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Genes & Diseases 2024年第1期11卷 64-66页

作者： Ying Li Lingli Ding Yage Zhang Bingyu Zhou Gene Chi Wai Man Min Wang Jinglan Li yamei liu Weiping Lin Haibin Wang Sien Lin Liangliang Xu Key Laboratory of Orthopaedics&Traumatology Lingnan Medical Research CenterThe First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong SAR 999077China Departments of Diagnostics of Traditional Chinese Medicine Guangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Orthopaedic Research Lab Affiliated Hospital of Guangdong Medical UniversityGuangdong Medical UniversityZhanjiangGuangdong 524001China

Fractures have an extraordinarily negative impact on individuals'quality of life and functional *** or disability of fracture is a major health issue with important clinical,social,and economic implications.1 Mesenchymal stem cells(MSCs)play an indispensable role in the initiation of the fracture repair process including the formation of a callus which is replaced by new *** use of MSCs in the treatment of fractures is very attractive as they can reduce the time of healing and occurrence of nonunion.

关键词： PI3K/Akt HIF1α healing

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高职学生网络素养调查与分析

天津职业院校联合学报 2024年第3期26卷 55-59,66页

作者：邢凯刘亚梅天津城市职业学院天津300250

在自媒体时代,人人都是网络信息的接收者和创造者。面对海量的数据信息如何去有效辨识和应用,对每个人的网络素养都是一种新的挑战。高职学生思维活跃,易于接受新鲜事物,但对于事物的把控能力不强,其网络素养亟待关注和提升。本文通过... 详细信息

在自媒体时代,人人都是网络信息的接收者和创造者。面对海量的数据信息如何去有效辨识和应用,对每个人的网络素养都是一种新的挑战。高职学生思维活跃,易于接受新鲜事物,但对于事物的把控能力不强,其网络素养亟待关注和提升。本文通过对天津市高职院校学生进行网络素养调研与分析,了解高职学生网络素养现状,并据此从社会、学校和学生层面提出相应提升学生网络素养的建议,以期为当代高职学生网络素养教育提供实证参考。

关键词：网络素养认知能力辨识能力

CLT OF WAVELET ESTIMATOR IN SEMIPARAMETRIC MODEL WITH CORRELATED ERRORS

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Journal of Systems Science & Complexity 2012年第3期25卷 567-581页

作者： Sili NIU yamei liu Department of Mathematics Tongji University Department of Mathematics and Physics Henan University of Urban Construction

这篇论文认为 semiparametric 回归模型 y i = x i 是 +g (t i )+V i (1 i n )(x i， t i ) 被知道设计点，是一个未知斜坡参数， g (

关键词：小波估计半参数模型协方差文化部半参数回归模型佛罗里达州边坡参数随机变量

新型危重症评分量表对患者转入重症监护室及死亡的预测价值

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重庆医学 2024年第14期53卷 2138-2142页

作者：席元晨康静刘亚梅田龙王晨宇河北北方学院附属第一医院重症监护室河北张家口075000

目的创建基于logistic回归预测模型的新型危重症评分量表,评价量表对患者转入重症监护室(ICU)及死亡的预测价值。方法回顾性收集2022年10月至2023年10月该院HIS系统1000例患者的临床资料,基于既往研究创建的logistic回归预测ICU转入率... 详细信息

目的创建基于logistic回归预测模型的新型危重症评分量表,评价量表对患者转入重症监护室(ICU)及死亡的预测价值。方法回顾性收集2022年10月至2023年10月该院HIS系统1000例患者的临床资料,基于既往研究创建的logistic回归预测ICU转入率模型创建新型危重症评分量表。分别以改良早期预警评分(MEWS)和急性生理学与慢性健康状况评分系统Ⅱ(APCHEⅡ)评分为参考,采用受试者工作特征(ROC)曲线和曲线下面积(AUC)评价新型危重症评分量表对患者转入ICU及死亡的预测价值。结果患者ICU转入率为29.8%,死亡率为8.10%。转入ICU或死亡患者的新型危重症评分量表、MEWS和APCHEⅡ评分明显高于未转入ICU或死亡患者(P<0.05)。新型危重症评分量表、MEWS和APCHEⅡ评分对转入ICU的预测价值均为高等(P<0.05),AUC分别为0.917、0.922、0.934,灵敏度分别为82.26%、84.22%、90.57%,特异度分别为80.36%、73.50%、83.45%,Youden指数分别为62.62%、57.72%、74.02%。新型危重症评分量表、MEWS和APCHEⅡ评分对死亡的预测价值均为高等(P<0.05),AUC分别为0.924、0.914、0.933,灵敏度分别为93.48%、86.38%、84.67%,特异度分别为73.46%、79.38%、88.69%,Youden指数分别为66.94%、65.76%、73.36%。结论新型危重症评分量表对患者转入ICU及死亡的预测价值同传统量表基本一致,可作为新的ICU患者评价工具。

关键词：新型危重症评分量表重症监护室转入死亡预测价值

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Impact of Sky Conditions on Net Ecosystem Productivity over a “Floating Blanket” Wetland in Southwest China

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Advances in Atmospheric Sciences 2024年第2期41卷 355-368页

作者： yamei SHAO Huizhi liu Qun DU Yang liu Jihua SUN Yaohui LI Jinlian LI State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100029China Yunnan Meteorological Observatory Kunming 530100China College of Aviation Meteorology Civil Aviation Flight University of ChinaGuanghan 618307China Meteorological Bureau of Tengchong County Baoshan 679100China

Based on eddy covariance(EC) measurements during 2016–20, the effects of sky conditions on the net ecosystem productivity(NEP) over a subtropical “floating blanket ” wetland were investigated. Sky conditions were divided into overcast, cloudy, and sunny conditions. On the half-hourly timescale, the daytime NEP responded more rapidly to the changes in the total photosynthetic active radiation(PARt) under overcast and cloudy skies than that under sunny skies. The increase in the apparent quantum yield under overcast and cloudy conditions was the greatest in spring and the least in summer. Additionally, lower atmospheric vapor pressure deficit(VPD) and moderate air temperature were more conducive to enhancing the apparent quantum yield under cloudy skies. On the daily timescale, NEP and the gross primary production(GPP) were higher under cloudy or sunny conditions than those under overcast conditions across seasons. The daily NEP and GPP during the wet season peaked under cloudy skies. The daily ecosystem light use efficiency(LUE) and water use efficiency(WUE) during the wet season also changed with sky conditions and reached their maximum under overcast and cloudy skies, respectively. The diffuse photosynthetic active radiation(PAR_d) and air temperature were primarily responsible for the variation of daily NEP from half-hourly to monthly timescales, and the direct photosynthetic active radiation(PAR_b) had a secondary effect on NEP. Under sunny conditions, PAR_b and air temperature were the dominant factors controlling daily NEP. While daily NEP was mainly controlled by PAR_d under cloudy and overcast conditions.

关键词： diffuse radiation eddy covariance NEP controlling factors wetland path analysis

Liquid-mediated Ostwald ripening of Ag-based clusters supported on oxides

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Nano Research 2024年第6期17卷 4971-4978页

作者： Conghui liu Rongtan Li yamei Fan Shiwen Li Xiaohui Feng Lu Feng Yanxiao Ning Qiang Fu School of Chemistry Dalian University of TechnologyDalian 116024China State Key Laboratory of Catalysis Chinese Academy of SciencesDalian Institute of Chemical PhysicsDalian 116023China

Reconstruction of supported nanocatalysts often occurs in gas-solid reactions and significantly affects the catalytic performance,yet it is much less explored in liquid-phase ***,we find that highly-dispersed Ag nanocatalysts,i.e.,AgOx clusters,supported on alumina,silica,and titania,can aggregate into larger Ag or Ag2O particles after immersing in liquid-phase media at room *** spontaneous aggregation of AgOx clusters in liquid water is attributed to liquid-phase Ostwald ripening through dissolution of AgOx clusters into water and subsequent redeposition to form Ag2O *** immersion into organic solvents such as ethanol leads to reduction of AgOx clusters and further growth into Ag *** work reveals that liquid-phase reaction media can induce substantial structural evolution of supported nanostructured catalysts,which should be carefully considered in liquid-solid interface catalytic reactions such as electrocatalysis,environmental catalysis,and organic synthesis in liquid phase.

关键词： Ag catalysts Ostwald ripening liquid phase media dissolution-deposition process

Genetic Variations and Nonalcoholic Fatty Liver Disease:Field Synopsis,Systematic Meta-Analysis,and Epidemiological Evidence

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Biomedical and Environmental Sciences 2024年第7期37卷 762-773页

作者： yamei Li Xiang Xiao Jie Wang Yixu liu Xiongfeng Pan Haibin Yu Jiayou Luo Miyang Luo Department of Epidemiology and Health Statistics School of Public HealthUniversity of South ChinaHengyang 421001HunanChina Department of Maternal and Child Health Xiangya School of Public HealthCentral South UniversityChangsha 410008HunanChina Supervision and Inspection Department of Shanghai Healthcare Security Bureau Shanghai 200003China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410008HunanChina

Objective To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease(NAFLD).Methods Literature from Web of Science,PubMed,and Embase between January 1980 and September 2022 was systematically ***-analyses of the genetic variants were conducted using at least five data *** epidemiologic credibility of the significant associations was graded using the Venice *** Based on literature screening,399 eligible studies were included,comprising 381 candidate gene association,16 genome-wide association,and 2 whole-exome sequencing *** identified 465 genetic variants in 173 genes in candidate gene association studies,and 25 genetic variants in 17 genes were included in the *** meta-analysis identified 11 variants in 10 genes that were significantly associated with NAFLD,with cumulative epidemiological evidence of an association graded as strong for two variants in two genes(HFE,TNF),moderate for four variants in three genes(TM6SF2,GCKR,and ADIPOQ),and weak for five variants in five genes(MBOAT7,PEMT,PNPLA3,LEPR,and MTHFR).Conclusion This study identified six variants in five genes that had moderate to strong evidence of an association with NAFLD,which may help understand the genetic architecture of NAFLD risk.

关键词： Nonalcoholic fatty liver disease Genetic association study Genetic variant Systematic review Meta-analysis

HIV encephalopathy is contributed by macrophages and microglia

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Science China(Life Sciences) 2024年第4期67卷 836-838页

作者： Si-Meng liu Man Li Chunhui Ma Chunying liu An Lv Qing Li yamei Niu Peng Wang Bo Huang Wei-Min Tong Department of Pathology China Medical UniversityShenyang 110122China Department of Pathology Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeNeuroscience CenterChinese Academy of Medical SciencesBeijing 100005China Department of Pathology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Molecular Pathology Research Center Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Center For Experimental Animal Research Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Department of Immunology and National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100010China Department of Biochemistry and Molecular Biology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Dear Editor,Acquired immunodeficiency syndrome(AIDS),characterized by a significant decrease in the number of CD4^(+)T cells,causes a defective T cell immune response,which subsequently leads to various conditional pathogenic infections and tumors(Calmy et al.,2018;Seligmann et al.,1987).Neurological disorders have been reported in 70%–80%of patients with AIDS(Saylor et al.,2016)。

关键词： encephalopathy immunodeficiency

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中医药高校“433”研究生导学模式构建

中医教育 2024年第4期43卷 5-10页

作者：吴祖春洪海都骆欢欢吴丽丽徐亮亮李嘉丽余丽娟刘亚梅广州中医药大学广州510006

广州中医药大学基础医学院围绕“立德树人”中心环节,剖析学术型研究生导学关系中存在的导师第一责任人认识不足、导学比例失衡、育人力量整合不够、管理与被管理者双向错位、导学关系紧张等问题,全程跟进研究生从复试选拔到毕业就业4... 详细信息

广州中医药大学基础医学院围绕“立德树人”中心环节,剖析学术型研究生导学关系中存在的导师第一责任人认识不足、导学比例失衡、育人力量整合不够、管理与被管理者双向错位、导学关系紧张等问题,全程跟进研究生从复试选拔到毕业就业4个不同阶段,探索和构建以研究生学业导师为主,科研导师、行业导师为辅的三方育人导学团队,三维立体全方位育人路径的新型“433”三全育人导学模式。导学效果显示,此模式可促进师生关系融洽、和谐,提升研究生学术修养、专业研究水平、科研实践等科学发展能力,同时还对研究生的思想政治品德、综合素质进行培养和引领,从而为国家培养更多德才兼备、知行合一的中医药高级创新人才。

关键词：中医药大学三全育人研究生导学模式人才培养

Molecule-based vertical transistor via intermolecular charge transport throughπ-πstacking

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Nano Research 2024年第5期17卷 4573-4581页

作者： Cheng liu Cheng Fu Lingyu Tang Jianghua Wu Zhangyan Mu yamei Sun Yanghang Pan Bailin Tian Kai Bao Jing Ma Qiyuan He Mengning Ding Key Laboratory of Mesoscopic Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied SciencesCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China

Theπ-πstacking is a well-recognized intermolecular interaction that is responsible for the construction of electron hopping channels in numerous conducting frameworks/***,the exact role ofπ-to-πchannels within typical single crystalline organic semiconductors remains unclear as the orientations of these molecules are diverse,and their control usually requires additional side chain groups that misrepresent the intrinsic properties of the original semiconducting ***,the construction of conduction channels with intrinsicπ-πstacking in the molecule-based device is crucial for the utilization of their unique transport characteristics and understanding of the transport *** this end,we present a molecular intercalation strategy that integrates two-dimensional layered materials with functional organic semiconductor molecules for functional molecule-based *** organic semiconductor molecules can be effectively intercalated into the van der Waals gaps of semi-metallic TaS_(2) withπ-πstacking configuration and controlled intercalant *** results show that the vertical charge transport in the stacking direction shows a tunneling-dominated mechanism that strongly depends on the molecular ***,we demonstrated a new type of molecule-based vertical transistor in which TaS_(2) andπ-πstacked organic molecules function as the electrical contact and the active channel,***/off ratios as high as 447 are achieved under electrostatic modulation in ionic liquid,comparable to the current state-of-the-art molecular *** study provides an ideal platform for probing intrinsic charge transport acrossπ-πstacked conjugated molecules and also a feasible approach for the construction of high-performance molecule-based electronic devices.

关键词： π-πstacking electrochemical intercalation organic semiconductor electrical transport tunneling field effect transistor