfeng Li State Key Laboratory of Heavy Oil Processing China University of PetroleumChangpingBeijing102249China

A novel strategy was developed to fabricate FeNx-doped carbon quantum dots(Fe-N-CQDs)to detect Cu^(2+) ions selectively as a fluorescence *** Fe-N-CQDs were synthesized by an efficient electrolysis of a carbon cloth electrode,which was coated with monoatomic ironanchored nitrogen-doped carbon(Fe-N-C).The obtained Fe-N-CQDs emitted blue fluorescence and possessed a quantum yield(QY)of 7.5%.An extremely wide linear relationship between the Cu^(2+) concentration and the fluorescence intensity was obtained in the range from 100 nmol L^(-1) to 1000 nmol L^(-1)(R^(2)=0.997),and the detection limit was calculated as 59 nmol L^(-1).Moreover,the Fe-N-CQDs demonstrated wide range pH compatibility between 2 and 13 due to the coordination between pyridine nitrogen and Fe^(3+),which dramatically reduced the affection of the protonation and deprotonation process between H^(+) and *** is notable that the Fe-N-CQDs exhibited a rapid response in Cu^(2+) detection,where stable quenching can be completed in 7 *** mechanism of excellent selective detection of Cu^(2+) was revealed by energy level simulation that the LUMO level of Fe-N-CQDs(-4.37 eV)was close to the redox potential of Cu^(2+),thus facilitating the electron transport from Fe-N-CQDs to Cu^(2+).

关键词： Electrolysis FeNx-doped CQDs Cu2t detection pH compatibility Quick response