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The Uptake and Distribution Evidence of Nano-and Microplastics in vivo after a Single High Dose of Oral Exposure

Biomedical and Environmental Sciences 2024年第1期37卷 31-41页

作者： HONG Tao SUN Wei DENG Yuan LYU Jian Da JIN Cui Hong BAI Ying Long NA jun ZHANG Rui GAO Yuan PAN Guo Wei yanG Zuo Sen yan ling jun Research Center for Universal Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Pain Management Shengjing Hospital of China Medical UniversityShenyang 110004LiaoningChina Department of Toxicology School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Maternal and Child Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Institute of Preventive Medicine China Medical UniversityShenyang 110122LiaoningChina Institute of Chronic Diseases Liaoning Provincial Center for Disease Control and PreventionShenyang 110000LiaoningChina

Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in *** Fluorescent microspheres(100 nm,3μm,and 10μm)were given once at a dose of 200 mg/(kg∙body weight).The fluorescence intensity(FI)in observed organs was measured using the IVIS Spectrum at 0.5,1,2,and 4 h after *** was performed to corroborate these *** In the 100 nm group,the FI of the stomach and small intestine were highest at 0.5 h,and the FI of the large intestine,excrement,lung,kidney,liver,and skeletal muscles were highest at 4 h compared with the control group(P<0.05).In the 3μm group,the FI only increased in the lung at 2 h(P<0.05).In the 10μm group,the FI increased in the large intestine and excrement at 2 h,and in the kidney at 4 h(P<0.05).The presence of nano-/microplastics in tissues was further verified by *** peak time of nanoplastic absorption in blood was *** Nanoplastics translocated rapidly to observed organs/tissues through blood circulation;however,only small amounts of MPs could penetrate the organs.

关键词： Microplastics Nanoplastics IVIS Spectrum small-animal imaging system Tissue distribution Blood

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Evidence on Invasion of Blood,Adipose Tissues,Nervous System and Reproductive System of Mice After a Single Oral Exposure:Nanoplastics versus Microplastics

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Biomedical and Environmental Sciences 2022年第11期35卷 1025-1037页

作者： yanG Zuo Sen BAI Ying Long JIN Cui Hong NA jun ZHANG Rui GAO Yuan PAN Guo Wei yan ling jun SUN Wei Institute of Preventive Medicine China Medical UniversityShenyang 110122LiaoningChina Institute of Chronic Diseases Liaoning Provincial Center for Disease Control and PreventionShenyang 110000LiaoningChina Department of Maternal and Child Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Toxicology School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Research Center for Universal Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina

Objective This study was designed to provide the evidences on the toxicokinetics of microplastics(MPs)and nanoplastics(NPs)in the bodies of *** 100 nm,3μm,and 10μm fluorescent polystyrene(PS)beads were administered to mice once by gavage at a dose of 200 mg/kg body *** levels and change of fluorescence intensity in samples of blood,subcutaneous fat,perirenal fat,peritesticular fat,cerebrum,cerebellum,testis,and epididymis were measured at 0.5,1,2,and 4 h after administration using an IVIS Spectrum small-animal imaging *** examination,confocal laser scanning,and transmission electron microscope were performed to corroborate the *** After confirming fluorescent dye leaching and impact of pH value,increased levels of fluorescence intensity in blood,all adipose tissues examined,cerebrum,cerebellum,and testis were measured in the 100 nm group,but not in the 3 and 10μm groups except in the cerebellum and testis at 4 h for the 3μm PS *** presence of PS beads was further *** After a single oral exposure,NPs are absorbed rapidly in the blood,accumulate in adipose tissues,and penetrate the blood-brain/testis *** expected,the toxicokinetics of MPs is significantly size-dependent in mammals.

关键词： Adipose accumulation Blood-brain barrier Blood-testis barrier Blood uptake Microplastics Nanoplastics

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Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells

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Asian Journal of Andrology 2024年第2期26卷 165-174页

作者： Hai-Wei Feng Yu Zhao yan-ling Gao Dong-Teng Liu Li-jun Huo Key Laboratory of Agricultural Animal Genetics Breeding and ReproductionEducation Ministry of ChinaCollege of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterThe University of Hong Kong-Shenzhen HospitalShenzhen 518053China Maternal-Fetal Medicine Institute Department of Obstetrics and GynaecologyShenzhen Baoan Women's and Children's HospitalJinan UniversityShenzhen 518100China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina

Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various *** mitochondrial protease complex(ClpXP),which consists of caseinolytic mitochondrial matrix peptidase X(ClpX)and caseinolytic protease P(ClpP)and mediates the degradation of misfolded,damaged,and oxidized proteins,is essential for maintaining mitochondrial *** has been implicated in meiosis regulation,but its precise role is currently *** this study,we engineered an inducible male germ cell-specific knockout caseinolytic mitochondrial matrix peptidase X(Clpx^(cKO))mouse model to investigate the function of ClpX in *** found that disrupting Clpx in male mice induced germ cell apoptosis and led to an absence of sperm in the ***,it caused asynapsis of homologous chromosomes and impaired meiotic recombination,resulting in meiotic arrest in the zygotene-to-pachytene transition *** loss of ClpX compromised the double-strand break(DSB)repair machinery by markedly reducing the recruitment of DNA repair protein RAD51 homolog 1(RAD51)to DSB *** dysfunction may be due to an insufficient supply of energy from the aberrant mitochondria in Clpx^(cKO) spermatocytes,as discerned by electron ***,ubiquitination signals on chromosomes and the expression of oxidative phosphorylation subunits were both significantly attenuated in Clpx^(cKO) *** together,we propose that ClpX is essential for maintaining mitochondrial protein homeostasis and ensuring homologous chromosome pairing,synapsis,and recombination in spermatocytes during meiotic prophase I.

关键词： ClpX homologous chromosome meiosis mitochondrial recombination synapsis

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不同药剂对苹果树腐烂病防治效果的影响

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北方果树 2024年第1期 18-20页

作者：赵会芳冯红利孙广平郑永全闫俊玲延安市果业研究发展中心陕西洛川727400 延安市黄龙县果业技术推广和营销服务中心陕西黄龙715700

为防治苹果树腐烂病,在刮病斑条件下涂化学药剂,调查治愈率和病斑愈合宽度。结果表明,苹果树腐烂病治愈率,甲硫萘乙酸+涂立康原液、43 g/L戊唑醇200倍液处理的最高,分别为96.15%、95.24%,高出对照12.82%、11.91%;其次为腐轮特原液、3%... 详细信息

为防治苹果树腐烂病,在刮病斑条件下涂化学药剂,调查治愈率和病斑愈合宽度。结果表明,苹果树腐烂病治愈率,甲硫萘乙酸+涂立康原液、43 g/L戊唑醇200倍液处理的最高,分别为96.15%、95.24%,高出对照12.82%、11.91%;其次为腐轮特原液、3%甲基硫菌灵原液、3.3%腐酸·硫酸铜原液、4.5%腐殖·硫酸铜原液,治愈率达90%以上,高出对照6.67%~7.58%;其余药剂治愈率在90%以下。病斑伤口两侧平均愈合宽度,甲硫萘乙酸+涂立康原液最高,为14.6 mm,高出对照44.55%;其次为4.5%腐殖·硫酸铜原液、腐轮特原液,分别为13.0、12.8 mm,高出对照28.71%、26.73%;再次为43 g/L戊唑醇200倍液、3%甲基硫菌灵原液,分别为11.3、11.1 mm,高出对照11.88%、9.90%;骨质种子提取液原液最低,为9.8 mm,低于对照。总之,刮净病斑涂抹甲硫萘乙酸+涂力康原液效果最好,43 g/L戊唑醇200倍液、腐轮特原液、4.5%腐殖·硫酸铜原液效果较好,建议生产上大面积推广应用。

关键词：红富士苹果树腐烂病不同药剂治愈率

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Analyzing topics in social media for improving digital twinning based product development

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Digital Communications and Networks 2024年第2期10卷 273-281页

作者： Wenyi Tang ling Tian Xu Zheng Ke yan School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

Digital twinning enables manufacturers to create digital representations of physical entities,thus implementing virtual simulations for product *** efforts of digital twinning neglect the decisive consumer feedback in product development stages,failing to cover the gap between physical and digital *** work mines real-world consumer feedbacks through social media topics,which is significant to product *** specifically analyze the prevalent time of a product topic,giving an insight into both consumer attention and the widely-discussed time of a *** primary body of current studies regards the prevalent time prediction as an accompanying task or assumes the existence of a preset ***,these proposed solutions are either biased in focused objectives and underlying patterns or weak in the capability of generalization towards diverse *** this end,this work combines deep learning and survival analysis to predict the prevalent time of *** propose a specialized deep survival model which consists of two *** first module enriches input covariates by incorporating latent features of the time-varying text,and the second module fully captures the temporal pattern of a rumor by a recurrent network ***,a specific loss function different from regular survival models is proposed to achieve a more reasonable *** experiments on real-world datasets demonstrate that our model significantly outperforms the state-of-the-art methods.

关键词： Digital twinning Product development Topic analysis Social media

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Overview of the immunological mechanisms in hepatitis B virus reactivation:Implications for disease progression and management strategies

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World Journal of Gastroenterology 2024年第10期30卷 1295-1312页

作者： Hui Ma Qing-Zhu yan Jing-Ru Ma Dong-Fu Li jun-ling yang Department of Clinical Laboratory The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Ultrasound Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Digestive Diseases Center Department of Hepatopancreatobiliary MedicineThe Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

Hepatitis B virus(HBV)reactivation is a clinically significant challenge in disease *** review explores the immunological mechanisms underlying HBV reactivation,emphasizing disease progression and *** delves into host immune responses and reactivation’s delicate balance,spanning innate and adaptive *** factors’disruption of this balance,as are interac-tions between viral antigens,immune cells,cytokine networks,and immune checkpoint pathways,are ***,the roles of T cells,natural killer cells,and antigen-presenting cells are discussed,highlighting their influence on disease *** reactivation’s impact on disease severity,hepatic flares,liver fibrosis progression,and hepatocellular carcinoma is *** strategies,including anti-viral and immunomodulatory approaches,are critically *** role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent *** conclusion,this compre-hensive review furnishes a holistic view of the immunological mechanisms that propel HBV *** a dedicated focus on understanding its implic-ations for disease progression and the prospects of efficient management stra-tegies,this article contributes significantly to the knowledge *** more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches,ultimately enhancing disease management and elevating patient *** dynamic landscape of management strategies is critically scrutinized,spanning anti-viral and immunomodulatory *** role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.

关键词： Hepatitis B virus reactivation Immunological mechanisms Disease progression Management strategies Immune response

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Topology Optimization of Two Fluid Heat Transfer Problems for Heat Exchanger Design

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1949-1974页

作者： Kun yan Yunyu Wang jun yan School of Chemical Engineering Dalian University of TechnologyDalian116024China Jianghuai Advanced Technology Center Hefei230000China State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsInternational Research Center for Computational MechanicsDalian University of TechnologyDalian116024China

Topology optimization of thermal-fluid coupling problems has received widespread *** article proposes a novel topology optimization method for laminar two-fluid heat exchanger *** proposed method utilizes an artificial density field to create two permeability interpolation functions that exhibit opposing trends,ensuring separation between the two fluid ***,a Gaussian function is employed to construct an interpolation function for the thermal conductivity ***,a computational program has been developed on the OpenFOAM platform for the topology optimization of two-fluid heat *** program leverages parallel computing,significantly reducing the time required for the topology optimization *** enhance computational speed and reduce the number of constraint conditions,we replaced the conventional pressure drop constraint condition in the optimization problem with a pressure inlet/outlet boundary *** 3D optimization results demonstrate the characteristic features of a surface structure,providing valuable guidance for designing heat exchangers that achieve high heat exchange efficiency while minimizing excessive pressure *** the same time,a new structure appears in large-scale topology optimization,which proves the effectiveness and stability of the topology optimization program written in this paper in large-scale calculation.

关键词： Topology optimization two fluid heat exchanger OpenFOAM large scale

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An overview and perspective of identifying lunar craters

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Science China Earth Sciences 2024年第5期67卷 1395-1416页

作者： yan JIANG Changyi Xu ling CHEN State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100029China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100049China

The spatiotemporal evolution of lunar impact craters is crucial for investigating lunar interior structure,internal and external dynamic processes,and interplanetary impact *** in lunar crater identification are reviewed based on topography and gravity data,and the features and mechanisms of topographic or buried craters are analyzed regarding morphology,gravity anomalies,gravity gradients,and the underlying crust-mantle interface *** on the compiled crater catalog,the early lunar impact flux and thermal evolution are further discussed according to the basin ages and their interior *** some ancient impact basins,the crater size-frequency distribution measurements revealed age discrepancies from previous studies,suggesting that the lunar late heavy bombardment event started at~3.95 *** degraded bulge structures of the crust-mantle interface beneath mare basins reveal that these basins formed on the lunar crust surface under high-temperature conditions and underwent prolonged relaxation compared to highland ***,we reveal that the up-to-date identification of lunar buried craters remains inaccurate and incomplete,preventing us from accurately reconstructing lunar and interplanetary impact ***,we propose that a gravity model constructed using localized orthogonal basis functions can be useful for identifying lunar craters.

关键词： Moon Gravity field Craters Impact flux Early evolution

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Light(Science & Applications) 2024年第2期13卷 333-346页

作者： Yifan Sun Qian Li ling-jun Kong Xiangdong Zhang Key Laboratory of advanced optoelectronic quantum architecture and measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081BeijingChina

Compared with electrical neural networks,optical neural networks(ONNs)have the potentials to break the limit of the bandwidth and reduce the consumption of energy,and therefore draw much attention in recent *** far,several types of ONNs have been ***,the current ONNs cannot realize the acceleration as powerful as that indicated by the models like quantum neural *** to construct and realize an ONN with the quantum speedup is a huge ***,we propose theoretically and demonstrate experimentally a new type of optical convolutional neural network by introducing the optical *** is called the correlated optical convolutional neural network(COCNN).We show that the COCNN can exhibit“quantum speedup”in the training *** character is verified from the two *** is the direct illustration of the faster convergence by comparing the loss function curves of the COCNN with that of the traditional convolutional neural network(CNN).Such a result is compatible with the training performance of the recently proposed quantum convolutional neural network(QCNN).The other is the demonstration of the COCNN’s capability to perform the QCNN phase recognition circuit,validating the connection between the COCNN and the ***,we take the COCNN analog to the 3-qubit QCNN phase recognition circuit as an example and perform an experiment to show the soundness and the feasibility of *** results perfectly match the theoretical *** proposal opens up a new avenue for realizing the ONNs with the quantum speedup,which will benefit the information processing in the era of big data.

关键词： process quantum convolution

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Clustering for Bivariate Functional Data

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 613-629页

作者： Shi-yun CAO yan-qiu ZHOU yan-ling WAN Tao ZHANG School of Science Guangxi University of Science and TechnologyLiuzhou 545006China School of Marxism Guangxi University of Science and TechnologyLiuzhou 545006China Key Laboratory of Intelligent Information Processing and Graph Processing Guangxi University of Science and TechnologyLiuzhou 545006China

In this paper,we consider the clustering of bivariate functional data where each random surface consists of a set of curves recorded repeatedly for each *** k-centres surface clustering method based on marginal functional principal component analysis is proposed for the bivariate functional data,and a novel clustering criterion is presented where both the random surface and its partial derivative function in two directions are *** addition,we also consider two other clustering methods,k-centres surface clustering methods based on product functional principal component analysis or double functional principal component *** results indicate that the proposed methods have a nice performance in terms of both the correct classification rate and the adjusted rand *** approaches are further illustrated through empirical analysis of human mortality data.

关键词： bivariate functional data -centres surface clustering functional principal component analysis partial derivative function

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