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Does high altitude increase risks of the elderly patients with coronary artery disease？

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Journal of Geriatric Cardiology 2009年第3期6卷 137-141页

作者： Tian-Yi Wu Zhong-yan zhan Qin-Li Wu Suo-Lung Baomu Yu-Ling Jie Min sun State Key Laboratory of High Altitude Medicine High Altitude Medical Research Institute Qinghai 810012 China Emergency Center of Qinghai-Tibet Railway Golmud 816000 China Qinghai- Tibet Railroad Company Xining 810016 China

Objective To assess the effect of altitude hypoxia on the elderly patients with coronary artery disease （CAD）. Methods Three subject groups were surveyed during their train trip on the highest railroad the Qinghai-Tibet Railway： 22 elderly individuals with documented CAD, 20 healthy elderly controls, and 20 healthy young controls, all of whom from Beijing near the sea level （76 m）, Survey questions addressed clinical features of their healthy conditions and aspects of their coronary disease. The baseline study was performed at Xining at an altitude of 2261m, and then during acute exposure to altitudes of 2808 m, 4768m, 5072 m and 4257 m by train for 24 hours. Resting pulse rate, blood pressure, oxygen saturation, electrocardiograph （ECG）, and cardiac work estimated by the heart rateblood pressure double product were obtained five times in each subject at different altitudes. Results On arrival to altitudes between 4768 m and 5072 m, the older passengers, especially those with preexisting coronary disease, had higher HR, higher BP, and lower SaO2, as well as more frequent abnormalities on ECG, as compared to the younger healthy subjects. As compared with the healthy elderly controls, incomplete right bundle branch block, left ventricular hypertrophy, and ST segment depression were more frequently seen in the elderly coronary patients （P〈0.01）. Cardiac work in group 1 was increased by 13% 12 hours after arrival to altitudes between 2808 m and 5072 m. Oxygen saturation decreased significantly with the altitude increasing by train ascent but improved after inhalation of oxygen. Most of the older subjects tolerated their sojourn at high altitude well except one who developed angina repeatedly with a significant ST segment depression. Conclusions Coronary events and ECG signs of myocardial ischemia are rare in elderly individuals with CAD who travel from sea level to moderate altitudes of 1500m to 2800 m. Patients with CAD who are well compensated at sea level generally t

关键词： coronary artery disease elderly high altitude hypoxia angina

Insecticidal activities and active components of the alcohol extract from green peel of Juglans mandshurica

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Journal of Forestry Research 2007年第1期18卷 62-64页

作者： sun Mo-long WANG yan-mei SONG zhan-qian FANG Gui-zhen College of Science Northeast Forestry University Harbin 150040 P. R. China Institute of Chemical Industry of Forest PProducts CAE Nanjing 210042 P. R. China College of Material Science and Engineering Northeast Forestry University Harbin 150040 P. R. China

The extract of green peel of Juglans mandshurica Maxim was extracted by common method for studying its insecticidal activities and analyzing the active components. Results showed that the alcohol extract and the chloroform part of extract （separated with chloroform from alcohol extract） form green peel of J. mandshurica have insecticidal activities in contact toxicity and stomach toxicity against larvae of Lymantria dispar L.. After application of the extracts for five days, the corrected mortality of larvae of Lymantria dispar for both extracts was more than 50% in contact toxicity and stomach toxicity at the concentration of ≥ 5 g·L^-1. The insecticidal activity for both alcohol extract and chloroform part of extract is more effect in contact toxicity than in stomach toxicity, but no significant difference in the insecticidal activities was found between alcohol extract and chloroform part of extract. The active components in the chloroform part of extract from green peel of.J. mandshurica were analyzed by GC-MS. The analyzed results showed that the active components in the chloroform part of extract are：（1） joglone （5-hydroxy-1,4- naphthaoquinone）, the relative content 27.11%, （2） 1,5-Naphthalenediol, the relative content 9.52%, （3） 7-Methoxy-1-tetralone, the relative content 6.81%, （4） Benzofuran, 2,3-dihydro-, the relative content 6.76%, （5） 4-Hydroxy-2-methoxycinnamaldehyde, the relative content 3.99%, （6） 2-Methoxy-4-vinylphenol, the relative content 3.05%.

关键词： Green peel, Juglans mandshurica Insecticidal activities Component analysis GC-MS Juglone

Study of the Correlation of EGFR and K-RAS Gene Mutations with Its Protein Expression in Non-small Cell Lung Cancer

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Clinical oncology and cancer researeh 2010年第2期7卷 97-102页

作者： Huan-ling L UAN Lei-na sun Na DONG yan GUO Bao-cun sun Zhong-li zhan Department of Pathology of Tianjin Can-cer Hospital Tianjin Medical University Tianjin Key Laboratory of Cancer Prevention and Therapy Tianjin Diagnosis and Therapy Center of Lung Cancer Tianjin 300060 China.

OBJECTIVE To investigate gene mutations of epidermal growth factor receptor （EGFR） and K-RAS （Kirsten rat sarcoma viral oncogene） in Chinese patients with non-small cell lung cancer （NSCLC）, and study the correlation with its protein expression and its clinical significance on *** Detect the EGFR and K-RAS gene mutations status by gene sequencing and use the method of immunohistochemistry to detect EGFR and K-RAS protein *** The frequency of EGFR mutations was 33%, mainly located in exon 19 and exon 21. The frequency of K-RAS mutations was 5.5%, mainly located in codon 12. There was no case which both had EGFR and K-RAS mutations, suggesting a mutually exclusive relationship between the two. EGFR mutations are more common in adenocarcinomas （particularly those with bronchioloalveolar features）, nonsmokers and females. 16% were detected EGFR positive expression and had no correlation with EGFR mutation （P 〉 0.05）, but had significant correlation with mutation in exon 19 （P 〈 0.05）. The frequency of K-RAS positive expression was 52.5% and had no correlation with K-RAS mutation （P 〉 0.05）. Twelve （8 cases were protein-negative） out of 15 gefitinib-treated NSCLC patients with disease control carry EGFR *** EGFR protein expression has some correlation with exon 19 mutations. Combined detection of EGFR and K-RAS gene mutations can help clinicians to choose patients who may benefit from EGFR tyrosine kinase inhibitor （EGFR-TKI） and to predict the response and prognosis of gefitinib.

关键词： Epidermal growth factor receptor (EGFR) Kirstenrat sarcoma viral oncogene (K-RAS) Non-small cell lung cancer(NSCLC) EGFR tyrosine kinase inhibitor (EGFR-TKI).

Aging behavior and precipitate characterization of Zn-rich Al-Zn-Mg-Cu alloys with various Mg and Cu contents

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Journal of Iron and Steel Research International 2021年第8期28卷 1064-1073页

作者： Hai-chao Li Ming Li Dong-ye yang Fu-yang Cao yan-dong Jia Zhi-shui Yu Jian Zhao Tong Liu Hong zhan Qiang Chen Jian-fei sun School of Materials Engineering Shanghai University of Engineering ScienceShanghai 201620China Sichuan Kelun Pharmaceutical Research Institute Chengdu 611138SichuanChina School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Laboratory for Microstructures Institute of MaterialsShanghai UniversityShanghai 200444China School of Mechanical and Automotive Engineering Anhui Polytechnic UniversityWuhu 241000AnhuiChina Southwest Technology and Engineering Research Institute Chongqing 400039China

Four Zn-rich Al-Zn-Mg-Cu alloys with different Mg and Cu contents were fabricated by spray *** effects of Mg and Cu contents on the aging behaviors of the whole precipitation process of the alloys were systematically *** results show that the primary precipitates in the under-aged and peak-aged alloys are GPⅡ and η'phases;no GPⅠ zones were *** aging,the dissolution driving force of the precipitates increases with increasing Mg content;therefore,the volume fraction of precipitates in the grain interior and the area fraction of precipitates at the grain boundary increase obviously,which contributes to a considerable improvement in yield strength and decrease in plasticity of the high Mg content *** content has no apparent effect on the size and volume fraction of ***,a higher Cu content can effectively prevent coarsening and transformation of precipitates,which is beneficial to maintain the peak aging state of the *** research provides a basis for the composition optimization of the rapid-solidified highly alloying Al-Zn-Mg-Cu alloys.

关键词： Al-Zn-Mg-Cu alloy Zn-rich alloy Aging behavior Precipitate characterization Property

Arbitrary manipulations of focused higher-order Poincare beams by a Fresnel zone metasurface with alternate binary geometric and propagation phases

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Photonics Research 2022年第4期10卷 1117-1126页

作者： xiangyu ZENG YUQIN zhanG MANNA GU ZIJUN zhan RUIRUI zhanG YU zhanG RUI sun CHANGWEI HE CHUNXIANG LIU CHUANFU CHENG School of Physics and Electronics Shandong Normal UniversityJinan 250014China School of Science Shandong Jianzhu UniversityJinan 250101China School of Computer Science and Technology Shandong University of Finance and EconomicsJinan 250014China

The manipulation of high-quality vector beams(VBs)with metasurfaces is an important topic and has potential for classical and quantum *** this paper,we propose a Fresnel zone(FZ)metasurface with metallic nanoslits arranged on FZs,which sets alternate binary geometric and propagation phases to cancel the incident spin component and focus the converted spin component(CSC).The rotation designs of nanoslits transform the incident polarization state on the conventional Poincare sphere to VBs on the higher-order Poincare(HOP)*** two orbital angular momentum states of the CSCs were manipulated,and the focused HOP beams were *** experimental results demonstrate the broadband generation of arbitrarily focused HOP beams of high quality under the illumination of the red(632.8 nm),green(532 nm),and blue(473 nm)*** work will be of significance for the applications of VBs in different areas,such as precision metrology,optical micromanipulation,and quantum information.

关键词： Poincare alternate Fresnel

Effects of Incretin-based Therapies on Weight-related Indicators among Patients with Type 2 Diabetes: A Network Meta-analysis

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Biomedical and Environmental Sciences 2020年第1期33卷 37-47页

作者： XU Lu YU Shu Qing GAO Le HUANG Yi WU Shan Shan yanG Jun sun Yi Xin yanG Zhi Rong CHAI San Bao zhanG Yuan JI Li Nong sun Feng zhan Si yan Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Mathematics and Statistics University of Maryland Baltimore CountyBaltimore MD 21250MarylandUSA National Clinical Research Center of Digestive Diseases Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China The Primary Care Unit School of Clinical MedicineUniversity of CambridgeCambridge CB21TNUK Department of Endocrinology and Metabolism Peking University International HospitalBeijing 102206China Department of Clinical Epidemiology and Biostatistics McMaster UniversityHamilton L8S 4L8OntarioCanada Department of Endocrinology and Metabolism Peking University People’s HospitalBeijing 100044China

Objective To evaluate the effects of incretin-based therapies on body weight as the primary outcome,as well as on body mass index(BMI)and waist circumference(WC)as secondary *** Databases including Medline,Embase,the Cochrane Library,and ***(***)were searched for randomized controlled trials(RCTs).Standard pairwise meta-analysis and network meta-analysis(NMA)were both carried *** risk of bias(ROB)tool recommended by the Cochrane handbook was used to assess the quality of *** analysis,sensitivity analysis,meta-regression,and quality evaluation based on the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)were also *** A total of 292 trials were included in this *** with placebo,dipeptidyl-peptidase IV inhibitors(DPP-4 Is)increased weight slightly by 0.31 kg[95%confidence interval(CI):0.05,0.58]and had negligible effects on BMI and *** with placebo,glucagon-like peptide-1 receptor agonists(GLP-1 RAs)lowered weight,BMI,and WC by-1.34 kg(95%CI:-1.60,-1.09),-1.10 kg/m2(95%CI:-1.42,-0.78),and-1.28 cm(95%CI:-1.69,-0.86),*** GLP-1 RAs were more effective than DPP-4 Is in lowering the three ***,the effects of GLP-1 RAs on weight,BMI,and WC were favorable.

关键词： Body mass index Body weight Diabetes mellitus Dipeptidyl-peptidase IV inhibitors Glucagon-like peptide-1 receptor agonists Network meta-analysis Waist circumference

Long-term outcomes of brainstem arteriovenous malformations after different management modalities: a single-centre experience

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Stroke & Vascular Neurology 2021年第1期6卷 65-73页

作者： Yu Chen Ruinan Li Li Ma xiangyu Meng Debin yan Hao Wang Xun Ye Hengwei Jin Youxiang Li Dezhi Gao Shibin sun Ali Liu Shuo Wang Xiaolin Chen Yuanli Zhao Department of Neurosurgery Beijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Interventional Neuroradiology Beijing Tiantan HospitalBeijingChina Stroke Center Beijing Institute for Brain DisordersBeijingChina Department of Neurosurgery Peking University International HospitalBeijingChina Department of Gamma-Knife Center Beijing Tiantan HospitalBeijingChina

Objective The aims of this study are to clarify the long-term outcomes of brainstem arteriovenous malformations(AVMs)after different management *** The authors retrospectively reviewed 61 brainstem AVMs in their institution between 2011 and *** rupture risk was represented by annualised haemorrhagic *** were divided into five groups:conservation,microsurgery,embolisation,stereotactic radiosurgery(SRS)and embolisation+*** outcomes were evaluated by the modified Rankin Scale(mRS).Subgroup analysis was conducted between different management modalities to compare the long-term outcomes in rupture or unruptured *** All of 61 brainstem AVMs(12 unruptured and 49 ruptured)were followed up for an average of 4.5 *** natural annualised rupture risk was 7.3%,and the natural annualised reruptured risk in the ruptured cohort was 8.9%.13 cases were conservative managed and 48 cases underwent intervention(including 6 microsurgery,12 embolisation,21 SRS and 9 embolisation+SRS).In the selection of interventional indication,diffuse nidus were often suggested conservative management(p=0.004)and nidus involving the midbrain were more likely to be recommended for intervention(p=0.034).The risk of subsequent haemorrhage was significantly increased in partial occlusion compared with complete occlusion and conservative management(p<0.001,p=0.036,respectively).In the subgroup analysis,the follow-up mRS scores of different management modalities were similar whether in the rupture cohort(p=0.064)or the unruptured cohort(p=0.391),as well as the haemorrhage-free survival(p=0.145).In the adjusted Bonferroni correction analysis of the ruptured cohort,microsurgery and SRS could significantly improve the obliteration rate compared with conservation(p<0.001,p=0.001,respectively)and SRS may have positive effect on avoiding new-onset neurofunctional deficit compared with microsurgery and embolisation(p=0.003,p=0.003,respectively).Conclusio

关键词： brainstem modalities conservative

比浊法测定土壤有效硫的优化及与ICP-OES法对比

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中国土壤与肥料 2024年第1期 238-246页

作者：潘政赵丽霞陕红占国艳潘晓威梁耀辉刘丽丽欧阳小雪孙宝利叶剑芝中国热带农业科学院农产品加工研究所/农业农村部农产品加工质量安全风险评估实验室(湛江) 广东湛江524001 农业农村部环境保护科研监测所/农田有机污染生物消减创新团队/农业农村部产地环境污染防控重点实验室/天津市农业环境与农产品安全重点实验室天津300191 中国农业科学院农业环境与可持续发展研究所/农业农村部农业环境重点实验室北京100081 天津市农业科学院农产品质量安全与营养研究所天津300381

第三次全国土壤普查意义重大,为确保普查数据真实可靠,需对行业标准检测方法进行反复验证以优选出适合在全国范围内推广的方法。由于NY/T 1121.14—2006比浊法测定土壤有效硫标准曲线线性较差,亟须优化其提取、测定条件以提高方法的准... 详细信息

第三次全国土壤普查意义重大,为确保普查数据真实可靠,需对行业标准检测方法进行反复验证以优选出适合在全国范围内推广的方法。由于NY/T 1121.14—2006比浊法测定土壤有效硫标准曲线线性较差,亟须优化其提取、测定条件以提高方法的准确度和精密度。鉴于此,主要探究了沉淀剂的状态、品牌及线性拟合方式对比浊法测定土壤有效硫标准曲线线性的影响,结果表明,有效硫标准曲线改用现用现配的40 g/L氯化钡溶液定容可显著提高标准曲线的线性,使其相关系数r>0.999,满足分析测试的要求。同时本实验室对电感耦合等离子体光谱法(ICP-OES)测定土壤有效硫进行方法验证、对比,比浊法、ICP-OES法的检出限分别为1.20、0.80 mg/kg,均满足分析测试的要求。方法准确度和精密度验证结果表明,二者均可用于土壤有效硫的测定并且测定结果无显著性差异。其中,比浊法适用于测定低含量(<48 mg/kg)样品,ICP-OES法适用于含量范围在0~150 mg/kg的样品。结合本实验室在第三次全国土壤普查内业检测试点工作中的经验,建议将ICP-OES法作为第三次全国土壤普查有效硫测定的首选方法,以期为第三次全国土壤普查内业检测提供参考和借鉴。

关键词：第三次全国土壤普查有效硫比浊法电感耦合等离子体光谱仪

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寻常痤疮120例皮肤镜特征研究

皮肤科学通报 2024年第2期41卷 163-169页

作者：李国星李玲双司晴晴颜仕立詹冶颖孙东杰昆明医科大学第一附属医院皮肤科云南昆明650032 湖北省十堰市太和医院皮肤科湖北十堰442000

目的利用皮肤镜采集不同形态皮损、严重程度的寻常型痤疮图像,并结合该皮损处组织病理特点评价不同形态皮损的皮肤镜表现与组织病理学的一致性关系,获得不同严重程度、不同形态痤疮的皮肤镜特征。方法选取符合痤疮诊断标准患者共120例... 详细信息

目的利用皮肤镜采集不同形态皮损、严重程度的寻常型痤疮图像,并结合该皮损处组织病理特点评价不同形态皮损的皮肤镜表现与组织病理学的一致性关系,获得不同严重程度、不同形态痤疮的皮肤镜特征。方法选取符合痤疮诊断标准患者共120例,按照Pillsbury分级标准分为Ⅰ~Ⅳ级,并选取粉刺、丘疹、脓疱、瘢痕等不同形态皮损采集图像。对照组:年龄、性别匹配的无痤疮的正常健康人。结果 (1)不同严重程度痤疮(轻、中、重度)的皮肤镜表现比较:血管形态、毳毛增多在不同严重程度痤疮中差异无统计学意义(P>0.05),轻度痤疮的淡红色背景、血管局灶性分布、毛孔粗大、毛囊周围淡黄色晕、肉芽组织样结构,中度痤疮的红色/黄红色背景、局灶性血管分布、毛孔粗大、毛囊周围淡黄色晕、肉芽组织样结构,重度痤疮的黄红色背景、弥漫性血管分布、毛孔粗大、毛囊周围淡黄色晕、肉芽组织样结构差异分别具有统计学意义(P<0.05)。(2)不同形态痤疮皮损的皮肤镜表现比较:粉刺以淡红色背景、点状血管、局灶性分布差异有统计学意义;脓疱以红色背景、花环状血管、弥漫性分布、毛周“红点征”差异有统计学意义;丘疹以黄红色背景、花环状血管、局灶性分布、毛周“红点征”差异有统计学意义;瘢痕黄红色背景、非典型血管、弥漫性分布差异有统计学意义(P<0.05)。结论不同严重程度、皮损形态的痤疮皮肤镜表现具有一定典型的模式与结构特征,在临床诊疗中有一定参考价值,也有助于基于人工智能的痤疮诊断、鉴别及疗效评估等深入开发应用。

关键词：痤疮寻常型皮肤镜分析