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A Bibliometric Analysis and Visualization of Current Research Trends in Chinese Medicine for Osteosarcoma

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Chinese Journal of Integrative Medicine 2022年第5期28卷 445-452页

作者： yin Meng-chen WANG Hong-shen yanG Xi XU Chong-qing WANG Tao yan yin-jie FAN Zhao-xiang MA Jun-ming YE jie MO Wen Department of Orthopaedics Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai(200032)China Division of Spine Surgery Center Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou(510120)China Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai(200032)China

Background:To illustrate the research framework,overall knowledge structure,and development trends of Chinese medicine(CM)treatment for osteosarcoma(OS)by using a bibliometric analysis and newly developed visualization ***:Research datasets were acquired from the Web of Science(WOS)database from January 1,1980 to September 30,*** viewer and Citespace software was used to analyze the data and generate visualization knowledge *** trends of publications,distribution of institutes,distribution of journals,citation and H-index status,co-authorship status,research hotspots and co-citation status were ***:A total of 223 publications in the WOS database met the *** number of published articles showed a rise but the citation frequency and the H-index of China were relatively *** cooperation between the countries,institutes and authors were relatively *** publications were basic *** of the previous researches focused on basic mechanisms of CM in treating OS,and therapy and improvement of dosage form may become a frontier in this research ***:Compared with other fields,the field of CM treatment for osteosarcome is still in *** distribution of researches is imbalanced and cooperation between countries,institutions and authors remains to be ***,basic research occupies an absolute dominant position,and the exploration of the molecular mechanism of CM in preventing and treating OS may become a key point in the future.

关键词： osteosarcoma Chinese medicine bibliometric analysis visualization research trends

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高效液相色谱法拆分盐酸昂丹司琼对映体

中国药学杂志 2014年第22期49卷 2027-2030页

作者：尹燕杰哈尔滨市食品药品检验检测中心哈尔滨150525

目的建立一种快速高效的盐酸昂丹司琼对映体分离方法,检查盐酸左昂丹司琼(R型)中异构体含量。方法手性柱为CHIRALPAK IC(4.6 mm×250 mm,5μm);流动相:正己烷-无水乙醇-乙二胺(50∶50∶0.1);检测波长:245 nm;流速:1.0 m L·min-1;柱温:2... 详细信息

目的建立一种快速高效的盐酸昂丹司琼对映体分离方法,检查盐酸左昂丹司琼(R型)中异构体含量。方法手性柱为CHIRALPAK IC(4.6 mm×250 mm,5μm);流动相:正己烷-无水乙醇-乙二胺(50∶50∶0.1);检测波长:245 nm;流速:1.0 m L·min-1;柱温:25℃。同时考察了醇改性剂的种类、比例、有机添加剂二乙胺的比例、流速、温度等因素对拆分的影响。结果盐酸昂丹司琼对映体在CHIRALPAK IC手性柱上分离度为6.5,盐酸左昂丹司琼中含0.02%的右旋异构体可被检出。结论方法专属性好、灵敏度高,适用于盐酸昂丹司琼对映体的分离以及盐酸左昂丹司琼中右旋异构体杂质的测定。

关键词：高效液相色谱法对映体拆分盐酸昂丹司琼手性固定相杂质

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang yan Liu jie Gao You yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

鼻用冷敷凝胶(露)中盐酸萘甲唑啉、盐酸苯海拉明及盐酸利多卡因补充检验方法研究

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药物分析杂志 2024年第9期44卷 1624-1631页

作者：王跃尹燕杰哈尔滨市药品和医疗器械检验检测中心哈尔滨150000

目的:建立HPLC方法检测鼻用冷敷凝胶(露)中添加的盐酸萘甲唑啉、盐酸苯海拉明及盐酸利多卡因3个化学药物。建立HPLC-MS/MS法对检出的阳性样品进行确认。方法:试样采用乙腈提取后,用HPLC法检测,采用外标法定量,考察试验方法学,对市售样... 详细信息

目的:建立HPLC方法检测鼻用冷敷凝胶(露)中添加的盐酸萘甲唑啉、盐酸苯海拉明及盐酸利多卡因3个化学药物。建立HPLC-MS/MS法对检出的阳性样品进行确认。方法:试样采用乙腈提取后,用HPLC法检测,采用外标法定量,考察试验方法学,对市售样品进行检测。对阳性样品采用HPLC-MS/MS法确证。HPLC方法:采用XTerra RP18(150 mm×4.6 mm,5μm)色谱柱,以50 mmol·L^(-1)乙酸铵(用乙酸或氨试液调节pH至7.8)-乙腈(72∶28)为流动相,流速1.0 mL·min^(-1),检测波长230 nm;LC-MS/MS方法:采用BEH C_(18)(100 mm×2.1 mm,1.7μm)色谱柱,以0.1%甲酸水溶液-0.1%甲酸乙腈溶液为流动相,梯度洗脱,柱温40℃,流速0.4 mL·min^(-1);电喷雾电离源(ESI),正离子模式下多反应监测(MRM)。结果:方法学考察试验表明,盐酸萘甲唑啉、盐酸苯海拉明和盐酸利多卡因的检测限分别为2.4、50和50 ng·mL^(-1),回收率为93.9%~104.6%,在10~200μg·mL^(-1)范围内,线性关系良好(r>0.9990)。对市售的42批样品进行检测,总体检出率达70%(36/42),其中34批检出盐酸萘甲唑啉,2批同时检出盐酸苯海拉明和盐酸利多卡因,存在较大的安全风险。结论:方法专属性强,灵敏度高,操作简单,准确可靠,可用于鼻用冷敷凝胶(露)中盐酸萘甲唑啉、盐酸苯海拉明及盐酸利多卡因的定性及定量检测。

关键词：鼻用冷敷凝胶(露) 盐酸萘甲唑啉盐酸苯海拉明盐酸利多卡因高效液相色谱法高效液相色谱串联质谱法补充检验方法

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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi Dennis yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run Song Shiyi yin Jiannan Wu Junqiang yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

高效液相色谱法分离和测定左奥硝唑中右旋异构体

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药物分析杂志 2014年第5期34卷 885-888页

作者：尹燕杰何志一孙超哈尔滨市食品药品检验检测中心哈尔滨150525

目的：建立手性高效液相色谱方法,用于测定左奥硝唑原料和制剂中的右旋异构体。方法：采用CHIRALPAK IC（250 mm×4.6 mm,5μm）手性柱,以正己烷-无水乙醇（90∶10）为流动相,流速1.0 mL·min-1,检测波长308 nm。结果：奥硝唑对映体之... 详细信息

目的：建立手性高效液相色谱方法,用于测定左奥硝唑原料和制剂中的右旋异构体。方法：采用CHIRALPAK IC（250 mm×4.6 mm,5μm）手性柱,以正己烷-无水乙醇（90∶10）为流动相,流速1.0 mL·min-1,检测波长308 nm。结果：奥硝唑对映体之间的分离度为3.9,奥硝唑右旋异构体的检测限为0.52 ng;线性范围为1.05～21.0μg·mL-1;低、中、高浓度的回收率（n=3）分别为101.3%、100.2%、100.5%,RSD分别为1.3%、0.9%、1.5%;供试溶液在12 h内基本稳定;温度和流速的影响试验表明该方法有良好的耐用性。结论：所建立的方法经方法验证可用于分离和测定左奥硝唑原料和制剂中的右旋异构体杂质。

关键词：左奥硝唑右旋异构体杂质检测手性分离手性固定相高效液相色谱

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AGP手性固定相分离6种药物对映体

中国药学杂志 2008年第9期43卷 702-704页

作者：尹燕杰张启明田颂九哈尔滨市食品药品检验检测中心哈尔滨150021 中国药品生物制品检定所北京100050

目的建立奈哌地尔、消旋卡多曲、坦洛新、西布曲明、罗格列酮和卡维地洛6种药物对映体手性分离方法。方法采用AGP手性柱,选用不同浓度和比例的醋酸铵或磷酸二氢钾溶液-乙腈为流动相,并考察了流动相组成及流速等因素对分离的影响。结果6... 详细信息

目的建立奈哌地尔、消旋卡多曲、坦洛新、西布曲明、罗格列酮和卡维地洛6种药物对映体手性分离方法。方法采用AGP手性柱,选用不同浓度和比例的醋酸铵或磷酸二氢钾溶液-乙腈为流动相,并考察了流动相组成及流速等因素对分离的影响。结果6种药物对映体均得到较好的分离。结论所建立的方法可方便地分离6种药物对映体。

关键词： α-酸性糖蛋白手性固定相手性分离对映体

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融入体演教学的高职大学英语课程真实性评价

武汉职业技术学院学报 2014年第4期13卷 73-77页

作者：尹衍杰青岛职业技术学院公共教学部山东青岛266555

我国高职英语课程的评价方式正在从终结性评价向过程化、真实性的评价发展,但是真实性评价的发展仍然步履维艰。对此作者对比研究了体演教学法和真实性评价方式。前者是一种在美国逐渐兴起的二语教学方法,后者是当今世界流行的课程评价... 详细信息

我国高职英语课程的评价方式正在从终结性评价向过程化、真实性的评价发展,但是真实性评价的发展仍然步履维艰。对此作者对比研究了体演教学法和真实性评价方式。前者是一种在美国逐渐兴起的二语教学方法,后者是当今世界流行的课程评价方式。分析研究后发现,二者在很多方面有着惊人的相似度,共同反映了课程教学和评价的本质特征和未来趋势。通过二者对比研究,认为高职英语教学课程评价需有独特的改革思路。推行融入体演教学法的高职大学英语真实性评价是一个能反应未来大学英语课程评价发展方向的勇敢尝试。

关键词：真实性评价体演教学大学英语