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特纳综合征合并大疱性类天疱疮1例

中国皮肤性病学杂志 2024年第3期38卷 325-328页

作者：董帅朱文静牟妍吉林大学第二医院皮肤科吉林长春130041

患者女,35岁,全身泛发红斑水疱8 d。皮肤科情况:全身泛发红斑,其上可见大小不等的水疱,部分水疱基底不红,为正常肤色,外阴及四肢部分水疱破溃渗出,水疱疱壁较厚,尼氏征(-),双下肢轻度肿胀。皮损组织病理及直接免疫荧光符合大疱性类天疱... 详细信息

患者女,35岁,全身泛发红斑水疱8 d。皮肤科情况:全身泛发红斑,其上可见大小不等的水疱,部分水疱基底不红,为正常肤色,外阴及四肢部分水疱破溃渗出,水疱疱壁较厚,尼氏征(-),双下肢轻度肿胀。皮损组织病理及直接免疫荧光符合大疱性类天疱疮。患者30年前于外院确诊为特纳综合征。诊断:特纳综合征合并大疱性类天疱疮。给予糖皮质激素等常规治疗后效果不佳,加用静脉注射人免疫球蛋白治疗2周后病情好转。

关键词：特纳综合征大疱性类天疱疮静脉注射免疫球蛋白

无创呼吸机联合吡非尼酮对特发性肺间质纤维化的临床疗效

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当代医学 2024年第1期30卷 157-160页

作者：齐荣艳牟艳临清市人民医院呼吸与危重症医学科山东聊城252600

目的分析无创呼吸机联合吡非尼酮对特发性肺间质纤维化(IPF)的临床疗效。方法选取2019年12月至2020年12月临清市人民医院收治的120例IPF患者作为研究对象,按照随机数字表法分为研究组与对照组,每组60例。对照组采用无创呼吸机治疗,研究... 详细信息

目的分析无创呼吸机联合吡非尼酮对特发性肺间质纤维化(IPF)的临床疗效。方法选取2019年12月至2020年12月临清市人民医院收治的120例IPF患者作为研究对象,按照随机数字表法分为研究组与对照组,每组60例。对照组采用无创呼吸机治疗,研究组在对照组基础上联用吡非尼酮,比较两组临床疗效、肺功能指标[第1秒用力呼气容积(FEV1)及第1秒用力呼气容积占预计值的百分比(FEV1/FVC%)]、血流动力学指标[平均动脉压(MAP)、心率(HR)]及血清炎症因子[肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)]水平。结果研究组治疗总有效率为96.67%,高于对照组的85.00%,差异有统计学意义(P<0.05);治疗后,两组FEV1、FEV1/FVC%均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组MAP、HR均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组TNF-ɑ、IL-6水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。结论无创呼吸机联合吡非尼酮治疗IPF的疗效显著,能有效缓解患者心肺功能指标,改善血流动力学指标和炎症因子水平,值得临床推广应用。

关键词：无创呼吸机吡非尼酮特发性肺间质纤维化心肺功能

三级甲等综合医院临床护士自我关怀量表的常模构建

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护理学杂志 2024年第16期39卷 47-50页

作者：牟艳潘珊史崇清谢梦瑶常红娟武汉科技大学医学院护理系湖北武汉430065 新乡医学院护理学院

目的建立我国三级甲等综合医院临床护士自我关怀量表常模,为评估临床护士自我关怀水平提供参考。方法采取分层随机抽样,抽取我国华北、东北、华东、中南、西南和西北6个地区16个城市的三级甲等综合性医院临床护士作为研究对象,采用一般... 详细信息

目的建立我国三级甲等综合医院临床护士自我关怀量表常模,为评估临床护士自我关怀水平提供参考。方法采取分层随机抽样,抽取我国华北、东北、华东、中南、西南和西北6个地区16个城市的三级甲等综合性医院临床护士作为研究对象,采用一般情况调查表和自我关怀量表进行调查,建立我国三级甲等综合医院临床护士自我关怀量表均数常模、百分位常模、划界常模和分类常模。结果共纳入3920名临床护士,自我关怀总均分为(3.24±0.44)分,自我友善维度(3.39±0.62)分、自我评判维度(3.14±0.66)分、普遍人性感维度(3.35±0.62)分、孤立感维度(3.14±0.75)、正念维度(3.44±0.65)分、过度沉迷维度(2.97±0.75)分;根据特征差异形成不同年龄、科室、职称、职务、学历、从事护理年限、劳动人事关系、平均月收入的分类常模;以5%为间隔构建百分位常模,根据总分的10%、30%、70%、90%百分位数建立划界常模,总分在区间[3.81,5.00)为高,在区间[3.38,3.81)为较高,在区间[3.00,3.38)为一般,在区间[2.81,3.00)为较低,在区间[0,2.81)为低。结论三级甲等综合医院临床护士自我关怀处于一般水平且受多种因素影响,护理管理者可依据该常模评估护士的自我关怀水平,并针对不同影响因素实施干预,提升护士的自我关怀水平。

关键词：护士自我关怀自我友善自我评判人性感孤立感正念常模

老年前列腺癌腹腔镜手术效果及术后生化复发的影响因素

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中华老年多器官疾病杂志 2024年第7期23卷 505-509页

作者：朱通牟燕何俊奉友刚遂宁市中心医院泌尿外科四川遂宁629000

目的评估不同腹腔镜手术入路方式在治疗老年前列腺癌中的应用效果,并分析患者术后生化复发的影响因素。方法收集2019年1月至2021年6月遂宁市中心医院行腹腔镜下前列腺癌根治术治疗的164例前列腺癌老年患者的临床资料,其中88例行膀胱前... 详细信息

目的评估不同腹腔镜手术入路方式在治疗老年前列腺癌中的应用效果,并分析患者术后生化复发的影响因素。方法收集2019年1月至2021年6月遂宁市中心医院行腹腔镜下前列腺癌根治术治疗的164例前列腺癌老年患者的临床资料,其中88例行膀胱前入路治疗(前入路组),76例行膀胱后入路治疗(后入路组)。比较两组围术期指标、并发症及术后生化复发情况。采用SPSS 24.0软件进行数据分析。根据数据类型,组间比较分别采用t检验及χ^(2)检验。采用Log Rank法检验未生化复发生存时间,采用logistic回归分析评估前列腺癌老年患者腹腔镜下前列腺癌根治术后生化复发的影响因素。结果前入路组手术时间、留置尿管时间及住院时间均低于后入路组(P0.05)。logistic回归分析显示,术前前列腺特异性抗原≥10.0μg/L(OR=2.924,95%CI 1.753~4.877)、术后Gleason评分>7分(OR=3.068,95%CI 1.852~5.081)、手术切缘阳性(OR=2.547,95%CI 1.417~4.578)均为腹腔镜下前列腺癌根治术后生化复发的危险因素(P<0.05)。结论膀胱前入路腹腔镜下前列腺癌根治术可缩短手术时间,有利于前列腺癌老年患者术后恢复;术前高PSA水平、术后高Gleason评分及手术切缘阳性患者更易发生生化复发,临床应密切监测。

关键词：老年人前列腺癌前列腺癌根治术膀胱前入路膀胱后入路生化复发

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基于内容分析法的国家谈判药品落地政策分析

中国医药工业杂志 2024年第7期55卷 1032-1036页

作者：强滟张好辰牟燕宋燕张前进山东第一医科大学(山东省医学科学院)医疗保障学院山东济南250117 山东省医药卫生科技信息研究所山东济南250062 山东省医疗保险基金稽核中心山东济南250024

国家谈判药品政策是降低药品价格、提升重大疾病保障能力的重要政策举措之一,目前已进入常态化趋势。文章采用内容分析法基于政策工具和利益相关者二维框架,分析促进国家谈判药品落地的相关政策文本,对政策进行量化编码,探讨现有政策的... 详细信息

国家谈判药品政策是降低药品价格、提升重大疾病保障能力的重要政策举措之一,目前已进入常态化趋势。文章采用内容分析法基于政策工具和利益相关者二维框架,分析促进国家谈判药品落地的相关政策文本,对政策进行量化编码,探讨现有政策的侧重点及不足,为后续政策的制定及优化提供一定参考,进一步提高国家谈判药品的可及性。

关键词：国家谈判药品内容分析法政策工具利益相关者

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声学三维量子霍尔态的观测

Science Bulletin 2024年第14期69卷 2187-2193页

作者：张学伟魏强彭冕邓伟胤陆久阳黄学勤贾锁堂严谋刘正猷陈刚 State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China Key Laboratory of Materials Physics Ministry of EducationSchool of PhysicsZhengzhou UniversityZhengzhou 450001China Laboratory of Zhongyuan Light School of PhysicsZhengzhou UniversityZhengzhou 450001China Institute of Quantum Materials and Physics Henan Academy of SciencesZhengzhou 450046China Key Laboratory of Artificial Micro-and Nanostructures of Ministry of Education and School of Physics and Technology Wuhan UniversityWuhan 430072China Institute for Advanced Studies Wuhan UniversityWuhan 430072China

Quantum Hall effect,the quantized transport phenomenon of electrons under strong magnetic fields,remains one of the hottest research topics in condensed matter physics since its discovery in 2D electronic ***,as a great advance in the research of quantum Hall effects,the quantum Hall effect in 3D systems,despite its big challenge,has been achieved in the bulk ZrTe_(5)and Cd_(3)As_(2)***,Cd_(3)As_(2)is a Weyl semimetal,and quantum Hall effect is hosted by the Fermi arc states on opposite surfaces via the Weyl nodes of the bulk,and induced by the unique edge states on the boundaries of the opposite ***,such intriguing edge state distribution has not yet been experimentally ***,we aim to reveal experimentally the unusual edge states of Fermi arcs in acoustic Weyl system with the aid of pseudo-magnetic *** from the macroscopic nature of acoustic crystals,the pseudo-magnetic field is introduced by elaborately designed the gradient onsite energy,and the edge states of Fermi arcs on the boundaries of the opposite surfaces are unambiguously demonstrated in *** system serves as an ideal and highly tunable platform to explore the Hall physics in 3D system,and has the potential in the application of new acoustic devices.

关键词： Quantum Hall effects Acoustic crystals Pseudo-magnetic field Landau levels Edge states

Unilateral lichen planus with Blaschko line distribution: A case report

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World Journal of Clinical Cases 2022年第24期10卷 8679-8685页

作者： Shuai Dong Wen-Jing Zhu Meng Xu Xue-Qi Zhao yan mou Department of Dermatology The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

BACKGROUND Lichen planus(LP)with distribution of lesions along Blaschko’s lines is a rare entity,accounting for 0.24%-0.62%of all *** distribution of lesions in arm,leg,trunk,and waist is even less *** 10%of patients with LP manifest nail *** SUMMARY A 20-year-old woman presented to our department with polygonal,purpuric,flattopped papules over the right arm,right leg,and right side of trunk and waist for the last 5 *** patient initially developed nail deformation in the left middle finger with no obvious cause,followed by development of blue-purple and red maculopapular rash with *** the disease course,the skin lesions aggravated and spread to several segments due to *** lesions showed unilateral distribution along the Blaschko’s *** diagnosis of LP along Blaschko’s lines was established based on dermoscopy and skin *** cutaneous lesions considerably improved after 4-wk treatment with intramuscular glucocorticoid,oral acitretin,topical glucocorticoid,and *** Cases of LP involving multiple segments of the body along the Blaschko’s lines with nail damage are rare.

关键词： Lichen planus Blaschko’lines Lichen planus involving nails Case report

Acoustic higher-order topology derived from first-order with built-in Zeeman-like fields

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Science Bulletin 2022年第5期67卷 488-494,M0004页

作者： Xueqin Huang Jiuyang Lu Zhongbo yan mou yan Weiyin Deng Gang Chen Zhengyou Liu School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China Key Laboratory of Artificial Micro-and Nanostructures of Ministry of Education and School of Physics and Technology Wuhan UniversityWuhan 430072China Institute for Advanced Studies Wuhan UniversityWuhan 430072China

Higher-order topological insulators(HOTIs),with topological corner or hinge states,have emerged as a thriving topic in the field of topological ***,few connections have been found for HOTIs with well-explored first-order topological *** a proposal asserted that a significant bridge can be established between the HOTIs and Z2 topological *** subjected to an inplane Zeeman field,corner states,the signature of the HOTIs,can be induced in a Z2 topological *** Zeeman fields can be produced,for example,by the ferromagnetic proximity effect or magnetic atom doping,which drastically increases the experimental ***,we show that a phononic crystal,designed as a bilayer of coupled acoustic cavities,exactly hosts the Kane-Mele model with built-in in-plane Zeeman *** helical edge states along the zigzag edges are gapped,and the corner states,localized spatially at the corners of the samples,appear in the *** verifies the Zeeman field induced higher-order *** further demonstrate the intriguing contrast properties of the corner states at the outer and inner corners in a hexagonal ring-shaped sample.

关键词： Higher-order topological insulator Corner state Kane-Mele model Zeeman field Phononic crystal

Microcystic adnexal carcinoma misdiagnosed as a“recurrent epidermal cyst”:A case report

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World Journal of Clinical Cases 2022年第22期10卷 8034-8039页

作者： Si-Xuan yang yan mou Shu Wang Xin Hu Fu-Qiu Li Department of Dermatology The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Radiotherapy The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Microbiology Graduate School of MedicineKyoto UniversityKyoto 606-8510Japan

BACKGROUND Microcystic adnexal carcinoma(MAC)is a rare malignant cutaneous adnexal neoplasm,often presenting as a flesh-colored and slow-growing indurated plaque or cystic nodule in the mid-facial *** characteristic indolent presentation usually leads to initial misdiagnosis,resulting in tumor mismanagement and added morbidity due to increased propensity for local *** SUMMARY A 63-year-old Chinese male patient with a long-term history of excessive ultraviolet irradiation had received two surgeries for an“epidermal cyst”on his glabella and was presented to our hospital’s Dermatology Department for further diagnosis and therapy of the lesion on his *** month ago,his two 7 mm×7 mm subcutaneous nodules were diagnosed as"recurrent epidermal cysts",and he underwent local excision ***,he has post medical history of surgery for right clear cell renal *** to his biopsy,the patient was diagnosed as MAC in our hospital,and a tumor remnant was found on his *** then underwent wide local excision to achieve negative margins and reconstruction of full-thickness flap transplantation for tissue *** remained tumor-free after six months of *** This case highlights the importance of MAC’s possible pathogenic factor of excessive ultraviolet exposure,its differential diagnosis to avoid misdiagnosis and mismanagement to adverse prognosis,the patient’s particular medical history of clear cell renal carcinoma,the alert for any tumor recurrence in older patients,and his uncommon multiple nodules mess consisting of two 7 mm×7 mm subcutaneous nodules,that will enrich the existing knowledge of MAC’s clinical features.

关键词： Microcystic adnexal carcinoma Recurrent epidermal cyst Differential diagnosis Clear cell renal carcinoma Excessive ultraviolet radiation Case report