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Chinese Journal of Structural Chemistry 2021年第10期40卷 1309-1316页

作者： yan zhen-shuo KANG yan-Hui CHEN yang-Ling HUO Li-Ni Guangxi University of Chinese Medicine Nanning 530001China Hebei University of Engineering Handan 056038China

A highly selective iron ions fluorescent probe based on the benz(c)acridine-1,2,3-triazole derivatives was produced by multi-step reactions. 1-(7-Benz[c]acridinyl)-4-(4-methylphenyl)-1,2,3-triazole(4 a), C_(26)H_(18)N_(4), was structurally determined by single-crystal X-ray diffraction. It crystallizes in the trigonal system, space group R-3 with a = 36.230(10), b = 36.230(10), c = 7.993(3)Å, β = 90°, V = 9086(6)Å^(3), Z = 18, D_(c)= 1.271 g/cm^(3), F(000) = 3636, μ = 0.602 mm^(-1), the final R = 0.0865 and wR = 0.1619 for 3951 observed reflections(I > 2σ(I)). X-ray analysis indicated that all four rings of benz(c)acridine are in the same plane, and the 1,2,3-triazole ring and the corresponding linked benzene(C(1)–C(6)–C(7)–C(8)–C(9)–N(1)) are approximately perpendicular with a dihedral angle of 106.5°. The crystal packing of the compound was stabilized by two weak interactions between C(11)–H(10)…N(4) and C(18)–H(18)…N(1). In fluorescence spectra studies, compound 4 c was exhibited good selectivity and sensitivity towards iron ions in DMSO: mops buffer solution. Furthermore, 4 c was successfully used for imaging iron ions in living He La cervical cancer cells.

关键词： benz(c)acridine-1 2 3-triazole crystal structure fluorescent probe iron ions

Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu zhen Gu Hua yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen zhen Wei Yufei Mei yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

化香树果序挥发油活性成分及药理作用机制研究

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中国新药杂志 2020年第10期29卷 1149-1158页

作者：刘本涛袁彩英陈睿黄嘉咏严振硕霍丽妮梁燕广西中医药大学药学院南宁530001 广西中医药大学赛恩斯新医药学院南宁530222 广西医科大学药学院南宁530021

目的:利用网络药理学方法研究化香树果序挥发油活性成分及其药理作用机制。方法:从已公开发表的文献中收集化香树果序挥发油的化学成分,筛选出活性成分并对其潜在靶点及信号通路进行预测,采用Cytoscape3.7.1软件构建活性成分-靶点-通路... 详细信息

目的:利用网络药理学方法研究化香树果序挥发油活性成分及其药理作用机制。方法:从已公开发表的文献中收集化香树果序挥发油的化学成分,筛选出活性成分并对其潜在靶点及信号通路进行预测,采用Cytoscape3.7.1软件构建活性成分-靶点-通路网络,阐明化香树果序挥发油防治疾病的作用机制,并利用分子对接软件SYBYL对活性成分与其核心靶点进行分子对接验证。结果:经筛选得到9个化香树果序挥发油活性成分,经基因本体(gene ontology,GO)注释和京都基因与基因百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路富集分析以及活性成分-靶点-通路网络的构建,预测到21个核心作用靶点和10条主要信号通路。分子对接结果显示,大多数活性成分与其核心靶点具有较高的对接得分,表明二者结合活性较好,并且活性化合物主要通过疏水作用和氢键与其靶蛋白结合。结论:化香树果序挥发油活性成分主要是通过氮代谢、PPAR信号通路在神经退行性疾病、炎症性疾病、心脑血管疾病、肿瘤等多种疾病中发挥其药效作用。

关键词：化香树果序挥发油网络药理学活性成分作用靶点信号通路

Integration of Electrical Properties and Polarization Loss Modulation on Atomic Fe–N‑RGO for Boosting Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang Yuefeng yan zhen Wang Guansheng Ma Dechang Jia Xiaoxiao Huang Yu Zhou State Key Laboratory of Precision Welding&Joining of Materials and Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key Laboratory of Advanced Structural‑Functional Integration Materials&Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing effective strategies to regulate graphene’s conduction loss and polarization has become a key to expanding its application in the electromagnetic wave absorption(EMWA)*** on the unique energy band structure of graphene,regulating its bandgap and electrical properties by introducing heteroatoms is considered a feasible ***,metal-nitrogen doping reduced graphene oxide(M–N-RGO)was prepared by embedding a series of single metal atoms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd,and Sn)in RGO using an N-coordination atom-assisted *** composites had adjustable conductivity and polarization to optimize dielectric loss and impedance matching for efficient EMWA *** results showed that the minimum reflection loss(RL_(min))of Fe–N-RGO reaches−74.05 dB(2.0 mm)and the maximum effective absorption bandwidth(EAB_(max))is 7.05 GHz(1.89 mm)even with a low filler loading of only 1 wt%.Combined with X-ray absorption spectra(XAFS),atomic force microscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the polarization center to increase dipole polarization,interface polarization and defect-induced polarization due to d-p orbital hybridization and structural ***,electron migration within the Fe further leads to conduction loss,thereby synergistically promoting energy *** study demonstrates the effectiveness of metal-nitrogen doping in regulating the graphene′s dielectric properties,which provides an important basis for further investigation of the loss mechanism.

关键词： Electromagnetic wave absorption Fe-N-RGO Dipole polarization Conduction loss Impedance matching

培美曲塞注射剂联合顺铂注射剂治疗非小细胞肺癌的临床疗效研究

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中国临床药理学杂志 2018年第7期34卷 790-792页

作者：袁征李珍孙彦珍郭力硕徐赟黄建敏南阳市中心医院病理科河南南阳473000 南阳市中心医院肿瘤科河南南阳473000 郑州大学第一附属医院生物细胞治疗中心郑州450052

目的观察培美曲塞注射剂联合顺铂注射剂治疗非小细胞肺癌的临床疗效及安全性。方法将42例非小细胞肺癌患者随机分为对照组21例和试验组21例。对照组予以静脉滴注500 mg·m^(-2)培美曲塞(第1天);试验组予以静脉滴注500 mg·m^(-2)培美曲... 详细信息

目的观察培美曲塞注射剂联合顺铂注射剂治疗非小细胞肺癌的临床疗效及安全性。方法将42例非小细胞肺癌患者随机分为对照组21例和试验组21例。对照组予以静脉滴注500 mg·m^(-2)培美曲塞(第1天);试验组予以静脉滴注500 mg·m^(-2)培美曲塞(第1天),30 min后,静脉滴注25 mg·m^(-2)顺铂(第1~3天)。2组患者1个疗程均为3周,共治疗2个疗程。比较2组患者的临床疗效和药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为52.38%(11例/21例)和23.81%(5例/21例),差异有统计学意义(P0.05)。结论培美曲塞注射剂联合顺铂注射剂治疗非小细胞肺癌的临床疗效确切,且不增加药物不良反应的发生率。

关键词：培美曲塞注射剂顺铂注射剂非小细胞肺癌安全性

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化香树果序化学成分及药理作用研究进展

中国实验方剂学杂志 2019年第21期25卷 227-234页

作者：刘本涛袁彩英黄嘉咏严振硕吕金燕霍丽妮陈睿广西中医药大学药学院南宁530001 广西中医药大学赛恩斯新医药学院南宁530200

化香树果序源自于我国传统药用植物化香树的干燥果序,具有清热解毒、散风止痛、活血化淤、通窍排脓的功效,民间常用其治疗急慢性鼻炎、鼻窦炎以及急性上呼吸道感染等引起的各种并发症,是一种极具开发空间和利用价值的中药,拥有着广阔的... 详细信息

化香树果序源自于我国传统药用植物化香树的干燥果序,具有清热解毒、散风止痛、活血化淤、通窍排脓的功效,民间常用其治疗急慢性鼻炎、鼻窦炎以及急性上呼吸道感染等引起的各种并发症,是一种极具开发空间和利用价值的中药,拥有着广阔的市场前景。化香树果序中含有多种化学成分,主要包括挥发油类、酚类、黄酮类、萜类、糖类以及其他化合物,其中挥发油类成分居多但缺乏相关活性研究;酚类、黄酮类以及萜类化合物是其主要的活性成分,但目前这些成分仅有少数被分离鉴定得到。现代药理研究表明化香树果序具有抗肿瘤、抗病毒、抗炎抑菌、抗衰老、促生长、降压镇静等多方面药理活性,但现有研究主要以抗病毒、抗炎抑菌、抗肿瘤作用为主,其他方面的活性还不曾进行深入探究。在今后的研究中,应该深层次进行化香树果序化学成分及药理活性研究,并进一步明确其作用机制,使其得到更加充分合理的应用。该文通过在中国知网、维普、万方及Pub Med等数据库查阅近年来国内外相关文献,将化香树果序化学成分、药理作用及临床应用等方面研究进行归纳、总结并对其研究进展概况加以阐述,以期为化香树果序的深入研究和进一步开发应用提供理论参考。

关键词：化香树果序挥发油酚类黄酮类抗肿瘤抗病毒抗炎抑菌

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing Zhao yan Song Yahong Cheng Tong Li zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

基于网络药理学的罗汉果止咳化痰活性成分靶点研究

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湖南师范大学自然科学学报 2019年第1期42卷 40-48页

作者：吕金燕黄嘉咏袁彩英霍丽妮陈睿严振硕赖泽锋广西中医药大学药学院中国南宁530001 广西中医药大学赛恩斯新医药学院中国南宁530222 广西医科大学药学院中国南宁530021

为预测罗汉果止咳化痰有效成分、潜在靶点及通路,探讨其"多成分—多靶点—多通路"的止咳化痰作用机制,首先通过TCMSP平台筛选罗汉果内13种具有止咳化痰活性的化学成分;然后利用PharmMapper筛选罗汉果止咳化痰的潜在靶点,同时借助DAVID... 详细信息

为预测罗汉果止咳化痰有效成分、潜在靶点及通路,探讨其"多成分—多靶点—多通路"的止咳化痰作用机制,首先通过TCMSP平台筛选罗汉果内13种具有止咳化痰活性的化学成分;然后利用PharmMapper筛选罗汉果止咳化痰的潜在靶点,同时借助DAVID数据库进行GO富集分析和KEGG通路注释分析;最后采用Cytoseape软件构建罗汉果止咳化痰病的"成分—靶点—通路"网络模型。结果表明,罗汉果的13个活性成分以罗汉果皂苷为主,其可能是通过HNMT,IL2,IGF1,ABO,TRAPPC3,SERPINA1,THRA等37个止咳化痰相关靶点调控Proteplycans in cancer,pathways in cancer,serotonergic synapse,Fox O signaling patheway,Glioma,Melanoma,Renin-angiotensin system等25条信号通路。此外,本文还通过SYBYL软件将罗汉果活性成分与靶点进行分子对接,进一步解析了罗汉果主要活性成分与止咳化痰靶点的作用方式,为下一步探讨其止咳化痰靶点及机制的验证实验指明了方向。

关键词：罗汉果网络药理学潜在靶点止咳化痰分子对接