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Deep electrical structures of Qinzhou-Fangcheng Junction Zone in Guangxi and seismogenic environment of the 1936 Lingshan M6^(3/4)earthquake

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Science China Earth Sciences 2024年第2期67卷 584-603页

作者： Bin ZHOU Chunheng yan yan zhan.xiangyu sun Sha LI Xiang WEN Yajun MO Yongdong YUAN Yuan YUAN Meili HUANG Earthquake Agency of Guangxi Zhuang Autonomous Region Nanning530022China State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing100029China Guangxi Geophysical Survey Institute Liuzhou545005China

The tectonic position of the southwest section of the Qinzhou Bay-Hangzhou Bay Tectonic Junction Zone(QHTJZ)can be determined by examining the Qinzhou-Fangcheng Junction Zone(QFJZ)in *** zone is significant because it was the location of the largest earthquake ever recorded in the inland region of South China,specifically the 1936 Lingshan M6^(3/4)earthquake in ***,this region serves as an optimal location for researching the origins of intraplate earthquakes in South *** study presents a display of a broadband magnetotelluric(MT)prospecting profile that traverses the Guangxi QFJZ and the Lingshan earthquake zone,extending from the northwest(NW)to the southeast(SE).A resistivity structure model was generated using three-dimensional(3D)inversion technology along the *** main faults in QFJZ were analyzed in terms of their deep extension forms and tectonic *** analysis was performed by integrating the results obtained from geology,gravity,wave velocity ratio,Global Position System(GPS),and geothermal *** results showed that(1)the Dongzhong-Xiaodong fault(DXf),the eastern Fangcheng-Lingshan fault(FLf2),and the eastern Hepu-Beiliu fault(HBf2)were all trans-crustal deep faults,and crust-mantle ductile shear zones developed in the deep *** electrical boundary zones,DXf and HBf2,were *** inclined towards the northwest,while HBf2 inclined towards the *** FangchengLingshan fault(FLf)exhibits a tectonic style resembling a“flower”shape in the upper *** the deeper section,it is characterized by an electrical boundary zone that gradually slopes towards the southeast direction.(2)The Hunan-Guangxi Passive Continental Margin(HGPCM)on the NW side of DXf had a stratified resistivity structure and relatively stable Bouguer gravity anomalies,which conformed to the quasi-craton tectonic attribute of the local failure at the southeastern margin of the yangtze Block(YB).The southeastern side of this bloc

关键词： South China Block Qinzhou-Fangcheng Junction Zone Magnetotelluric 1936 Lingshan M6^(3/4)earthquake Deep seismogenic environment

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Engineering Cu_(2)O/Cu/N-C interface to induce directional migration of charge for driving photocatalytic homo-coupling of terminal alkynes

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Nano Research 2024年第8期17卷 6895-6902页

作者： Xiaoqin yan Tianyi Xu Wenwen zhan yang yang yang Yu Jianjian Yi Xiaoxiao He Lei yang Jianwei Zhao Liming sun Xiguang Han Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Department of ChemistrySchool of Chemistry&Materials ScienceJiangsu Normal UniversityXuzhou 221116China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China College of Environmental Science and Engineering Yangzhou UniversityYangzhou 225009China Shenzhen HUASUAN Technology Co. LtdShenzhen 518055China

The efficient utilization of visible light catalysts for organic reactions necessitates not only the effective separation of photogenerated electrons and holes to participate in the reaction,but also their ability to form key intermediates with reactant *** present study successfully synthesized a crusiform-like mesoporous structure of nitrogen-doped carbon-coated Cu_(2)O/Cu(Cu_(2)O/Cu/N-C)with a Cu_(2)O/dual electron acceptor interface using etched HKUST-1 as the precursor.A series of theoretical and experimental studies have demonstrated that the Cu_(2)O/Cu/N-C interface in the photocatalytic homo-coupling of terminal alkynes not only effectively enhances the separation of photogenerated electron−hole pairs,but also facilitates the formation of the key intermediate[Cu_(2)O/Cu/N-C]-phenylacetylide and promotes the rearrangement of its internal *** a result,the homo-coupling reaction can be effectively *** primary reason for the functional role of Cu_(2)O/Cu/N-C interface lies in the downward bending of energy band from Cu_(2)O to N-doped C layers,induced by the different work functions of Cu_(2)O,Cu and N-doped C ***,Cu_(2)O/Cu/N-C photocatalysts demonstrate exceptional photocatalytic activity in the homo-coupling reaction of terminal alkynes under blue-light irradiation and air *** present study presents a novel research methodology for the development of highly efficient visible light catalysts to facilitate organic reactions in future applications.

关键词： photocatalysis homo-coupling of terminal alkynes directional migration of charges heterojunction interface Cu_(2)O carbon coated

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Inactivated H9N2 vaccines developed with early strains do not protect against recent H9N2 viruses:Call for a change in H9N2 control policy

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Journal of Integrative Agriculture 2024年第6期23卷 2144-2148页

作者： yanjing Liu Qingqing Yu xiangyu Zhou Wenxin Li Xinwen He yan Wang Guohua Deng Jianzhong Shi Guobin Tian Xianying Zeng Hualan Chen College of Veterinary Medicine Gansu Agricultural UniversityLanzhou 730070China State Key Laboratory for Animal Disease Control and Prevention Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry DiseasesMinistry of Agriculture and Rural Affairs/Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China National Poultry Laboratory Animal Resource Center Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China Harbin Weike Biotechnology Co. Ltd.Harbin 150009China

H9N2 virus has been widely distributed in wild birds and poultry around the world since its first emergence in the United States of America in 1966(Gu et al.2017;Carnaccini and Perez 2020).The virus appeared in chickens in China in the early 1990s,and over the last two decades has gradually become the dominant epidemic subtype(sun and Liu 2015;Bi et al.2020).Although H9N2 virus infection alone cannot cause severe disease or death in poultry,H9N2 virus-infected birds experience a degree of egg production drop and can be easily infected by other pathogens,thus causing economic losses for poultry industry.

关键词： H9N2 poultry policy

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Immune-tumor interaction dictates spatially directed evolution of esophageal squamous cell carcinoma

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National Science Review 2024年第5期11卷 170-185页

作者： Yong Zhou Shanlan Mo Heyang Cui Ruifang sun Weimin zhang Xiaofei Zhuang Enwei Xu Hongyi Li Yikun Cheng Yongsheng Meng Meilin Liu Ting yan Huijuan Liu Ling zhang Bin yang yanfeng Xi Shubin Wang Xiaolong Cheng Shuai Cheng Li Zhihua Liu Qimin zhan Zheng Hu Yongping Cui Cancer Institute Department of Pathology Peking University Shenzhen Hospital Shenzhen Peking University-the Hong Kong University of Science and Technology(PKU-HKUST) Medical Center Institute of Cancer ResearchShenzhen Bay Laboratory Key Laboratory of Cellular Physiology of the Ministry of Education Department of Pathology Shanxi Medical University City University of Hong Kong Shenzhen Research Institute CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of Sciences Department of Surgery Faculty of Medicine The Chinese University of Hong Kong Department of Tumor Biobank Shanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesCancer Hospital Affiliated to Shanxi Medical University Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular Oncology Peking University Cancer Hospital & Institute Research Unit of Molecular Cancer Research Chinese Academy of Medical Sciences Department of Thoracic Surgery Shanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesCancer Hospital Affiliated to Shanxi Medical University Department of Pathology Shanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesCancer Hospital Affiliated to Shanxi Medical University College of Letters & Science University of California Berkeley State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Esophageal squamous cell carcinoma（ESCC） is a poor-prognostic cancer type with extensive intra-and inter-patient heterogeneity in both genomic variations and tumor microenvironment（TME）. However, the patterns and drivers of spatial genomic and microenvironmental heterogeneity of ESCC remain largely unknown. Here, we generated a spatial multi-omic atlas by whole-exome, transcriptome, and methylome sequencing of 507 tumor samples from 103 patients. We identified a novel tumor suppressor PREX2,accounting for 22% of ESCCs with frequent somatic mutations or hyper-methylation, which promoted migration and invasion of ESCC cells in vitro. Analysis of the TME and quantification of subclonal expansion indicated that ESCCs undergo spatially directed evolution, where subclones mostly originated from the tumor center but had a biased clonal expansion to the upper direction of the ***, we found upper regions of ESCCs often underwent stronger immunoediting with increased selective fitness, suggesting more stringent immune selection. In addition, distinct TMEs were associated with variable genomic and clinical outcomes. Among them, hot TME was associated with high immune evasion and subclonal heterogeneity. We also found that immunoediting, instead of CD8+T cell abundance, acts as an independent prognostic factor of ESCCs. Importantly, we found significant heterogeneity in previously considered potential therapeutic targets, as well as BRCAness characteristics in a subset of patients, emphasizing the importance of focusing on heterogeneity in ESCC targeted ***, these findings provide novel insights into the mechanisms of the spatial evolution of ESCC and inform precision therapeutic strategies.

关键词： squamous cell carcinoma heterogeneity multi-omics evolution tumor microenvironment

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MOSS:An Open Conversational Large Language Model

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Machine Intelligence Research 2024年第5期21卷 888-905页

作者： Tianxiang sun Xiaotian zhang Zhengfu He Peng Li Qinyuan Cheng Xiangyang Liu Hang yan Yunfan Shao Qiong Tang Shiduo zhang Xingjian Zhao Ke Chen Yining Zheng Zhejian Zhou Ruixiao Li Jun zhan Yunhua Zhou Linyang Li Xiaogui yang Lingling Wu zhangyue Yin Xuanjing Huang Yu-Gang Jiang Xipeng Qiu Fudan University Shanghai200438China

Conversational large language models(LLMs)such as ChatGPT and GPT-4 have recently exhibited remarkable capabilities across various domains,capturing widespread attention from the *** facilitate this line of research,in this paper,we report the development of MOSS,an open-sourced conversational LLM that contains 16 B parameters and can perform a variety of instructions in multi-turn interactions with *** base model of MOSS is pre-trained on large-scale unlabeled English,Chinese,and code *** optimize the model for dialogue,we generate 1.1 M synthetic conversations based on user prompts collected through our earlier versions of the model *** then perform preference-aware training on preference data annotated from AI *** results on real-world use cases and academic benchmarks demonstrate the effectiveness of the proposed *** addition,we present an effective practice to augment MOSS with several external *** the development of MOSS,we have established a complete technical roadmap for large language models from pre-training,supervised fine-tuning to alignment,verifying the feasibility of chatGPT under resource-limited conditions and providing a reference for both the academic and industrial *** weights and code are publicly available at https://***/OpenMOSS/MOSS.

关键词： Large language models natural language processing pre-training alignment chatGPT MOSS

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Upper crustal velocity and seismogenic environment of the M7.0 Jiuzhaigou earthquake region in Sichuan, China

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Earth and Planetary Physics 2021年第4期5卷 348-361页

作者： DaHu Li ZhiFeng Ding yan zhan PingPing Wu LiJun Chang xiangyu sun Chengdu Institute of the Tibetan Plateau Earthquake Research China Earthquake AdministrationChengdu 610041China Institute of Geophysics China Earthquake AdministrationBeijing 100081China Institute of Geology China Earthquake AdministrationBeijing 100029China

On August 8,2017,a magnitude 7.0 earthquake occurred in Jiuzhaigou County,Sichuan Province,*** deep seismogenic environment and potential seismic risk in the eastern margin of Tibetan Plateau have once again attracted the close attention of seismologists and scholars at home and *** post-earthquake scientific investigation could not identify noticeable surface rupture zones in the affected area;the complex tectonic background and the reason(s)for the frequent seismicity in the Jiuzhaigou earthquake region are *** order to reveal the characteristics of the deep medium and the seismogenic environment of the M7.0 Jiuzhaigou earthquake region,and to interpret the tectonic background and genesis of the seismicity comprehensively,in this paper,we have reviewed all available observation data recorded by the regional digital seismic networks and large-scale,dense mobile seismic array(China Array)for the northern section of the North-South Seismic Belt around Jiuzhaigou earthquake *** double-difference seismic tomography method to invert the three-dimensional P-wave velocity structure characteristics of the upper crust around the Jiuzhaigou earthquake region,we have analyzed and discussed such scientific questions as the relationship between the velocity structure characteristics and seismicity in the Jiuzhaigou earthquake region,its deep tectonic environment,and the ongoing seismic risk in this *** report that:the P-wave velocity structure of the upper crust around the Jiuzhaigoug earthquake region exhibits obvious lateral inhomogeneity;the distribution characteristics of the shallow P-wave velocity structure are closely related to surface geological structure and formation lithology;the M7.0 Jiuzhaigou earthquake sequence is closely related to the velocity structure of the upper crust;the mainshock of the M7.0 earthquake occurred in the upper crust;the inhomogeneous variation of the velocity structure of the Jiuzhaigou earthquake area and

关键词： the M7.0 Jiuzhaigou earthquake 3D P-wave velocity structure deep tectonic seismogenic environment

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Characteristics of the three-dimensional deep electrical structure in the Helan Mountains-Yinchuan Basin and its geodynamic implications

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Science China Earth Sciences 2023年第3期66卷 505-520页

作者： Lingqiang ZHAO xiangyu sun yan zhan Jing HAN Haibo yanG Peijie WANG Xuehua LIU State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China Lhasa National Geophysical Observation and Research Station Lhasa 850004China The Second Monitoring and Application Center China Earthquake AdministrationXi’an 710043China

Located in the north segment of the North-South seismic belt where the Alxa block(AB)and the Ordos block(OB)contact,the Helan Mountains-Yinchuan Basin(HLM-YCB)constitutes a typical normal faulting basin-mountain structure on the Chinese *** 1739 M8.0 Pingluo earthquake occurred in the Yinchuan fault depression basin with such a basinmountain *** on five magnetotelluric profiles encompassing distinct segments of the HLM-YCB were utilized for three-dimensional(3D)joint inversion in order to collect fine 3D electrical structure information at a crustal and upper mantle scale across the entire *** electrical structure between the main blocks in the HLM-YCB and adjacent areas is characterized by east-west horizontal blocks OB,YCB,and HLM,which are divided by the Yellow River fault(F5)with the HLM eastern piedmont fault(F2)as electrical boundary zones on the east and west *** two main block units,AB and OB,exhibit an obvious layered resistivity ***,the HLM-YCB is characterized by a typical basin-mountain structure with the mountains as a high-resistivity body and the basin as a low-resistivity body,and in the northern YCB a large-scale lowresistivity structure exists,extending to the upper mantle,probably derived from the upwelling of mantle-derived *** is speculated from a combination of recent 3D crustal movement field information and other data that the HLM-YCB is an active tectonic zone formed via regional tensile *** formation of the HLM-YCB lies in the interaction of the Tibetan Plateau(TP),AB,and OB and abnormal mantle activities beneath the *** HLM-YCB reflects the joint action of upwelling and diffluence caused by the underplating of hot materials from the deep mantle with gravity and the redistribution of regional tectonic stress on the earth’s surface,which may be the main dynamic reason for the 1739 M8.0 Pingluo earthquake.

关键词： Helan Mountains Yinchuan Basin Magnetotelluric 3D electrical structure The 1739 Pingluo earthquake

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医患共同决策过程中医生行为潜在类别及其影响因素研究

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中华医院管理杂志 2024年第4期40卷 269-275页

作者：孙可马燕郝金娟许华钊罗翔予北京医院院办公室、国家老年医学中心、中国医学科学院老年医学研究院北京100730

目的探索医患共同决策过程中医生行为的潜在类别,并分析其影响因素。方法使用便利抽样法,于2023年8—9月选取北京市东城区4所三级甲等医院的临床医生作为研究对象,使用一般资料调查表、共同决策问卷医生版、医患关系量表、杰弗逊共情量... 详细信息

目的探索医患共同决策过程中医生行为的潜在类别,并分析其影响因素。方法使用便利抽样法,于2023年8—9月选取北京市东城区4所三级甲等医院的临床医生作为研究对象,使用一般资料调查表、共同决策问卷医生版、医患关系量表、杰弗逊共情量表、医师信任患者量表进行调查。根据共同决策问卷医生版各条目进行潜在剖面分析,采用有序logistic回归分析探索临床医生共同决策行为潜在类别的影响因素。结果共纳入480名临床医生。潜在剖面分析结果显示,临床医生共同决策行为可分为3个潜在类别,分别为共同决策缺失组(17.3%,83人)、共同权衡不足组(52.5%,252人)、共同决策充分组(30.2%,145人)。有序多分类logistic回归分析结果显示,职业发展机会(OR=0.509,P=0.038)、工作年限(OR=1.103,P=0.019)、共情能力(OR=1.096,P<0.001)与医患信任(OR=1.053,P<0.001)是临床医生共同决策行为的独立影响因素。结论医患共同决策过程中医生行为存在群体异质性,工作年限长、职业发展机会充足、共情能力高、医患信任程度高是其促进因素。未来可以此为靶点,从医院管理者与临床医生两个角度,规划改善提升方案。

关键词：医师共同决策潜在剖面分析影响因素分析横断面研究

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基于低碳需求响应的含煤制氢与碳捕集电厂的综合能源系统优化调度

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电力自动化设备 2024年第4期44卷 25-32页

作者：杨周义邢海军江伟建王华昕孙怡文颜湛上海电力大学电气工程学院上海200090 国网浙江省电力有限公司嘉兴供电公司浙江嘉兴314000

为了提高综合能源系统的低碳性与经济性,提出了煤制氢与碳捕集电厂联合运行模式下考虑低碳需求响应机制的综合能源系统优化调度。对煤制氢与富氧燃烧类型碳捕集电厂进行建模,并引入储碳罐、电转气装置以提高捕碳灵活性,降低制氧、制氢成... 详细信息

为了提高综合能源系统的低碳性与经济性,提出了煤制氢与碳捕集电厂联合运行模式下考虑低碳需求响应机制的综合能源系统优化调度。对煤制氢与富氧燃烧类型碳捕集电厂进行建模,并引入储碳罐、电转气装置以提高捕碳灵活性,降低制氧、制氢成本;将低碳需求响应机制引入综合能源系统调度模型中,并分析其减排能力;以运行成本最小为目标函数建立了综合能源系统的低碳经济调度模型。通过算例对所提策略进行验证,结果表明该策略能够提高风电消纳水平,降低整体系统的碳排放量,提升系统经济性。

关键词：煤制氢碳捕集电厂低碳制氢低碳需求响应综合能源系统低碳经济调度

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The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype,promoting a favorable response to anti-PD-1 therapy via NLRP3 activation

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Cellular & Molecular Immunology 2024年第1期21卷 60-79页

作者： Fan Luo Han Li Wenjuan Ma Jiaxin Cao Qun Chen Feiteng Lu Miaozhen Qiu Penghui Zhou Zengfei Xia Kangmei Zeng Jianhua zhan Ting Zhou Qiuyun Luo Wentao Pan Lin zhang Chaozhuo Lin yan Huang Li zhang Dajun yang Hongyun Zhao State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Ascentage Pharma(Suzhou)Co Ltd 218 Xinghu StreetSuzhouJiangsu ProvinceChina

The main challenges in the use of immune checkpoint inhibitors(ICIs)are ascribed to the immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated CD8+T *** the tumor microenvironment(TME)from“cold”to“hot”and thus more likely to potentiate the effects of ICIs is a promising strategy for cancer *** found that the selective BCL-2 inhibitor APG-2575 can enhance the antitumor efficacy of anti-PD-1 therapy in syngeneic and humanized CD34+mouse *** single-cell RNA sequencing,we found that APG-2575 polarized M2-like immunosuppressive macrophages toward the M1-like immunostimulatory phenotype with increased CCL5 and CXCL10 secretion,restoring T-cell function and promoting a favorable immunotherapy ***,we demonstrated that APG-2575 directly binds to NF-κB p65 to activate NLRP3 signaling,thereby mediating macrophage repolarization and the activation of proinflammatory caspases and subsequently increasing CCL5 and CXCL10 chemokine *** a result,APG-2575-induced macrophage repolarization could remodel the tumor immune microenvironment,thus improving tumor immunosuppression and further enhancing antitumor T-cell *** immunohistochemistry confirmed that patients with better immunotherapeutic efficacy had higher CD86,p-NF-κB p65 and NLRP3 levels,accompanied by lower CD206 expression on ***,these data provide evidence that further study on APG-2575 in combination with immunotherapy for tumor treatment is required.

关键词： BCL-2 APG-2575 ICIs Macrophages NLRP3

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