检索结果-南通市图书馆

Food Science and Human Wellness 2023年

作者： Qingxue Chen Liu yang Fangqin Xiang Ignatius Man-Yau Szeto yalu yan Biao Liu Jinju Cheng Lu Liu Bailiang Li Sufang Duan Key Laboratory of Dairy Science， Ministry of Education， Northeast Agricultural University Food College， Northeast Agricultural University National Center of Technology Innovation for Dairy Hohhot Inner Mongolia Yili Industrial Group， Co.Ltd.， Yili Maternal and Infant Nutrition Institute (YMINI)

2′-Fucosyllactose (2’-FL) shows the potential to support intestinal health as a natural prebiotic that bridges the gap between infant formula feeding and breastfeeding. However， the effect and mechanism of 2’-FL in improving intestinal permeability are not clear. In this study， we constructed human microbiota-associated (HMA) mouse models by colonizing healthy infant feces in mice with antibiotic-depleted intestinal microbiota. The protective effect of 2’-FL on the intestinal permeability was explored using the HMA mouse models， and the combination of metagenomics was used to analyze the possible mechanisms by which the microorganisms reduced the intestinal permeability. The results showed that 2’-FL decreased the concentration of markers of intestinal permeability (enterotoxin and DAO) and increased the expression levels of tight junctions (occludin and claudin). Metagenomics revealed the enrichment of Bifidobacterium and increased the expression of glycoside hydrolases (GHs)， including GH31， GH28， and GH5. In conclusion， 2’-FL strengthened intestinal permeability function by improving microbiota composition to control the translocation of harmful substance.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

浅谈等高式采煤系统

煤矿机械 2024年第11期45卷 77-79页

作者：高武孝李旺闫亚录沈丰宁夏天地奔牛实业集团有限公司宁夏石嘴山753000 煤矿综采输送设备智能制造技术国家地方联合工程实验室宁夏石嘴山753000

为实现薄煤层资源的低成本、安全、高效、规模化开采,国内引入等高式采煤系统。该系统结合了滚筒式采煤机主动截煤和刨煤机的链条拖拽牵引特点,简化了采煤机的结构,单滚筒传递的截割功率大,具备较强的局部截岩能力,既可以斜切进刀,也可... 详细信息

为实现薄煤层资源的低成本、安全、高效、规模化开采,国内引入等高式采煤系统。该系统结合了滚筒式采煤机主动截煤和刨煤机的链条拖拽牵引特点,简化了采煤机的结构,单滚筒传递的截割功率大,具备较强的局部截岩能力,既可以斜切进刀,也可以垂直进刀,简化了采煤工艺。但是,对于工作面的适应性一般,随层能力不足,需要在合适的应用场景才能发挥其最大效率。

关键词：等高式采煤系统垂直进刀合适的应用场景

在线全文

学校读者我要写书评

暂无评论

煤矿井下更换链轮轴组辅助装置的研究

煤矿机械 2024年第11期45卷 106-108页

作者：闫亚录李旺高武孝沈丰宁夏天地奔牛实业集团有限公司宁夏石嘴山753000 煤矿综采输送设备智能制造技术国家地方联合工程实验室宁夏石嘴山753000

为解决井下更换链轮轴组劳动强度大、安全系数低等问题,研发了一种煤矿井下刮板输送机链轮轴组更换辅助装置。该装置含可移动支座、链轮轴组拆除组件、链轮轴组装配组件。可移动支座的上端顺序设置凹形底座以及支承轴组的V形架。链轮轴... 详细信息

为解决井下更换链轮轴组劳动强度大、安全系数低等问题,研发了一种煤矿井下刮板输送机链轮轴组更换辅助装置。该装置含可移动支座、链轮轴组拆除组件、链轮轴组装配组件。可移动支座的上端顺序设置凹形底座以及支承轴组的V形架。链轮轴组拆除组件布置在凹形底座的下端,进行拆除作业时,链拆除组件缓慢地将轴组从刮板输送机牵引至固定架。装配组件使用时安装在凹形底座的顶部,当装配组件旋转至水平并面向固定架时,将放置在固定架上的链轮轴组推至刮板输送机的安装处。

关键词：链轮轴组拆装刮板输送机

在线全文

学校读者我要写书评

暂无评论

高刚度D型侧挂式电机减速器联接罩筒研究

煤矿机械 2024年第4期45卷 105-107页

作者：秦俊严小明杨皓闫亚录刘益添沈丰宁夏天地奔牛实业集团有限公司宁夏石嘴山753000 煤矿综采输送设备智能制造技术国家地方联合工程实验室宁夏石嘴山753000 府谷能源投资集团郭家湾矿业有限公司陕西榆林719400

煤矿井下采煤工作面的输送、破碎装备的动力部常用的安装方式为减速器输出端与设备转轴相联接,减速器输入端通过罩筒与电动机相互联接,整个电机-罩筒-减速器部件构成一个悬臂结构,与设备主体联接。现有悬臂结构动力部安装方式会造成两... 详细信息

煤矿井下采煤工作面的输送、破碎装备的动力部常用的安装方式为减速器输出端与设备转轴相联接,减速器输入端通过罩筒与电动机相互联接,整个电机-罩筒-减速器部件构成一个悬臂结构,与设备主体联接。现有悬臂结构动力部安装方式会造成两方面问题:一方面悬臂结构上的电机在重力作用下变形,无法保证与减速器联接同轴度,在高速运行状态下容易损坏减速器输入轴和联轴器,造成减速器故障频发、联轴器寿命短等问题;另一方面电机-罩筒-减速器部件整体因联接长度偏短产生整体偏沉,导致设备主体变形,与减速器联接的设备轴组等部件因变形造成寿命短、易损坏。研制了一种高刚度D型侧挂式电机减速器联接罩筒,能够有效减少动力部因偏沉变形而造成的故障,提高装备可靠性。

关键词：动力部罩筒防偏沉

Fabrication of NiCoP decorated TiO_(2)/polypyrrole nanocomposites for the effective photocatalytic degradation of tetracycline

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第5期33卷 2741-2746页

作者： yalu Wu Yinyin Xu yan Zhang Jingbo Feng Yuanyuan Li Jiaying Lan Xiuwen Cheng Key Laboratory for Environmental Pollution Prediction and Control College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China

Due to the massive discharge of antibiotics in water,it is an urgent matter to remove antibiotics from waste *** photocatalysts with high stability and activity have attracted extensive attention from *** an in-situ polymerization method,polypyrrole(PPy)was modified on the surface of TiO_(2)(named as TiO_(2)/PPy).By one-step reduction method,NiCoP was grafted on the surface of TiO_(2)/PPy(named as TiO_(2)/PPy/NiCoP)to synthesize the photocatalyst of TiO_(2)/PPy/NiCoP for degradation of tetra-cycline(TC)*** characterization results revealed that NiCoP was deposited on the surface of TiO_(2)/PPy *** photocatalytic experiment results illustrated that 83.2%of TC could be de-graded at natural pH with 20 mg of TiO_(2)/PPy/NiCoP in 50 mL of TC solution(10 mg/L)under visible light *** high catalytic activity is attributed to the attachment of NiCoP on the surface of TiO_(2)/PPy which can enlarge the light response range of TiO_(2)*** studies revealed that the degra-dation of TC was dominated by•O_(2)−and h+.The photodegradation efficiency of TC with TiO_(2)/PPy/NiCoP still reached over 74%after 5 consecutive cycles,indicating the potential applications in practical wastew-ater.

关键词： TiO_(2) NiCoP Polypyrrole Visible light photocatalytic Tetracycline

Association Between Physical Activity and Physical Fitness Among Adults Aged 40 to 79 Years—Beijing,China,2020–2021

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2022年第42期4卷 936-940页

作者： Xiaojin yan Heming Pei yalu Zhang Ning Kang Gong Chen Dongmin Wang Institute of Population Research Peking UniversityBeijingChina Department of Physical Education Peking UniversityBeijingChina

Summary What is already known about this topic?Physical fitness is well documented to be associated with physical activity among adults in the United *** China,research on this association places a heavier emphasis on the populations of children and *** is added by this report?Physical fitness was shown to be positively associated with physical activity among adults aged 40 to 79 years in *** populations with lower levels of physical fitness,this association was *** coefficients of the log-transformed metabolic equivalent value of physical activity(logPA)in quantile regression models at the 25th,50th,75th,and 90th percentile of the physical fitness indicators were 1.14,1.04,0.89,and 0.84,respectively.

关键词： Physical logP transformed

PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton,modulating emotional behavior

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2024年第3期45卷 535-550页

作者： Laidong Yu Fangfang Zeng Mengshu Fan Kexuan Zhang Jingjing Duan yalu Tan Panlin Liao Jin Wen Chenyu Wang Meilin Wang Jialong Yuan Xinxin Pang yan Huang yangzhou Zhang Jia-Da Li Zhuohua Zhang Zhonghua Hu Hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Provincial Clinical Research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China MOE Key Lab of Rare Pediatric Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China Department of Neurosciences University of South China Medical SchoolHengyangHunan 421001China

Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain *** abnormalities,such as defects in the density and morphology of postsynaptic dendritic spines,underlie the pathology of various neuropsychiatric *** 17(PCDH17)is associated with major mood disorders,including bipolar disorder and ***,the molecular mechanisms by which PCDH17 regulates spine number,morphology,and behavior remain *** this study,we found that PCDH17 functions at postsynaptic sites,restricting the number and size of dendritic spines in excitatory *** overexpression of PCDH17 in the ventral hippocampal CA1 results in spine loss and anxiety-and depression-like behaviors in ***,PCDH17 interacts with actin-relevant proteins and regulates actin filament(F-actin)***,PCDH17 binds to ROCK2,increasing its expression and subsequently enhancing the activity of downstream targets such as LIMK1 and the phosphorylation of cofilin serine-3(Ser3).Inhibition of ROCK2 activity with belumosudil(KD025)ameliorates the defective F-actin organization and spine structure induced by PCDH17 overexpression,suggesting that ROCK2 mediates the effects of PCDH17 on F-actin content and spine ***,these findings reveal a novel mechanism by which PCDH17 regulates synapse development and behavior,providing pathological insights into the neurobiological basis of mood disorders.

关键词： Synapse development Dendritic spine Mood disorder Actin cytoskeleton Animal behavior

在线全文

学校读者我要写书评

暂无评论

高速公路收益权的资产证券化问题研究

金融研究 2016年第5期 111-123页

作者：闫妍顾亚露朱晓武中国科学院大学经济与管理学院北京100080 中国科学院大数据挖掘与知识管理重点实验室北京100080 中国政法大学商学院北京102249

本文研究了高速公路的资产证券化问题,设计以高速公路收益权作为基础资产的资产支持票据(ABN),并根据高速公路收费额的预期值和利率期限结构确定ABN的发行规模和票面利率。我们还对本文设计的ABN产品进行利率风险分析。

关键词：资产证券化资产支持票据高速公路

在线全文

学校读者我要写书评

暂无评论

大动态信号的高分辨采集电路设计方法

传感技术学报 2022年第2期35卷 148-153页

作者：邵亚璐王鉴庞存锁韩焱中北大学信息探测与处理山西省重点实验室山西太原030051 省部共建动态测试技术国家重点实验室山西太原030051

针对在数字采集中,受ADC的量化分辨力限制,大动态范围信号难以满足信号分辨力的要求的问题,提出了一种适应大动态范围信号高分辨力采集电路系统的设计方法。首先根据信号的动态范围、分辨力指标和关注度,将信号进行逆序分段放大到ADC的... 详细信息

针对在数字采集中,受ADC的量化分辨力限制,大动态范围信号难以满足信号分辨力的要求的问题,提出了一种适应大动态范围信号高分辨力采集电路系统的设计方法。首先根据信号的动态范围、分辨力指标和关注度,将信号进行逆序分段放大到ADC的输入动态范围,之后,根据各分段采集到的不同分辨力数据,进行数据加权合成,实现大动态范围信号的分段高分辨实时采集。仿真实验验证表明,此方法既可满足大动态范围信号的高分辨采集,同时可根据不同段信号的关注度,实现特定的分辨力采集,且误差率低于3%。

关键词：信号采集处理分段放大高分辨采集关注度大动态范围

川芎指纹图谱的建立及60Co-γ辐照对其有效成分的影响

在线全文

学校读者我要写书评

暂无评论

辐射研究与辐射工艺学报 2023年第5期41卷 60-72页

作者：邱娅璐高鹏何江陈谦王艳四川省原子能研究院成都610101 辐照保藏四川省重点实验室成都610101 成都理工大学核技术与自动化工程学院成都610059

为了建立川芎指纹图谱,考察不同剂量60Co-γ辐照对川芎8种有效成分的影响,以川芎为材料,采用SHIMADZU Shim-pack GIST C18色谱柱(250 mm×4.6 mm,5μm)对8种有效成分的标准品和对照品储备液进行分析。设定不同剂量(3 kGy、6 kGy、10 kGy... 详细信息

为了建立川芎指纹图谱,考察不同剂量60Co-γ辐照对川芎8种有效成分的影响,以川芎为材料,采用SHIMADZU Shim-pack GIST C18色谱柱(250 mm×4.6 mm,5μm)对8种有效成分的标准品和对照品储备液进行分析。设定不同剂量(3 kGy、6 kGy、10 kGy、15 kGy)60Co-γ辐照处理川芎,处理后样品通过液相色谱法得到指纹图谱。采用《中药色谱指纹图谱相似度评价系统(2004A版)》对相似度进行评价。结果表明:川芎各成分相似度均大于0.988;在低于10 kGy的射线辐照处理后,川芎的8种有效成分含量无明显差异。结果表明该方法稳定可靠。该研究为辐照技术在川芎品质保障及川芎药材辐照标准的制定提供理论依据和支撑。

关键词：川芎 60Co-γ辐照有效成分指纹图谱