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Assessment of internal quality of billets using ultrasonic three-dimensional layered characterization

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Journal of Iron and Steel Research International 2024年第11期31卷 2727-2739页

作者： yan-bo liu Min Li Zheng Zhao Zhong-xin Wang De-bin yang School of Mechanical Engineering University of Science and Technology BeijingBeijing100083China Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China

To address the challenge of visualizing internal defects within castings, ultrasonic nondestructive testing technology has been introduced for the detection and characterization of internal defects in castings. Ultrasonic testing is widely utilized for detecting and characterizing internal defects in materials, thanks to its strong penetration ability, wide testing area, and fast scanning speed. However, traditional ultrasonic testing primarily relies on one-dimensional waveforms or two-dimensional images to analyze internal defects in billets, which hinders intuitive characterization of defect quantity, size, spatial distribution, and other relevant information. Consequently, a three-dimensional (3D) layered characterization method of billets internal quality based on scanning acoustic microscope (SAM) is proposed. The method starts with a layered focus scanning of the billet using SAM and pre-processing the obtained sequence of ultrasonic images. Next, the ray casting is employed to reconstruct 3D shape of defects in billets, allowing for characterization of their quality by obtaining characteristic information on defect spatial distributions, quantity, and sizes. To validate the effectiveness of the proposed method, specimens of 42CrMo billets are prepared using five different processes, and the method is employed to evaluate their internal quality. Finally, a comparison between the ultrasonic image and the metallographic image reveals a difference in dimensional accuracy of only 2.94%. The results indicate that the new method enables visualization of internal defect information in billets, serving as a valuable complement to the traditional method of characterizing their internal quality.

关键词： Internal quality of billets Ultrasonic testing Scanning acoustic microscope Layered characterization Three-dimensional reconstruction

The Application of Deep Brain Stimulation for Parkinson’s Disease on the Motor Pathway:A Bibliometric Analysis across 10 Years

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Current Medical Science 2023年第6期43卷 1247-1257页

作者： Yong-tang SONG yan-bo liu Hong-bing XIANG Anne Manyande Zhi-gang HE Medical Association of Hubei Province Wuhan430060China Department of Anesthesiology Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain HealthWuhan Clinical Research Center for Geriatric AnesthesiaTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China School of Human and Social Sciences University of West LondonLondon0044UK Department of Emergency Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Background and Objective Since its initial report by James Parkinson in 1817,Parkinson’s disease(PD)has remained a central subject of research and clinical *** disease is estimated to affect approximately 1%of adults aged 60 and *** brain stimulation,emerging as an alternative therapy for end-stage cases,has offered a lifeline to numerous *** review aimed to analyze publications pertaining to the impact of deep brain stimulation on the motor pathway in patients with PD over the last *** Data were obtained from the Web of Science Core Collection through the library of Huazhong University of Science and Technology(China).The search strategy encompassed the following keywords:“deep brain stimulation”,“Parkinson’s disease”,“motor pathway”,and“human”,from January 1,2012,to December 1,***,this review visualized the findings using the Citespace *** The results indicated that the United States,the United Kingdom,Germany,and China were the primary contributors to this research *** College London,Capital Medical University,and Maastricht University were the top 3 research institutions in the research *** Foltynie ranked first with 6 publications,and the journals of Brain and Brain Stimulation published the greatest number of relevant *** prevailing research focal points in this domain,as determined by keywords“burst analysis”,“encompassed neuronal activity”,“nucleus”,“hyper direct pathway”,*** This study has provided a new perspective through bibliometric analysis of the deep brain stimulation therapy for treating patients with PD,which can shed light on future research to advance our comprehension of this particular field of study.

关键词： deep brain stimulation Parkinson’s disease motor pathway bibliometric analysis

Intermediate phase-assisted growth of CsPbBr_(3) for high performance of carbon-based perovskite solar cells

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Rare Metals 2024年第5期43卷 2222-2229页

作者： bo-yan liu He-Ming yang Yu-Dong Zuo Zhi-Hao Tao Jun-Chun Li Ya-Jing Chang Guo-Qing Tong yang Jiang School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Pulsed Power Laser Technology National University of Defense TechnologyHefei 230037China

CsPbBr_(3)inorganic perovskites have been regarded as the promising materials in the field of photo-voltaics because of the high tolerance against *** high energy barrier of phase transition from lead bromide(PbBr_(2))to CsPbBr_(3)perovskite and low solubility of perovskite in organic solvent impede the further improvement of device performance in terms of CsPbBr_(3)solar ***,an intermediate phase-assisted growth of CsPbBr_(3)perovskite was proposed by introducing tetraphenylphosphonium bromide(TPPB)as *** TPPB is expected to react with PbBr_(2)in organic solvent to form an intermediate phase of[***]-PbBr_(2),which not only effectively improves the crystallinity of PbBr2 crystals,but also greatly reduces the phase transition energy barrier,leading to uniform and compact CsPbBr_(3)perovskite films with large grain size and high *** combination with carbon electrode,the CsPbBr_(3)solar cells yield a champion device performance of 9.57%in comparison of pristine CsPbBr_(3)solar cells showing a low efficiency of 8.17%.Furthermore,the intermediate phaseassisted growth of CsPbBr_(3)-based solar cells displays an outstanding storage over720 h.

关键词： CsPbBr_(3) Perovskite solar cells Carbon electrode Hole transport layer free Intermediate phase

;~lasmid-based Survivin shRNA and GRIM-19 carried by attenuated Salmonella suppresses tumor cell growth

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Asian Journal of Andrology 2012年第4期14卷 536-545页

作者： yan-bo liu Ling Zhang Ya-Xiong Guo Li-Fang Gao Xi-Chun liu Li-Juan Zhao Bao-Feng Guo Li-Jing Zhao Xue-Jian Zhao De-Qi Xu Prostate Diseases Prevention and Treatment Research Centre and Department of Pathophysiology Norman Bethune Medical SchoolJilin UniversityChangchun 130021 China Department of Pathophysiology School of Bacic MedicineBeihua UniversityJilin132013China Urology center The First Hospital of Jilin University Changchun 130021China New Vaccine National Engineering Research Center Beijing 100176China

Persistent activation of Survivin and its overexpression contribute to the formation, progression and metastasis of several different tumor types. Therefore, Survivin is an ideal target for RNA interference mediated-growth inhibition. Blockade of Survivin using specific short hairpin RNAs （shRNA） can significantly reduce prostate tumor growth. RNA interference does not fully ablate target gene expression, owing to the idiosyncrasies associated with shRNAs and their targets. To enhance the therapeutic efficacy of Survivin-specific shRNA, we employed a combinatorial expression of Survivin-specific shRNA and gene associated with retinoid-interferon-induced mortality-19 （GRIM-19）. Then, the GRIM-19 coding sequences and Survivin-specific shRNAs were used to create a dual expression plasmid vector and were carried by an attenuated strain of Salmonella enteric serovar typhimurium （S. typhimurium） to treat prostate cancer in vitro and in vivo. We found that the co-expressed Survivin-specific shRNA and GRIM-19 synergistically and more effectively inhibited prostate tumor proliferation and survival, when compared with treatment with either single agent alone in vitroand in vivo. This study has provided a novel cancer gene therapeutic approach for prostate cancer.

关键词： GRIM-19 prostate cancer RNAi Salmonella enterica serovar typhimurium Survivin tumor cell growth

Papillary thyroid microcarcinoma presenting as skull base netastasis

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Chinese Medical Journal 2010年第19期123卷 2750-2752页

作者： yan bo liu Dian-gang LU Hai-li ZHANG Qiu-hang Department of Otolaryngology Head and Neck Surgery Department of General Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China

Papillary thyroid carcinoma （PTC） is the most common type of well-differentiated thyroid cancer and is considered to be a relatively indolent tumor in which distant metastasis and death are *** metastasis of PTC is ... 详细信息

关键词： thyroid carcinoma skull base metastasis

Rules of Ren Shunping's prescription for trearing Spleen Deficiency and Qi Stagnation Syndrome of Functional Dyspepsia Based on Data Mining

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Journal of Hainan Medical University 2020年第24期26卷 53-59页

作者： yan-bo liu Xin-Tong Wang Shun-Ping Ren Shanxi University of Traditional Chinese Medicine Taiyuan 030024 China Affiliated Hospital of Shanxi University of Traditional Chinese Medicine Taiyuan 030024 China

Objective:To explore the medication rules of Professor Ren Shunping treating spleen deficiency and qi stagnation syndrome of functional dyspepsia,so as to provide reference for clinical prevention and development of new ***:The 144 Chinese herbal formulas considered as active prescribed by professor Ren Shunping for the first time treating the patients with spleen deficiency and qi stagnation syndrome of functional dyspepsia were collected,entered into TCM inheritance auxiliary platform(V2.5),and then mined by some data mining methods of the software,such as the association rules and unsupervised entropy hierarchical ***:This study involved 144 Chinese herbal formulas,including a total of 56 Chinese herbal *** these Chinese herbal medicines,the herbs of cold and warm nature,and pungent,bitter and sweet in flavors were used in a quite high frequency,all of which act on spleen,stomach,lungs,large intestine,liver and gallbladder *** core Chinese herbal formula was excavated,composed of patchouli,perilla stem,radix bupleuri,scutellaria,ginger pinellia,codonopsispilosula,magnolia bark,tangerine peel,large-headed atractylodes,immature bitter orange,wood incense,fructus amomi,inula britannica chinensis,ginger,medicated leaven,fried rice and fried malt based on the association *** a total of 17 groups of core used drugs and 2 groups of new Chinese herbal formulas undiscovered were mined based on unsupervised entropy hierarchical ***:In treating spleen deficiency and qi stagnation syndrome of functional dyspepsia,professor Ren is good at treating spleen deficiency and qi stagnation syndrome of functional dyspepsia from the perspective of"tong jiang",using the"five-in-one"strategy of strengthening the spleen,evacuating the liver,coming down qi from the stomach,dispersing lung,and bowel-reflexing to treat patients as a *** the herbal medicines were light in dose,lovely and mild in nature for the formular

关键词： TCM inheritance support platfom Functional dyspepsia Spleen deficiency and qi stagnation syndrome Ren Shun-ping Rules of prescription

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需求扰动下风险规避型双渠道供应链的决策

系统工程 2016年第8期34卷 116-122页

作者：颜波刘艳萍华南理工大学经济与贸易学院广东广州510006

考虑一条风险规避型的"单制造商—单零售商"双渠道供应链,通过求解供应链系统分别在集权模式和分权模式下最大效用的Karush-Kuhn-Tucker(KKT)条件,得到其在需求扰动前后的最优定价策略和生产决策。研究表明,风险规避系数与最优价格成反... 详细信息

考虑一条风险规避型的"单制造商—单零售商"双渠道供应链,通过求解供应链系统分别在集权模式和分权模式下最大效用的Karush-Kuhn-Tucker(KKT)条件,得到其在需求扰动前后的最优定价策略和生产决策。研究表明,风险规避系数与最优价格成反比,与最优生产量成正比,与二者的值有关,与不同决策的分界点无关;需求扰动时供应链的决策只与扰动量有关,与风险规避系数无关;集权模式下供应链知道需求扰动的价值与风险规避系数正相关。

关键词：需求扰动风险规避双渠道供应链管理

GFRF R-CNN:Object Detection Algorithm for Transmission Lines

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Computers, Materials & Continua 2025年第1期82卷 1439-1458页

作者： Xunguang yan Wenrui Wang Fanglin Lu Hongyong Fan bo Wu Jianfeng Yu Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China University of Chinese Academy of Sciences Beijing100049China Jingwei Textile Machinery Co. Ltd.Beijing100176China

To maintain the reliability of power systems,routine inspections using drones equipped with advanced object detection algorithms are essential for preempting power-related *** increasing resolution of drone-captured images has posed a challenge for traditional target detection methods,especially in identifying small objects in high-resolution *** study presents an enhanced object detection algorithm based on the Faster Regionbased Convolutional Neural Network(Faster R-CNN)framework,specifically tailored for detecting small-scale electrical components like insulators,shock hammers,and screws in transmission *** algorithm features an improved backbone network for Faster R-CNN,which significantly boosts the feature extraction network’s ability to detect fine *** Region Proposal Network is optimized using a method of guided feature refinement(GFR),which achieves a balance between accuracy and *** incorporation of Generalized Intersection over Union(GIOU)and Region of Interest(ROI)Align further refines themodel’s *** results demonstrate a notable improvement in mean Average Precision,reaching 89.3%,an 11.1%increase compared to the standard Faster *** highlights the effectiveness of the proposed algorithm in identifying electrical components in high-resolution aerial images.

关键词： Faster R-CNN transmission line object detection GIOU GFR

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han bo yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K