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A review of integrated surface-subsurface numerical hydrological models

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Science China Earth Sciences 2024年第5期67卷 1459-1479页

作者： Lele SHU Hao CHEN Xianhong MENG yan chang Litang HU Wenke WANG Longcang SHU Xuan YU Christopher DUFFY Yingying YAO Donghai ZHENG Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Water Sciences Beijing Normal UniversityBeijing 100038China School of Water and Environment Chang’an UniversityXi’an 710064China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Department of Civil and Environmental Engineering Pennsylvania State UniversityState CollegePA 16801USA Department of Earth and Environmental Science School of Human Settlements and Civil EngineeringXi’an Jiaotong UniversityXi’an 710049China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China

Hydrological modeling,leveraging mathematical formulations to represent the hydrological cycle,is a pivotal tool in representing the spatiotemporal dynamics and distribution patterns inherent in *** models serve a dual purpose:they validate theoretical robustness and applicability via observational data and project future trends,thereby bridging the understanding and prediction of natural *** rapid advancements in computational methodologies and the continuous evolution of observational and experimental techniques,the development of numerical hydrological models based on physicallybased surface-subsurface process coupling have *** in micro-scale conservation principles and physical equations,these models employ numerical techniques to integrate surface and subsurface hydrodynamics,thus replicating the macro-scale hydrological responses of *** hydrological models have emerged as a leading and predominant trend in hydrological modeling due to their explicit representation of physical processes,heightened by their spatiotemporal resolution and reliance on interdisciplinary *** article focuses on the theoretical foundation of surface-subsurface numerical hydrological *** includes a comparative and analytical discussion of leading numerical hydrological models,encompassing model architecture,numerical solution strategies,spatial representation,and coupling ***,this paper contrasts these models with traditional hydrological models,thereby delineating the relative merits,drawbacks,and future directions of numerical hydrological modeling.

关键词： Numerical Hydrological Models Surface-Subsurface Process Coupling Numerical Methods Hydrological Modeling

General anesthetic agents induce neurotoxicity through oligodendrocytes in the developing brain

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Zoological Research 2024年第3期45卷 691-703页

作者： Wen-Xin Hang yan-chang yang Yu-Han Hu Fu-Quan Fang Lang Wang Xing-Hua Qian Patrick M.McQuillan Hui Xiong Jian-Hang Leng Zhi-Yong Hu Department of Anesthesiology First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Cell Biology Yale UniversityNew HavenCT 06520USA Department of Neurology of the First Affiliated Hospital Interdisciplinary Institute of Neuroscience and TechnologySchool of Brain Science and Brain MedicineZhejiang University School of MedicineHangzhouZhejiang 310027China Department of Anesthesiology Jiaxing Maternity and Childcare Health HospitalJiaxingZhejiang 314009China Department of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPA 17033USA Department of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang 310006China

General anesthetic agents can impact brain function through interactions with neurons and their effects on glial *** perform essential roles in the central nervous system,including myelin sheath formation,axonal metabolism,and neuroplasticity *** are particularly vulnerable to the effects of general anesthetic agents resulting in impaired proliferation,differentiation,and *** are increasingly interested in the effects of general anesthetic agents on *** agents not only act on the surface receptors of oligodendrocytes to elicit neuroinflammation through modulation of signaling pathways,but also disrupt metabolic processes and alter the expression of genes involved in oligodendrocyte development and *** this review,we summarize the effects of general anesthetic agents on *** anticipate that future research will continue to explore these effects and develop strategies to decrease the incidence of adverse reactions associated with the use of general anesthetic agents.

关键词： Oligodendrocytes General anesthetic agents Neurotoxicity Central nervous system Perioperative neurocognitive disorders

犬尿氨酸3-单加氧酶在疾病中的作用及其靶向药物研究进展

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药学学报 2024年第5期59卷 1101-1112页

作者：王燚魏伟常艳安徽医科大学临床药理研究所/抗炎免疫药物教育部重点实验室/安徽省抗炎免疫药物协同创新中心/安徽医科大学类风湿关节炎研究中心安徽合肥230000

犬尿氨酸3-单加氧酶(kynurenine 3-monooxygenase,KMO)是机体犬尿氨酸代谢途径(kynurenine pathway,KP)分解代谢下游的一种关键限速酶。在KMO催化下,中间产物犬尿氨酸被代谢为多种活性代谢物,包括3-羟基犬尿氨酸(3-hydroxykynurenine,3-HK)、喹啉酸(quinolinicacid,QA)和烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD+)等。越来越多的研究表明,KMO表达活性异常介导KP代谢紊乱,参与了神经系统疾病、自身免疫病、感染性疾病及肿瘤等的发生发展,提示其可作为一个潜在、有效的药物治疗靶点。本文重点介绍KMO在多种疾病病理机制中的作用,并总结了已有的KMO抑制剂,为靶向KMO治疗提供方法和思路。

关键词：犬尿氨酸3-单加氧酶犬尿氨酸途径肿瘤神经系统免疫系统

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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu yan-chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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秦汉彩绘陶器中“汉紫”应用及对西域的影响

中国陶瓷 2024年第1期60卷 98-104页

作者：常艳丛欢西安外国语大学艺术遗产研究中心西安710128

“汉紫”是中国战汉时代特有的人造硅酸铜钡材料。它在彩绘陶中的使用既表现出强烈的地域性特征,又具有统一的哲学思想。基于“汉紫”在秦汉墓葬中彩绘陶的相关考古资料,梳理了它在陕西、河南、山东、江苏不同地域的应用情况和表现出的... 详细信息

“汉紫”是中国战汉时代特有的人造硅酸铜钡材料。它在彩绘陶中的使用既表现出强烈的地域性特征,又具有统一的哲学思想。基于“汉紫”在秦汉墓葬中彩绘陶的相关考古资料,梳理了它在陕西、河南、山东、江苏不同地域的应用情况和表现出的共性与个性,蠡测它集中发生于北方的多种原因及用色观念,分析它与“埃及蓝”的关系及对西域的影响。

关键词：秦汉彩绘陶汉紫汉蓝西域

空间生产视角下社区治理共同体的营造——以老旧小区电梯加装为透镜

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理论与改革 2024年第1期 126-138,166,167页

作者：颜昌武杨怡宁暨南大学公共管理学院

共同体蕴含情感性与空间性两个基本要素。既有的社区共同体研究较为突出社区认同等情感性要素而忽略其空间性要素,而今天的城市社区作为邻里空间,承载着各种关于空间连接、割裂与冲突的社区记忆,因而有必要把空间性带回社区治理共同体... 详细信息

共同体蕴含情感性与空间性两个基本要素。既有的社区共同体研究较为突出社区认同等情感性要素而忽略其空间性要素,而今天的城市社区作为邻里空间,承载着各种关于空间连接、割裂与冲突的社区记忆,因而有必要把空间性带回社区治理共同体建设中。基于南方G市J小区电梯加装的田野调查表明:电梯加装不只是一个物理空间的生产过程,也是作为社会关系载体的社会空间生产的过程,还是作为精神空间的价值观念的再生产过程。在空间生产理论视角下,要营造好社区治理共同体,就要在强调社区物理空间特征的同时,重视社区作为社会空间在丰富社会联结方式、重构社会关系方面的独特价值。

关键词：社会治理社区建设共同体空间生产老旧小区电梯加装

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免疫功能与梅毒血清固定的相关性研究

医学信息 2024年第13期37卷 106-109页

作者：闫薇臣吴捷林昌炎钟娜海南省第五人民医院检验科

目的了解梅毒血清固定患者免疫功能变化情况，并分析其相关影响因素。方法收集2017年1月-2022年12月在我院就诊的梅毒血清患者临床资料进行回顾性分析，其中发生血清固定者202例设为血清固定组，同期驱梅治疗转阴197例设为治疗有效组... 详细信息

目的了解梅毒血清固定患者免疫功能变化情况，并分析其相关影响因素。方法收集2017年1月-2022年12月在我院就诊的梅毒血清患者临床资料进行回顾性分析，其中发生血清固定者202例设为血清固定组，同期驱梅治疗转阴197例设为治疗有效组。采用多因素Logistic回归方法梅毒血清固定发生的相关因素。结果单因素分析显示，性别、梅毒分期、TRUST初始滴度、IgG和C4是影响梅毒血清固定的危险因素（P0.05）。多因素Logistic分析显示，性别（OR=1.83,95%CI:1.138～2.941,P<0.05）、TRUST初始滴度（OR=1.01,95%CI:1.009～1.022,P<0.05）、IgG(OR=1.07,95%CI:1.019～1.127,P<0.05)和补体C4(OR=0.04,95%CI:0.004～0.465,P<0.05)与梅毒血清固定的发生有关，是梅毒血清固定的独立危险因素。结论机体免疫功能异常状态可能与梅毒血清固定的发生有关。

关键词：免疫功能梅毒血清固定影响因素 Logistic分析

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新时代国内外美术馆儿童美育项目比较分析

玩具世界 2024年第5期 6-10页

作者：颜昌肖娅晖颜剑英长沙师范学院

随着社会的不断进步和文化的多元发展，儿童美育逐渐成为关注焦点。美术馆作为艺术教育的载体，在培养儿童审美情感、创造力、跨文化认知等方面发挥着重要作用。文章深入探讨新时代国内外美术馆儿童美育项目的差异与相似之处，通过比较... 详细信息

随着社会的不断进步和文化的多元发展，儿童美育逐渐成为关注焦点。美术馆作为艺术教育的载体，在培养儿童审美情感、创造力、跨文化认知等方面发挥着重要作用。文章深入探讨新时代国内外美术馆儿童美育项目的差异与相似之处，通过比较分析，挖掘各自的特点与经验，希望为我国儿童美育事业的发展提供有益的启示。

关键词：国内外美术馆儿童美育项目比较分析

2014-2023年HIV与HCV共感染的文献计量学分析

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中国艾滋病性病 2024年第6期30卷 612-617页

作者：胡莹闫畅张福杰首都医科大学附属北京地坛医院北京100015

目的通过对2014-2023年HIV/AIDS患者与HCV共感染相关文献的可视化分析,了解该领域的研究热点和未来趋势。方法检索2014-2023年Web of Science Core Collection数据库中HIV/AIDS患者合并感染HCV的相关文献,使用VOSviewer和CiteSpace对... 详细信息

目的通过对2014-2023年HIV/AIDS患者与HCV共感染相关文献的可视化分析,了解该领域的研究热点和未来趋势。方法检索2014-2023年Web of Science Core Collection数据库中HIV/AIDS患者合并感染HCV的相关文献,使用VOSviewer和CiteSpace对相关文献进行可视化分析。结果共检出文献1 955篇,其中发表文献最多的国家是美国(769篇),发文量前10的机构以高校为主。聚类分析将高频关键词主要分为三大类,依次为流行病学和危险人群研究,合并感染的治疗研究,合并感染的慢性肝病研究。2014-2023年合并感染的治疗以及合并感染危险人群中的注射吸毒人群始终是研究重点,2021-2023年,合并感染的护理研究热度增加。结论 2014-2023年HIV/AIDS患者合并HCV感染的治疗及注射吸毒人群始终受到研究者关注,合并感染的护理研究可能是未来研究趋势。

关键词：艾滋病病毒丙型肝炎病毒文献计量学可视化分析