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农村人力资本积累对农业产业结构升级的影响

现代农业研究 2024年第9期30卷 41-44页

作者：全勇严靖华福建农业职业技术学院

本文旨在探讨农村人力资本定义、重要性和现状。系统阐述农业产业结构升级的必要性及其驱动力。详细分析农村人力资本在技术创新、管理优化、市场需求变动和农业产业链完善中的作用。同时，分析农业产业结构升级对农村人力资本的新要求... 详细信息

本文旨在探讨农村人力资本定义、重要性和现状。系统阐述农业产业结构升级的必要性及其驱动力。详细分析农村人力资本在技术创新、管理优化、市场需求变动和农业产业链完善中的作用。同时，分析农业产业结构升级对农村人力资本的新要求，并探讨两者之间的协同发展关系。强调农村人力资本是农业产业结构升级的核心力量，两者间存在紧密互动。

关键词：农村人力资本农业产业结构升级技术创新管理优化市场需求变化产业链条完善

COVID-19 mRNA vaccines

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Journal of Genetics and Genomics 2021年第2期48卷 107-114页

作者： Qingrui Huang Jiawei Zeng jinghua yan CAS Key Laboratory of Microbial Physiological and Metabolic Engineenng Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Check for updates

The ongoing COVID-19 pandemic and its unprecedented global societal and economic disruptive impact highlight the urgent need for safe and effective *** substantial advantages of versatility and rapid development,two m RNA vaccines against COVID-19 have completed late-stage clinical assessment at an unprecedented speed and reported positive *** this review,we outline keynotes in m RNA vaccine development,discuss recently published data on COVID-19 m RNA vaccine candidates,focusing on those in clinical trials and analyze future potential challenges.

关键词： vaccines vaccine clinical

MicroRNAs: the novel targets for Ebola drugs

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Science China(Life Sciences) 2014年第10期57卷 985-986页

作者： yan jinghua GAO George Fu CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Research Network of Immunity and Health Beijing Institutes of Life Science Chinese Academy of Sciences National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Office of Director-General Chinese Center for Disease Control and Prevention

The re-emergence of Ebola viral disease （EVD） in West Africa has caused an international alarm, even panic. As of August 27th, 2014, the Ebola virus （EBOV） has infected 3069 people with 1552 death cases starting from December 2013 （http：//***/csr/don/2014 08 28 ebola/en/）. Recently, an outbreak of Ebola hemorrhagic fever in the north of Congo （Democratic Republic） has been confirmed besides Guinea, Liberia, Sierra Leone and Nigeria. So far the epidemic has not been effectively controlled.

关键词：微RNA 埃博拉病毒靶点药物 HTTP 死亡病例利比里亚尼日利亚

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中小学教师教育科研影响因素的研究及其启示

西北成人教育学院学报 2024年第1期 108-112页

作者：杨彩芬闫婧华郝照兰州二中甘肃兰州730010 甘肃省教育厅甘肃省教育科学研究院甘肃兰州730010 甘肃省教育厅甘肃省电化教育中心甘肃兰州730010

鼓励支持中小学教师增强科研意识,积极参与教育教学研究活动,不断深化教育教学改革的发展过程,探索适应我国中小学教育现状及发展规律的教师教育科研工作,是我国教育现代化的一种必然趋势。本研究从中小学教师做好教育科研的价值意蕴、... 详细信息

鼓励支持中小学教师增强科研意识,积极参与教育教学研究活动,不断深化教育教学改革的发展过程,探索适应我国中小学教育现状及发展规律的教师教育科研工作,是我国教育现代化的一种必然趋势。本研究从中小学教师做好教育科研的价值意蕴、影响因素与实践启示三个维度,对我国当前中小学教师在教育科研方面面临的相关问题展开了一定的分析与讨论,针对存在的问题提出了可供参考的实施策略。

关键词：中小学教师教育科研影响因素

SARS-CoV-2 virus: Vaccines in development

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Fundamental Research 2021年第2期1卷 131-138页

作者： Qingrui Huang jinghua yan CAS Key Laboratory of Microbial Physiological and Metabolic Engineering Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China

The ongoing COVID-19 pandemic,caused by SARS-CoV-2,is an imprecedented challenge to *** herd immunity may be necessary before resumption of normal economic and societal *** the beginning of the outbreak,the development of COVID-19 vaccines has proceeded at record speed using nearly all available platforms or strategies to maximize vaccine success.A total of 42 vaccine candidates have now entered clinical trials and encouraging data from several vaccine candidates in phase 1 or 2 clinical trials have been *** this review,we examine current COVID-19 vaccine candidates,discuss their strengths and weaknesses,summarize published clinical data and analyze future challenges.

关键词： SARS-CoV-2 COVID-19 Vaccine Clinical trial Virus

An infectious clone of the highly pathogenic porcine reproductive and respiratory syndrome virus: Topology of glycoprotein 3 (GP3) addressing the intrachain disulfide bonds

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Chinese Science Bulletin 2011年第26期56卷 2785-2793页

作者： FENG Chunyan LIU YueHuan yan jinghua George F. Gao CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI) Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Institute of Animal Husbandry and Veterinary Medicine Beijing Academy of Agriculture and Forestry Sciences Beijing 100097 China Beifing Institutes of Life Science Chinese Academy of Sciences Beijing 100101 China

The highly pathogenic porcine reproductive and respiratory virus (hpPRRSV) with discontinuous 30 amino acid (aa) deletion as a gene marker has caused great economic loss in pig industry and since 2007 has become the dominant strain prevalent in China and Vietnam since *** genetics method is a powerful tool urgently needed to be used on the hpPRRSV to study the intriguing molecular mechanism of transcription,replication and the virulence determinant *** our study,we successfully constructed a fulllength infectious clone,prBJSY07,based on hpPRRSV isolate,*** rescued virus,vrBJSY07,showed similar growth characters to those of the parental virus,*** also found that a rescued virus vBJSY07 generated from pBJSY07 was viable but displayed decreased and delayed reproductive capacity,which might be caused by two amino acids mutations,S83C and S117C in glycoprotein 3 (GP3),acquired during the preparation of the infectious *** topology of the wild type GP3 and the mutant were further analyzed by bioinformatics and revealed that the mutated GP3 possessed slightly altered structure,most likely by forming a new disulfide bond between the two new cysteine *** GP3 is a cysteine-rich glycoprotein,common for viral glycoproteins,our results show that GP3 can accommodate even more cysteine *** on this,a topological model of GP3 is proposed by addressing the intrachain disulfides.

关键词：猪繁殖与呼吸综合征病毒病毒糖蛋白感染性克隆拓扑结构高致病性二硫键半胱氨酸残基链

Targeted disruption of Noc4l leads to preimplantation embryonic lethality in mice

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Protein & Cell 2017年第3期8卷 230-247页

作者： Yongli Qin Haifeng Li Lina Jia jinghua yan George Fu Gao Xiangdong Li State Key Laboratory of the Agro-Biotechnology College of Biological Sciences China Agricultural University CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences

Dear Editor,Human Nucleolar complex associated 4 homolog(NOC4L,GenBank accession number NM＿024078) is the human ortholog of yeast Noc4p. However, with few functional studies evaluated, the physiological contributions of NOC4L have yet to be defined. The Noc4p gene in yeast encodes a63-kilodalton(KDa) protein that forms a stable heterodimer with Nop14p, which mediates the maturation and nuclear export of 40S ribosomal subunits(Dlakic and Tollervey,2004; Kuhn et al., 2009; Liu and Thiele, 2001; Milkereit et al.,2003).

关键词： Brown Adipose Tissue Embryonic Lethality Ribosome Biogenesis Preimplantation Embryo Cytoplasmic Granule

Novel 1,3,5-thiadiazine-2-thione derivatives containing a hydrazide moiety:Design, synthesis and bioactive evaluation against phytopathogenic fungi in vitro and in vivo

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Chinese Chemical Letters 2019年第7期30卷 1419-1422页

作者： Xiaobin Wang Xincan Fu Min Chen An Wang jinghua yan Yudong Mei Mengqi Wang Chunlong yang Jiangsu Key Laboratory of Pesticide Science Nanjing Agricultural University Nanjing 210095 China Department of Chemistry College of Sciences Nanjing Agricultural University Nanjing 210095 China

A series of novel 1,3,5-thiadiazine-2-thione derivatives bearing a hydrazide moiety were designed, synthesized and evaluated for their antifungal activities against Rhizoctonia solani (Rs), Fusarium graminearum (Fg), Botrytis cinerea (Bc) and Colletotrichum capsici (Cc). The in vitro antifungal bioassays indicated that most of title compounds displayed good selectivity and specificity aganist Rs relative to Fg, Bc and Cc. Strikingly, the title compound N'-(4-chlorophenyl)-2-(5-phenyl-6-thioxo-1,3,5-thiadiazinan-3-yl)acethydrazide (5b) obviously inhibited the Rs growth in vitro with the EC50 value of 0.24μg/mL, which is approximately 2-folds more effective than the commercialized fungicide carbendazim (0.55 μg/mL). The in vivo anti-Rs effects of title compound 5b were further evaluated on rice leaves with control efficacies of 98.58% at 200 μg/mL and 61.27% at 100 μg/mL. The above researches provide a significant reference for the further structural optimization of 1,3,5-thiadiazine-2-thione derivatives bearing a hydrazide moiety as potential fungicides.

关键词： 1,3,5-Thiadiazine-2-thione Hydrazide Crop protection Antifungal activity Rhizoctonia solani

hNUDT16:a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

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Protein & Cell 2011年第1期2卷 64-73页

作者： Guangwen Lu Jie Zhang yan Li Zhixin Li Na Zhang Xiang Xu Tingting Wang Zhenhong Guan George F.Gao jinghua yan CAS Key Laboratory of Pathogenic Microbiology and Immunology(CASPMI) Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Graduate University Chinese Academy of SciencesBeijing 100049China College of Life Science Anhui Agricultural UniversityAnhui 230036China Beijing Institutes of Life Science Chinese Academy of SciencesBeijing 100101China

Human NUDT16(hNUDT16)is a decapping enzyme initially identified as the human homolog to the Xenopus laevis *** a metalloenzyme,hNUDT16 relies on divalent cations for its cap-hydrolysis activity to remove m7 GDP and m227GDP from *** also determines substrate specificity of the *** far,only U8 small nucleolar RNA(snoRNA)has been identified as the substrate of hNUDT16 in the presence of Mg2+.Here we demonstrate that besides U8,hNUDT16 can also actively cleave the m7 GDP cap from mRNAs in the presence of Mg2+or Mn2+.We further show that hNUDT16 does not preferentially recognize U8 or mRNA substrates by our cross-inhibition and quantitative decapping *** addition,our mutagenesis analysis identifies several key residues involved in hydrolysis and confirms the key role of the REXXEE motif in *** an investigation into the subcellular localization of hNUDT16 revealed its abundance in both cytoplasm and *** findings extend the substrate spectrum of hNUDT16 beyond snoRNAs to also include mRNA,demonstrating the pleiotropic decapping activity of hNUDT16.

关键词： hNUDT16 mRNA U8 small nucleolar RNA decapping activity substrate specificity subcellular localization