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MAPKs signaling in 5-LOX pathway-associated inflammatory responses

中国药理学与毒理学杂志 2019年第10期 912-913页

作者： yan meng-die JIA Xiao-xia LI Cheng-tan QIU Ya-qing WANG yan-fang ZHANG Li-hui Department of Pharmacology Hangzhou Key Laboratory of Medical Neurobiology School of Medicine Hangzhou Normal University

5-Lipoxygenase(5-LOX) is a crucial enzyme catalyzing arachidonic acid to form cysteinyl leukotrienes(Cys LTs, including LTC4, LTD4, LTE4). Cys LTs are potent inflammatory mediators that mediate many pathophysiological responses by activating two distinct G-protein-coupled receptors(CysLT1R and CysLT2R). 5-LOX pathway is implicated in inflammatory pathological processes. Mitogenactivated protein kinases(MAPKs) are important signal transduction pathways of complex cellular *** MAPK families in mammalian cells include the P38 MAPK, extracellular signal-regulated kinases(ERK)and c-Jun amino N-terminal kinase(JNK). Increasing evidence has suggested that MAPKs signaling acts as key modulator in 5-LOX pathway-related pathological processes. It was reported that P38 MAPK and 5-LOX were dramatically activated to mediate neuronal injury in oxygen-glucose deprivation(OGD)-treated PC12 cells,which could be inhibited by P38 MAPK inhibitor SB203580 and nonselective 5-LOX inhibitor caffeic acid. In primary cultured rat astrocytes, OGD induced increased expression of CysLT2R and aquaporin 4, and ischemic astrocyte injury. Also, OGD increased phosphorylation of ERK and P38 MAPK. These astrocyte responses were attenuated by P38 MAPK inhibitor SB203580, ERK inhibitor U0126, CysLT2R antagonist Bay Cys LT2 and non-selective Cys LTR antagonist Bay u9773, but not by JNK inhibitor SP600125 and CysLT1R antagonist montelukast. These data demonstrate the roles of ERK and P38 MAPK signaling pathways in 5-LOX and CysLT2R-mediated ischemic-like injury in neuron-like PC12 cel s and rat astrocytes. Furthermore, CysLT1R and ERK signaling were found to be involved in regulation of LTD4-stimulated expression of glial fibrillary acidic protein and cell proliferation in astrocytes. ERK inhibitor PD98059 and CysLT1R antagonist montelukast, MK-571 abolished Cys LTs-induced astrocyte proliferation. Vascular endothelial cells play a pivotal role in maintaining brain homeostasis. Endothelial

关键词： mitogen-activated protein kinases cysteinylleukotrienes 5-lipoxygenase inflammation

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Adaptive admittance tracking control for interactive robot with prescribed performance

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Journal of Systems Engineering and Electronics 2024年第2期35卷 444-450页

作者： meng Qingrui LIN yan School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100190China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

An adaptive control approach is presented in this paper for tracking desired trajectories in interactive manipulators. The controller design incorporates prescribed performance functions (PPFs) to improve dynamic performance. Notably, the performance of the output error is confined in an envelope characterized by exponential convergence, leading to convergence to zero. This feature ensures a prompt response from admittance control and establishes a reliable safety framework for interactions. Simulation results provide practical insights,demonstrating the viability of the control scheme proposed in this paper.

关键词： prescribed performance admittance control adaptive control robots

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Cucurbit[8]uril-regulated face-to-face dimerization assembly enhanced photosensitization and photocatalysis

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Science China Chemistry 2024年第5期67卷 1605-1612页

作者： Haigen Nie die Hu Zhiyao Zeng yan Fan Yaxin Zhai Xin-Long Ni Key Laboratory of Chemical Biology and Traditional Chinese Medicine Ministry of Educational of ChinaKey Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan ProvinceCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangsha 410081China

In water, N,N′-diarylpyridinium thiazolo[5,4-d]thiazole guests(G1–G3) were encapsulated by cucurbit[8]uril(Q[8]) to construct Q[8]_(3)/G_(2) complexes, in which the encapsulated G molecules exist as an exact face-to-face dimer. These complexation behaviors have been indicated by proton nuclear magnetic resonance(~1H NMR) spectroscopy and isothermal titration calorimetry(ITC),and have been confirmed by X-ray single crystal structural analysis of Q[8]_(3)/G2_(2). While free guests G1–G3 have no ability to sensitize singlet oxygen, they all become effective singlet oxygen sensitizers when complexed with Q[8]. By irradiation of white light, Q[8]_(3)/G_(2) complexes induced selective oxidation of aryl sulfide to aryl sulfoxide in good yields and selective oxidation of dimethyl sulfide(DMS) to dimethyl sulfoxide(DMSO) in excellent yields without over-oxidation to dimethyl sulfone(DMSO_(2))even for elongated irradiation. High-yield photo-oxidation of DMS to DMSO_(2) was only achieved by irradiation of blue light in the presence of Q[8]_(3)/G1_(2), which was also effective in photobleaching of Rhodamine B in water. The higher photo-oxidation power of Q[8]_(3)/G1_(2) has been ascribed to an additional generation of reactive oxygen species besides singlet oxygen.

关键词： host-guest interaction dimerization macrocycles photosensitization

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Prediction of solar activities:Sunspot numbers and solar magnetic synoptic maps

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Science China Earth Sciences 2024年第8期67卷 2460-2477页

作者： Rui ZHUO Jiansen HE die DUAN Rong LIN Ziqi WU Limei yan Yong WEI School of Earth and Space Sciences Peking UniversityBeijing 100091China College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Centre for Mathematical Plasma Astrophysics Department of MathematicsKU LeuvenLeuven 3001Belgium Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The evolution of solar magnetic fields is significant for understanding and predicting solar *** our knowledge of solar magnetic fields largely depends on the photospheric magnetic *** this paper,based on the spherical harmonic expansion of the photospheric magnetic field observed by Wilcox Solar Observatory,we analyze the time series of spherical harmonic coefficients and predict Sunspot Number as well as synoptic maps for Solar Cycle *** find that solar maximum years have complex short-period disturbances,and the time series of coefficient g_(7)~0 is nearly in-phase with Sunspot Number,which may be related to solar meridional *** Long Short-Term Memory networks(LSTM),our prediction suggests that the maximum of Solar Cycle 25 is likely to occur in June 2024 with an error of 8 months,the peak sunspot number may be 166.9±22.6,and the next solar minimum may occur around January *** incorporating Empirical Mode Decomposition,we enhance our forecast of synoptic maps truncated to Order 5,validating their relative *** prediction not only addresses a gap in forecasting the global distribution of the solar magnetic field but also holds potential reference value for forthcoming solar observation plans.

关键词： Solar activity prediction Solar magnetic field Spherical harmonic expansion Long-Short Term Memory(LSTM) Empirical Mode Decomposition(EMD)

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Application and progress of artificial intelligence technology in the segmentation of hyperreflective foci in OCT images for ophthalmic disease research

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1138-1143页

作者： Jia-Ning Ying Hu Li yan-yan Zhang Wen-die Li Quan-Yong Yi Ningbo Eye Hospital Wenzhou Medical UniversityNingbo 315042Zhejiang ProvinceChina Health Science Center Ningbo UniversityNingbo 315211Zhejiang ProvinceChina

With the advancement of retinal imaging,hyperreflective foci(HRF)on optical coherence tomography(OCT)images have gained significant attention as potential biological biomarkers for retinal ***,these biomarkers,represented by HRF,present pose challenges in terms of localization,quantification,and require substantial time and *** recent years,the progress and utilization of artificial intelligence(AI)have provided powerful tools for the analysis of biological *** technology enables use machine learning(ML),deep learning(DL)and other technologies to precise characterization of changes in biological biomarkers during disease progression and facilitates quantitative *** on ophthalmic images,AI has significant implications for early screening,diagnostic grading,treatment efficacy evaluation,treatment recommendations,and prognosis development in common ophthalmic ***,it will help reduce the reliance of the healthcare system on human labor,which has the potential to simplify and expedite clinical trials,enhance the reliability and professionalism of disease management,and improve the prediction of adverse *** article offers a comprehensive review of the application of AI in combination with HRF on OCT images in ophthalmic diseases including age-related macular degeneration(AMD),diabetic macular edema(DME),retinal vein occlusion(RVO)and other retinal diseases and presents prospects for their utilization.

关键词： artificial intelligence deep learning hyperreflective foci image analysis

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High temperature lubrication performance of chlorophenyl silicone oil

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Friction 2024年第8期12卷 1716-1727页

作者： yan meng Xiangli WEN Jie CHENG Pengpeng BAI Yonggang meng Yu TIAN School of Mechanical and Electrical Engineering China University of Mining and Technology-BeijingBeijing 100083China Department of Mechanical Engineering State Key Laboratory of Tribology in Advanced EquipmentTsinghua UniversityBeijing 100084China

Most studies of liquid lubricants were carried out at temperatures below 200°***,the service temperature of lubricants for aerospace and aeroengine has reached above 300°*** order to investigate the friction mechanism and provide data for high temperature lubrication,the friction and wear properties of chlorophenyl silicone oil(CPSO)-lubricated M50 steel and Si3N4 friction pairs were investigated ***-on-disk experimental results show that the lubrication performance of CPSO varies significantly with *** 150°C,coefficient of friction(COF)remains at 0.13–0.15 after the short running-in stage(600 s),while the COF in the running-in stage is 0.2–*** 200°C and above,the running-in time is much longer(1,200 s),and the initial instantaneous maximum COF can reach *** this condition,the COF gradually decreases and finally stabilizes at around 0.16–0.17 *** phenomenon is mainly due to the different thickness of boundary adsorption *** importantly,the wear rate of M50 steel increases significantly with the temperature,while the wear rate barely changes at temperatures above 200°*** anti-wear mechanism is explained as tribochemical reactions are more likely to occur between CPSO and steel surface with the increased temperature,generating the FeCl2 protective film on the metal ***,FeCl2 tribochemical film improves the lubrication and anti-wear capacity of the *** high temperatures(200–350°C),FeCl2 film becomes thicker,and the contact region pressure becomes lower due to the larger wear scar size,so the wear rate growth of M50 steel is much smaller compared with that of low temperatures(22–150°C).The main findings in this study demonstrate that CPSO lubricant has good anti-wear and lubrication capacity,which is capable of working under temperatures up to 350°C.

关键词： chlorophenyl silicone oil(CPSO) liquid lubricant anti-wear high temperature

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Restoring cosmological concordance with axion-like early dark energy and dark matter characterized by a constant equation of state?

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Communications in Theoretical Physics 2024年第7期76卷 74-82页

作者： yan-Hong Yao Xin-He meng School of Physics and Astronomy Sun Yatsen University 2 Daxue RoadTangjiaZhuhaiChina School of Physics Nankai University 94 Weijin RoadNankaiTianjinChina

The Hubble tension persists as a challenge in *** early dark energy(EDE)models,initially considered the most promising for alleviating the Hubble tension,fall short of addressing the issue without exacerbating other tensions,such as the S_(8)*** that a negative dark matter(DM)equation of state(EoS)parameter is conducive to reduce the value of the σ_(8)parameter,we extend the axion-like EDE model in this paper by replacing the cold dark matter(CDM)with DM characterized by a constant EoS w_(dm)(referred to as WDM hereafter).We then impose constraints on this axion-like EDE extension model,along with three other models:the axion-like EDE model,ΛWDM,and Λ*** constraints are derived from a comprehensive analysis incorporating data from the Planck 2018 cosmic microwave background,baryon acoustic oscillations,and the Pantheon compilation,as well as a prior on H_(0)(i.e.H_(0)=73.04±1.04,based on the latest local measurement by Riess et al)and a Gaussianized prior on S_(8)(i.e.S_(8)=0.766±0.017,determined through the joint analysis of KID1000+BOSS+2dLenS).We find that although the new model maintains the ability to alleviate the Hubble tension to~1.4σ,it still exacerbates the S_(8)tension to a level similar to that of the axion-like EDE model.

关键词： Hubble tension early dark energy noncold dark matter S8 tension

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Fuzzy-Model-Based Finite Frequency Fault Detection Filtering Design for Two-Dimensional Nonlinear Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2099-2110页

作者： meng Wang Huaicheng yan Jianbin Qiu Wenqiang Ji Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationSchool of Information Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Research Institute of Intelligent Control and Systems School of AstronauticsHarbin Institute of TechnologyHarbin 150080China School of Artificial Intelligence Hebei University of TechnologyTianjin 300401China IEEE

This article studies the fault detection filtering design problem for Roesser type two-dimensional(2-D)nonlinear systems described by uncertain 2-D Takagi-Sugeno(T-S)fuzzy ***,fuzzy Lyapunov functions are constructed and the 2-D Fourier transform is exploited,based on which a finite frequency fault detection filtering design method is proposed such that a residual signal is generated with robustness to external disturbances and sensitivity to *** has been shown that the utilization of available frequency spectrum information of faults and disturbances makes the proposed filtering design method more general and less conservative compared with a conventional nonfrequency based filtering design ***,with the proposed evaluation function and its threshold,a novel mixed finite frequency H_(∞)/H_(-)fault detection algorithm is developed,based on which the fault can be immediately detected once the evaluation function exceeds the ***,it is verified with simulation studies that the proposed method is effective and less conservative than conventional non-frequency and/or common Lyapunov function based filtering design methods.

关键词： Fault diagnosis finite frequency specifications mixed H_(∞)/H_(-)performance two-dimensional nonlinear systems

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Glasesterterpenoids A-C:three sesterterpenoids with 7-cyclohexyl-decahydronaphthalene carbon skeleton isolated from the root of Lindera glauca

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Chinese Journal of Natural Medicines 2024年第9期22卷 864-868页

作者： HE Shiting ZOU Qinghui ZHANG Qi LUO Yingming yan die HE Jingxin LIU Yena CUI Hui School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060China

Three novel sesterterpenoids glasesterterpenoids A-C(1-3),featuring an unprecedented 7-cyclohexyldecahydronaphthalene carbon skeleton,were isolated from the root of Lindera glauca(***).Their structures were elucidated by quantum chemical calculations and spectroscopic *** biogenetic pathway for 1-3 is *** the bioassay,glasesterterpenoid C exhibited DNA topoisomerase 1(Top1)inhibitory activity compared with the positive control,*** findings represent the first examples of sesterterpenoids with a 7-cyclohexyldecahydronaphthalene carbon skeleton from the root of ***.

关键词： Sesterterpenoids Lindera glauca

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Research status and perspectives of MXene-based materials for aqueous zinc-ion batteries

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Rare Metals 2024年第5期43卷 1867-1885页

作者： Xiao-Yu Wang Qi-Hang yang Xin-yan meng meng-meng Zhen Zhen-Zhong Hu Bo-Xiong Shen School of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300071China

Aqueous zinc-ion batteries(AZIBs)as green battery systems have attracted widespread attention in large-scale electrochemical energy storage devices,owing to their high safety,abundant Zn materials,high theoretica specific capacity and low redox *** there are some thorny issues in AZIBs that hinder their practical application,such as low intrinsic electron conductivity,slow ion migration kinetics,zinc dendrites and side ***-based materials with superior conductivity,large polar surface and abundant active sites can simultaneously serve as cathode materials,electrolyte additive and protection layer of anode to regulate redox reactions of *** various materials have been used to improve electrochemical performances of AZIBs there is a lack of in-depth discussion on the regulation mechanism of MXene-based materials for *** this review,we elaborate the research progress of MXenebased materials in AZIBs,including their application in cathode materials and inhibition of zinc *** the future prospects and development directions of MXenebased materials that may improve performance of AZIBs are prospected.

关键词： MXene Aqueous zinc-ion batteries Composite materials Zinc dendrites

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