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Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms

Asian Journal of Andrology 2008年第5期10卷 777-785页

作者： Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu akira yamada Kyogo Itoh Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka Departments of Urology Kurume University School of Medicine Kurume 830-0011 Japan Departments of Bio-statistics Kurume University School of Medicine Kurume 830-0011 Japan Departments of Immunology Kurume University School of Medicine Kurume 830-0011 Japan Research Laboratories Chlorella Industry Co Ltd Chikugo 833-0056 Japan Department of Forest and Forest Products Science Faculty of Agriculture Kyushu University Fukuoka 812-8582 Japan

Aim： To evaluate the safety and efficacy of an extract of Ganoderma lucidum that shows the strongest 5α-reductase inhibitory activity among the extracts of 19 edible and medicinal mushrooms by a double-blind, placebo-controlled, randomized and dose-ranging study in men with lower urinary tract symptoms （LUTS）. Methods： In this trial, we randomly assigned 88 men over the age of 49 years who had slight-to-moderate LUTS to 12 weeks of treatment with G. lucidum extract （6 mg once a day） or placebo. The primary outcome measures were changes in the International Prostate Symptom Score （IPSS） and variables of uroflowmetry. Secondary outcome measures included changes in prostate size, residual urinary volume after voiding, laboratory values and the reported adverse effects. Results： G. lucidum was effective and significantly superior to placebo for improving total IPSS with 2.1 points decreasing at the end of treatment （mean difference, -1.18 points; 95% confidence interval, -1.74 to -0.62; P 〈 0.0001）. No changes were observed with respect to quality of life scores, peak urinary flow, mean urinary flow, residual urine, prostate volume, serum prostate-specific antigen or testosterone levels. Overall treatment was well tolerated with no severe adverse effects. Conclusion： The extract of G. lucidum was well tolerated and improved IPSS scores. These results encouraged a further, large-scale evaluation of phytotherapy for a long duration using the extract of G. lucidum on men with LUTS.

关键词： lower urinary tract symptoms phytotherapy outcome randomized trial Ganoderma lucidum

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精确测量的地幔体波走时及地幔非均匀性的强度(英文)

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地学前缘 2006年第2期13卷 37-47页

作者： akira yamada Yuhei OHTA Geodynamics Research Center Ehi me University Matsuyama790-8577 Japan

用波形相关法精确地测定了在世界各地发生的87个6级以上地震的P波, PP波和Pdiff波的503个走时数据。记录这些地震波形的是新建于西太平洋地区的海洋半球地震观测网。我们利用这些高精度的走时数据研究了地幔体波的走时残差的范围及地幔... 详细信息

用波形相关法精确地测定了在世界各地发生的87个6级以上地震的P波, PP波和Pdiff波的503个走时数据。记录这些地震波形的是新建于西太平洋地区的海洋半球地震观测网。我们利用这些高精度的走时数据研究了地幔体波的走时残差的范围及地幔非均匀性的强度。结果表明,P波、PP波和Pdiff波的走时残差最大分别为9 s ,11 s和15 s ,这为地幔层析成像反演中应该使用的体波走时残差数据的范围提供了重要信息。超出这一范围的走时残差数据不应该用于反演中,以免歪曲成像结果。我们发现,当震中距小于40°时,P波走时残差的范围为-6到+9 s。而对于40°到99°之间的震中距,P波走时残差的范围为-3到+5s。由于震中距越大,P波穿透地幔越深,我们这一结果提供了直接和确凿的证据,表明上地幔和地幔转换带中的横向非均匀性的强度要远胜于下地幔。我们精确测量的Pdiff波的走时数据表明,在地幔底部存在显著的低速异常,可能与地幔热柱或者超级地幔柱有关。我们使用了一个最新的三维全球层析成像模型来解释这些体波走时数据的空间变化。

关键词：地幔体波地震层析成像地幔非均匀性地幔热柱俯冲板片

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Passive Seismic Deployments from the Lützow-Holm Bay to Inland Plateau of East Antarctica: The Japanese IPY Contribution to Structure and Seismicity

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International Journal of Geosciences 2013年第5期4卷 837-843页

作者： Masaki Kanao akira yamada Genti Toyokuni Geodynamics Research Center Ehime University Matsuyama Japan National Institute of Polar Research Tokyo Japan Research Center for Prediction of Earthquakes and Volcanic Eruptions Graduate School of Science Tohoku University Sendai Japan

Deployments of seismic stations in Antarctica are an ambitious project to improve the spatial resolution of the Antarctic Plate and surrounding regions. Several international programs had been conducted in wide area of the Antarctic continent during the International Polar Year (IPY 2007-2008). The “Antarctica’s GAmburtsev Province (AGAP)”, the “GAmburtsev Mountain SEISmic experiment (GAMSEIS)” as a part of AGAP, and the “Polar Earth Observing Network (POLENET)” were major contributions to the IPY. The AGAP/GAMSEIS was an internationally coordinated deployments of more than few tens of broadband seismographs over the wide area of East Antarctica. Detailed information on crustal thickness and mantle structure provides key constraints on an origin of the Gamburtsev Mountains;and more broad structure and evolution of the East Antarctic craton and sub-glacial environment. From POLENET data obtained, local and regional signals associated with ice movements were recorded together with a significant number of teleseismic events. Moreover, seismic deployments have been carried out in the Lützow-Holm Bay (LHB), East Antarctica, by Japanese activities. The recorded teleseismic and local events are of sufficient quality to image the structure and dynamics of the crust and mantle, such as the studies by receiver functions suggesting a heterogeneous upper mantle. In addition to studies on the shallow part of the Earth, we place emphasis on these seismic deployments’ ability to image the Earth’s deep interior, as viewed from Antarctica, as a large aperture array in the southern high latitude.

关键词： Passive Seismic Deployments Lützow-Holm Bay East Antarctica Mantle Structure Earth’s Deep Interiors

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Preparation of substituted rare-earth metal diphthalocyanine complexes and study of their electrochemical behavior

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Acta Chimica Sinica English Edition 1989年第3期7卷 209-218页

作者： SHIGEHARA Kiyotaka yamada akira The Institute of Physical and Chemical Research WakoSaitama 351-01Japan

Rare-earth metal diphthalocyanine complexes with R substituents,R_8Pc_2MH(where Pc=phthalocyanine;R=propoxy,t-butyl;M=Er,Lu),were *** films on basal plane pyrolytic graphite and on indium-tin oxide Ncsa glass electrodes in several aqueous electrolytes were investigated by voltammetric analysis and in situ electronic absorption spectroscopy at controlled *** modified electrodes showed multi-color electrochromic behavior as a result of multi-step redox *** film color turned from original green through orange to red in an oxidation process,and through dark blue to purplish in a reduction process.

关键词： MH pH In SCE

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TOWARD THE REALIZATION OF THE ULTRASONIC INVERSE SCATTERING COMPUTED TOMOGRAPHY BASED ON THE LIMITED VIEW REFLECTION AND TRANSMISSION OBSERVATION DATA

TOWARD THE REALIZATION OF THE ULTRASONIC INVERSE SCATTERING ...

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2002中国—日本声学学术会议

作者： ung-Soon Kim akira yamada Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology Koganei Tokyo 184-8588 Japan Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology Koganei Tokyo 184-8588 Japan

A method of ultrasonic inverse scattering computed tomography was presented using the multi-frequency scattered data received by the fixed array elements on the sector semicircular positions. The vali

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Development of Novel Nanocrystalline SiC, Si1-xGexC and Ge1-yCy for Solar Cell Applications

Development of Novel Nanocrystalline SiC, Si1-xGexC and Ge1-...

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第十五届国际光伏科学与工程大会

作者： Makoto Konagai Shinsuke Miyajima akira yamada Department of Physical Electronics Quantum Nanoelectronics Research Center Tokyo Institute of Technology

The research and development of nanocrystalline(nc) 3C-SiC, SiGeC and GeC thin films for solar cell applications are presented. Hot Wire CVD technique is employed to prepare high quality nc-3C-SiC thin films whose bandgap is 2.2eV. Monomethylsilane and hydrogen are used as reactant gases for the deposition of nc-SiC thin films. N and Al are used as dopants to successfully obtain n and p type nc-3C-SiC thin films. High conductive doped nc-3C-SiC is very attractive for the potential window layer applications in Si thin film and Si heterojunction solar cells. The pin solar cell structures in which all p,i,n layers consist of nc-3C-SiC have been prepared for the first time. A novel Si HIT solar cell with an n-type nc-3C-SiC showed an efficiency of 13.3%. Furthermore, attempts to control the bandgap of nc-3C-SiC are done by incorporating Ge into SiC. Of late, we have succeeded to prepare nc-3C-SiGeC with a Ge content of 2%, which showed about 0.2eV lower absorption spectra compared to that of 3C-SiC.

关键词： Nanocrystalline Alloy Thin Film Solar Cells SiC HIT Solar Cells

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器官异种移植的历史、现状和未来

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中国实用外科杂志 2001年第5期21卷 314-316页

作者： akira yamada Hugh Auchincloss Jr 黄昕毛一雷哈佛大学麻省总医院外科移植中心波士顿02114

首先，我很荣幸受《中国实用外科杂志》编辑部邀请，对器官异种移植进行回顾和展望。异种移植是指在不同种类的动物间进行的器官或组织的移植。近年来对于异种移植的临床和基础的研究有了很大的拓展。本文综述了异种移植的历史及研究... 详细信息

首先，我很荣幸受《中国实用外科杂志》编辑部邀请，对器官异种移植进行回顾和展望。异种移植是指在不同种类的动物间进行的器官或组织的移植。近年来对于异种移植的临床和基础的研究有了很大的拓展。本文综述了异种移植的历史及研究的进展，并提出了将来异种移植的方向。

关键词：器官移植异种移植排斥反应预防

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利用地幔内反射波探测日本列岛下660km不连续面的深度变化(英文)

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地学前缘 2007年第3期14卷 47-56页

作者：山田朗日本爱媛大学地球动力学研究中心

通过分析发生在日本周边深源地震的宽频带波形资料,估计了日本列岛下的660km不连续面(d660)的深度变化。许多宽频带波形记录到了在d660顶部发生反射的sScS的后续波。sScS后续波与sScS间的到时差包含了震中与台站下方的d660深度变化的信... 详细信息

通过分析发生在日本周边深源地震的宽频带波形资料,估计了日本列岛下的660km不连续面(d660)的深度变化。许多宽频带波形记录到了在d660顶部发生反射的sScS的后续波。sScS后续波与sScS间的到时差包含了震中与台站下方的d660深度变化的信息。我们成功地检测到这两种震相并将其分离,到目前为止还没有这方面研究的报道。我们由sScS与其后续波的到时差来求每个震中与记录台站下的d660的深度变化。研究结果显示,西部日本下的d660较深(大于660km),这可能是滞留在地幔转换带中的冷的太平洋板块造成的。在日本中部,d660变深,显然这不是太平洋板块本身造成的,因为日本中部已经位于该滞留板片的东部。日本东北部下的d660变得较浅,这可能是太平洋板片形状变化或下地幔热物质上涌形成局部热异常造成的。

关键词： 660 km不连续面 ScS反射波后续波俯冲板片温度异常

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Characterization of Microcrystalline Germanium Carbon Thin Films-A Novel Absorber Material for PV Applications

Characterization of Microcrystalline Germanium Carbon Thin F...

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第十五届国际光伏科学与工程大会

作者： Yasutoshi Yashiki Shinsuke Miyajima akira yamada Makoto Konagai Department of Physical Electronics Tokyo Institute of Technology Quantum Nanoelectronics Research Center Tokyo Institute of Technology 2-12-1-S9-9O-okayamaMeguro-kuTokyo 152-8552Japan

Thin films of amorphous germanium carbon (a-GeC) and microcrystalline germanium carbon (μc-GeC) were deposited by Hotwire CVD technque. Monomethylgermane and hydrogen were used as source gases during the deposition of these films. Optical properties of these films were characterized by photothermal deflection spectroscopy. Optical absorption spectra of a-GeC and μc-GeC thin films shifted up to the higher energy side compared with amorphous germanium and crystal germanium. The Tauc gap of a-GeC thin films is found to be 1.45 eV, and the absorption spectra of μc-GeC thin films is shifted up by 0.3 eV. The Urbach energy of a-GeC and μe-GeC films are found to be 82meV and 79meV, respectively.

关键词： Germanium carbon Hot wire chemical vapor deposition Optical property

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Managing High Volume Data for Network Attack Detection Using Real-Time Flow Filtering

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China Communications 2013年第3期10卷 56-66页

作者： Abhrajit Ghosh Yitzchak M. Gottlieb Aditya Naidu Akshay Vashist Alexander Poylisher Ayumu Kubota Yukiko Sawaya akira yamada Applied Communication Sciences 150 Mount Airy RoadBasking Ridge NJ 07920 USA KDDI R&D Laboratories 2-1-15 Ohara Fujimino-shiSaitama 356-8502 Japan

In this paper, we present Real-Time Flow Filter (RTFF) -a system that adopts a middle ground between coarse-grained volume anomaly detection and deep packet inspection. RTFF was designed with the goal of scaling to high volume data feeds that are common in large Tier-1 ISP networks and providing rich, timely information on observed attacks. It is a software solution that is designed to run on off-the-shelf hardware platforms and incorporates a scalable data processing architecture along with lightweight analysis algorithms that make it suitable for deployment in large networks. RTFF also makes use of state of the art machine learning algorithms to construct attack models that can be used to detect as well as predict attacks.

关键词： network security intrusion detection scaling

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