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Targeting autophagic pathways for cancer drug discovery

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Chinese Journal of Cancer 2013年第3期32卷 113-120页

作者： Bo Liu jin-Ku Bao jin-Ming yang yan Cheng State Key Laboratory of Biotherapy and Cancer Center West China Hospital School of Life Sciences Sichuan UniversityChengdu Sichuan 610041 P. R. China Department of Pharmacology and The Penn State Cancer Institute The Pennsylvania State University College of Medicine and Milton S. Hershey Medical CenterHershey Pennsylvania USA.

Autophagy , an evolutionarily conserved lysosomal degradation process , has drawn an increasing amount of attention in recent years for its role in a variety of human diseases, such as cancer. Notably, autophagy plays an important role in regulating several survival and death signaling pathways that determine cell fate in cancer. To date, substantial evidence has demonstrated that some key autophagic mediators, such as autophagy-related genes (ATGs), PI3K, mTOR, p53, and Beclin-1, may play crucial roles in modulating autophagic activity in cancer initiation and progression. Because autophagy-modulating agents such as rapamycin and chloroquine have already been used clinically to treat cancer, it is conceivable that targeting autophagic pathways may provide a new opportunity for discovery and development of more novel cancer therapeutics. With a deeper understanding of the regulatory mechanisms governing autophagy, we will have a better opportunity to facilitate the exploitation of autophagy as a target for therapeutic intervention in cancer. This review discusses the current status of targeting autophagic pathways as a potential cancer therapy.

关键词：癌症治疗自噬药物发现信号转导通路降解过程人类疾病 ATGs mTOR

Real-time monitoring of the lithiation process in organic electrode 7,7,8,8-tetracyanoquinodimethane by in situ EPR

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Journal of Energy Chemistry 2021年第9期30卷 9-15页

作者： Mingxue Tang Nhat N.Bui jin Zheng Likai Song yan-yan Hu Department of Chemistry and Biochemistry Florida State University32306 TallahasseeUSA National High Magnetic Field Laboratory 1800 East Paul Dirac Drive32310 TallahasseeUSA

Organic electrodes are advantageous for rechargeable lithium-ion batteries owing to their high theoretical capacities, diverse functionalities, and environmental compatibility. Understanding the working mechanism of organic electrodes is vital to strategic materials design. However, due to lack of suitable characterization tools, it has been challenging to probe the reaction processes of organic electrodes in real-time. Here, non-destructive in situ electron paramagnetic resonance(EPR) was performed on a model organic electrode, 7,7,8,8-tetracyanoquinodimethane(TCNQ) used in rechargeable lithium-ion batteries,to directly follow the redox reactions in real-time. In order to minimize interfering signals from other parts of the batteries than the TCNQ electrode of interest, two sets of batteries are fabricated and studied with in situ EPR:(1) a Li CoO_(2)//Li_(4)Ti_5O_(12) full-cell battery to determine the EPR signal evolution of additives and electrolytes;(2) a Li CoO_(2)//TCNQ battery, and the difference in the observed EPR signals reflects purely the redox reactions of TCNQ upon lithiation and delithiation. A two-electron reversible redox reaction is delineated for TCNQ. TCNQ dimers form during the first electron injection upon lithiation and followed by the break-down of the dimers and associated electron coupling to produce massive delocalized electrons, resulting in increased EPR signal during the 2 nd electron injection. Reversible trends are observed during electron ejection upon delithiation. In situ EPR is very sensitive to electron activities,thus is a powerful tool to follow redox reactions of organic electrodes, allowing for improved fundamental understanding of how organic electrodes work and for informed design of high-performance organic materials for energy storage.

关键词： Organic electrode In situ EPR Rechargeable batteries 7 7 8 8-tetracyanoquinodimethane

Equilibrium and kinetics of copper(Ⅱ) biosorption by Myriophyllum spicatum L.

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Journal of Environmental Sciences 2005年第6期17卷 1025-1029页

作者： yan Chang-zhou WANG Sheng-rui ZENG A-yan jin Xiang-can XU Qiu-jin ZHAO jing-zhu Key Lab of System Ecology Research Center of Eco-environmental Sciences Chinese Academy of Sciences Beijing 100085 China Research Center of Lake Eco-environment Chinese Research Academy of Environmental Sciences Beijing 100012 China College of Environment and Resources Jilin University Changchun 130023 China

The potential use of Myriophyllum spicatum L. biomass as a biosorbent for the removal of copper（ Ⅱ ） from aqueous solution was investigated in laboratory condition. The sorption experiments were undertaken to obtain copper（ Ⅱ ） biosorption properties of M. spicatum L., i.e. equilibrium time, the maximum capacity, and rate constants. Copper（ Ⅱ ） biosorption was fast and equilibrium was attained within 35 min at initial copper（ Ⅱ ） concentration of 6 mg/L. Different isotherm models including the Langmuir, Freundlich, Temkin and Redlich-Peterson model, were used to investigate the sorption capacity and isotherm. These models showed an excellent match with the experimental data except for the Freundlich model. According to the Langmuir coefficients, the maximum sorption capacity of copper onto M. spicatum L. was 10.80 mg/g. The kinetics of copper（ Ⅱ ） sorption was also analysed and rate constants were derived. It was found that the overall sorption process was best described by the pseudo second-order equation, and that intraparticle diffusion was not the rate determining step. The results of this study showed that M. spicatum L. can be considered as useful vehicles for the removal and recovery of copper（ Ⅱ ） from aqueous solutions.

关键词： aquatic plants biosorption copper sorption isotherm pseudo second-order

Effects of Infrasound on Gastric Motility, Gastric Morphology and Expression of Nitric Oxide Synthase in Rat

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Biomedical and Environmental Sciences 2018年第5期31卷 399-402页

作者： zhao ju hui wang jin hai luo jin yan guo xiao yan wang yan cheng yan department of gastroenterology second affiliated hospital of xi'an jiao tong universityXi'an 710004ShaanxiChina

Infrasound widely condition, productive exists in nature, our living and traffic environment. Gastrointestinal tract is relatively sensitive to infrasound. However, the effect of infrasound on gastrointestinal function is unclear. Therefore, the purpose of our study was to observe the effects of infrasound on gastric motiliW and gastric morphology and to assess the expression of nitric oxide synthase （NOS） in gastric antrum after exposure to infrasound of 8 Hz - 130 dB for 2 hours per day for 14 consecutive days. Gastric motility was assessed by gastric fluid-emptying rate. Gastric morphology was evaluated by HE. The expression of NOS was measured by tissue microarray technology. The results would contribute to understand the role of infrasound in gastroenterology, and help to explain the mechanism of infrasound on gastroenterology.

关键词： NOS In Effects of Infrasound on Gastric Motility,Gastric Morphology and Expression of Nitric Oxide Synthase in Rat

Primary chondrosarcoma of the liver:A case report

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World Journal of Clinical Cases 2020年第20期8卷 5042-5048页

作者： Zhuo-yan Liu Xue-Mei jin Guang-Hai yan Guang-Yu jin Department of Radiology Affiliated Hospital of Yanbian UniversityYanji 133000Jilin ProvinceChina Department of Pathology Affiliated Hospital of Yanbian UniversityYanji 33000Jilin ProvinceChina Department of Anatomy Basic Medical CollegeYanbian UniversityYanji 133002Jilin ProvinceChina

BACKGROUND Primary chondrosarcoma of the liver are extremely ***,there are few reports focusing on typical clinical symptoms and imaging ***,the diagnosis of chondrosarcoma of the liver remains a *** SUMMARY A 59-year-old male was admitted due to a lesion occupying the right liver lobe that was found by physical *** resonance imaging showed a lobular mass with high T2 weighted image and low T1 weighted image with enhanced internal separation and edge in the right *** was diagnosed with liver cystadenoma by using magnetic resonance *** 3 mo later,the magnetic resonance scan showed that the mass was *** liver tumor resection was performed with a pathological diagnosis of liver *** he received a surgical resection for the recurrent ***,intrahepatic and abdominal metastases were found again at 8 mo after the second *** patient then received conservative management and is now under *** Primary liver chondrosarcoma generally is presented as lobulated and heterogeneous density/signal,cystic,solid masses without calcification with enhanced edge,internal septa and solid *** imaging features are closely related to pathology,which may be helpful for clinical diagnosis.

关键词： Extraskeletal chondrosarcoma Liver tumor Differential diagnosis Case report

A data-driven model predictive control for lighting system based on historical occupancy in an office building: Methodology development

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Building Simulation 2021年第1期14卷 219-235页

作者： Yuan jin Da yan Xingxing Zhang jingjing An Mengjie Han School of Architecture Tsinghua UniversityBeijing100084China School of Industrial Technology and Business Studies Dalarna UniversityFalun79188Sweden

The lighting system accounts for 8%of the total electricity consumption in commercial buildings in the United States and 12%of the total electricity consumption in public buildings *** consumption share can be effectively reduced using the demand-response *** traditional lighting system control method commonly depends on the real-time occupancy data collected using the passive infrared(PIR)***,the detection inaccuracy of the PIR sensor usually results in *** diminish the false-error frequency,the existing lighting system control simply deploys a delayed reaction period(e.g.,5 to 20 min),which is not sufficiently accurate for the demand-response ***,in this research,a novel data-driven model predictive control(MPC)method that is based on the temporal sequential-based artificial neural network(TS-ANN)is proposed to overcome this challenge using an updated historical occupancy *** an office as case study,the proposed model is also compared with the traditional lighting system control *** the proposed model,the occupancy data was trained to predict the occupancy pattern to improve the *** was found that the occupancy prediction mainly correlates with the historical occupancy ratio and the time sequential *** simulation results indicated that the proposed method achieved higher accuracy(97.4%)and fewer false-offs(from 79.5 with traditional time delay method to 0.6 times per day)are achieved by the MPC *** proposed TS-ANN-MPC method integrates the analysis of the occupant behavior routine into on-site control and has the potential to further enhance the control performance practice for maximum energy conservation.

关键词： lighting system occupant behavior data-driven model predictive control

Creep and tensile properties of press molding joined GMT-sheets

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 170-174页

作者： jin-Woo KIM Dong-Gi lee Center for NDE Iowa State University Department of Mechatronics Engineering Chosun University

GMT-sheet is used in automobile bumper with high rigidity and strength, and its joining strength is influenced by lap length, one of the joined molding conditions. Fracture strength was calculated by dividing fracture load with cross-sectional area. Total five repeated measurements were made to obtain the average value. Tensile test was conducted at room temperature for 10 specimens. In addition, the effect of compression ratio on creep and tensile performance during lap joined molding was discussed. With increasing lap length, the lap joining efficiency of GMT-sheet was increased. However, higher compression ratio reduced the joining efficiency. Creep test on GMT-sheet showed abrupt fracture without tertiary creep. This can be explained by the weak thermal resistance of the resin. If GMT-sheet was exposed to high temperature for a long time, it was easily failed by external force.

关键词： GMT-sheet randomly oriented composite unidirectional oriented composite compression ratio lap joint

Reconciling the father tongue and mother tongue hypotheses in Indo-European populations

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National Science Review 2019年第2期6卷 293-300页

作者： Menghan Zhang Hong-Xiang Zheng Shi yan Li jin State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life SciencesFudan University Human Phenome Institute Fudan University Ministry of Education Key Laboratory of Contemporary Anthropology School of Life SciencesFudan University Chinese Academy of Sciences Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational Biology SIBS CAS

In opposition to the mother tongue hypothesis, the father tongue hypothesis states that humans tend to speak their fathers’ language, based on a stronger correlation of languages to paternal lineages(Y-chromosome) than to maternal lineages(mitochondria). To reassess these two competing hypotheses,we conducted a genetic–linguistic study of 34 modern Indo-European(IE) populations. In this study,genetic histories of paternal and maternal migrations in these IE populations were elucidated using phylogenetic networks of Y-chromosomal and mitochondrial DNA haplogroups, respectively. Unlike previous studies, we quantitatively characterized the languages based on lexical and phonemic systems separately. We showed that genetic and linguistic distances are significantly correlated with each other and that both are correlated with geographical distances among these populations. However, when controlling for geographical factors, only the correlation between the distances of paternal and lexical characteristics,and between those of maternal and phonemic characteristics, remained. These unbalanced correlations reconciled the two seemingly conflicting hypotheses.

关键词： Indo-European populations Y-chromosomal haplogroup mitochondrial DNA haplogroup lexical system phonemic system

Experimental investigation and correlations for proppant distribution in narrow fractures of deep shale gas reservoirs

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Petroleum Science 2022年第2期19卷 619-628页

作者： Hao Zeng yan jin Hai Qu Yun-Hu Lu College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China College of Petroleum Engineering Chongqing University of Science and TechnologyChongqing401331China

Hydraulic fracturing is a crucial stimulation for the development of deep shale gas reservoirs.A key challenge to the effectiveness of hydraulic fracturing is to place small proppants in complex narrow fractures *** experiments with varied particle and fluid parameters are carried out in a narrow planar channel to understand particle transport and *** four dimensionless parameters,including the Reynold number,Shields number,density ratio,and particle volume fraction,are introduced to describe the particle transport in narrow *** results indicate that the narrow channel probably induces fluid fingers and small particle aggregation in a highly viscous fluid,leading to particle settlement near the *** low viscous fluid is beneficial to disperse particles further into the fracture,especially in the high-speed fluid *** linear and natural logarithmic laws have relationships with dimensionless parameters *** multiple linear regression method developed two correlation models with four dimensionless parameters to predict the bed equilibrium height and covered area of small particles in narrow *** study provides fundamental insight into understanding small size proppant distribution in deep reservoirs.

关键词： Proppant transport Multiphase flow Hydraulic fracturing Deep reservoir Narrow fractures