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Centrifuge modeling of unreinforced and multi-row stabilizing piles reinforced landslides subjected to reservoir water level fluctuation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1600-1614页

作者： Chenyang Zhang Yueping Yin Hui yan Sainan zhu Ming Zhang Luqi Wang Department of Civil Engineering The University of Hong KongHong KongChina China Institute of Geo-environment Monitoring BeijingChina Chongqing 107 Municipal Construction Engineering Co. Ltd.ChongqingChina Faculty of Engineering China University of GeosciencesWuhanChina School of Civil Engineering Chongqing UniversityChongqingChina

With the construction of the Three Gorges Reservoir dam,frequent reservoir landslide events have been *** recent years,multi-row stabilizing piles(MRSPs)have been used to stabilize massive reservoir landslides in *** this study,two centrifuge model tests were carried out to study the unreinforced and MRSP-reinforced slopes subjected to reservoir water level(RWL)operation,using the Taping landslide as a *** results indicate that the RWL rising can provide lateral support within the submerged zone and then produce the inward seepage force,eventually strengthening the slope ***,a rapid RWL drawdown may induce outward seepage forces and a sudden debuttressing effect,consequently reducing the effective soil normal stress and triggering partial pre-failure within the RWL fluctuation ***,partial deformation and subsequent soil structure damage generate excess pore water pressures,ultimately leading to the overall failure of the reservoir *** study also reveals that a rapid increase in the downslope driving force due to RWL drawdown significantly intensifies the lateral earth pressures exerted on the ***,the MRSPs possess a considerable reinforcement effect on the reservoir landslide,transforming the overall failure into a partial deformation and failure situated above and in front of the *** mechanical transfer behavior observed in the MRSPs demonstrates a progressive alteration in relation to RWL *** the RWL rises,the mechanical states among MRSPs exhibit a growing *** shear force transfer factor(*** ratio of shear forces on pile of the n th row to that of the first row)increases significantly with the RWL *** indicates that the mechanical states among MRSPs tend toward an enhanced *** insights gained from this study contribute to a more comprehensive understanding of the failure mechanisms of reservoir landslides and the mechanical behavior of M

关键词： Reservoir landslide Failure mechanism Multi-row stabilizing piles Mechanical behavior

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Modeling and analysis of gradient metamaterials for broad fusion bandgaps

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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1155-1170页

作者： Changqi CAI Chenjie zhu Fengyi ZHANG Jiaojiao SUN Kai WANG Bo yan Jiaxi ZHOU School of Mechanical Engineering Zhejiang Sci-Tech UniversityHangzhou310018China School of Material and Environmental Engineering Hangzhou Dianzi UniversityHangzhou310018China College of Mechanical and Vehicle Engineering Hunan UniversityChangsha410082China

A gradient metamaterial with varying-stiffness local resonators is proposed to open the multiple bandgaps and further form a broad fusion ***,three local resonators with linearly increasing stiffness are periodically attached to the spring-mass chain to construct the gradient *** dispersion relation is then derived based on Bloch's theorem to reveal the fusion bandgap *** dynamic characteristic of the finite spring-mass chain is investigated to validate the fusion of multiple ***,the effects of the design parameters on multiple bandgaps are *** results show that the metamaterial with a non-uniform stiffness gradient pattern is capable of opening a broad fusion bandgap and effectively attenuating the longitudinal waves within a broad frequency region.

关键词： local resonance mechanism elastic metamaterial stiffness gradient bandgap fusion broadband wave attenuation

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Alanine aminotransferase as a risk marker for new-onset metabolic dysfunction-associated fatty liver disease

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World Journal of Gastroenterology 2024年第25期30卷 3132-3139页

作者： Di Wang bing-yan Zhou Lei Xiang Xu-Yong Chen Jie-Xiong Feng Department of Pediatric Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

In this editorial,we comment on the article by Chen et *** dysfunction-associated fatty liver disease(MAFLD)is a global public health burden whose incidence has risen concurrently with overweight and *** its detri-mental health impact,early identification of at-risk individuals is *** diagnosis is based on evidence of hepatic steatosis indicated by liver biopsy,imaging,or blood biomarkers,and one of the following conditions:Overweight/obesity,type 2 diabetes mellitus,or metabolic ***,in large-scale epidemiological studies,liver biopsies are not *** application of techniques such as ultrasonography,computed tomography,magnetic resonance imaging,and magnetic resonance spectroscopy is restricted by their limited sensitivity,low effectiveness,high costs,and need for specialized *** biomarkers offer several advantages,particularly in large-scale epidemiological studies or clinical scenarios where traditional imaging techniques are *** of cumulative effects of excess high-normal blood alanine aminotrans-ferase(ALT)levels of blood ALT levels could facilitate identification of at-risk patients who might not be detected through conventional imaging ***,investigating the utility of blood biomarkers in MAFLD should enhance early detection and monitoring,enabling timely inter-vention and management and improving patient outcomes.

关键词： Nonalcoholic fatty liver disease Metabolic dysfunction-associated fatty liver disease Alanine aminotransferase Screening Risk marker

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A cognitive spectrum allocation scheme for data transmission in smart distribution grids

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High-Confidence Computing 2024年第3期4卷 32-40页

作者： Zhongguo Zhou You Li Ziming zhu Qinghe Gao Sisi Xiao Tao yan yan Huo AoStar Information Technologies CO. LTD.Chengdu 610094China School of Electronics and Information EngineeringBeijing Jiaotong UniversityBeijing 100044China

As the communication needs in the smart distribution grid continue to rise,using existing resources to meet this growing demand poses a significant *** paper researches on spectrum allocation strategies utilizing cognitive radio(CR)*** consider a model containing strong time-sensitive and regular communication service requirements such as distribution terminal communication services,which can be seen as a user with primary data(PD)and weak time-sensitive services such as power quality monitoring,which can be seen as a user with secondary data(SD).To fit the diversity of services in smart distribution grids(SDGs),we formulate an optimization problem with two indicators,including the sum of SD transmission rates and the maximum latency of ***,we analyze the two convex sub-problems and utilize convex optimization methods to obtain the optimal power and frequency bandwidth allocation for the users with *** simulation results indicate that,when the available transmission power of SD is low,Maximization of Transmission Sum Rate(MTSR)achieves lower maximum transmit ***,when the available transmission power is high,the performance of Minimization of the Maximum Latency(MML)is better,compared with MTSR.

关键词： Cognitive radio technologies Smart distribution grids Spectrum allocation Convex optimization

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Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： yan Sun Xiu-Na yang Shuang-Shuang yang Yi-zhu Lyu bing Zhang Kai-Wen Liu Na Li Jia-Chen Cui Guang-Xiang Huang Cheng-Lin Liu Jie Xu Jian-Qing Mi zhu Chen Xiao-Hu Fan Sai-Juan Chen Shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China National Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular ***,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based *** co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple *** we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated *** analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in ***-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived *** results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

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Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway

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Science China(Life Sciences) 2024年第4期67卷 663-679页

作者： yanfang Liu yan Wang bing Liu Wenzhong Liu Yuanyuan Ma Yiren Cao Shi yan Panpan Zhang Lixin Zhou Qimin Zhan Nan Wu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Surgery IIPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Oncology IIPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of PathologyPeking University Cancer Hospital and InstituteBeijing 100142China Peking University International Cancer Institute Beijing 100191China Institute of Cancer Research Shenzhen Bay LaboratoryShenzhen 518132China

Chemoresistance is a significant barrier to effective cancer *** mechanisms for chemoresistance include reactive oxygen species(ROS)accumulation and expression of chemoresistance-promoting ***,we report a novel function of lncRNA16 in the inhibition of ROS generation and the progression of *** analyzing the serum levels of lncRNA16 in a cohort of 35 patients with non-small cell lung cancer(NSCLC)and paired serum samples pre-and post-treatment from 10 NSCLC patients receiving neoadjuvant platinum-based chemotherapy,performing immunohistochemistry(IHC)assays on 188 NSCLC tumor samples,using comprehensive identification of RNA-binding proteins by mass spectrometry(ChIRP-MS)assays,as well as RNA immunoprecipitation(RIP)and RNA pull-down analyses,we discovered that patients with increased serum levels of lncRNA16 exhibited a poor response to platinum-based *** expression of hemoglobin subunit beta(HBB)and NDUFAF5 significantly increases with the development of ***16 binds to HBB and promotes HBB accumulation by inhibiting ***16 can also inhibit ROS generation via the HBB/NDUFAF5 axis and function as a scaffold to facilitate the colocalization of HBB and NDUFAF5 in the ***,preclinical studies in mouse models of chemo-resistant NSCLC have suggested that lncRNA16 targeting by trivalent N-acetylgalactosamine(GalNAc)-conjugated siRNA restores chemosensitivity and results in tumor growth inhibition with no detectable toxicity in ***,lncRNA16 is a promising therapeutic target for overcoming chemoresistance,and the combination of first-line platinum-based chemotherapy with lncRNA16 intervention can substantially enhance anti-tumor efficacy.

关键词： chemoresistance lncRNARNA interference ROs chemosensitizer

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Reconfigurable memlogic long wave infrared sensing with superconductors

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Light(Science & Applications) 2024年第5期13卷 908-920页

作者： bingxin Chen Huanyi Xue Hong Pan Liping zhu Xiaomi yan Jingzhe Wang yanru Song Zhenghua An State Key Laboratory of Surface Physics and Institute for Nanoelectronic Devices and Quantum Computing Department of PhysicsFudan UniversityShanghai 200438China. ShanghaiTech Quantum Device Lab ShanghaiTech UniversityShanghai 201210China. Shanghai Qi Zhi Institute 41th FloorAI TowerNo.701 Yunjin RoadXuhui DistrictShanghai 200232China. Yiwu Research Institute of Fudan University Chengbei RoadYiwu City 322000 ZhejiangChina. Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China

Optical sensors with in-cell logic and memory capabilities offer new horizons in realizing machine vision beyond von Neumann architectures and have been attempted with two-dimensional materials,memristive oxides,phasechanging materials *** the unparalleled performance of superconductors with both quantum-limited optical sensitivities and ultra-wide spectrum coverage,here we report a superconducting memlogic long-wave infrared sensor based on the bistability in hysteretic superconductor-normal phase *** cooperatively by electrical and optical pulses,the device offers deterministic in-sensor switching between resistive and superconducting(hence dissipationless)states with persistence>105 *** results in a resilient reconfigurable memlogic system applicable for,e.g.,encrypted ***,a high infrared sensitivity at 12.2μm is achieved through its in-situ metamaterial perfect absorber *** work opens the avenue to realize all-in-one superconducting memlogic sensors,surpassing biological retina capabilities in both sensitivity and wavelength,and presents a groundbreaking opportunity to integrate visional perception capabilities into superconductor-based intelligent quantum machines.

关键词： wave superconductor quantum

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Detwinning and Anneal-Hardening Behaviors of Pre-Twinned AZ31 Alloys under Cryogenic Loading

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1551-1563页

作者： Lingyu Zhao Wei zhu Chao Zhang Yunchang Xin Changjian yan Yao Cheng Zhaoyang Jin School of Mechanical Engineering Yangzhou UniversityYangzhou225127China Key Laboratory for Light-Weight Materials Nanjing Tech UniversityNanjing210009China Institute of Corrosion Science and Technology Guangzhou510070GuangdongChina Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing Institute of TechnologyNanjing211167China

Detwinning behavior of a pre-twinned magnesium alloy AZ31 at cryogenic temperature was investigated,also with a focus on the annealing hardening behavior of samples with different fractions of ***-compression along the transverse direction with strains of 1.7%,3.0%,and 6.0% was applied to generated[1012]*** behavior,microstructure,and texture evolution during subsequent tension were *** results show that low temperature did not change the fact that detwinning still pre-dominated in the pre-twinned samples under reverse ***,a relatively harder migration of twin boundaries was found at cryogenic *** annealing hardening of 27-40 MPa was observed in the pre-twinned samples,and such a hardening effect shows a close relation with the fraction of pre-twins or the level of *** annealing hardening effect disappeared if the matrix was consumed by twins along with the increased pre-compression *** corresponding reasons for the annealing hardening behavior were discussed.

关键词： Mg alloys Detwinning Annealing hardening Cryogenic temperature Mechanical property

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Atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction

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Nuclear Science and Techniques 2024年第3期35卷 40-52页

作者： Ding-Han zhu Xiong Zhang Xiao-Qiang Li Peng Li yan-Bin Wang Shuang Zhang State Key Laboratory of NBC Protection for Civilian Beijing 102205China

In high-altitude nuclear detonations,the proportion of pulsed X-ray energy can exceed 70%,making it a specific monitoring signal for such *** pulsed X-rays can be captured using a satellite-borne X-ray detector following atmospheric *** quantitatively analyze the effects of different satellite detection altitudes,burst heights,and transmission angles on the physical processes of X-ray transport and energy fluence,we developed an atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering *** proposed method is an improvement over the traditional analytical method that only computes direct-transmission *** traditional analytical method exhibits a maximum relative error of 67.79% compared with the Monte Carlo *** improved method reduces this error to within 10% under the same conditions,even reaching 1% in certain ***,its computation time is 48,000 times faster than that of the Monte Carlo *** results have important theoretical significance and engineering application value for designing satellite-borne nuclear detonation pulsed X-ray detectors,inverting nuclear detonation source terms,and assessing ionospheric effects.

关键词： High-altitude nuclear detonation Atmospheric transmission Pulsed X-rays Scattering correction Analytical method Monte Carlo method

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Effect of Phase Separation Size on the Properties of Self-healing Elastomer

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Chinese Journal of Polymer Science 2024年第6期42卷 798-804页

作者： Jun Xu Lei zhu Xian-Qi Feng Cong Sui Wen-Peng Zhao Shou-Ke yan School of Chemical Engineering Qingdao University of Science&TechnologyQingdao266042China College of Engineering Yanching institute of TechnologyLangfang065210China Key Laboratory of Rubber-plastics Qingdao University of Science&TechnologyQingdao266042China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China

Regulation of phase structure has been recognized as one of the most effective ways to fabricate self-healing polymers with high mechanical *** mechanical properties of the resultant polymers are certainly affected by the size of separated phase ***,the study on this aspect is absence,because it can hardly exclude the influence of variation in monomer proportion required for tuning the separated phase ***,we report the first study on tuning the phase size through reversible addition-fragmentation chain transfer(RAFT)polymerization without changing the proportion of *** expected,the size of separated phase has been successfully mediated from 15 nm to 9 nm by tuning the molecular weight of the chain transfer *** is found that the mechanical strength and the self-healing efficiency of the resultant polymers increase simultaneously with the decrease of phase *** study on the formation kinetics of hydrogen bonds reveals that the decrease of phase size can facilitate the re-bonding rate of hydrogen bonds,even if the migration of polymer chains is restricted.

关键词： Self-healing polymers Phase separation Reversible addition-fragmentation chain transfer

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