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Exosome-encapsulated lncRNA HOTAIRM1 contributes to PM_(2.5)-aggravated COPD airway remodeling by enhancing myofibroblast differentiation

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Science China(life Sciences) 2024年第5期67卷 970-985页

作者： Huaqi Guo Luo Fei Hengyi Yu yan li yan Feng Shaowei Wu yan Wang The Ninth People’s Hospital of Shanghai Jiao Tong University School of Medicine Shanghai 200011China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200020China Department of Occupational and Environmental Health Sciences School of Public HealthXi’an Jiao Tong University Health Science CenterXi’an 710049China

Emphysema,myofibroblast accumulation and airway remodeling can occur in the lungs due to exposure to atmospheric pollution,especially fine particulate matter(PM_(2.5)),leading to chronic obstructive pulmonary disease(COPD).Specifically,bronchial epithelium-fibroblast communication participates in airway remodeling,which results in COPD.An increasing number of studies are now being conducted on the role of exosome-mediated cell-cell communication in disease pathogenesis.Here,we investigated whether exosomes generated from bronchial epithelial cells could deliver information to normal stromal fibroblasts and provoke cellular responses,resulting in airway obstruction in COPD.We studied the mechanism of exosome-mediated intercellular communication between human bronchial epithelial(HBE) cells and primary lung fibroblasts(pLFs).We found that PM_(2.5)-induced HBE-derived exosomes promoted myofibroblast differentiation in pLFs.Then,the exosomal lncRNA expression profiles derived from PM_(2.5)-treated HBE cells and nontreated HBE cells were investigated using an Agilent Human LncRNA Array.Combining coculture assays and direct exosome treatment,we found that HBE cell-derived exosomal HOTAIRM1 facilitated the myofibroblast differentiation of pLFs.Surprisingly,we discovered that exosomal HOTAIRM1 enhanced p LF proliferation to secrete excessive collagen secretion,leading to airway obstruction by stimulating the TGF-β/SMAD3 signaling pathway.Significantly,PM_(2.5)reduced FEV1/FVC and FEV1 and increased the level of serum exosomal HOTAIRM1 in healthy people;moreover,serum exosomal HOTAIRM1 was associated with PM_(2.5)-related reductions in FEV1/FVC and FVC.These findings show that PM_(2.5)triggers alterations in exosome components and clarify that one of the paracrine mediators of myofibroblast differentiation is bronchial epithelial cell-derived HOTAIRM1,which has the potential to be an effective prevention and therapeutic target for PM_(2.5)-induced COPD.

关键词： PM2.5 exosomal lncRNAs HOTAIRM1 chronic obstructive pulmonary disease

Xuebijing improves intestinal microcirculation dysfunction in septic rats by regulating the VEGF-A/PI3K/Akt signaling pathway

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World Journal of Emergency Medicine 2024年第3期15卷 206-213页

作者： A-ling Tang yan li li-chao Sun Xiao-yu liu Nan Gao Sheng-tao yan Guo-qiang Zhang Department of Emergency China-Japan Friendship HospitalBeijing 100029China Graduate School Beijing University of Chinese MedicineBeijing 100105China

BACKGROUND:This study aims to explore whether Xuebijing(XBJ) can improve intestinal microcirculation dysfunction in sepsis and its mechanism.METHODS:A rat model of sepsis was established by cecal ligation and puncture(CLP).A total of 30 male SD rats were divided into four groups:sham group,CLP group,XBJ + axitinib group,and XBJ group.XBJ was intraperitoneally injected 2 h before CLP.Hemodynamic data(blood pressure and heart rate) were recorded.The intestinal microcirculation data of the rats were analyzed via microcirculation imaging.Enzyme-linked immunosorbent assay(EliSA) kits were used to detect the serum levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α) in the rats.Histological analysis and transmission electron microscopy were used to analyze the injury of small intestinal microvascular endothelial cells and small intestinal mucosa in rats.The expression of vascular endothelial growth factor A(VEGF-A),phosphoinositide 3-kinase(PI3K),phosphorylated PI3K(p-PI3K),protein kinase B(Akt),and phosphorylated Akt(p-Akt) in the small intestine was analyzed via Western blotting.RESULTS:XBJ improved intestinal microcirculation dysfunction in septic rats,alleviated the injury of small intestinal microvascular endothelial cells and small intestinal mucosa,and reduced the systemic inflammatory response.Moreover,XBJ upregulated the expression of VEGF-A,p-PI3K/total PI3K,and p-Akt/total Akt in the rat small intestine.CONCLUSION:XBJ may improve intestinal microcirculation dysfunction in septic rats possibly through the VEGF-A/PI3K/Akt signaling pathway.

关键词： Sepsis Xuebijing Vascular endothelial growth factor A Microcirculation Rat Phosphoinositide 3-kinase Protein kinase B

High-speed impulsive stimulated Brillouin microscopy

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Photonics Research 2024年第4期12卷 730-739页

作者： JIARUI li TAORAN LE HONGYUAN ZHANG HAOYUN WEI yan li State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China Cole Eye Institute Cleveland ClinicClevelandOhio 44195USA

Brillouin microscopy, which maps the elastic modulus from the frequency shift of scattered light, has evolved to a faster speed for the investigation of rapid biomechanical changes. Impulsive stimulated Brillouin scattering (ISBS)spectroscopy has the potential to speed up measurement through the resonant amplification interaction from pulsed excitation and time-domain continuous detection. However, significant progress has not been achieved due to the limitation in signal-to-noise ratio (SNR) and the corresponding need for excessive averaging to maintain high spectral precision. Moreover, the limited spatial resolution also hinders its application in mechanical imaging. Here, by scrutinizing the SNR model, we design a high-speed ISBS microscope through multi-parameter optimization including phase, reference power, and acquisition time. Leveraging this, with the further assistance of the Matrix Pencil method for data processing, three-dimensional mechanical images are mapped under multiple contrast mechanisms for a millimeter-scale polydimethylsiloxane pattern immersed in methanol, enabling the identification of these two transparent materials without any contact or labeling. Our experimental results demonstrate the capability to maintain high spectral precision and resolution at a sub-millisecond integration time for one pixel. With a two-order improvement in the speed and a tenfold improvement in the spatial resolution over the state-of-the-art systems, this method makes it possible for ISBS microscopes to sensitively investigate rapid mechanical changes in time and space.

关键词： Brillouin maintain methanol

Flight Time Minimization of UAV for Cooperative Data Collection in Probabilistic LoS Channel

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China Communications 2024年第2期21卷 210-226页

作者： yan li Shaoyi Xu Yunpu Wu Dongji li School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China School of Electrical Engineering and Electronic Information Xihua UniversityChengdu 610039China

This paper investigates the data collection in an unmanned aerial vehicle(UAV)-aided Internet of Things(IoT) network, where a UAV is dispatched to collect data from ground sensors in a practical and accurate probabilistic line-of-sight(LoS) channel. Especially, access points(APs) are introduced to collect data from some sensors in the unlicensed band to improve data collection efficiency. We formulate a mixed-integer non-convex optimization problem to minimize the UAV flight time by jointly designing the UAV 3D trajectory and sensors’ scheduling, while ensuring the required amount of data can be collected under the limited UAV energy. To solve this nonconvex problem, we recast the objective problem into a tractable form. Then, the problem is further divided into several sub-problems to solve iteratively, and the successive convex approximation(SCA) scheme is applied to solve each non-convex subproblem. Finally,the bisection search is adopted to speed up the searching for the minimum UAV flight time. Simulation results verify that the UAV flight time can be shortened by the proposed method effectively.

关键词： data collection flight time probabilistic line-of-sight channel unlicensed band unmanned aerial vehicle

Pricing and production strategies in remanufacturing from the perspectives of supply chain: Review and future directions

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Frontiers of Engineering Management 2024年第1期11卷 1-15页

作者： Kai li yan li Nenggui ZHAO School of Management Hefei University of TechnologyHefei 230009China Key Laboratory of Process Optimization and Intelligent Decision-making Ministry of EducationHefei 230009China

Remanufacturing is widely recognized as beneficial to the environment and a circular economy. However, remanufacturing is more complex than traditional manufacturing due to the effects of government policy, uncertainty of consumer preferences, competition and cooperation among firms, and so on. These factors motivate academics to optimize remanufacturing outcomes, especially for product pricing and production. This study reviews the published literature on pricing and production strategies in remanufacturing from four perspectives of supply chain, namely, government policy, consumer characteristics, relationships among firms, and supply chain structures. Review results can benefit scholars/practitioners in the future by highlighting the challenges and opportunities in remanufacturing strategies.

关键词： remanufacturing reverse and closed-loop supply chain circular economy

Model architecture level privacy leakage in neural networks

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Science China(Information Sciences) 2024年第3期67卷 20-32页

作者： yan li Hongyang yan Teng HUANG Zijie PAN Jiewei LAI Xiaoxue ZHANG Kongyang CHEN Jin li Institute of Artificial Intelligent and Blockchain Guangzhou University Pazhou Lab

Privacy leakage is one of the most critical issues in machine learning and has attracted growing interest for tasks such as demonstrating potential threats in model attacks and creating model defenses.In recent years, numerous studies have revealed various privacy leakage risks(e.g., data reconstruction attack, membership inference attack, backdoor attack, and adversarial attack) and several targeted defense approaches(e.g., data denoising, differential privacy, and data encryption). However, existing solutions generally focus on model parameter levels to disclose(or repair) privacy threats during the model training and/or model interference process, which are rarely applied at the model architecture level. Thus, in this paper, we aim to exploit the potential privacy leakage at the model architecture level through a pioneer study on neural architecture search(NAS) paradigms which serves as a powerful tool to automate a neural network design.By investigating the NAS procedure, we discover two attack threats in the model architecture level called the architectural dataset reconstruction attack and the architectural membership inference attack. Our theoretical analysis and experimental evaluation reveal that an attacker may leverage the output architecture of an ongoing NAS paradigm to reconstruct its original training set, or accurately infer the memberships of its training set simply from the model architecture. In this work, we also propose several defense approaches related to these model architecture attacks. We hope our work can highlight the need for greater attention to privacy protection in model architecture levels(e.g., NAS paradigms).

关键词： neural architecture search data reconstruction attack membership inference attack

Intestinal microecological transplantation for a patient with chronic radiation enteritis:A case report

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World Journal of Gastroenterology 2024年第19期30卷 2603-2611页

作者： lin Wang yan li Yu-Jing Zhang li-Hua Peng Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Gastroenterology and Hepatology Chinese PLA Medical SchoolBeijing 100853China

BACKGROUND The gut microbiota is strongly associated with radiation-induced gut damage.This study aimed to assess the effectiveness and safety of intestinal microecological transplantation for treating patients with chronic radiation enteritis.CASE SUMMARY A 64-year-old female with cervical cancer developed abdominal pain,diarrhea,and blood in the stool 1 year after radiotherapy.An electronic colonoscopy was performed to diagnose chronic radiation enteritis.Two courses of intestinal microecological transplantation and full-length 16S rRNA microbiological analysis were performed.The patient experienced short-and long-term relief from symptoms without adverse effects.Whole 16S rRNA sequencing revealed significant differences in the intestinal flora’s composition between patient and healthy donors.Pathogenic bacteria,such as Escherichia fergusonii and Romboutsia timonensis,were more in the patient.Beneficial bacteria such as Faecalibacterium prausnitzii,Fusicatenibacter saccharivorans,Ruminococcus bromii,and Bifidobacterium longum were more in the healthy donors.Intestinal microbiota transplantation resulted in a significant change in the patient's intestinal flora composition.The composition converged with the donor's flora,with an increase in core beneficial intestinal bacteria,such as Eubacterium rectale,and a decrease in pathogenic bacteria.Changes in the intestinal flora corresponded with the patients'alleviating clinical symptoms.CONCLUSION Intestinal microecological transplantation is an effective treatment for relieving the clinical symptoms of chronic radiation enteritis by altering the composition of the intestinal flora.This study provides a new approach for treating patients with chronic radiation enteritis.

关键词： Chronic radiation enteritis Gut microbial transplantation Intestinal microecology Cancer Quality of life Case report

A Modified Iterative Learning Control Approach for the Active Suppression of Rotor Vibration Induced by Coupled Unbalance and Misalignment

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 242-253页

作者： Yifan Bao Jianfei Yao Fabrizio Scarpa yan li College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of High-end Compressor and System Technology Beijing 100029China Beijing Key Laboratory of High-end Mechanical Equipment Health Monitoring and Self-Recovery Beijing University of Chemical TechnologyBeijing 100029China Key Lab of Engine Health Monitoring-Control and Networking of Ministry of Education Beijing University of Chemical TechnologyBeijing 100029China Bristol Composites Institute(ACCIS) University of BristolBristol BS81TRUK Dynamics and Control Research Group(DCRG) University of BristolBristol BS81TRUK

This paper proposes a modified iterative learning control(MILC)periodical feedback-feedforward algorithm to reduce the vibration of a rotor caused by coupled unbalance and parallel misalignment.The control of the vibration of the rotor is provided by an active magnetic actuator(AMA).The iterative gain of the MILC algorithm here presented has a self-adjustment based on the magnitude of the vibration.Notch filters are adopted to extract the synchronous(1×Ω)and twice rotational frequency(2×Ω)components of the rotor vibration.Both the notch frequency of the filter and the size of feedforward storage used during the experiment have a real-time adaptation to the rotational speed.The method proposed in this work can provide effective suppression of the vibration of the rotor in case of sudden changes or fluctuations of the rotor speed.Simulations and experiments using the MILC algorithm proposed here are carried out and give evidence to the feasibility and robustness of the technique proposed.

关键词： Rotor vibration suppression Modified iterative learning control Unbalance Parallel misalignment Active magnetic actuator

Two-way shape memory effect in a Ti-Zr-Nb-Ta high-temperature shape memory alloy

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Rare Metals 2024年第3期43卷 1257-1262页

作者： Cheng-yang Xiong Tuo li Jun Wang yan li School of Materials Science and Engineering Beihang UniversityBeijing100191China

The two-way shape memory effect in a Ti-18.5Zr-10Nb-3.5Ta high-temperature shape memory alloy was investigated.X-ray diffraction measurem ent shows that the alloy is composed of orthorhombicα"-martensite.ωphase is not found in Ti-18.5Zr-10Nb-3.5Ta alloy due to the suppressing effect of Ta element.Theα"-martensite laths are found in the transmission electron microscope observation;after the bending deformation,there appear a lot of dislocations.The alloy exhibits a shape memory strain of 3.8%aud a high reverse martensite transformation start temperature of 464 K.The maximum two-way shape memory strain of 1.2%is obtained in the alloy with the prebending training strain of 10%.The mechanism can be ascribed to the effect of internal stress field caused by dislocations.

关键词： Ti-Zr Shape memory alloys Two-way shape memory effect