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Elevated peroxidative glutathione redox status in atherosclerotic patients with increased thickness of carotid intima media

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Chinese Medical Journal 2009年第23期122卷 2827-2832页

作者： HUANG yan-sheng WANG Li-xia SUN Lin WU Yu LU Jian-min ZHAO Shi-chao DAI Fu-min xu Bo-shi WANG Shu-ren department of Cardiology Henan Provincial People's HospitalZhengzhou Henan 450003 China department of Pathophysiology West China School of Preclinicaland Forensic Medicine Sichuan University Chengdu Sichuan610041 China

Background Atherosclerosis is a chronic inflammatory disease. Accumulated evidences suggest a deep involvement of oxidative damage in the development of atherosclerosis, but little is discussed over the relationship between plasma glutathione redox status as the most important intrinsic antioxidant defensive mechanism and the atherosclerosis. Methods A total of 132 patients suspected with atherosclerosis were assigned to three groups by high frequency ultrasonic examination of the carotid artery. With the thickness of intima of the carotid artery as an index of degree of atherosclerosis progression, 56 were included in plaque-forming group （A）, 42 in carotid artery intima-thickening group （B）, and 34 in normal carotid artery intima-thickness group （C）. All patients were subjected to the measurement of plasma glutathione （GSH）（reduced form GSH and oxidized form GSSG）, nicotinamide adenine dinucleotide phosphate （NADP）（reduced form NADPH and oxidized form NADP^＋）, oxidized low density lipoprotein （oxLDL）, and malondialdehyde （MDA） The GSH/GSSG and NADPH/NADP^＋ redox potentials were calculated according to the Nernst equation, and their correlation with intima thickness and oxLDL was analyzed. Results With the thickening of artery intima （from group C to A）, GSH concentration and the ratio of GSH/GSSG gradually reduced, and GSSG and GSH/GSSG redox potential gradually increased （more positive）（P 〈0.05）. The NADPH and NADPH/NADP^＋ redox status also showed similar but milder changes. The products of oxidative stress oxLDL and MDA increased significantly along with the thickening of artery intima （P 〈0.05）. The analysis of the relationship between GSH/GSSG redox potential, intima thickness, and oxLDL showed positive correlations （P 〈0.05）. The plasma GSH/GSSG redox status was positively correlated with the intima thickness of the carotid artery and the oxidized injury of LDL. The redox status shifted to oxidizing direction along with the intima thickening and plaque-for

关键词： atherosclerosis redox status glutathione nicotinamide adenine dinucleotide phosphate low density lipoprotein, oxidized

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Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the china Cardiometabolic Disease and Cancer Cohort(4C)Study

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Biomedical and Environmental Sciences 2021年第1期34卷 9-18页

作者： ZHU Yuan Yue ZHENG rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing xu min xu Yu CHEN Yu Hong YU xue Feng yan Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You min WU Sheng Li yanG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi ming TANG xu Lei HU ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin Hospital.Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China The First Hospital of Jilin university Changchun 130021JinlinChina Qilu Hospital of Shandong university Jinan 250012ShandongChina Affiliated Hospital of Guiyang Medical College Guiyang 550004GuizhouChina Xinhua Hospital Affiliated to Shanghai Jiaotong university School of Medicine Shanghai 200092China Tongji Hospital.Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030HubeiChina Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120GuangdongChina The First Affiliated Hospital of Zhengzhou university Zhengzhou 450052HenanChina The Affiliated Hospital of Southwest Medical university Luzhou 646099SichuanChina Fujian Provincial Hospital Fujian Medical UniversityFuzhou 350001FujianChina Dalian Municipal Central Hospital Dalian 116003LiaoningChina The First Affiliated Hospital of Wenzhou Medical university Wenzhou 325000ZhejiangChina The First Affiliated Hospital of Guangxi Medical university Nanning 530021GuangxiChina Jiangxi Provincial People's Hospital Affiliated to Nanchang university Nanchang 330006JiangxiChina The Second Affiliated Hospital of Harbin Medical university Harbin 150086HeilongjiangChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051ZhejiangChina Central Hospital of Shanghai Jiading District Shanghai 201800China Jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing 210028JiangsuChina The First Affiliated Hospital of Anhui Medical university Hefei 230022AnhuiChina Karamay Municipal

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains *** aimed to explore the associations between glycemic indices and SUA levels in the general Chinese *** The current study was a cross-sectional analysis using the first follow-up survey data from The china Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid *** nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive *** A total of 30,941 men and 62,361 women were eligible for the current *** additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and *** thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.

关键词： Cross-sectional study Serum uric acid Glycemic index Glycemic status

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双极电凝治疗结膜松弛症

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眼外伤职业眼病杂志 2008年第12期30卷 935-937页

作者：许琰张兴儒李青松项敏泓严雅静上海中医药大学附属普陀医院眼科上海200062

目的探讨安全、简单、有效的治疗结膜松弛症的方法。方法对21例(36眼)结膜松弛症用眼科双极电凝器进行治疗。治疗后随访观察:症状评估,结膜松弛观察,泪河测量,泪膜破裂时间测定等。结果手术后4周:36眼中症状消失和改善者25眼(69.44%);... 详细信息

目的探讨安全、简单、有效的治疗结膜松弛症的方法。方法对21例(36眼)结膜松弛症用眼科双极电凝器进行治疗。治疗后随访观察:症状评估,结膜松弛观察,泪河测量,泪膜破裂时间测定等。结果手术后4周:36眼中症状消失和改善者25眼(69.44%);裂隙灯显微镜检查松弛结膜皱褶消失者17眼(47.22%),改善者9眼(25.00%);泪河恢复正常者24眼(66.67%);泪膜破裂时间≥10 s者22眼(61.11%)。结论双极电凝治疗结膜松弛症简单、安全、有效。

关键词：结膜松弛症治疗双极电凝

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Anti-BCMA CAR-T Cell Therapy in Relapsed or Refractory Multiple Myeloma Patients with Impaired Renal Function

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Current Medical Science 2021年第3期41卷 474-481页

作者： Shao-long HE Yu-hang CHENG Di WANG Meng-lei xu Yi-mei QUE yan-jie xu Liang-ming MA Chun-rui LI Jian-feng ZHOU department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Third Hospital of Shanxi Medical university Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTongji Medical CollegeHuazhong University of Science and TechnologyTaiyuan 030032China

Anti-B cell maturation antigen(BCMA)chimeric antigen receptor(CAR)T-cell therapyis effective and well-tolerated for refractory or relapsed multiple myeloma(RRMM).The purposcof the present study was to analyze efficacy in RRMM patients with renal impairment treated byanti-BCMA CAR-T cell therapy.A total of 59 RRMM patients were selected,and divided intoimpaired renal function(lRF)group[basclinc cstimated giomerular filtration rate(eSFR)min/1.73 m^2(n=18)]and normal renal function(NRF)group(baseline eGFR≥90 mL/min/1.73 m,n=41).For patients with IRF,eGFR at the 6th month post-CAR-T cells infusion was significantlyhigher than the baseline(Prum ***-free survival(PFS)in the NRF group and IRF group was 266 days and 181 *** survival(OS)in the NRF group and lRF group was 877 days and 238 *** was no significant difference in the objective response rate(ORR)between thelRF group and the NRF *** is suggested that CAR-T cells therapy could improve the renalfunction during the treatment of *** renal function could be more significantly improvedin RRMM patients with light chain type than with other types.

关键词： relapsed or refractory multiple myeloma chimeric antigen receptor T-cell therapy impaired renal function B cell maturation antigen

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基于肌筋膜触发点的研究探讨针灸穴位和经络本质

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中国针灸 2021年第6期41卷 633-640页

作者：郭少卿徐基民马彦韬张艳茹蒋佳黄强民浙江中医药大学附属第三医院推拿科杭州310005 中国康复研究中心上海华东医院上海南翔医院长沙天心爱博门诊部上海体育学院运动康复系上海200438

在现代解剖生理学基础上,将各个肌肉的肌筋膜触发点牵涉痛区域进行整合,对比传统经络的十二经脉和任督二脉,观察二者位置和走行的相似性;并通过目前肌筋膜触发点和筋膜学的研究进展,在触发点牵涉痛路径的基础上,结合筋膜力学、神经和血... 详细信息

在现代解剖生理学基础上,将各个肌肉的肌筋膜触发点牵涉痛区域进行整合,对比传统经络的十二经脉和任督二脉,观察二者位置和走行的相似性;并通过目前肌筋膜触发点和筋膜学的研究进展,在触发点牵涉痛路径的基础上,结合筋膜力学、神经和血管思路深入理解穴位的定位和经络,以及穴位和经络的关系。

关键词：肌筋膜触发点牵涉痛穴位经络

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新型心肺复苏术血流动力学效果的模型研究

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华南理工大学学报（自然科学版） 2009年第12期37卷 100-104页

作者：张燕儒吴效明袁衡新徐林华南理工大学计算机科学与工程学院广东广州510006 华南理工大学生物科学与工程学院广东广州510006 中山大学中山医学院广东广州510080

为实现新型复苏术——辅以增强型体外反搏和吸气阻力阀的主动按压放松心肺复苏术(AEI-CPR)的数字化,用计算机仿真模型模拟了人体在正常情况、心脏骤停以及采取新型复苏术后的血流动力学效果,并将标准复苏术(S-CPR)、主动按压复苏术(ACD-... 详细信息

为实现新型复苏术——辅以增强型体外反搏和吸气阻力阀的主动按压放松心肺复苏术(AEI-CPR)的数字化,用计算机仿真模型模拟了人体在正常情况、心脏骤停以及采取新型复苏术后的血流动力学效果,并将标准复苏术(S-CPR)、主动按压复苏术(ACD-CPR)、以及带有增强型体外反搏的标准复苏术(SE-CPR)和新型复苏术AEI-CPR等的仿真结果进行了比较.结果表明:S-CPR产生的前向血流(FF)为1.1L/min,冠脉灌注压(CPP)为30.2 mmHg;ACD-CPR产生的FF为1.2L/min,CPP为31.3 mmHg;SE-CPR产生的FF为5.2L/min,CPP为57.4mmHg;AEI-CPR产生的FF为5.6L/min,CPP为57.6mmHg;带有增强型体外反搏的复苏术SE-CPR和AEI-CPR可显著提高前向血流,AEI-CPR的血流动力学效果最好。

关键词：心肺复苏术数学模型增强型体外反搏前向血流冠脉灌注压

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关联规则的高效向量法数据挖掘

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济南大学学报（自然科学版） 2005年第1期19卷 59-63页

作者：蔡卫东徐章艳杨炳儒济南大学信息科学与工程学院广西师范大学计算机系北京科技大学信息工程学院

对经典的向量挖掘算法和Apriori算法的思想及其复杂度进行分析后 ,提出了一种新的高效向量数据挖掘算法。新算法通过避免不必要的计算以达到提高算法的计算效率 ,通过避免不必要的存贮以达到减少算法的空间复杂度 ,与经典的向量挖掘算... 详细信息

对经典的向量挖掘算法和Apriori算法的思想及其复杂度进行分析后 ,提出了一种新的高效向量数据挖掘算法。新算法通过避免不必要的计算以达到提高算法的计算效率 ,通过避免不必要的存贮以达到减少算法的空间复杂度 ,与经典的向量挖掘算法相比有如下优点 :(1)空间复杂度为o(n|L1|) ,比经典的挖掘算法的空间复杂度要小得多 ;(2 )计算量比经典的挖掘算法要小。

关键词：计算机应用技术关联规则 Apriori算法算法效率向量数据挖掘

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以神经系统受累为主的Adams-Oliver综合征2型临床和基因分析

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临床儿科杂志 2021年第3期39卷 227-230页

作者：徐敏何燕郭虎南京医科大学附属儿童医院神经内科江苏南京210008

目的探讨DOCK 6基因变异导致的Adams-Oliver综合征2型(AOS2)的临床和基因型。方法回顾分析1例确诊AOS2患儿的临床资料,并复习相关文献。结果患儿,女,自幼发育落后,6月龄时出现抽搐,头围小,双侧大腿皮肤局部毛细血管扩张。头颅磁共振成... 详细信息

目的探讨DOCK 6基因变异导致的Adams-Oliver综合征2型(AOS2)的临床和基因型。方法回顾分析1例确诊AOS2患儿的临床资料,并复习相关文献。结果患儿,女,自幼发育落后,6月龄时出现抽搐,头围小,双侧大腿皮肤局部毛细血管扩张。头颅磁共振成像示两侧脑室壁、室管膜下多发钙化,伴脑室旁片状脱髓鞘,脑发育不良,双侧海马轻度萎缩,右侧颞枕叶异常信号。基因检测发现患儿DOCK 6基因存在c.3069_3069del和c.5220+1G>A复合杂合变异,分别来自于表型正常的父母亲,为致病性变异。结论新发现AOS2致病基因,扩大了DOCK 6基因变异谱。

关键词： Adams-Oliver综合征2型 DOCK 6基因临床表型

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Functional organization of complex brain networks modulated by acupuncture at different acupoints belonging to the same anatomic segment

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Chinese Medical Journal 2012年第15期125卷 2694-2700页

作者： CHEN Shang-jie MENG Lan yan Hao BAI Li-jun WANG Fang HUANG Yong LI Jian-ping PENG xu-ming SHI xue-min department of Acupuncture Baoan Hospital Southern MedicalUniversity Shenzhen Guangdong 518101 China department of Acupuncture The First Affiliated Hospital TianjinUniversity of Traditional Chinese Medicine Tianjin 300193 China department of Anesthesiology Beijing Tiantan Hospital CapitalMedical University Beijing 100050 China School of Psychology Shaanxi Normal University Xi'an Shaanxi710062 China Institute of Automation Chinese Academy of Sciences Beijing100190 China department of Linguistics Xidian University Xi'an Shaanxi710126 China

Background Noninvasive functional magnetic resonance imaging （fMRI） techniques have opened a ＂window＂ into the brain, allowing us to investigate the anatomical and physiological function involving acupuncture needling. Imaging its sustained effect rather than acute effect on the brain networks may further help elucidate the mechanisms by which acupuncture achieves its therapeutic effects. In this study, we aimed to investigate the functional brain networks during the post-resting state following acupuncture at KI3 in comparison with acupuncture at GB40. Methods Needling at acupoints GB40 and KI3 was performed in twelve subjects. Six minutes of scanning at rest were adopted before and after acupuncture at different acupoints. Then we divided the whole brain into 39 regions and constructed functional brain networks during the post-acupuncture resting states （PARS）. Results For direct comparisons, increased correlations during post-resting state following acupuncture at KI3 compared to resting state （RS） were primarily located between the dorsolateral prefrontal cortex （DLPFC） and post temporal cortex, ventromedial prefrontal cortex （vmPFC） and post temporal cortex. These brain regions were all cognitive-related functions. In contrast, the increased connections between the anterior insula and temporal cortex mainly emerged following acupuncture at GB40 compared with the RS. Conclusions The present study demonstrates that acupuncture at different acupoints belonging to the same anatomic segment can exert different modulatory effects on the reorganizations of post-acupuncture RS networks. The heterogeneous modulation patterns between twoconditions may relate to the functional specific modulatory effects of acupuncture.

关键词： acupuncture functional magnetic resonance imaging," complex brain networks

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双侧陈旧性颞下颌关节脱位诊疗经验总结

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临床口腔医学杂志 2024年第4期40卷 200-204页

作者：邹姣姣侯笑茹王淋李立峰李彦秋虎小毅邢晓涛西安交通大学口腔医院陕西省颅颌面精准医学研究重点实验室陕西西安710000 陕西省牙颌疾病临床研究中心陕西西安710000 西安交通大学口腔医院创伤整形外科陕西西安710000

目的:探讨并总结我院收治的双侧陈旧性颞下颌关节脱位(chronic protracted mandibular dislocation,CPMD)的病例特征、治疗方案及预后,为陈旧性颞下颌关节脱位的防治提供临床参考。方法:回顾性分析2019年12月~2023年5月于我院住院治疗的... 详细信息

目的:探讨并总结我院收治的双侧陈旧性颞下颌关节脱位(chronic protracted mandibular dislocation,CPMD)的病例特征、治疗方案及预后,为陈旧性颞下颌关节脱位的防治提供临床参考。方法:回顾性分析2019年12月~2023年5月于我院住院治疗的9例CPMD病例,总结并分析CPMD患者的基本资料、脱位类型、脱位时间及临床症状;发病时所伴随的其他系统疾病及意识状态;复位方法、复位用时、住院天数及并发症;出院随访张口度、咬合关系及复发情况。结果:9例CPMD患者平均年龄(67±11.3)岁,女性占比88.9%;脱位类型均为双侧前脱位,脱位平均时间(2.1±1.4)个月。神经系统损伤是CPMD发病联系最密切的危险因素,发病时意识不清的患者占77.8%,仅22.2%的患者在初期感知脱位症状;约88.9%的CPMD病例发病与医疗活动存在密切联系。8例患者在麻醉下手法复位,手法复位率达88.9%,平均时间(24.3±10.9)min,1例患者行手术复位。复位后均给予弹性牵引及后期张口功能训练。除手术复位患者存在轻微张口受限及面神经损伤外,其他患者随访期间咬合关系及张口度正常,无复发及并发症。结论:CPMD主要继发于意识丧失的颅脑损伤性疾病;全麻下手法复位配合牵引钉+橡皮圈弹性牵引是治疗CPMD的首选及有效方法,但必要时仍需手术复位。

关键词：陈旧性颞下颌关节脱位手法复位弹性颌间牵引手术复位

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