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持续性透析患者矿物质和骨代谢紊乱与hs-CRP水平的关系

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中国当代医药 2017年第13期24卷 57-59页

作者：秦艳东晏文芬吴小兰李敏晖周国用广东省佛山市南海区第三人民医院肾内科广东佛山528244

目的探讨持续性透析(MHD)患者矿物质和骨代谢紊乱与高敏C反应蛋白(hs-CRP)水平的关系。方法选择2015年10月~2016年10月在我院血透室进行MHD的78例患者,测定其hs-CRP水平以及矿物质和骨代谢相关指标[血钙(Ca)、血磷(P)和甲状旁腺素(PTH)]... 详细信息

目的探讨持续性透析(MHD)患者矿物质和骨代谢紊乱与高敏C反应蛋白(hs-CRP)水平的关系。方法选择2015年10月~2016年10月在我院血透室进行MHD的78例患者,测定其hs-CRP水平以及矿物质和骨代谢相关指标[血钙(Ca)、血磷(P)和甲状旁腺素(PTH)],统计患者的透析充分性,采用多元线性回归分析hs-CRP水平与Ca、P和PTH的关系。结果 78例患者中,24例达到了美国肾脏病患者生存质量指南(K/DNOQI)推荐的电解质标准,达标率为30.77%(24/78)。达标组与未达标组间的hs-CRP水平比较,差异有统计学意义(P<0.05)。hsCRP水平与血P水平成正相关,与血Ca和PTH水平无相关性。结论 MHD患者矿物质和骨代谢紊乱与hs-CRP水平高度相关,血P为hs-CRP水平增高的危险因素。

关键词：持续性透析高敏C反应蛋白慢性肾脏病骨代谢紊乱

Data-Driven Fault-Tolerant Bipartite Consensus Tracking for Multi-Agent Systems With a Non-Autonomous Leader

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 279-281页

作者： yan Zhou Guanghui wen Jialing Zhou Tao yang the Department of Systems Science Southeast University the State Key Laboratory of CNS/ATM Beijing Institute of Technology the Beijing Institute of Technology (Zhuhai) the State Key Laboratory of Synthetical Automation for Process Industries Northeastern University

Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.

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Based on the Characteristics of Respondents and the Voice of the Urban Neighborhood Public Space Business Facilities Noise Environment Evaluation Research

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Journal of Harbin Institute of Technology(New Series) 2014年第4期21卷 103-109页

作者： Jun-yan dong wen Cheng School of Architecture Harbin Institute of Technology School of Architecture and Design Changchun Institute of Technology

Comfort is one of the important indicators evaluation of voice. In order to understand the urban neighborhood public space environment of comfort,this paper is to explore characteristics of consumer society on the public space environment evaluation of the effect,and using the questionnaire survey method,to evaluate the Harbin city neighborhood area public space as the typical case analysis. Based on one of the main sound source in neighborhood public space,environment,business facilities environment as the breakthrough point,it is to consider neighborhood public space environment evaluation and social characteristics.

关键词： neighborhood public space acoustic environment business facilities noise characteristics of respondents social features

超高效液相色谱-串联质谱法检测大鼠血浆中非洲防己碱

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中国卫生检验杂志 2020年第11期30卷 1300-1302页

作者：谢海丽陈东鑫董嫣文王贤亲宁波市医疗中心李惠利医院药剂科浙江宁波315040 温州医科大学分析测试中心浙江温州325035

目的建立超高效液相色谱-串联质谱(UPLC-MS/MS)法检测大鼠血浆中非洲防己碱,并研究非洲防己碱的药代动力学及其绝对生物利用度。方法以格兰地新为内标,采用UPLC BEH C18柱(2. 1 mm×50 mm,1. 7μm)为分离柱,以乙腈-0. 1%甲酸为流动相,... 详细信息

目的建立超高效液相色谱-串联质谱(UPLC-MS/MS)法检测大鼠血浆中非洲防己碱,并研究非洲防己碱的药代动力学及其绝对生物利用度。方法以格兰地新为内标,采用UPLC BEH C18柱(2. 1 mm×50 mm,1. 7μm)为分离柱,以乙腈-0. 1%甲酸为流动相,进行梯度洗脱,流速为0. 4 ml/min。大鼠血浆样本通过乙腈沉淀法去除蛋白,MRM模式监测定量,非洲防己碱m/z 338→322和内标m/z 322→307,正离子模式电喷雾离子源(ESI)。18只SD雄性大鼠用来药动学研究,分别静脉给药(0. 5 mg/kg和1. 0 mg/kg)和口服给药(10. 0 mg/kg)。结果在1 ng/ml^500 ng/ml内,该方法线性良好(r> 0. 995)。准确度在87. 5%~104. 3%,精密度<15%,基质效应在84. 2%~97. 7%,回收率≥78. 1%。结论该建立的UPLC-MS/MS方法简单、快速,并成功应用于非洲防己碱大鼠静脉和口服后的药代动力学,绝对生物利用率为15. 1%。

关键词：超高效液相色谱-串联质谱法非洲防己碱药代动力学生物利用度

花生Δ~9-硬脂酰-ACP脱氢酶基因启动子的克隆及功能分析

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作物学报 2016年第11期42卷 1629-1637页

作者：石磊苗利娟齐飞艳张忠信高伟孙子淇黄冰艳董文召汤丰收张新友河南省农业科学院经济作物研究所/农业部黄淮海油料作物重点实验室/河南省油料作物遗传改良重点实验室/花生遗传改良国家地方联合工程实验室河南郑州450002

Δ~9-硬脂酰-ACP脱氢酶（SAD）是决定植物体内饱和脂肪酸与不饱和脂肪酸比值的关键酶。以花生品种豫花9326基因组DNA为模板,通过基因组步移技术,克隆到花生Δ~9-硬脂酰-ACP脱氢酶基因（Ah SAD）起始密码子ATG上游720 bp片段,利用5＇RAC... 详细信息

Δ~9-硬脂酰-ACP脱氢酶（SAD）是决定植物体内饱和脂肪酸与不饱和脂肪酸比值的关键酶。以花生品种豫花9326基因组DNA为模板,通过基因组步移技术,克隆到花生Δ~9-硬脂酰-ACP脱氢酶基因（Ah SAD）起始密码子ATG上游720 bp片段,利用5＇RACE方法获得了该基因的5＇UTR序列,通过序列比对确定720 bp片段为Ah SAD启动子区域。PLACE在线启动子预测分析表明,该序列具有真核生物启动子必需的核心元件TATA-box和CAAT-box,含有多个与光诱导和激素响应相关顺式序列元件。将Ah SAD启动子片段替换pBI121质粒中的CaMV35S启动子驱动下游GUS基因表达,构建植物表达载体pBI-PAh SAD。通过农杆菌介导法转化拟南芥和在花生不同组织中瞬时表达,利用GUS组织化学染色研究其表达特性。表明在拟南芥和花生受体中,AhSAD启动子主要调控下游基因在根、茎、叶片和子叶中表达,在花生的果针中也检测到GUS活性;拟南芥的茎生叶只有叶脉中具有GUS活性,而花生整个叶片中都具有GUS活性。

关键词：花生 Δ9-硬脂酰-ACP脱氢酶基因(SAD) 启动子基因组步移 GUS报告基因

Lightweight innovation ADIs help development of renewable energy and new technology industries in China

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China Foundry 2024年第5期21卷 507-515页

作者： Qi-dong yan Xu-dong Gong wen-bang Gong Jin-cheng Liu ADI Committee of China Foundry Association Beijing 100000China Yuzhou Henglilai New Materials Co. Ltd.Xuchang 452570HenanChina Kunshan Changjian Foundry Industry Co.Ltd. Kunshan 215311JiangsuChina School of Mechanical Engineering and Automation Wuhan Textile UniversityWuhan 430200China WFO Ferrous Metals Commission Shenyang 110022China

The world is undergoing profound changes in energy and *** are vigorously developing new sustainable energy sources and *** energy sources encompass various technologies such as wind turbines,solar energy,nuclear energy,and ***,emerging technology fields include new energy vehicles,robots,and artificial intelligence devices,among *** renewable energy industries and implementation of new technologies necessitate the development and adoption of new equipment and *** ductile iron(ADI)is renowned for its unique microstructure and superior *** utilizing ADI,lightweight and innovative castings can be designed to not only reduce weight but also save energy and decrease *** importantly,these castings enhance the efficiency and reliability of new energy equipment and emerging technology *** paper describes the development,applications,and future prospects of lightweight and innovative ADI castings within sectors such as solar photovoltaic(PV),wind power generation,industry robots,and trucks in China.

关键词： lightweight ADI renewable energy emission reduction

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单嘧磺酯对原生动物群落的毒性

农药 2008年第1期47卷 61-63页

作者：严东文田庆玲郑占英刘桂龙张树军童军南开大学农药国家工程研究中心天津300071 天津创业环保股份有限公司天津300381

单嘧磺酯是我国自主研发的一种新型除草剂,目前已经在农业生产中推广应用。以原生动物为靶标生物对单嘧磺酯进行24h急性毒性试验,结果表明,原生动物群落急性中毒的最大无致死量为0.25g/L,随着单嘧磺酯质量浓度的增加,原生动物种类越来越... 详细信息

单嘧磺酯是我国自主研发的一种新型除草剂,目前已经在农业生产中推广应用。以原生动物为靶标生物对单嘧磺酯进行24h急性毒性试验,结果表明,原生动物群落急性中毒的最大无致死量为0.25g/L,随着单嘧磺酯质量浓度的增加,原生动物种类越来越少,肉足类的变形虫耐受力最差,其次是鞭毛类,其中以固着型纤毛虫和后生动物的耐受力最好,且单嘧磺酯质量浓度越大,其耐受优势越明显。

关键词：毒性试验单嘧磺酯原生动物

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia wenting Ye yan Sun Jing Cai Fubing Yu Haiping wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Synergetic effect of BiOCl/Bi12O17Cl2 and MoS2: in situ DRIFTS investigation on photocatalytic NO oxidation pathway

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Rare Metals 2019年第5期38卷 437-445页

作者： wen-dong Zhang Xing-An dong Yi Liang Rui Liu yan-Juan Sun Fan dong Chongqing Key Laboratory of Inorganic Functional Materials Department of Scientific Research ManagementChongqing Normal UniversityChongqing 401331China Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and ResourcesChongqing Technology and Business UniversityChongqing 400067China Chongqing Key Laboratory of Earth Surface Processes and Environmental Remote Sensing in Three Gorges Reservoir Area Chongqing Normal UniversityChongqing 401331.China Research Center for Environmental Science and Technology Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China

The BiOCl/Bi12O17Cl2@MoS2(BOC-MS)composites were successfully synthesized by a facile method at room *** physicochemical properties of the as-obtained samples were characterized by X-ray diffractometer(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS),ultraviolet–visible diffuse reflection spectra(UV–Vis DRS),photoluminescence(PL),Brunauer–Emmett–Teller–Barrett–Joyner–Halenda(BET–BJH),and electron spin resonance(ESR)in ***,the in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)was applied to elucidate the adsorption and photocatalytic reaction *** optimized BOC-MS-1.0 composites exhibited excellent visible light photocatalytic capability(51.1%)and photochemical stability for removal of *** on the DMPOESR spin trapping,the·O2-radicals andáOH radicals were identified as the main active species generated from BOCMS-1.0 under visible light *** enhanced photocatalytic performance can be ascribed to the positive synergetic effect of the MoS2 and the effective carrier separation ability.

关键词： Synergetic effect BiOCl/Bi12O17Cl2 MoS2 In situ DRIFTS investigation NO Oxidation pathway