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Hepatocyte growth factor promotes retinal pigment epithelium cell activity through MET/AKT signaling pathway

International Journal of Ophthalmology(English edition) 2024年第5期17卷 806-814页

作者： Si-Rui Zhou Yu-Sheng Zhu Wen-Ting Yuan Xiao-yan Pan Tong Wang Xiao-Dong Chen Faculty of Life Sciences and Medicine Northwest UniversityXi’an 710069Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Shaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina

AIM:To explore the effects of hepatocyte growth factor(HGF)on retinal pigment epithelium(RPE)cell ***:The human adult retinal pigment epithelial cell line-19(ARPE-19)were treated by HGF or mesenchymalepithelial transition factor(MET)inhibitor SU11274 in *** viability was detected by a Cell Counting Kit-8 *** proliferation and motility was detected by a bromodeoxyuridine incorporation assay and a wound healing assay,*** expression levels of MET,phosphorylated MET,protein kinase B(AKT),and phosphorylated AKT proteins were determined by Western blot *** MET and phosphorylated MET proteins were also determined by immunofluorescence ***:HGF increased ARPE-19 cells’viability,proliferation and migration,and induced an increase of phosphorylated MET and phosphorylated AKT ***11274 significantly reduced cell viability,proliferation,and migration and decreased the expression of MET and AKT ***11274 suppressed HGF-induced increase of viability,proliferation,and migration in ARPE-19 ***,SU11274 also blocked HGF-induced phosphorylation of MET and AKT ***:HGF enhances cellular viability,proliferation,and migration in RPE cells through the MET/AKT signaling pathway,whereas this enhancement is suppressed by the MET inhibitor ***-induced MET/AKT signaling might be a vital contributor of RPE cells survival.

关键词： hepatocyte growth factor mesenchymal epithelial transition factor SU11274 retinal pigment epithelial cells

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The Optimization of Binary Randomized Response Based on Lanke Privacy and Utility Analysis

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Chinese Journal of Electronics 2024年

作者： Yihui ZHOU Wenli WANG Jun yan Zhenqiang WU Laifeng LU School of Computer Science Shaanxi Normal University School of Mathematics and Statistics Shaanxi Normal University School of Mathematics and Computer Applications Shangluo College

Currently, it has become a consensus to enhance privacy protection. Randomized response(RR) technique, as the mainstream perturbation mechanism for local differential privacy, has been widely studied. However,most of the research in literature managed to modify existing RR schemes and propose new mechanisms with better privacy protection and utility, which are illustrated only by numerical experiments. We study the properties of generalized binary randomized response mechanisms from the perspectives of Lanke privacy and utility. The mathematical expressions of privacy and utility for the binary RR mechanism are given respectively. Moreover, the comparison principle for privacy and utility of any two mechanisms is proved. Finally, the optimization problem of the binary RR mechanism is discussed. Our work is based on a rigorous mathematical proof of privacy and utility for the general binary RR mechanism, and numerical verification illustrates the correctness of the conclusions. It can provide theoretical support for the design of binary RR mechanism and can be applied in data collection, analysis and publishing.

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DLP printing of BT/HA nanocomposite ceramic scaffolds using low refractive index BT crystals

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Journal of Materiomics 2024年第5期10卷 1036-1048页

作者： Ruixuan Xue Peimei Yuan Bo Zhao Fei Jing Xuyuan Kou Wangyang Yue yan wang Dongmei Wang Galhenage Asha Sewvandi Dengwei Hu Faculty of Chemistry and Chemical Engineering Baoji University of Arts and SciencesKey Laboratory of Functional Materials of Baoji Engineering Research Center for Titanium Based Functional Materials and DevicesUniversities of Shaanxi Province1 Hi-Tech AvenueBaoji721013ShaanxiChina Department of Materials Science and Engineering Faculty of EngineeringUniversity of MoratuwaKatubeddaSri Lanka

Biological piezoelectric materials have significant potential for bone repair and energy harvesting owing to their excellent biocompatibility and piezoelectric *** BaTiO3/Ca10(PO4)6(OH)2(BT/HA)composite material is an outstanding representative of biological piezoelectric materials,which has not been individually designed using digital light processing(DLP)3D printing because of the large difference in the refractive index of its ***,in this work,double-sided-tooth plate-like BT crystals with high curvature were prepared via a hydrothermal process,and BT/HA ceramic slurries were grinded out using dispersed intermittent ball milling scheme,and BT/HA nanocomposite ceramic scaffolds were fabricated by DLP 3D printing *** nanostructure,dielectric properties,and piezoelectric energy harvesting performance of the BT/HA nanocomposite ceramic scaffolds were *** influences of different morphologies and contents for BT on the piezoelectric potential and stress distribution were analyzed based on a multi-physics coupling finite element *** cell proliferation and adhesion abilities were investigated *** BT/HA nanocomposite ceramic scaffolds present excellent dielectric properties,cell proliferation and adhesion abilities,and an open circuit voltage of 8 V during piezoelectric energy *** material properties and multi-physics coupling finite element analysis imply that the double-sided-tooth plate-like BT plays an important role for the fastness structure and electric field distribution in the BT/HA ***,this work provides a strategy for the application of the customized BT/HA nanocomposite ceramic scaffolds in new-generation orthopedic implants and biological energy harvesting.

关键词： 3D printing BT/HA nanocomposite ceramics Bio-piezoelectric scaffolds Energy harvesting

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Punicalagin alleviates hypercholesterolemia in mice through modulating farnesoid X receptor signaling and modulating gut microbiota

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Food Science and Human Wellness 2024年

作者： Huanhuan Liu Hongli Liu Chunhong yan Jiaxiu Liu Yu Cao Guopeng Li Xiaodong Xia State Key Laboratory of Marine Food Processing and Safety Control， National Engineering Research Center of Seafood， School of Food Science and Technology， Dalian Polytechnic University Beijing Advanced Innovation Center for Food Nutrition and Human Health， College of Food Science and Nutritional Engineering， China Agricultural University

Punicalagin has been demonstrated to exhibit anti-oxidant and anti-inflammatory properties， but whether and how it could impact hypercholesterolemia remains not fully explored. The aim of this study was to investigate the influence of punicalagin on hypercholesterolemia in mice and its related mechanisms. After 6 weeks’ intervention， punicalagin significantly reduced serum total cholesterol and low density lipoprotein cholesterol (LDL-C) levels in mice fed a high-fat high-cholesterol (HFHC) diet. Meanwhile， punicalagin supplementation lowered hepatic cholesterol level， which corresponded to the down-regulation of cholesterol synthesis genes (Fdps， Cyp51) and up-regulated bile acid synthesis genes (Cyp7a1， Cyp27a1). In addition， bile acid reabsorption was retarded in punicalagin-fed mice through down-regulating ileal apical sodium-dependent BA transporter (ASBT). Furthermore， intestinal farnesoid X receptor (FXR)-fibroblast growth factor 15 (Fgf15) pathway was inhibited while hepatic FXR-small heterodimeric partner (SHP) pathway was activated in punicalagin group. Microbiota analysis and targeted metabolomics showed that punicalagin decreased the abundance of bile-salt hydrolase (BSH)-producing bacteria (Clostridiaceae and Bifidobacteriaceae) and the ratio of primary BAs to secondary BAs. In conclusion， the cholesterol-lowering effect of punicalagin partly through down-regulating cholesterol synthesis and increasing cholesterol catabolism， which could be achieved by regulating gut microbiota， altering bile acid composition and modulating FXR signaling pathway. These findings indicate the potential application of punicalagin-related products as an alternative strategy for hypercholesterolemia prevention and mitigation.

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富铁酿酒酵母菌株的选育及其培养条件优化

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西北农林科技大学学报（自然科学版） 2024年第3期52卷 19-29页

作者：曾艳湖南省微生物研究院湖南长沙410009

【目的】分离鉴定高效富铁酿酒酵母菌株,优化其培养基组分和发酵条件。【方法】从果园根际土壤中分离选育耐铁酿酒酵母菌,对其进行形态学、生理生化分析和26 S rDNA基因序列分析鉴定;采用单因素试验,分别设置不同碳源种类(葡萄糖、蔗糖... 详细信息

【目的】分离鉴定高效富铁酿酒酵母菌株,优化其培养基组分和发酵条件。【方法】从果园根际土壤中分离选育耐铁酿酒酵母菌,对其进行形态学、生理生化分析和26 S rDNA基因序列分析鉴定;采用单因素试验,分别设置不同碳源种类(葡萄糖、蔗糖、乳糖、果糖、麦芽糖)、氮源种类(硫酸铵、酵母膏、蛋白胨、尿素)及不同质量浓度Fe^(2+)(100,200,300,…,1000,1200,1600,2000μg/mL)、碳源(10,20,30,40,50,60,70,80,90 g/L)、氮源(无机氮源2,4,6,8,10,20 g/L;有机氮源4,8,12,16,20,24,28 g/L)、无机盐(MgSO4·7H2O 0.3,0.5,1.0,1.5,2.0 g/L;KH2PO40.5,1.5,2.5,3.5,4.5 g/L)的培养基进行试验,探究不同培养基组分对酿酒酵母富铁能力的影响。采用单因素试验研究温度(26,28,30,32,34,36,38℃)、初始pH值(3.5,4.0,4.5,5.0,5.5,6.0,6.5,7.0,7.5)、接种量(2%,4%,6%,8%,10%,12%)、转速(140,160,180,200,220 r/min)、装液量(250 mL三角瓶中分别装20,30,40,50,60,70 mL)对酿酒酵母富铁能力的影响。选择温度、初始pH值、接种量、转速进行L9(34)正交试验设计,获得最佳发酵培养条件,并进行验证试验。【结果】从三叶木通果园土壤中分离鉴定获得1株耐铁酿酒酵母菌株ZY-jm16,通过单因素试验,获得该菌株最优培养基组成为:蔗糖50 g/L、尿素4 g/L、酵母膏24 g/L、KH_(2)PO_(4)2.5 g/L、MgSO_(4)·7H_(2)O 0.5 g/L、Fe^(2+)900μg/mL(FeSO_(4)·7H_(2)O 4.5 g/L);通过单因素试验和正交试验优化,发现该菌株高富铁率最佳发酵条件为:起始pH值4.8、温度28℃、转速180 r/min、接种量6%、装液量50 mL(250 mL锥形瓶),发酵时间为40 h。在此条件下,该菌株铁富集率达到91.80%,较优化前提高了229.27%;菌体生物量达13.06 g/L,较优化前提高了59.07%。【结论】获得1株高效富铁酿酒酵母菌ZY-jm16,对其培养条件进行了优化,明晰了其生长规律。

关键词：酿酒酵母菌株选育饲料添加剂培养基优化培养条件优化

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磁性浮珠VMB@Fe_(3)O_(4)@CS对鱼腥藻和微囊藻的去除

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中国环境科学 2024年第3期44卷 1526-1533页

作者：车文露赵岩张高山李彦鹏长安大学水利与环境学院陕西西安710054 长安大学旱区地下水文与生态效应教育部重点实验室陕西西安710054

为了有效处理有害藻华,并避免化学物质二次污染,结合磁絮凝与浮珠浮选方法,以玻化微珠、Fe_(3)O_(4)、壳聚糖为原料合成磁浮珠VMB@Fe_(3)O_(4)@CS,对水华鱼腥藻和铜绿微囊藻进行去除实验.结果表明,磁浮珠对2种水华藻的最佳去除效率分别... 详细信息

为了有效处理有害藻华,并避免化学物质二次污染,结合磁絮凝与浮珠浮选方法,以玻化微珠、Fe_(3)O_(4)、壳聚糖为原料合成磁浮珠VMB@Fe_(3)O_(4)@CS,对水华鱼腥藻和铜绿微囊藻进行去除实验.结果表明,磁浮珠对2种水华藻的最佳去除效率分别达到99.01%(0.12g/L)、98.6%(0.21g/L).VMB@Fe_(3)O_(4)@CS在较宽的pH值范围(4~10)和水温范围(5℃~35℃)内实现较高的去除率(>60%),离子强度的增加对微藻的去除起负面影响.通过形态学观察、表面疏水率及Zeta电位分析确定静电吸引、吸附架桥是磁浮珠对藻细胞主要的絮凝机理.制备的VMB@Fe_(3)O_(4)@CS去除有害藻华具有很大应用潜力.

关键词：有害藻华磁性浮珠浮选絮凝

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Elevated nitrogen and co-evolution history with competitors shape the invasion process of Galinsoga quadriradiata

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Journal of Plant Ecology 2024年第4期17卷 9-22页

作者： Wen-Gang Zhang Xing-Jiang Song Laís Petri Gang Liu Xiao-yan Chen Rui-Ling Liu Fang-Fang Huang Jia-Bin Zou Zhi-Hong Zhu College of Life Sciences Shaanxi Normal UniversityXi’an 710119China School for Environment and Sustainability University of MichiganAnn ArborMI 48109USA Research Center for UAV Remote Sensing Shaanxi Normal UniversityXi’an 710119China Changqing Teaching&Research Base of Ecology Shaanxi Normal UniversityXi’an 710119China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China

Invasive plants usually experience population differentiation as they expand from their initial invasive range to the ***,invasive plants usually encounter competitors which shared different co-evolutionary histories with *** factors may lead to varying responses of invasive plant populations to elevated nitrogen deposition during ***,this issue has received limited attention in prior *** address these challenges,we conducted a greenhouse experiment to investigate how population differentiation of Galinsoga quadriradiata interacts with the presence of various competitors in response to increased nitrogen *** types(new or old that shared short or long co-evolutionary history with the invader,respectively)were set to compete with the invasive central and edge populations under different nitrogen addition *** from the central population of ***,originating from the initial invasion range,showed greater total mass,reproduction and interspecific competitiveness compared with the edge *** addition improved growth and reproductive performance in both populations,and the central population had a stronger response compared with the edge *** performance of *** was inhibited more effectively by old competitors than new *** results indicate that population differentiation occurs in terms of growth and competitiveness during the range expansion of ***,with the central population exhibiting superior ***-evolutionary history with competitors is considered unfavorable for invasive plants in this *** results highlight the combined effects of population differentiation in invasive species and their co-evolution history with competitors in the context of global change factors.

关键词： Galinsoga quadriradiata central population edge population interspecific competition population differentiation elevated nitrogen

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MoS_(2)/Ti_(3)C_(2)T_(x)对磷酸盐涂层宽温域摩擦学性能的影响

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表面技术 2024年第1期53卷 56-64页

作者：方媛闫嘉琪赵顺强曾立军吴燕陕西科技大学材料科学与工程学院西安710021 陕西科技大学陕西省无机材料绿色制备与功能化重点实验室西安710021

目的以MoS_(2)/Ti_(3)C_(2)T_(x)为固体润滑剂,在25(室温)~400℃下制备具有优异摩擦学性能的MoS_(2)/Ti_(3)C_(2)T_(x)磷酸盐涂层,并研究它在不同温度下的减摩抗磨机制。方法以氢氟酸为MAX相(Ti_(3)AlC_(2))粉体的蚀刻剂,制备具有“手... 详细信息

目的以MoS_(2)/Ti_(3)C_(2)T_(x)为固体润滑剂,在25(室温)~400℃下制备具有优异摩擦学性能的MoS_(2)/Ti_(3)C_(2)T_(x)磷酸盐涂层,并研究它在不同温度下的减摩抗磨机制。方法以氢氟酸为MAX相(Ti_(3)AlC_(2))粉体的蚀刻剂,制备具有“手风琴”形貌的Ti3C2TxMXene。以硫脲、钼酸铵、MXene为原料,制备MoS_(2)/Ti_(3)C_(2)T_(x)复合材料。以Al(H2PO4)3为黏结剂,以Cu O为固化剂,分别以Ti_(3)C_(2)T_(x)和MoS_(2)/Ti_(3)C_(2)T_(x)为固体润滑剂,制备Ti3C2Tx磷酸盐涂层和MoS_(2)/Ti_(3)C_(2)T_(x)磷酸盐涂层。通过高温摩擦磨损试验机和光学数码显微镜测试涂层在25~400℃时的摩擦因数和磨损率,采用扫描电子显微镜和显微共焦激光拉曼光谱仪分析磨痕表面形貌、物相,进而探讨磨损机理。结果当Ti_(3)C_(2)T_(x)与Al(H_(2)PO_(4))_(3)的质量比为2∶1时,Ti3C2Tx磷酸盐涂层在室温(25℃)下的摩擦因数和磨损率均最低,分别为0.38和2.75×10-4mm3/(N·m)。在Ti_(3)C_(2)T_(x)表面负载MoS2,将MoS_(2)/Ti_(3)C_(2)T_(x)作为固体润滑剂,能够显著降低磷酸盐涂层在25~400℃下的摩擦因数,同时磨损率也有所降低。MoS_(2)/Ti_(3)C_(2)T_(x)磷酸盐涂层在室温下的摩擦因数低至0.11,相较于Ti3C2Tx磷酸盐涂层降低了71.1%,其磨损率相较于Ti3C2Tx磷酸盐涂层降低了1个数量级。在25~400℃范围内,MoS_(2)/Ti_(3)C_(2)T_(x)磷酸盐涂层的摩擦因数均低于0.21。随着温度的升高,摩擦因数呈先减小后增大的趋势,磨损率整体上呈增大趋势。结论相较于Ti_(3)C_(2)T_(x)磷酸盐涂层,MoS_(2)/Ti_(3)C_(2)T_(x)磷酸盐涂层在25~400℃下的摩擦学性能均得到显著提升。

关键词： Ti_(3)C_(2)T_(x) 宽温域摩擦磨损性能磷酸盐涂层磨损机制

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碳量子点@金纳米团簇比率荧光传感器的制备及应用

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硅酸盐学报 2024年第2期52卷 661-670页

作者：郑佳红周艳长安大学材料科学与工程学院西安710061

比率荧光传感器与单波长荧光传感器相比抗干扰能力强、更加灵敏、可视化检测结果可靠。采用水热法合成氮、硫掺杂的碳量子点(N,S-CQDs)及稳定性良好的金纳米团簇(BSA-Au NCs),构建了N,S-CQDs@BSA-AuNCs比率荧光传感器,用于连续测定Ce^(... 详细信息

比率荧光传感器与单波长荧光传感器相比抗干扰能力强、更加灵敏、可视化检测结果可靠。采用水热法合成氮、硫掺杂的碳量子点(N,S-CQDs)及稳定性良好的金纳米团簇(BSA-Au NCs),构建了N,S-CQDs@BSA-AuNCs比率荧光传感器,用于连续测定Ce^(4+)和AA(维生素C)。结果表明,该比率荧光传感器基于“关-开-关”检测机理在最优条件下,I_(F_(429))/I_(F_(692))与Ce^(4+)浓度之间有良好的线性关系,检测限为0.12μmmol/L;N,S-CQDs@BSA-AuNCs/Ce^(4+)加入AA后,I_(F_(429))/I_(F_(692))与不同浓度的AA在1~10μmol/L范围内也呈现良好的线性关系,检测限为0.19μmol/L。探究了一些可能共存物质的干扰,实现该比率荧光传感器对Ce^(4+)、AA的选择性识别和快速检测。

关键词：抗坏血酸铈离子比率荧光传感器碳量子点

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煤矿井下巷道行驶车辆车前障碍物检测方法研究

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矿业安全与环保 2024年第1期51卷 168-174页

作者：闫明伟国能榆林能源有限责任公司、青龙寺煤矿分公司陕西榆林719408

为了解决巷道内运输车辆在行驶过程中对障碍物的检测易受到光照条件影响的问题,提出了一种基于图像增强的障碍物检测方法。该方法先利用VOC数据集格式制作井下车辆行驶过程中的障碍物数据集,然后利用MSR(Multi Scale Retinex)算法对井... 详细信息

为了解决巷道内运输车辆在行驶过程中对障碍物的检测易受到光照条件影响的问题,提出了一种基于图像增强的障碍物检测方法。该方法先利用VOC数据集格式制作井下车辆行驶过程中的障碍物数据集,然后利用MSR(Multi Scale Retinex)算法对井下采集到的低照度图像进行增强;通过改进CenterNet网络,设计了ResNetBN-18轻量级网络,再基于改进后的CenterNet目标检测算法训练数据集,最后实现对井下运输车辆车前障碍物的准确检测。实验结果表明,改进后的检测模型保持了原网络的高实时性,检测精度比原网络提高了10.1%,帧率提高了6.7%。

关键词：井下运输车辆低照度障碍物检测 CenterNet网络

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