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Risk Factors of Depression Screened by Two-Sample Mendelian Randomization Analysis:A Systematic Review

Biomedical and Environmental Sciences 2024年第1期37卷 85-95页

作者： WANG Han Lin xue yan feng CUI Bao Qiu LIU Hong SHEN Xin Xin Shandong Provincial Research Center for Bioinformatic Engineering and Technique School of Life SciencesShandong University of TechnologyZibo 255049ShandongChina Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013ShanxiChina State Key Laboratory of Infectious Disease Prevention and Control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective This study explored the potentially modifiable factors for depression and major depressive disorder(MDD)from the MR-Base database and further evaluated the associations between drug targets with *** We analyzed two-sample of Mendelian randomization(2SMR)using genetic variant depression(n=113,154)and MDD(n=208,811)from Genome-Wide Association Studies(GWAS).Separate calculations were performed with modifiable risk factors from MR-Base for 1,001 *** MR analysis was performed by screening drug targets with MDD in the DrugBank database to explore the therapeutic targets for *** variance weighted(IVW),fixed-effect inverse variance weighted(FE-IVW),MR-Egger,weighted median,and weighted mode were used for complementary *** The potential causal relationship between modifiable risk factors and depression contained 459 results for depression and 424 for ***,the associations between drug targets and MDD showed that SLC6A4,GRIN2A,GRIN2C,SCN10A,and IL1B expression are associated with an increased risk of *** contrast,ADRB1,CHRNA3,HTR3A,GSTP1,and GABRG2 genes are candidate protective factors against *** This study identified the risk factors causally associated with depression and MDD,and estimated 10 drug targets with significant impact on MDD,providing essential information for formulating strategies to prevent and treat depression.

关键词： Risk factors Drug targets Depression Major depressive disorder Two-sample Mendelian randomization

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Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

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World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma xue-yan feng Li-Na Ma Department of Infectious Disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Infectious Disease Clinical Research Center of Ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic *** the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been *** To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC *** This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December *** were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment *** samples were collected at the onset and conclusion of the 12-wk intervention *** structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were *** Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(P<0.05),and the structure of the intestinal microbiota was characterized by an increase in the proportions of probiotic microbes and a reduction in harmful ***,the intervention group demonstrated notable improvements in liver function indices and significantly lower levels of inflammatory factors(P<0.05).CONCLUSION LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota,improving liver function,and reducing inflammatory factor levels.

关键词： Hepatitis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnospiraceae incertae sedis Probiotic

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乌龙江斜拉桥主塔钢锚梁定位测量技术

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现代测绘 2024年第2期47卷 51-54页

作者：秦环兵燕雪峰中铁大桥局集团第二工程有限公司江苏南京210015

乌龙江斜拉桥主桥结构复杂,主塔钢锚梁的精密定位测量是斜拉桥的关键技术之一。针对其测量定位精度要求高、测量难度大的问题,分别介绍了几种适用于主桥钢锚梁精密定位方法。经过比选,最终采用全站仪三维坐标法进行钢锚梁精密定位,平面... 详细信息

乌龙江斜拉桥主桥结构复杂,主塔钢锚梁的精密定位测量是斜拉桥的关键技术之一。针对其测量定位精度要求高、测量难度大的问题,分别介绍了几种适用于主桥钢锚梁精密定位方法。经过比选,最终采用全站仪三维坐标法进行钢锚梁精密定位,平面定位实施时通过加入主塔变形监测变化值进行修正,高程定位实施时通过高程差分来消除和减弱地球曲率及折光影响。该方法不仅满足精度要求,还可以全天候作业。实践证明,该方法安全、高效、经济、技术先进,具有显著的社会和经济效益。

关键词：斜拉桥钢锚梁精密定位坐标转换变形监测测量方法

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Synthesis of O-glycosylα-aryl nitrones

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Chinese Chemical Letters 2010年第9期21卷 1075-1078页

作者： Ying Fu Huai Yuan Zhang yan Hua Liu xue feng Li Dan feng Huang Yu Lai Hu Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education Key Laboratory of Polymer Material of Gansu Province College of Chemistry & Chemical Engineering Northwest Normal University Lanzhou 730070 China

α-Aryl nitrone are one of the most useful kinds of nitrones and have been extensively explored in recent ***,the sugar moieties have not been introduced into these molecules *** presented here an efficient synthesis ofα-aryl nitrone Oglycosides via condensation of N-substituted hydroxylamine and aryl aldehydes glycosides in benzene.

关键词： Nitrones Glycosides Aryl aldehyde Hydroxylamine Synthesis

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Fault diagnosis and process monitoring using a statistical pattern framework based on a self-organizing map

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Journal of Central South University 2015年第2期22卷 601-609页

作者：宋羽姜庆超颜学峰 Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education(East China University of Science and Technology)

A multivariate method for fault diagnosis and process monitoring is proposed. This technique is based on a statistical pattern(SP) framework integrated with a self-organizing map(SOM). An SP-based SOM is used as a classifier to distinguish various states on the output map, which can visually monitor abnormal states. A case study of the Tennessee Eastman(TE) process is presented to demonstrate the fault diagnosis and process monitoring performance of the proposed method. Results show that the SP-based SOM method is a visual tool for real-time monitoring and fault diagnosis that can be used in complex chemical *** with other SOM-based methods, the proposed method can more efficiently monitor and diagnose faults.

关键词： statistic pattern framework self-organizing map fault diagnosis process monitoring

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Protective Role of Ca Against NaCl Toxicity in Jerusalem Artichoke by Up-Regulation of Antioxidant Enzymes

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Pedosphere 2008年第6期18卷 766-774页

作者： xue yan-feng LIU Ling LIU Zhao-Pu S. K. MEHTA ZHAO Geng-Mao Department of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 （China）. State Key Laboratory Breeding Base Key Laboratory of Food Quality and Safety of Jiangsu Province Nanjing 210014 （China） Department of Life Sciences Nanjing Agricultural University Nanjing 210095 （China）

The ameliorative effect of external Ca^2＋ on Jerusalem artichoke （Helianthus tuberosus L.） under salt stress was studied through biochemical and physiological analyses of Jerusalem artichoke seedlings treated with or without 10 mol L^-1 CaCl2, 150 mmol L^-1 NaCl, and/or 5 mmol L^-1 ethylene-bis（oxyethylenenitrilo）-tetraacetic acid （EGTA） for five days. Exposure to NaC1 （150 mmol L^-1） decreased growth, leaf chlorophyll content, and photosynthetic rate of Jerusalem artichoke seedlings. NaC1 treatment showed 59% and 37% higher lipid peroxidation and electrolyte leakage, respectively, than the control. The activities of superoxide dismutase （SOD）, peroxidase （POD）, and catalase （CAT） were decreased by NaCl, indicating an impeded antioxidant defense mechanism of Jerusalem artichoke grown under salt stress. Addition of 10 mmol L^-1 CaCl2 to the salt solutions significantly decreased the damaging effect of NaC1 on growth and chlorophyll content and simultaneously restored the rate of photosynthesis almost to the level of the control. Ca^2＋ addition decreased the leaf malondialdehyde （MDA） content and electrolyte leakage from NaCl-treated seedlings by 47% and 24%, respectively, and significantly improved the activities of SOD, POD, and CAT in NaCl-treated plants. Addition of EGTA, a specific chelator of Ca2＋, decreased the growth, chlorophyll content, and photosynthesis, and increased level of MDA and electrolyte leakage from NaCl-treated plants and from the control plants. EGTA addition to the growth medium also repressed the activities of SOD, POD, and CAT in NaCl-treated and control seedlings. External Ca2＋ might protect Jerusalem artichoke against NaC1 stress by up-regulating the activities of antioxidant enzymes and thereby decreasing the oxidative stress.

关键词： antioxidant enzymes calcium Jerusalem artichoke lipid peroxidation salt stress

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Self-Powered Flexible Multicolor Electrochromic Devices for Information Displays

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Research 2024年第2期2023卷 529-540页

作者： Wenzhao xue Yun Zhang feng Liu Yao Dou Mei yan Wenshou Wang School of Chemistry and Chemical Engineering University of JinanJinan 250022P.R.China

The development of self-powered flexible multicolor electrochromic(EC)systems that could switch different color without an external power supply has remained extremely ***,a new trilayer film structure for achieving self-powered flexible multicolor EC displays based on self-charging/discharging mechanism is proposed,which is simply assembled by sandwiching an ionic gel film between 2 cathodic nickel hexacyanoferrate(NiHCF)and Prussian blue(PB)nanoparticle films on indium tin oxide *** display exhibits independent self-powered color switching of NiHCF and PB films with fast responsive time and high reversibility by selectively connecting the Al wire as anodes with the 2 EC *** switching is thus achieved through a color overlay effect by superimposing the 2 EC films,including green,blue,yellow,and *** bleaching/coloration process of the displays is driven by the discharging/self-charging mechanism for NiHCF and PB films,respectively,ensuring the self-powered color switching of the displays reversibly without an external power *** is further demonstrated that patterns can be easily created in the self-powered EC displays by the spray-coating method,allowing multicolor changing to convey specific ***,a self-powered ionic writing board is demonstrated based on the self-powered EC displays that can be repeatedly written freehand without the need of an external power *** believe that the design concept may provide new insights into the development of self-powered flexible multicolor EC displays with self-recovered energy for widespread applications.

关键词： connecting repeatedly powered

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Synthesis of ZrSiO_4 and Coesite in SiO_2-ZrO_2 System Under High Pressure

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Chemical Research in Chinese Universities 2008年第2期24卷 135-137页

作者： xue yan-feng XU Da-peng ZHANG Guang-qiang ZHOU Xian-feng DING Zhan-hui LIU Xiao-mei SU Wen-hui College of Physics Jilin University Changchun 130012 P. R. China Center for the Condensed-MatterScience and Technology Harbin Institute of Technology Harbin 150001 P. R. China International Center for Materials Physics Chinese Academy of Sciences Shenyang 110015 P. R. China

ZrSiO4 and coesite were obtained under high-pressure and high-temperature from the nano precursor of a-SiO2 and ZrO2. XRD and Raman measurements indicate that ZrSiO4 was formed at a temperature higher than 920 ℃ under a pressure of 3.6 GPa. As the pressure increased to 3.9 GPa, the ZrSiO4 formation temperature was reduced to 815 ℃. The formation temperature for coesite was 990 ℃ under 3.9 GPa. The lower formation temperature for ZrSiO4, as compared to that for coesite, provided an experimental evidence that the coesite in the Earth＇s surface usually occurs as inclusions in ZrSiO4.

关键词： ZrSiO4 Coesite High pressure synthesis Mechanical ball milling

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Robust multi-layer extreme learning machine using bias-variance tradeoff

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Journal of Central South University 2020年第12期27卷 3744-3753页

作者： YU Tian-jun yan xue-feng Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education East China University of Science and TechnologyShanghai 200237China

As a new neural network model,extreme learning machine(ELM)has a good learning rate and generalization ***,ELM with a single hidden layer structure often fails to achieve good results when faced with large-scale multi-featured *** resolve this problem,we propose a multi-layer framework for the ELM learning algorithm to improve the model’s generalization ***,noises or abnormal points often exist in practical applications,and they result in the inability to obtain clean training *** generalization ability of the original ELM decreases under such *** address this issue,we add model bias and variance to the loss function so that the model gains the ability to minimize model bias and model variance,thus reducing the influence of noise signals.A new robust multi-layer algorithm called ML-RELM is proposed to enhance outlier robustness in complex *** results show that the method has high generalization ability and strong robustness to noise.

关键词： extreme learning machine deep neural network robustness unsupervised feature learning

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基于径基函数-加权偏最小二乘回归的干点软测量

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自动化学报 2007年第2期33卷 193-196页

作者：颜学峰华东理工大学自动化研究所上海200237

针对影响石油馏分产品干点因素众多且呈高度非线性的特征,提出了一种径基函数(Radial basis function,RBF)和加权偏最小二乘回归(Weighted partial least squares regression,WPLSR)相结合的建模方法建立干点软测量模型．该组合方法首... 详细信息

针对影响石油馏分产品干点因素众多且呈高度非线性的特征,提出了一种径基函数(Radial basis function,RBF)和加权偏最小二乘回归(Weighted partial least squares regression,WPLSR)相结合的建模方法建立干点软测量模型．该组合方法首先应用RBF实现样本数据的非线性变换;然后根据非线性变换后样本在结构参数空间中的分布,分析它们对预测对象的预报能力,自适应地为各个样本分配权值,并进而从中提取和选用PLS成分,实施加权PLSR,以获得预报性能良好的模型．在实际应用于初顶石脑油干点软测量建模中,RBF-WPLSR获得比PLSR、WPLSR及RBF-PLSR更高精度的模型．

关键词：径基函数加权偏最小二乘回归干点

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