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Science China(Technological Sciences) 2024年第2期67卷 587-596页

作者： TANG Jian WU YuTing MA ShiDong ZHANG YuMin XU RuoJie yan tao PAN ZhiJuan College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123China National Engineering Laboratory for Modern Silk Suzhou 215123China

Various yarn-shaped flexible strain sensors have recently been ***,research is lacking on additive manufacturing for smart clothing for integrating yarn sensors with commercial ***,a strain-sensing yarn is sewn into a piece of fabric through a novel stitching technique,and the influence of the stitching method and needle pitch on the sensing performance is investigated using finite element analysis(FEA).The sensing performance could be improved when the sensing yarn is self-locked in the fabric at the needle eyes,and the needle pitch was reduced to 0.5 cm,which is attributed to the enhanced stress and strain ***,the composite sensing fabric featured outstanding performance,including a low detection limit(0.1%),rapid response(280 ms),excellent durability(10000 cycles),and high stability(negligible drift and frequency independence).In addition,the remarkable wear resistance,washability,and anti-interference to ambient humidity and perspiration were ***,the optimal stitch trace lengths of sensing yarn for detecting elbow motion,breathing,and heartbeats are ***,a smart clothing system composed of smart clothing,data acquisition unit,and mobile APP was developed to simultaneously detect human movement and physiological *** work provides a reference to produce intelligent garments based on yarn sensors for health monitoring.

关键词： strain-sensing yarn composite sensing fabric smart clothing system stitching technology health monitoring

Xuebijing improves intestinal microcirculation dysfunction in septic rats by regulating the VEGF-A/PI3K/Akt signaling pathway

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World Journal of Emergency Medicine 2024年第3期15卷 206-213页

作者： A-ling Tang yan Li Li-chao Sun Xiao-yu Liu Nan Gao Sheng-tao yan Guo-qiang Zhang Department of Emergency China-Japan Friendship HospitalBeijing 100029China Graduate School Beijing University of Chinese MedicineBeijing 100105China

BACKGROUND:This study aims to explore whether Xuebijing(XBJ) can improve intestinal microcirculation dysfunction in sepsis and its ***:A rat model of sepsis was established by cecal ligation and puncture(CLP).A total of 30 male SD rats were divided into four groups:sham group,CLP group,XBJ + axitinib group,and XBJ *** was intraperitoneally injected 2 h before *** data(blood pressure and heart rate) were *** intestinal microcirculation data of the rats were analyzed via microcirculation ***-linked immunosorbent assay(ELISA) kits were used to detect the serum levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α) in the *** analysis and transmission electron microscopy were used to analyze the injury of small intestinal microvascular endothelial cells and small intestinal mucosa in *** expression of vascular endothelial growth factor A(VEGF-A),phosphoinositide 3-kinase(PI3K),phosphorylated PI3K(p-PI3K),protein kinase B(Akt),and phosphorylated Akt(p-Akt) in the small intestine was analyzed via Western ***:XBJ improved intestinal microcirculation dysfunction in septic rats,alleviated the injury of small intestinal microvascular endothelial cells and small intestinal mucosa,and reduced the systemic inflammatory ***,XBJ upregulated the expression of VEGF-A,p-PI3K/total PI3K,and p-Akt/total Akt in the rat small ***:XBJ may improve intestinal microcirculation dysfunction in septic rats possibly through the VEGF-A/PI3K/Akt signaling pathway.

关键词： Sepsis Xuebijing Vascular endothelial growth factor A Microcirculation Rat Phosphoinositide 3-kinase Protein kinase B

Effects of cooling rate on microstructure and microhardness of directionally solidified Galvalume alloy

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China Foundry 2024年第3期21卷 213-220页

作者： Ji-peng Li De-gao Qiao Jian Li Xiao-yang Luo Peng Peng Xian-tao yan Xu-dong Zhang Gansu Jiu Steel Group Hongxing Iron and Steel Co. Ltd.Jiayuguan 735111GansuChina School of Materials and Energy Lanzhou UniversityLanzhou 730000China

The influences of cooling rate on the phase constitution,microstructural length scale,and microhardness of directionally solidified Galvalume(Zn-55Al-1.6Si)alloy were investigated by directional solidification experiments at different withdrawal speeds(5,10,20,50,100,200,and 400μm·s^(-1)).The results show that the microstructure of directionally solidified Galvalume alloys is composed of primary Al dendrites,Si-rich phase and(Zn-Al-Si)ternary eutectics at the withdrawal speed ranging from 5 to 400μm·s^(-1).As the withdrawal speed increases,the segregation of Si element intensifies,resulting in an increase in the area fraction of the Si-rich *** addition,the primary Al dendrites show significant refinement with an increase in the withdrawal *** relationship between the primary dendrite arm spacing(λ_(1))and the thermal parameters of solidification is obtained:λ_(1)=127.3V^(-0.31).Moreover,as the withdrawal speed increases from 5 to 400μm·s^(-1),the microhardness of the alloy increases from 90 HV to 151 *** is a combined effect of grain refinement and second-phase strengthening.

关键词： Galvalume alloy directional solidification microstructure length scale microhardness

Treatment with β-sitosterol ameliorates the effects of cerebral ischemia/reperfusion injury by suppressing cholesterol overload, endoplasmic reticulum stress, and apoptosis

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Neural Regeneration Research 2024年第3期19卷 642-649页

作者： Xiuling Tang tao yan Saiying Wang Qingqing Liu Qi yang Yongqiang Zhang Yujiao Li Yumei Wu Shuibing Liu Yulong Ma Le yang Precision Pharmacy&Drug Development Center Department of PharmacyTangdu HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Clinical Pharmacy Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu ProvinceChina Department of Pharmacology School of PharmacyAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Anesthesiology The First Medical Center of Chinese PLA General HospitalBeijingChina Department of Anatomy Histology and Embryology and K.K.Leung Brain Research CentreAir Force Medical UniversityXi’anShaanxi ProvinceChina

β-Sitosterol is a type of phytosterol that occurs naturally in *** studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic *** we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced *** investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic *** addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its *** conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.

关键词： apoptosis blood-brain barrier β-sitosterol cerebral ischemia/reperfusion injury cholesterol overload cholesterol transport endoplasmic reticulum stress ischemic stroke molecular docking NPC1L1

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异化与共鸣:H.罗萨批判理论审思

世界哲学 2024年第1期 26-36页

作者：闫涛天津大学马克思主义学院

人在追求幸福生活的过程中难免会遭遇问题与困境,法兰克福学派第四代代表人物罗萨提出了自己的新异化与共鸣理论,笔者试图剖析、审思罗萨的社会批判理论的逻辑本质,进而明确马克思的人本逻辑终将代替资本逻辑是人追求幸福生活的根本路... 详细信息

人在追求幸福生活的过程中难免会遭遇问题与困境,法兰克福学派第四代代表人物罗萨提出了自己的新异化与共鸣理论,笔者试图剖析、审思罗萨的社会批判理论的逻辑本质,进而明确马克思的人本逻辑终将代替资本逻辑是人追求幸福生活的根本路径。罗萨从对耶给的异化概念的批判出发,对现代社会的种种新异化现象进行剖析,并以其“共鸣”理论作为疗愈方案。在“加速”成为现代人普遍心理感受的当下,罗萨对现代社会的病理分析和诊断也引发了不少“共鸣”。然而,罗萨的新异化理论归根到底仍然只是解释世界的理论,罗萨用以破解异化问题的共鸣是主体与世界关系的偶然状态,共鸣犹如昙花一现,这也使得这一理论本身呈现出偶然性、不确定性的特点。从马克思主义人学视角出发,批判性反思罗萨的异化和共鸣理论,可更好地呈现其理论的合理性以及先天缺陷,从而在一种自觉的理论对话中,丰富马克思主义伦理学研究。

关键词：批判罗萨异化共鸣

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冯友兰哲学“负的方法”平议

哲学分析 2024年第3期15卷 53-64,197页

作者：阎韬南京大学学报编辑部

冯友兰先生对于所谓哲学的“负的方法”,即神秘主义的方法,曾下很大功夫来阐释。他认为关于宇宙本体,负的方法是“不说它”而“表显”它。他对禅宗的“表显”进行过多方面的考察,但因以“六经注我”的方式利用史料,许多解释都有背原意... 详细信息

冯友兰先生对于所谓哲学的“负的方法”,即神秘主义的方法,曾下很大功夫来阐释。他认为关于宇宙本体,负的方法是“不说它”而“表显”它。他对禅宗的“表显”进行过多方面的考察,但因以“六经注我”的方式利用史料,许多解释都有背原意。他自己编制的“表显”公式——新“五位”说,也不成功。所谓“表显”,实质上不过是另类言说,花样翻新地重复着“说不可说”的自反式悖论。

关键词：禅宗维特根斯坦负的方法表显

2013~2020年甘肃省PM_(2.5)健康负担的时空变化趋势及驱动力

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环境科学 2024年第7期45卷 3893-3902页

作者：廖琴李勇陶燕兰州大学资源环境学院西部环境教育部重点实验室兰州730000 中国科学院西北生态环境资源研究院兰州730000 贵州医科大学环境污染与疾病监控教育部重点实验室贵阳550025

为评估大气污染防治行动计划以来,甘肃省PM_(2.5)相关健康影响的时空变化趋势及其驱动因素,应用最新的全球暴露死亡模型(GEMM)估算了2013~2020年甘肃省归因于PM_(2.5)的健康负担,并通过因素分解法进一步探讨了PM_(2.5)归因死亡长期变化... 详细信息

为评估大气污染防治行动计划以来,甘肃省PM_(2.5)相关健康影响的时空变化趋势及其驱动因素,应用最新的全球暴露死亡模型(GEMM)估算了2013~2020年甘肃省归因于PM_(2.5)的健康负担,并通过因素分解法进一步探讨了PM_(2.5)归因死亡长期变化的主要原因.结果表明,2013~2020年,甘肃省人口加权PM_(2.5)浓度下降了34.57%,暴露于PM_(2.5)年均浓度超过35μg·m^(-3)的人口比例从72.89%大幅下降至11.61%.研究期间,甘肃省PM_(2.5)归因死亡人数从12 826(95%CI:7 840~17 408)人下降至9 814(95%CI:6 407~13 036)人,下降了23.48%;其中,缺血性心脏病的归因死亡人数有所增加(12.11%),而中风、慢性阻塞性肺病、肺癌和下呼吸道感染的归因死亡人数呈下降趋势;60岁及以上人群的归因死亡人数占80%以上;中东部地区的PM_(2.5)归因死亡人数显著高于河西地区,且大部分地区呈下降趋势;人口规模、年龄结构、基线死亡率和PM_(2.5)浓度在归因死亡人数变化中的贡献分别为-1.26%、16.16%、-9.84%和-28.55%,人口老龄化和PM_(2.5)浓度降低是PM_(2.5)归因死亡增加和减少的主要因素.甘肃省积极的清洁空气政策减轻了PM_(2.5)污染造成的健康负担,但在人口老龄化加剧的趋势下,未来需要大幅降低PM_(2.5)浓度才能避免更多的归因死亡.

关键词： PM_(2.5) 过早死亡 GEMM模型驱动因素健康效益

Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling

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World Journal of Diabetes 2024年第2期15卷 287-304页

作者： Huai-Jie Wang Li-Bin Zhang Si-Peng Sun Qing-tao yan Zhi-Qin Gao Fang-Ming Fu Mei-Hua Qu Translational Medical Center Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Endocrinology Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Pediatric Surgery Weifang People’s HospitalWeifang 261041Shandong ProvinceChina School of Bioscience and Technology Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Endocrinology Jinan Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)is often accompanied by impaired glucose utilization in the brain,leading to oxidative stress,neuronal cell injury and *** studies have shown that duodenal jejunal bypass(DJB)surgery significantly improves brain glucose metabolism in T2DM rats,the role and the metabolism of DJB in improving brain oxidative stress and inflammation condition in T2DM rats remain *** To investigate the role and metabolism of DJB in improving hypothalamic oxidative stress and inflammation condition in T2DM *** A T2DM rat model was induced via a high-glucose and high-fat diet,combined with a low-dose streptozotocin injection.T2DM rats were divided into DJB operation and Sham operation *** surgical intervention was carried out on T2DM *** differential expression of hypothalamic proteins was analyzed using quantitative proteomics *** related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of T2DM rats were analyzed by flow cytometry,quantitative real-time PCR,Western blotting,and *** Quantitative proteomics analysis showed significant differences in proteins related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of rats with T2DM-DJB after DJB surgery,compared to the T2DM-Sham groups of *** stress-related proteins(glucagon-like peptide 1 receptor,Nrf2,and HO-1)were significantly increased(P<0.05)in the hypothalamus of rats with T2DM after DJB *** surgery significantly reduced(P<0.05)hypothalamic inflammation in T2DM rats by inhibiting the activation of NF-κB and decreasing the expression of interleukin(IL)-1βand *** surgery significantly reduced(P<0.05)the expression of factors related to neuronal injury(glial fibrillary acidic protein and Caspase-3)in the hypothalamus of T2DM rats and upregulated(P<0.05)the expression of neuroprotective factors(C-fos,Ki67,Bcl-2,and BDNF),thereby reducing hypot

关键词： Duodenal jejunal bypass surgery Type 2 diabetes mellitus Neuron apoptosis Inflammatory Oxidative stress Hypothalamic injury

EEG光子处理器——基于衍射光子计算单元的癫痫发作检测

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Engineering 2024年第4期35卷 56-66页

作者： tao yan Maoqi Zhang Hang Chen Sen Wan Kaifeng Shang Haiou Zhang Xun Cao Xing Lin Qionghai Dai Department of Automation Tsinghua UniversityBeijing 100084China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Institute for Brain and Cognitive Sciences Tsinghua UniversityBeijing 100084China School of Electronic Science and Engineering Nanjing UniversityNanjing 210023China Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China

Electroencephalography(EEG)analysis extracts critical information from brain signals,enabling brain disease diagnosis and providing fundamental support for brain–computer ***,performing an artificial intelligence analysis of EEG signals with high energy efficiency poses significant challenges for electronic processors on edge computing devices,especially with large neural network ***,we propose an EEG opto-processor based on diffractive photonic computing units(DPUs)to process extracranial and intracranial EEG signals effectively and to detect epileptic *** signals of the EEG channels within a second-time window are optically encoded as inputs to the constructed diffractive neural networks for classification,which monitors the brain state to identify symptoms of an epileptic *** developed both free-space and integrated DPUs as edge computing systems and demonstrated their applications for real-time epileptic seizure detection using benchmark datasets,that is,the Children’s Hospital Boston(CHB)–Massachusetts Institute of Technology(MIT)extracranial and Epilepsy-iEEG-Multicenter intracranial EEG datasets,with excellent computing performance *** with the channel selection mechanism,both numerical evaluations and experimental results validated the sufficiently high classification accuracies of the proposed opto-processors for supervising clinical *** study opens a new research direction for utilizing photonic computing techniques to process large-scale EEG signals and promote broader applications.

关键词： Epileptic seizure detection EEG analysis Diffractive photonic computing unit Photonic computing

基于ABAQUS二次开发的6016铝合金热连轧过程有限元分析

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塑性工程学报 2024年第6期31卷 87-94页

作者：闫松涛杨斌江海涛北京科技大学国家材料服役安全科学中心北京102206 重庆美利信科技股份有限公司重庆401321 北京科技大学高效轧制与智能制造国家工程研究中心北京100083

通过ABAQUS建立了6016铝合金热连轧有限元模型,在VUSDFLD用户子程序的基础上,用Fortran语言编写了静态再结晶函数,二次开发了ABAQUS软件。通过引入材料本构模型以及再结晶晶粒演变模型,实现了6016铝合金热连轧过程热、力及微观组织多参... 详细信息

通过ABAQUS建立了6016铝合金热连轧有限元模型,在VUSDFLD用户子程序的基础上,用Fortran语言编写了静态再结晶函数,二次开发了ABAQUS软件。通过引入材料本构模型以及再结晶晶粒演变模型,实现了6016铝合金热连轧过程热、力及微观组织多参数耦合。利用该模型研究了多道次(17道次)热连轧过程中6016铝合金等效应力场、等效应变场、温度场和组织的演变,并通过实验验证了热连轧过程中的再结晶行为。结果表明:与心部相比,轧板表面温度低、变形大、再结晶百分数低、晶粒尺寸大。触换热系数是影响热连轧过程温度场变化的主要因素,应力场及轧制力与摩擦因数、接触面积等因素相关;在轧制温度和塑性变形的综合作用下, 6016铝合金发生再结晶。模拟结果与实际生产数据对比表明,该数值计算模型符合实际生产。

关键词：有限元模拟二次开发铝合金热连轧