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Evaluation of Interferon-Gamma Release Assay Testing and Tuberculin Skin Test for Early Diagnosis of Tuberculosis in Children and Adolescents

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Open Journal of Pediatrics 2024年第3期14卷 558-567页

作者： Yelda Sorguç Miray Çelebi Yılmaz Yüce Ayhan yakup yaman Şener Tulumoğlu Aybüke Akaslan Kara İlker Devrim University of Health Sciences Dr. Beh&#231et Uz Child Disease and Pediatric Surgery Training and Research Hospital Medical Microbiology &#304zmir T&#252rkiye Department of Pediatric Infectious Diseases University of Health Sciences Dr. Beh&#231et Uz Child Disease and Pediatric Surgery Training and Research Hospital &#304zmir T&#252rkiye

Background: This study aimed to evaluate the diagnostic value of interferon-γ release assay (IGRA), a sensitive microbiological diagnostic method, in children and adolescents with suspected tuberculosis in a country with a high burden of tuberculosis. Method: This study included 581 children and adolescents aged 4 - 19 years who were suspected of having tuberculosis, were latently infected with Mycobacterium tuberculosis, and had received at least one dose of BCG vaccine between April 17, 2019, and February 24, 2021. The study evaluated the TST results of 106 patients who had a positive Quantiferon test and were suspected of having tuberculosis. Results: The study included 581 patients aged between 4 and 19 years. Of these, 106 patients tested positive for the Quantiferon test, while 19 were indeterminate and 456 were negative. The Quantiferon test positivity rate was 18.24%. Among the 106 QFT-Plus-positive cases, 23 patients also tested positive for TST. The difference in distribution was found to be statistically significant. Conclusion: The QFT-Plus test is considered an alternative to TST and other microbiological diagnostic methods for early tuberculosis diagnosis, particularly in children and adolescents.

关键词： Interferon Gamma Release Assay Children Tuberculin Test Children Latent Tuberculosis

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Is sarcopenia effective on survival in patients with metastatic gastric cancer?

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1861-1868页

作者： Ozlem Dogan Hayriye Sahinli yakup Duzkopru Tuba Akdag Abdulkadir Kocanoglu Department of Medical Oncology Adıyaman University Training and Research HospitalAdiyaman 02100Turkey Department of Medical Oncology Ankara Etlik City HospitalAnkara 06170Turkey Department of Radiology University of Health SciencesDiskapi Yildirim Beyazit Training and Research HospitalAnkara 06000Turkey Department of Medical Oncology Ankara Ataturk Sanatoryum Training and Research HospitalAnkara 06170Turkey

BACKGROUND Sarcopenia is a progressively diminishing state characterized by the reduction of muscle mass and density,which is frequently observed in malignancies of solid *** To assess how sarcopenia affects the overall survival of individuals who have been diagnosed with metastatic gastric *** The study retrospectively included individuals who had been diagnosed with metastatic gastric cancer between January 2008 and December *** was identified through the calculation of the average Hounsfield units(HUAC)using computed tomography(CT)images taken at the time of diagnosis in *** A total of 118 patients with metastatic gastric cancer were *** was detected in 29 patients(24.6%).The median survival of all patients was 8(1-43)*** median survival of patients with sarcopenia was 2 mo,while it was 10 mo for those without sarcopenia(P<0.001).A significant relationship was found between sarcopenia and *** Sarcopenia has been observed to impact survival outcomes in various types of solid tumor *** patients can be identified in a short time,easily and inexpensively,by HUAC measurements from CT images used for diagnosis,and survival could be promoted with nutritional support.

关键词： Hounsfield units Sarcopenia Gastric cancer Survival Psoas muscle mass Muscle density

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