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Identification of QTLs Conferring Agronomic and Quality Traits in Hexaploid Wheat

Journal of Integrative Agriculture 2012年第9期11卷 1399-1408页

作者： MAjun ZHANG Cai-ying yan gui-jun LILT Chun-ji CSIRO Plant Industry St Lucia QLD 4067 Australia Key Laboratory for Crop Germplasm Resources of Hebei Province~College of Life Science Agricultural University of Hebei Baoding 071001 P.R.China School of Plant Biology The University of Western Australia Perth WA 6009 Australia

The availability of elite germplasm resources with high yield and quality potentials is very important for development of cultivars in wheat. Thus, seeking such resources has been the continuous effort of breeder community. In this study, genetic analysis of a novel resource, Triticum spelta line CSCR6, from Australia was made by use of a recombination inbred line （RIL） population of 82 individuals from the cross between CSCR6 and another Australian hexaploid wheat cultivar, Lang. Data of a multiple environmental test was employed to genetically dissect quantitative trait loci （QTL） for agronomic traits such as plant height （PH）, spike length （SL）, spikelet per spike （SPI）, grain number per spike （GNS） and thousand grains weight （TGW） and for quality traits including grain protein content （GPC）, gluten content （GC）, grain hardness （GH）, falling number （FN） and sedimentation value （SV）. A 24 QTLs with additive effects were detected for all the investigated traits, and were located on chromosomes 1B, 1D, 2B, 3A, 3B, 3D, 4B, 5A, 5B, 7A, and 7B, respectively. Some QTLs located on 2B and 4B showed higher explanation of phenotypic variances and were not obviously interacted with environment. A QTL in the marker interval of wPT-5334-wPT-4918 （near the locus barc 0199） on 4B gave the highest contribution ratio of 30.76% on PH, while Qgpc-4B and Qgc-4B gave 13.07 and 14.70% contribution ratio on GPC and GC, respectively. Qph-2B, Qgns-2B, and Qgpc-2B showed 13.36, 10.00, and 10.79% contribution ratio on PH, GNS and GPC, respectively. Also, a QTL on 5A, Qsl- 5A, could explain 25.12% of phenotypic variance on SL. For most of agronomic and quality traits, CSCR6 alleles produced increase effects. The fact that a number of loci affecting the investigated traits were detected in T. spelta line CSCR6 revealed that it could offer a new opportunity for the manipulation of these traits in wheat breeding programs.

关键词： wheat QTL analysis RILs agronomic traits quality traits

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Classification of Chinese Wintersweet (Chimonanthus praecox) Cultivars Supported by Pollen Morphology

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Agricultural Sciences in China 2010年第7期9卷 958-964页

作者： FAN Li-kun LU Ying-min yan gui-jun ZHANG Qi-xiang College of Landscape Architecture Beijing Forestry University Beijing 100083 P.R. China School of Plant Biology Faculty of Natural and Agricultural Sciences University of Western Australia Perth 6009 Australia

To classify the Chinese wintersweet（Chimonanthus praecox） cultivars and to study their evolution based on pollen *** of 12 representative wintersweet cultivars were examined by scanning electron microscopy（SEM）.Q-cluster analysis was carried out based on the observation *** are as follows：（1） The pollen grains were 2lobed circular in polar view,elliptic in equatorial *** pollen shapes were spheroidal or super-spheroidal by P/E（polar axis length/equatorial axis length） criteria.（2） According to pollen exine ornamentation,it was indicated that white wintersweet is most *** floral group could be classified into three subgroups：purple-hearted,halo-hearted and yellow-hearted *** evolutionary relationship was purple-hearted halo-hearted yellow-hearted.（3） Different wintersweet cultivars showed a different exine *** analysis could be used in the classification of wintersweet *** result of cluster analysis indicated that the cultivars could be classified into three groups with a similarity coefficient of *** group had similar pollen exine *** was found that the palynological classification coincided well with morphological *** results support the suggestion that purple streaks or patches of inner-petals should be served as the first-order criteria in wintersweet classification.

关键词： wintersweet cultivars pollen-morphological characteristics classification

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Emerging memristors and applications in reservoir computing

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Frontiers of physics 2024年第1期19卷 219-239页

作者： Hao Chen Xin-gui Tang Zhihao Shen Wen-Tao Guo Qi-jun Sun Zhenhua Tang yan-Ping Jiang School of Physics and Optoelectronic Engineering Guangdong University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou 510006China

Recently, with the emergence of ChatGPT, the field of artificial intelligence has garnered widespread attention from various sectors of society. Reservoir Computing (RC) is a neuromorphic computing algorithm used to analyze time-series data. Unlike traditional artificial neural networks that require the weight values of all nodes in the trained network, RC only needs to train the readout layer. This makes the training process faster and more efficient, and it has been used in various applications, including speech recognition, image classification, and control systems. Its flexibility and efficiency make it a popular choice for processing large amounts of complex data. A recent research trend is to develop physical RC, which utilizes the nonlinear dynamic and short-term memory properties of physical systems (photonic modules, spintronic devices, memristors, etc.) to construct a fixed random neural network structure for processing input data to reduce computing time and energy. In this paper, we introduced the recent development of memristors and demonstrated the remarkable data processing capability of RC systems based on memristors. Not only do they possess excellent data processing ability comparable to digital RC systems, but they also have lower energy consumption and greater robustness. Finally, we discussed the development prospects and challenges faced by memristors-based RC systems.

关键词： reservoir computing memristor resistive switching artificial synapse neuromorphic computing

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The identification of AMZ2 as a candidate causative gene in a severe teratozoospermia patient characterized by vacuolated spermatozoa

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Asian Journal of Andrology 2024年第1期26卷 107-111页

作者： Liu Liu Jing yang Wen-Jing Zhang Yi-Ling Zhou gui-jun Zhao Ya Huang Shu-yan Tang Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development Department of Computational BiologySchool of Life SciencesFudan UniversityShanghai 200436China Shanghai Towako Hospital Shanghai 200131China Shanghai Institute of Medical Genetics Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China

Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to *** several monogenic factors are linked to cephalic abnormalities,such as globozoospermia and macrozoospermia,the genetic cause of vacuolated spermatozoa remains inadequately ***,we analyzed whole-exome sequencing(WES)data for an individual from a consanguineous family with severely vacuolated *** analysis revealed a novel homozygous c.520A>G(***174Ala)variant in the archaelysin family metallopeptidase 2(AMZ2),a gene that encodes a zinc metalloprotease previously shown to be highly expressed in the testes and *** algorithms predicted this variant to be a damaging *** with an autosomal recessive mode of inheritance,this variant was inherited from heterozygous parental *** investigate the potential pathogenicity of the identified variant,we compared the AMZ2 expression in sperm cells from the patient with the AMZ2 variant and from a healthy *** analysis revealed that the homozygous missense variant in AMZ2 abolished AMZ2 expression in the *** findings reveal a candidate causative gene for vacuolated spermatozoa.

关键词： AMZ2 male infertility sperm quality teratozoospermia

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Topology Optimization of Two Fluid Heat Transfer Problems for Heat Exchanger Design

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1949-1974页

作者： Kun yan Yunyu Wang jun yan School of Chemical Engineering Dalian University of TechnologyDalian116024China Jianghuai Advanced Technology Center Hefei230000China State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsInternational Research Center for Computational MechanicsDalian University of TechnologyDalian116024China

Topology optimization of thermal-fluid coupling problems has received widespread *** article proposes a novel topology optimization method for laminar two-fluid heat exchanger *** proposed method utilizes an artificial density field to create two permeability interpolation functions that exhibit opposing trends,ensuring separation between the two fluid ***,a Gaussian function is employed to construct an interpolation function for the thermal conductivity ***,a computational program has been developed on the OpenFOAM platform for the topology optimization of two-fluid heat *** program leverages parallel computing,significantly reducing the time required for the topology optimization *** enhance computational speed and reduce the number of constraint conditions,we replaced the conventional pressure drop constraint condition in the optimization problem with a pressure inlet/outlet boundary *** 3D optimization results demonstrate the characteristic features of a surface structure,providing valuable guidance for designing heat exchangers that achieve high heat exchange efficiency while minimizing excessive pressure *** the same time,a new structure appears in large-scale topology optimization,which proves the effectiveness and stability of the topology optimization program written in this paper in large-scale calculation.

关键词： Topology optimization two fluid heat exchanger OpenFOAM large scale

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Thermal fatigue and wear of compacted graphite iron brake discs with various thermomechanical properties

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China Foundry 2024年第3期21卷 248-256页

作者： gui-quan Wang Zhuo Xu Zhong-li Liu Xiang Chen yan-xiang Li School of Nuclear Equipment and Nuclear Engineering Yantai UniversityYantai 264005ShandongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

The increase in payload capacity of trucks has heightened the demand for cost-effective yet high performance brake *** this work,the thermal fatigue and wear of compacted graphite iron brake discs were investigated,aiming to provide an experimental foundation for achieving a balance between their thermal and mechanical *** graphite iron brake discs with different tensile strengths,macrohardnesses,specific heat capacities and thermal diffusion coefficients were produced by changing the proportion and strength of *** peak temperature,pressure load and friction coefficient of compacted graphite iron brake discs were analyzed through inertia friction *** morphology of thermal cracks and 3D profiles of the worn surfaces were also *** is found that the thermal fatigue of compacted graphite iron discs is determined by their thermal properties.A compacted graphite iron with the highest specific heat capacity and thermal diffusion coefficient exhibits optimal thermal fatigue *** of the matrix at low temperatures significantly weakens the function of alloy strengthening in hindering the propagation of thermal *** the reduced hardness,increasing the ferrite proportion can mitigate wear loss resulting from low disc temperatures and the absence of abrasive wear.

关键词： compacted graphite iron brake disc thermomechanical properties thermal fatigue wear

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Artificial synaptic simulating pain-perceptual nociceptor and brain-inspired computing based on Au/Bi_(3.2)La_(0.8)Ti_(3)O_(12)/ITO memristor

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Journal of Materiomics 2024年第6期10卷 1308-1316页

作者： Hao Chen Zhihao Shen Wen-Tao Guo yan-Ping Jiang Wenhua Li Dan Zhang Zhenhua Tang Qi-jun Sun Xin-gui Tang School of Physics and Optoelectronic Engineering Guangdong University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou510006China

Recently, memristors have garnered widespread attention as neuromorphic devices that can simulate synaptic behavior, holding promise for future commercial applications in neuromorphic computing. In this paper, we present a memristor with an Au/Bi_(3.2)La_(0.8)Ti_(3)O_(12) (BLTO)/ITO structure, demonstrating a switching ratio of nearly 103 over a duration of 104 s. It successfully simulates a range of synaptic behaviors, including long-term potentiation and depression, paired-pulse facilitation, spike-timing-dependent plasticity, spike-rate-dependent plasticity etc. Interestingly, we also employ it to simulate pain threshold, sensitization, and desensitization behaviors of pain-perceptual nociceptor (PPN). Lastly, by introducing memristor differential pairs (1T1R-1T1R), we train a neural network, effectively simplifying the learning process, reducing training time, and achieving a handwriting digit recognition accuracy of up to 97.19 %. Overall, the proposed device holds immense potential in the field of neuromorphic computing, offering possibilities for the next generation of high-performance neuromorphic computing chips.

关键词： Artificial synapse Memristor Resistive switching Pain-perceptual nociceptor Neuromorphic computing

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Advances of Electrochemical and Electrochemiluminescent Sensors Based on Covalent Organic Frameworks

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Nano-Micro Letters 2024年第2期16卷 395-422页

作者： Yue Cao Ru Wu yan‑yan Gao yang Zhou jun‑Jie Zhu Key Laboratory for Organic Electronics and Information Displays(KLOEID)and Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023People’s Republic of China

Covalent organic frameworks(COFs),a rapidly developing category of crystalline conjugated organic polymers,possess highly ordered structures,large specific surface areas,stable chemical properties,and tunable pore *** the first report of boroxine/boronate ester-linked COFs in 2005,COFs have rapidly gained popularity,showing important application prospects in various fields,such as sensing,catalysis,separation,and energy *** them,COFs-based electrochemical(EC)sensors with upgraded analytical performance are arousing extensive *** this review,therefore,we summarize the basic properties and the general synthesis methods of COFs used in the field of electroanalytical chemistry,with special emphasis on their usages in the fabrication of chemical sensors,ions sensors,immunosensors,and ***,the emerged COFs in the electrochemiluminescence(ECL)realm are thoroughly covered along with their preliminary ***,final conclusions on state-of-the-art COFs are provided in terms of EC and ECL sensors,as well as challenges and prospects for extending and improving the research and applications of COFs in electroanalytical chemistry.

关键词： Covalent organic frameworks Electrochemistry Electrochemiluminescence Sensors

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Potential evaluation of saline aquifers for the geological storage of carbon dioxide: A case study of saline aquifers in the Qian-5 member in northeastern Ordos Basin

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China Geology 2024年第1期7卷 12-25页

作者： yan Li Peng Li Hong-jun Qu gui-wen Wang Xiao-han Sun Chang Ma Tian-xing Yao Guoneng Jinjie Energy Co. Ltd.Shenmu 719319China Department of Geology Northwest UniversityXi’an 710069China Carbon Neutrality College(Yulin) Northwest UniversityXi’an 710069China National&Local Joint Engineering Research Center of Carbon Capture and Storage Technology Xi’an 710069China

The well-developed coal electricity generation and coal chemical industries have led to huge carbon dioxide(CO_(2))emissions in the northeastern Ordos *** geological storage of CO_(2) in saline aquifers is an effective backup way to achieve carbon *** this case,the potential of saline aquifers for CO_(2) storage serves as a critical basis for subsequent geological storage *** study calculated the technical control capacities of CO_(2) of the saline aquifers in the fifth member of the Shiqianfeng Formation(the Qian-5 member)based on the statistical analysis of the logging and the drilling and core data from more than 200 wells in the northeastern Ordos Basin,as well as the sedimentary facies,formation lithology,and saline aquifer development patterns of the Qian-5 *** results show that(1)the reservoirs of saline aquifers in the Qian-5 member,which comprise distributary channel sand bodies of deltaic plains,feature low porosities and permeabilities;(2)The study area hosts three NNE-directed saline aquifer zones,where saline aquifers generally have a single-layer thickness of 3‒8 m and a cumulative thickness of 8‒24 m;(3)The saline aquifers of the Qian-5 member have a total technical control capacity of CO_(2) of 119.25×10^(6) *** the largest scale and the highest technical control capacity(accounting for 61%of the total technical control capacity),the Jinjie-Yulin saline aquifer zone is an important prospect area for the geological storage of CO_(2) in the saline aquifers of the Qian-5 member in the study area.

关键词： Carbon burial Carbon neutral CO_(2) storage in saline aquifer Distributary channel sand body Potential evaluation Technical control capacity CO_(2)geological storage engineering Ordos Basin

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基于小鼠谱系追踪的围着床期子宫内膜上皮-间质转化探究

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生殖医学杂志 2024年第3期33卷 355-364页

作者：唐心怡曹志文王晓莹周继东张阳岳秋玲姜瑞伟李朝军颜桂军孙海翔南京大学医学院附属鼓楼医院生殖医学中心南京210008 南京医科大学生殖医学与子代健康全国重点实验室南京211116

目的利用Ltf cre Rosa26^(mT/mG)小鼠模型,进行围着床期子宫内膜上皮-间质转化(EMT)的谱系追踪研究,寻找子宫内膜EMT的直接形态学证据。方法收集8周龄雌性Ltf cre Rosa26^(mT/mG)小鼠子宫组织进行冰冻切片,分别与上皮细胞、间质细胞、... 详细信息

目的利用Ltf cre Rosa26^(mT/mG)小鼠模型,进行围着床期子宫内膜上皮-间质转化(EMT)的谱系追踪研究,寻找子宫内膜EMT的直接形态学证据。方法收集8周龄雌性Ltf cre Rosa26^(mT/mG)小鼠子宫组织进行冰冻切片,分别与上皮细胞、间质细胞、免疫细胞的标志物E-cadherin、Vimentin、CD45共染后,激光共聚焦荧光显微镜(confocal)观察成像。围着床期研究:8周龄的Ltf cre Rosa26^(mT/mG)雌鼠与可育雄鼠按1:1合笼,以见栓当日上午为0.5 dpc,收集2.5 dpc、3.5 dpc、4.0 dpc、4.5 dpc的小鼠子宫进行冰冻切片,分析胚胎种植对子宫内膜EMT的影响。雌孕激素序贯刺激模型:8周龄的雌性Ltf cre Rosa26^(mT/mG)小鼠进行卵巢切除术,2周后进行雌激素(E_(2))、孕激素(P 4)序贯刺激,在不同处理后收集小鼠子宫组织,分析雌孕激素对子宫内膜EMT的影响。结果Ltf cre Rosa26^(mT/mG)小鼠子宫内膜间质中零星分布着增强绿色荧光蛋白阳性(EGFP+)细胞,与E-cadherin、Vimentin、CD45共染后,confocal结果显示,部分EGFP+细胞表现为Vimentin+,这部分Vimentin+EGFP+细胞即为由上皮细胞EMT形成的间质细胞。围着床期研究:围着床期中,与2.5 dpc、4.0 dpc相比,3.5 dpc时子宫内膜间质中EGFP+细胞个数显著降低(P<0.01)。雌孕激素序贯刺激模型:与卵巢切除后相比,E_(2)刺激后间质中EGFP+细胞数量显著降低,休息2 d后间质中EGFP+细胞数量显著增加,P 4刺激后间质中EGFP+细胞数量又显著降低(P<0.05)。结论子宫内膜中存在上皮细胞EMT形成的间质细胞,子宫内膜EMT在非胚胎植入时期就已经存在,且受到雌孕激素的严格调控。

关键词：上皮-间质转化胚胎种植谱系追踪

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