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医学隔离社区卫生服务人员的心理护理

护理实践与研究 2020年第7期17卷 14-16页

作者：董彦雯华中农业大学社区卫生服务中心门诊输液室武汉市430070

目的调查武汉市社区抗击新型冠状病毒肺炎疫情过程中我社区卫生服务人员的创伤后心理危机现状。方法采用焦虑自评量表(SAS)和抑郁自评量表(SDS)对56名医学隔离社区卫生服务人员的心理健康状况进行问卷调查。结果56名医学隔离社区卫生服... 详细信息

目的调查武汉市社区抗击新型冠状病毒肺炎疫情过程中我社区卫生服务人员的创伤后心理危机现状。方法采用焦虑自评量表(SAS)和抑郁自评量表(SDS)对56名医学隔离社区卫生服务人员的心理健康状况进行问卷调查。结果56名医学隔离社区卫生服务人员心理护理干预前后的SAS评分和SDS评分比较差异有统计学意义(P<0.05)。结论新型冠状病毒肺炎疫情期间,对隔离社区卫生服务人员加强心理护理,可有效缓解其心理紧张和焦虑情绪,有效改善其心理状态。

关键词：新型冠状病毒肺炎社区卫生服务人员心理危机心理护理

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医院经营管理中内部控制制度的有效性探究

中国卫生产业 2020年第28期17卷 73-75页

作者：闫文栋河南省柘城县人民医院河南柘城476200

全面提高内部控制制度的有效性才能够全面提高医院的管理水平,由于影响到医院经营管理的内部控制制度比较复杂,为了全面提高管理的实际效果,应该结合影响到内部控制制度有效性的相关因素,展开行之有效的管理工作。该文主要围绕医院管理... 详细信息

全面提高内部控制制度的有效性才能够全面提高医院的管理水平,由于影响到医院经营管理的内部控制制度比较复杂,为了全面提高管理的实际效果,应该结合影响到内部控制制度有效性的相关因素,展开行之有效的管理工作。该文主要围绕医院管理过程当中内部控制制度有效性展开分析和论述,首先介绍影响医院经济管理的内部控制制度的相关因素,然后提出提高内部控制制度有效性的关键举措。

关键词：医院管理内部控制制度有效性影响因素

2D CaWO4 nanosheets derived from scheelite minerals for enhanced electrocatalysis in oxygen evolution reaction

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Science China Chemistry 2025年

作者： Qing Sun Yongxiang Sun yan dong Hong Zhong Hongbo Zeng National&Local United Engineering Laboratory for New Petrochemical Materials&Fine Utilization of Resources College of Chemistry and Chemical EngineeringHunan Normal University Department of Chemical and Materials Engineering University of Alberta College of Chemistry and Materials Engineering Hunan University of Arts and Science College of Chemistry and Chemical Engineering Central South University

Scheelite （CaWO4） mineral holds promise as a cost-effective and efficient catalyst for the oxygen evolution reaction （OER）crucial in renewable energy ***,challenges such as limited active site exposure and low electrocatalytic performance need *** this work,we have fabricated two-dimensional （2D） CaWO4nanosheets from scheelite minerals via a straightforward ultrasonic exfoliation method and evaluated their efficacy as OER *** to scheelite powders,these 2D nanosheets exhibited superior crystallinity and a 1.26-fold increase in electrochemical surface area,promoting active site *** 2D CaWO4nanosheet electrode demonstrated outstanding OER catalytic performance,achieving a current density of 20 mA/cm2at an overpotential of 290 m V in alkaline conditions,which was lower than that of bulk CaWO4electrodes （～340 mV）.Density functional theory calculations attributed this enhanced catalytic performance to moderate adsorption of oxygenated intermediates （*OH,*O,and*OOH） on the W sites of 2D *** situ electrochemical atomic force microscopy tests also confirmed the catalytic enhancement by 2D CaWO4nanosheets during *** findings demonstrate the potential of affordable and abundant mineral resources in advancing electrochemical catalysts for oxygen evolution,highlighting their broader application in sustainable energy technologies.

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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： yan Li Peng Hao Hongmei Duan Fei Hao wen Zhao Yudan Gao Zhaoyang yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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儿童睾丸附件扭转诊治体会

临床小儿外科杂志 2003年第2期2卷 89-91页

作者：王斌颜东文深圳市儿童医院外科广东深圳518026 甘肃省人民医院泌尿外科甘肃兰州730000

目的对儿童睾丸附件扭转的病因、诊断及治疗进行分析总结。方法对1993年～2002年收治的48例患儿的临床资料进行回顾性分析。结果36例行睾丸附件手术切除,12例行保守治疗,经抗生素治疗后炎症消退,复查睾丸正常,均取得满意疗效。结论睾丸... 详细信息

目的对儿童睾丸附件扭转的病因、诊断及治疗进行分析总结。方法对1993年～2002年收治的48例患儿的临床资料进行回顾性分析。结果36例行睾丸附件手术切除,12例行保守治疗,经抗生素治疗后炎症消退,复查睾丸正常,均取得满意疗效。结论睾丸附件不具备任何生理功能,早期手术治疗睾丸附件扭转有利于睾丸及附睾炎症吸收。对病程长、症状轻的病例,采取保守治疗也可取得满意效果。

关键词：儿童睾丸附件扭转手术治疗保守治疗病因

Effects of neonatal hypoxia-ischemia on dendrite development of CA1 pyramidal neurons in the rat and the protection of glucocorticoid

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Effects of neonatal hypoxia-ischemia on dendrite development...

Lung-targeted polyzwitterionic lipid nanoparticles for effective treatment of lung inflammation

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： yan-dong ZHAO,wen-Juan HE,Jin-Hai ZHANG,Huai-Zhen RUAN~* Department of Neurobiology,College of Basic Medical Science,Third Military Medical University,Chongqing 400038, China

Hypoxic-ischemic(HI) brain injury in the perinatal period can result from several pathological processes and is an important cause of neonatal mortality and subsequent *** combined effects of cellular energy failure, acidosis,glutamate release,intracellular Ca accumulation,lipid peroxidation,and nitric-oxide neurotoxicity lead to neuron *** is an important clinical therapeutic medicine for HI at present,but the therapeutic mechanism needs more *** HI brain injury rat models were obtained by unilateral occlusion of left carotid artery, followed by exposure to hypoxia(92%N,8%O) for 1.5 h at 7-day-old *** were divided into four groups:control group,hypoxia-ischemia group,hypoxia-ischemia given glucocorticoid and hypoxia-ischemia given GR antagonist-Ru38486 *** development of dendrite was evaluated at P10,P14,P21,P28 and P42 ***-Cox-impregnated tissue has been used to examine the effects of early life manipulations on neuronal morphology include quantification of the dendrite length and spine density of pyramidal neurons in the hippocampus CA1 region under different conditions and in different *** result manifested an age-related increase in total dendrite length of pyramidal *** with a naive control group,CA1 pyramidal neurons of HI models showed lesser bifurcations and length of dendrite than that of control *** of dendrite spines of hippocampus CA1 pyramidal neurons was significantly lower in HI than in control rats. It is interesting that in the HI group,the hippocampus just experiencing hypoxia(the right side) has more complex dendrite and higher density of spine than opposite side and *** results -total dendrite length and spine density- imply that the opposite side can partly supersede the function of injury *** glucocorticoid levels can not prevent the reduction of dendrite tree complexity,but it can promote the generation of dendritic spines from the 21st

关键词： hypoxic-ischemic brain Injury golgi-Cox glucocorticoid dendrite

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Science China Chemistry 2025年

作者： wen Zhang Jiaxin Li Nan Wang Muzi Li Chen Peng Xinyue Zhang Guanghui Ouyang yan Li Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological Engineering University of Science and Technology Beijing CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences

Lipid nanoparticles (LNPs) are non-viral nucleic acid delivery systems that show great potential in vaccine development and disease treatment. Although LNPs are particularly advantageous for in vivo delivery, the wide application of LNPs is impeded as their systemic delivery of nucleic acid drugs to extrahepatic tissues remains highly challenging. To address this issue, we developed lung-targeted polyzwitterionic LNPs with zwitterionic polymer poly(2-methyacryloyloxyethyl phosphorylcholine)(PMPC) modified 1,2-dimyristoyl-sn-glycerol lipid for the delivery of small interfering RNA (siRNA). Three libraries with 90PMPC-LNPs@siRNA were established. The polyzwitterionic PMPC-LNPs had high siRNA encapsulation efficiency of about90%. The findings revealed that polyzwitterionic PMPC-LNPs@siRNA absorbed protein corona with the main component of Vitronectin, mediating lung-targeted delivery of siRNA. With good cellular uptake and endo/lysosomal escape ability, in vitro and in vivo studies demonstrated that polyzwitterionic PMPC-LNPs with siRNA against tumor necrosis factor-α (TNF-α) could significantly down-regulate the TNF-α in mRNA and protein levels, and improved the pathological features of lung inflammation. Polyzwitterionic PMPC-LNPs@siRNA achieved safe and efficient treatment of lung inflammation. Therefore, this work offered a promising siRNA therapeutic approach for lung diseases.

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炎症因子与心房颤动关系的研究

内蒙古医学杂志 2015年第10期47卷 1175-1176页

作者：牧骑董彦文赤峰学院附属医院心内科内蒙古赤峰024000

目的探讨炎症因子与房颤的相互关系。方法选取心房颤动患者130例,其中永久性房颤35例,持续性房颤47例,阵发性房颤48例。窦性心律患者60例为对照组,测定血清白细胞介素IL-6、IL-8、肿瘤坏死因子TNF-α进行比较。结果房颤组IL-6、IL-8、T... 详细信息

目的探讨炎症因子与房颤的相互关系。方法选取心房颤动患者130例,其中永久性房颤35例,持续性房颤47例,阵发性房颤48例。窦性心律患者60例为对照组,测定血清白细胞介素IL-6、IL-8、肿瘤坏死因子TNF-α进行比较。结果房颤组IL-6、IL-8、TNF-α浓度均较对照组增高,在阵发性、持续性和永久性3种房颤亚型中,血清IL-6、IL-8、TNF-α浓度逐级增加。结论炎症与房颤的发生密切相关。

关键词：炎症因子房颤

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng Wang wen-Jie Shi Yu-Xin yang Bao-Xia dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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