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Frontiers of Materials Science 2019年第4期13卷 375-381页

作者： Wei sun Rui ZHAO Tian WANG Ke zhan Zheng yanG Bin ZHAO Ya yan School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Innovation Institute for Materials Shanghai 200444China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The homogenous dispersion of graphene in Al powders is a key challenge that limits the development of graphene-reinforced metal matrix composites with high ***,uniform distribution of graphene oxide(GO)coated on flake Al powders were obtained by a simply stirring and ultrasonic treatment in the water/alcohol *** effect of water volume content on the formation of GO/Al composite powders was *** results showed that GO adsorbed with synchronous reduction on the surface of Al powders,but when the water content was higher than 80%in the solution,Al powders were totally changed into Al(OH)*** optimizing the water content of 60%in the solution,reduced GO was homogenously coated onto the surface of flake Al *** formation mechanism can be ascribed to the balance control between the liquid/solid interaction and the hydrolysis reaction.

关键词： graphene Al powder composite morphology electrostatic interaction

补肾中药复方对高盐摄入去卵巢大鼠骨代谢及ENaCα、NCC和ClC-3表达的影响

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中国病理生理杂志 2024年第1期40卷 141-147页

作者：崔琰孙珂焕詹小瑶莫枢肖雅雯王攀攀杨丽张荣华朱晓峰暨南大学附属第一医院广东广州510632 暨南大学中医学院广东广州510632 深圳市第二人民医院广东深圳518025 深圳市中医院广东深圳518000 暨南大学药学院广东广州510632

目的:探讨补肾中药复方(Bushen formulae,BHF)对高盐摄入去卵巢大鼠骨代谢的影响及其可能的作用机制。方法:80只SPF级SD雌性大鼠按随机数字表法分为假手术组、模型组、中高盐组、高盐组、补肾方组、补肾方+生理盐水组、补肾方+中高盐组... 详细信息

目的:探讨补肾中药复方(Bushen formulae,BHF)对高盐摄入去卵巢大鼠骨代谢的影响及其可能的作用机制。方法:80只SPF级SD雌性大鼠按随机数字表法分为假手术组、模型组、中高盐组、高盐组、补肾方组、补肾方+生理盐水组、补肾方+中高盐组、补肾方+高盐组,每组各10只,造模后给予不同饮食、补肾中药复方干预,中高盐饮食、高盐饮食中氯化钠添加浓度分别为2%w/w、8%w/w,补肾中药复方干预剂量为7.8 g·kg^(-1)·d^(-1),每日1次,连续给药12周。检测各组骨密度、骨微结构、骨参数、骨代谢生物标志物、骨组织病理变化情况以及采用Western blot检测骨组织上皮钠离子通道α(ENaCα)、钠-氯同向转运体(NCC)、电压门控性氯离子通道3(ClC-3)蛋白的表达。结果:与假手术组相比,模型组大鼠骨密度降低,骨微结构破坏;与模型组相比,中高盐、高盐饮食组大鼠骨微结构破坏更为明显,同时高盐组骨形成标志物骨钙素(BGP)、Ⅰ型原胶原氨基端前肽(PINP)水平显著上升(P<0.05),骨吸收标志物Ⅰ型胶原氨基端肽(NTX)、Ⅰ型胶原羧基端肽(CTX)、抗酒石酸酸性磷酸酶(TRACP)均显著增加(P<0.05),骨代谢处于高转换状态;高盐饮食加速骨小梁结构的破坏,Western blot结果显示高盐饮食引起股骨组织ENaCα、ClC-3蛋白表达水平下降(P<0.05),NCC蛋白表达水平升高(P<0.05),补肾中药复方干预后能够不同程度的调节高盐引起的相关离子通道的表达。结论:补肾中药复方能够不同程度的调节高盐引起的相关离子通道ENaCα、ClC-3、NCC的表达,对骨代谢失衡具有一定的改善和治疗作用。

关键词：高盐摄入骨代谢离子通道补肾中药复方

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Diagnosis and treatment of thyroglossal duct carcinoma:Report of three cases with review of literatures

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Frontiers of Medicine 2008年第1期2卷 58-62页

作者： Zhipeng sun Chuanbin GUO Guangyan YU Yi zhan yan CHEN yan GAO Department of Oral and Maxillofacial Surgery Peking University School and Hospital of StomatologyBeijing 100081China Department of Oral Pathology Peking University School and Hospital of StomatologyBeijing 100081China

Thyroglossal duct carcinoma,which is usually diagnosed postoperatively,is a rare malignant tumor arising in the thyroglossal duct *** definitive diagnosis can be made only after microscopic *** retrospectively reviewed three cases of thyroglossal duct carcinoma diagnosed in Peking University School and Hospital of Stomatology from January 1986 to August *** and pathological features were investigated and the optimal treatment protocol was *** constituent ratio of thyroglossal duct carcinoma among surgically excised thyroglossal duct lesions was 2.9%.The clinical presentation of thyroglossal duct carcinoma was very similar to that of its benign *** cases were diagnosed as thyroglossal duct cyst prior to the operation,the remaining one as dermoid *** three cases were diagnosed as papillary carcinoma of thyroid origin after microscopic *** thyroglossal duct carcinoma should conform to the following criteria:localization of the carcinoma to a clearly demonstrable thyroglossal duct cyst or tract;clinically or histologically confirmed absence of carcinoma of the thyroid *** carcinoma is the most common histological type,which usually develops slowly with an excellent *** histological characteristics including:formation of papillary structure;nuclear morphological variations such as ground glass nuclei,pseudoinclusions,intranuclear grooves and filaments;concentrically calcified structures termed psammoma bodies which is regarded as a strong indication of papillary carcinoma;and positivity in immunohistological staining for *** procedure of excision is the choice for treatment.A close follow-up is *** the presence of thyroid gland masses or cervical lymphadenopathy,thyroidectomy or neck dissection should be *** effect of thyroid suppression therapy and radioactive iodine therapy is not conclusive.

关键词： thyroglossal duct carcinoma thyroglossal cyst carcinoma,papillary

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超声处理对‘烟73’干红葡萄酒颜色的影响

中外葡萄与葡萄酒 2024年第2期 56-62页

作者：魏滨生李超王家琪房玉林孙翔宇烟台张裕集团陕西张裕瑞那城堡酒庄陕西西安712042 西北农林科技大学葡萄酒学院陕西杨凌712100

近年来,超声技术已在液体食品中得到了广泛应用。本文探究了一次性超声破碎(OU)和一次性超声水浴(OUB)处理后高花色苷‘烟73’干红葡萄酒颜色的变化及对酚类等物质的影响。结果表明,OU和OUB处理后葡萄酒颜色发生显著变化,颜色强度降低,... 详细信息

近年来,超声技术已在液体食品中得到了广泛应用。本文探究了一次性超声破碎(OU)和一次性超声水浴(OUB)处理后高花色苷‘烟73’干红葡萄酒颜色的变化及对酚类等物质的影响。结果表明,OU和OUB处理后葡萄酒颜色发生显著变化,颜色强度降低,色调升高,Red%值显著下降,Yellow%值和Blue%值显著上升,整体向紫红色方向演变;超声处理有效减缓了红葡萄酒颜色的褐变,显著提升了聚合色素含量,有利于葡萄酒颜色的稳定。同时,超声处理降低了钙离子、总酚和总花色苷含量,增加了铁离子和单宁含量。整体来说,OU处理对红葡萄酒颜色的影响高于OUB处理,表明超声破碎是加快葡萄酒陈酿和感官改善的有效方式。

关键词：超声破碎超声水浴花色苷颜色催陈

馄饨结构的KB@Co-C_(3)N_(4)在中性电解质中作为锌空气电池的高活性和稳定性氧催化剂

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Chinese Journal of Catalysis 2024年第5期60卷 178-189页

作者：吴维凡范晋歌赵振宏潘建敏杨静阎兴斌詹怡中山大学化学工程与技术学院广东珠海519082 中山大学低碳化学与节能工程重点实验室广东广州510275 中山大学材料科学与工程学院光电材料与技术国家重点实验室广东广州510275

金属和氮共掺杂碳(M-N-Cs)由于具有高原子利用率、良好的活性和选择性,因而被认为是具有潜力的氧电催化剂.但其热力学氧化势较低,碳材料在高电位下容易腐蚀.在放电过程中,锌空气电池正极的电位始终比碳氧化的热力学电位高约0.5 V,这导... 详细信息

金属和氮共掺杂碳(M-N-Cs)由于具有高原子利用率、良好的活性和选择性,因而被认为是具有潜力的氧电催化剂.但其热力学氧化势较低,碳材料在高电位下容易腐蚀.在放电过程中,锌空气电池正极的电位始终比碳氧化的热力学电位高约0.5 V,这导致阴极中碳的严重腐蚀.对于M-N-C,腐蚀会破坏金属氮配位(M-Nx)活性位点,导致活性比表面积减少,同时还会改变孔隙形貌和表面特性,进而降低其催化活性.在充电(即氧气析出反应,OER)过程中,这种腐蚀现象会进一步加剧.因此,开发一种既具有高效双功能催化活性,又具有良好抗电化学腐蚀性能的M-N-C催化剂,对于解决上述问题至关重要.本文利用氮化碳(g-C_(3)N_(4))支撑钴氮配位(Co-Nx)活性位点,同时包覆科琴黑(KB)形成馄饨结构,制备了双功能氧催化剂KB@Co-C_(3)N_(4).首先,将剥离的C_(3)N_(4)与KB混合后煅烧,得到C_(3)N_(4)包覆的KB材料(KB@C_(3)N_(4));随后,再次煅烧将Co单原子引入KB@C_(3)N_(4)中,形成具有高活性和高稳定性的KB@Co-C_(3)N_(4)氧催化剂.红外光谱结果证实了,KB@Co-C_(3)N_(4)中存在C_(3)N_(4)成分.透射电镜和元素标记结果表明,C_(3)N_(4)均匀包覆在KB基底上.同步辐射测试确定了Co单原子的配位环境为CoN4结构.在0.5 mol L^(-1) NH_(4)Cl溶液中测试了KB@Co-C_(3)N_(4)氧催化剂ORR/OER的催化活性和稳定性.结果表明,KB@CoC_(3)N_(4)表现出较好的ORR性能,半波电位为0.723 V,显著优于商业铂碳催化剂(0.673 V)和普通Co-N-C催化剂(0.694 V).经过40000圈加速耐久性测试,KB@Co-C_(3)N_(4)仅衰减9 mV,而商业铂碳和Co-N-C在7500圈测试后分别衰减41和44 mV.在OER方面,KB@Co-C_(3)N_(4)在10 mA cm^(-2)时的过电位为550 mV,优于氧化钌的560 mV和Co-N-C的600 mV.经过20000圈测试,KB@Co-C_(3)N_(4)的OER过电位几乎保持不变,而氧化钌和Co-N-C经过4000圈测试后分别增加了37和20 mV.透射电镜观察发现,KB@Co-C_(3)N_(4)在实验前后形貌未发生明显变化,证明了其较好的稳定性.理论计算揭示,C_(3)N_(4)能够优化Co金属活性位点的电子结构,改善Co中心的电荷分布并增强Co-N键强度;同时,C_(3)N_(4)对KB基底的包覆有效避免了KB在高电位下的腐蚀,确保了KB@Co-C_(3)N_(4)的高稳定性和催化活性.将KB@Co-C_(3)N_(4)应用于中性锌空气电池中,该电池展现出1.52 V的开路电压,并在5 mA cm^(-2)的高电流密度下稳定循环运行超过985 h,性能优于大多数报道的采用碳基材料作为阴极催化剂的中性锌空气电池.综上所述,馄饨结构的KB@Co-C_(3)N_(4)具有较好的氧催化活性和稳定性,为设计高稳定性高活性的M-N-C催化剂提供了一定的参考.

关键词：氧电催化单原子催化剂中性电解液抗腐蚀

自发性脑出血患者术后合并肺栓塞的预测模型的构建与验证

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陆军军医大学学报 2024年第11期46卷 1270-1276页

作者：林巡孙晓川石全红但炜詹彦周建鑫夏宇隆谢延风蒋理重庆医科大学附属第一医院神经外科重庆400016 重庆大学附属三峡医院神经外科重庆404000

目的探讨自发性脑出血患者术后合并肺栓塞的危险因素,构建并验证列线图模型。方法本研究是回顾性队列研究,回顾性选取2015年1月至2023年1月于重庆医科大学附属第一医院及重庆大学附属三峡医院住院治疗的393例患者为训练组,165例患者为... 详细信息

目的探讨自发性脑出血患者术后合并肺栓塞的危险因素,构建并验证列线图模型。方法本研究是回顾性队列研究,回顾性选取2015年1月至2023年1月于重庆医科大学附属第一医院及重庆大学附属三峡医院住院治疗的393例患者为训练组,165例患者为验证组,采用单因素和多因素逐步Logistic回归分析,筛选出与自发性脑出血术后合并肺栓塞相关的危险因素,构建并验证基于这些因素的列线图模型。结果基于年龄、出血量、格拉斯哥昏迷评分(Glasgow coma scale,GCS)、手术方式、纤维蛋白(原)降解产物(fibrinogen degradation product,FDP)、D-二聚体、血红蛋白和血浆、渗透压、有无深静脉血栓等危险因素绘制列线图模型,受试者工作特征曲线(receiver operating characteristic curve,ROC)显示模型对是否存在肺栓塞区分度良好,曲线下面积(area under curve,AUC)=0.908,验证集的Hosmer-Lemeshow拟合优度检验表明此模型对于验证集的拟合度良好(χ^(2)=14.805,df=8,P=0.063),校正曲线与理想曲线较为接近,模型的预测概率与实际发生概率接近,说明该模型准确性较高,决策曲线分析显示在较大范围的阈值概率下,建立的列线图模型均可获得收益。结论本研究建立的自发性脑出血患者术后合并肺栓塞的预测模型具有良好的预测性能,可在临床工作中准确、及时、快速识别肺栓塞的发生。

关键词：自发性脑出血肺栓塞预测模型危险因素列线图

Local sustained release of PD-1 monoclonal antibody and lenvatinib by thermo-sensitive hydrogel for improving tumor immunotherapy

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中国化学快报:英文版 2023年第8期34卷 241-247页

作者： Lin Zhai Yujie Shi Yi yan An Lu Xiaoyu Liu Lei Lei Yi sun Linxia Jiang xiangyu Wang Honggang Qian Jiancheng Wang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Pharmaceutical Analysis School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Hepato-Pancreato-Biliary SurgeryPeking University Cancer Hospital&InstituteBeijing 100142China

In clinic,the combination of intravenous pembrolizumab(PD-1 monoclonal antibody)with oral Lenvatinib(LEN)exhibited an enhanced synergistic benefit for cancer ***,the clinical outcomes were always limited by the problems of inconsistent pharmacokinetic profiles of two drugs,lower drug accumulation in tumor and obvious side effects during the combination ***,in situ-forming thermosensitive hydrogels based on PLGA-PEG-PLGA triblock copolymers were prepared for local administration of anti-PD1 and LEN(P&L@Gel)to improve therapeutic efficacy and *** peritumoral or surgical resection site injection,the significant increased concentrations of both drugs in tumor were observed with the local sustained release of P&L@*** comparison with the group of intraperitoneal anti-PD1 plus oral LEN(P-ip&L-po),significantly higher tumor inhibition efficiency on CT26 tumor models could be obtained in P&L@Gel group,even at the dose of one-eighth of the former,same tumorinhibition effects could be *** enhanced antitumor efficacy of P&L@Gel group was probably associated with the 2.2 folds of increased level of CD8+T cells and the polarization of tumor associated macrophage from M2 to M1 along with the increased drug ***,compared with the obvious side effects of P-ip&L-po group,no significant changes of PLT,ALT and UA in blood,as well as IL-1αand IL-1βin mice paws were observed between P&L@Gel group and untreated *** results suggested that local administration of anti-PD1 and LEN with thermosensitive hydrogel could offer a potential strategy for tumors or tumor postoperative adjuvant treatment.

关键词： Lenvatinib PD-1 antibody Thermosensitive hydrogels Topical administration Tumor immunotherapy

A substorm-associated enhancement in the XUV radiation measuring channel observed by ESP/EVE/SDO

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Research in Astronomy and Astrophysics 2016年第6期16卷 21-28页

作者： yan yan Hua-NingWang Chao Shen zhan-Le Du National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Key Laboratory of Solar Activity Chinese Academy of Sciences Beijing 100012 China School of Natural Sciences and Humanity Harbin Institute of Technology Shenzhen Graduate School Shenzhen518055 China University of Chinese Academy of Sciences Beijing 100049 China

Comparing the ESP/EVE/SDO flux data of 2011 Feb 6, with the counterparts of XRS/GOES and SEM/SOHO, we find that there is an enhancement that is not apparent in the two latter datasets. The enhancement, possibly regarded as a flare at first glimpse, nevertheless, does not involve an energy-release from the sun. Based on the enhancement, we combine data from SXI/GOES 15 into a synthesized analysis, and concluded that it arises from a particle-associated enhancement in the channel that measures XUV radiation. Paradoxically, it seems to be somewhat of a particle-avalanching process. Prior to the event, a moderate geomagnetic storm took place. Subsequently, while the event is proceeding, a geomagnetic substorm is simultaneously observed. Therefore, the particles, though unidentified, are probably energetic electrons induced by substorm injection.

关键词： sun: X-rays gamma rays -- sun: flares -- sun: solar-terrestrial relations

CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1889-1900页

作者： Qiong Yuan Yunwei sun Fan yang Dan yan Meihua Shen Zhigang Jin Lin zhan Guangqi Liu Ling yang Qianyi Zhou Zhijun Yu xiangyu Zhou yang Yu Yong Xu Qingming Wu Jianfang Luo Xiamin Hu Chunxiang zhang Department of Cardiology the Affiliated Hospital of Southwest Medical University and Key Laboratory of Medical ElectrophysiologyMinistry of EducationInstitute of Cardiovascular Research and Institute of Metabolic DiseasesSouthwest Medical UniversityLuzhou 646000China College of Medicine Wuhan University of Science and TechnologyWuhan 430065China Department of Emergency and Critical Care Medicine Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China China Resource&WISCO General Hospital Wuhan University of Science and TechnologyWuhan 430065China Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong General HospitalGuangzhouChina College of Pharmacy Shanghai University of Medicine and Health SciencesShanghai 210000China

In this study,we identified that a conserved circular RNA(circRNA)DICAR,which was downregulated in diabetic mouse *** had an inhibitory effect on diabetic cardiomyopathy(DCM),as the spontaneous cardiac dysfunction,cardiac cell hypertrophy,and cardiac fibrosis occurred in DICAR deficiency(DICAR+/−)mice,whereas the DCM was alleviated in DICARoverexpressed DICARTg *** the cellular level,we found that overexpression of DICAR inhibited,but knockdown of DICAR enhanced the diabetic cardiomyocyte *** the molecular level,we identified that DICAR-VCP-Med12 degradation could be the underlying molecular mechanism in DICAR-mediated *** synthesized DICAR junction part(DICAR-JP)exhibited a similar effect to the entire *** addition,the expression of DICAR in circulating blood cells and plasma from diabetic patients was lower than that from health controls,which was consistent with the decreased DICAR expression in diabetic *** and the synthesized DICAR-JP may be drug candidates for DCM.

关键词： diabetic endogenous cardiomyopathy

基于纯惯性导航系统的智慧铁路人员定位系统研究

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自动化应用 2024年第13期65卷 217-222页

作者：闫双建闫永刚邢渊博陈召阳段祥玉张开法孙满盈河南思维轨道交通技术研究院有限公司河南郑州450001 上海麒德机电设备工程有限公司上海201114 北京思维鑫科信息技术有限公司北京100071

针对GPS与IMU组合导航定位系统在不同应用场景下,存在GPS无线信号失锁和惯性传感器导航解算过程误差累积等问题,提出了一种纯惯性导航系统的智慧铁路人员定位方法。利用惯性传感器采集铁路巡检员的足部数据,并分析其运动特征;提出机器... 详细信息

针对GPS与IMU组合导航定位系统在不同应用场景下,存在GPS无线信号失锁和惯性传感器导航解算过程误差累积等问题,提出了一种纯惯性导航系统的智慧铁路人员定位方法。利用惯性传感器采集铁路巡检员的足部数据,并分析其运动特征;提出机器学习智能分类算法,检测行人在行走过程中的静止阶段和运动阶段。在初始状态下进行初始对准,以确定初始方位;在零速状态下,通过扩展卡尔曼滤波估计航向误差、角速度误差、速度误差,实现导航解算的姿态、速度和位置的零速修正。对比巡检员导航实验与GPS RTK差分定位实验发现,提出的基于纯惯性导航系统的智慧铁路人员定位系统可以准确跟踪巡检员的实时位置,并且平均误差为2.674%,最大误差不超过3.3%。

关键词：机器学习初始对准导航解算扩展卡尔曼滤波零速修正