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Immunotherapy in gastric cancer with liver metastasis:Challenges and opportunities

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1513-1516页

作者： murat Bardakçi yakup Ergun Department of medical Oncology Diyarbakır Gazi Yasargil Training and Research HospitalDiyarbakir 021000KayapinarTürkiye Department of medical Oncology Antalya City HospitalAntalya 07080Türkiye

In this editorial,we review the article by Liu et al published in the World Journal of Gastrointestinal Surgery investigating the efficacy and safety of immunotherapy in patients with gastric cancer(GC)and liver ***,the fifth most com-monly diagnosed malignancy worldwide,presents a significant challenge due to its multifactorial etiology and a grim prognosis for unresectable or recurrent *** advent of immune checkpoint inhibitors(ICIs)has revolutionized oncology;yet liver metastasis has been associated with reduced response rates,progression-free survival,and overall survival in various *** Che-ckmate-649 and KEyNOTE-859 trials demonstrated promising results with ICIs in advanced GC,particularly in patients with liver ***,a meta-analysis of liver metastatic solid tumors revealed worse outcomes with ICIs,high-lighting the need for further *** combined therapies,including ICIs with local treatments,show promise in improving outcomes,the nuanced landscape of ICIs in liver metastatic GC necessitates continued research for robust *** current contradictions in the literature underscore the impor-tance of cautious interpretation and the exploration of tailored approaches to enhance clinical efficacy in this challenging patient population.

关键词： Gastric cancer Liver metastasis Immunotherapy Immune checkpoint in-hibitors Transarterial chemoembolization Tumor microenvironment

Is sarcopenia effective on survival in patients with metastatic gastric cancer?

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1861-1868页

作者： Ozlem Dogan Hayriye Sahinli yakup Duzkopru Tuba Akdag Abdulkadir Kocanoglu Department of medical Oncology Adıyaman University Training and Research HospitalAdiyaman 02100Turkey Department of medical Oncology Ankara Etlik City HospitalAnkara 06170Turkey Department of radiology University of Health SciencesDiskapi Yildirim Beyazit Training and Research HospitalAnkara 06000Turkey Department of medical Oncology Ankara Ataturk Sanatoryum Training and Research HospitalAnkara 06170Turkey

BACKGrOUND Sarcopenia is a progressively diminishing state characterized by the reduction of muscle mass and density,which is frequently observed in malignancies of solid *** To assess how sarcopenia affects the overall survival of individuals who have been diagnosed with metastatic gastric *** The study retrospectively included individuals who had been diagnosed with metastatic gastric cancer between January 2008 and December *** was identified through the calculation of the average Hounsfield units(HUAC)using computed tomography(CT)images taken at the time of diagnosis in *** A total of 118 patients with metastatic gastric cancer were *** was detected in 29 patients(24.6%).The median survival of all patients was 8(1-43)*** median survival of patients with sarcopenia was 2 mo,while it was 10 mo for those without sarcopenia(Prelationship was found between sarcopenia and *** Sarcopenia has been observed to impact survival outcomes in various types of solid tumor *** patients can be identified in a short time,easily and inexpensively,by HUAC measurements from CT images used for diagnosis,and survival could be promoted with nutritional support.

关键词： Hounsfield units Sarcopenia Gastric cancer Survival Psoas muscle mass muscle density

Evaluation of Interferon-Gamma release Assay Testing and Tuberculin Skin Test for Early Diagnosis of Tuberculosis in Children and Adolescents

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Open Journal of Pediatrics 2024年第3期14卷 558-567页

作者： yelda Sorguç miray Çelebi yılmaz yüce Ayhan yakup yaman Şener Tulumoğlu Aybüke Akaslan Kara İlker Devrim University of Health Sciences Dr. Beh&#231et Uz Child Disease and Pediatric Surgery Training and Research Hospital Medical Microbiology &#304zmir T&#252rkiye Department of Pediatric Infectious Diseases University of Health Sciences Dr. Beh&#231et Uz Child Disease and Pediatric Surgery Training and Research Hospital &#304zmir T&#252rkiye

Background: This study aimed to evaluate the diagnostic value of interferon-γ release assay (IGrA), a sensitive microbiological diagnostic method, in children and adolescents with suspected tuberculosis in a country with a high burden of tuberculosis. method: This study included 581 children and adolescents aged 4 - 19 years who were suspected of having tuberculosis, were latently infected with mycobacterium tuberculosis, and had received at least one dose of BCG vaccine between April 17, 2019, and February 24, 2021. The study evaluated the TST results of 106 patients who had a positive Quantiferon test and were suspected of having tuberculosis. results: The study included 581 patients aged between 4 and 19 years. Of these, 106 patients tested positive for the Quantiferon test, while 19 were indeterminate and 456 were negative. The Quantiferon test positivity rate was 18.24%. Among the 106 QFT-Plus-positive cases, 23 patients also tested positive for TST. The difference in distribution was found to be statistically significant. Conclusion: The QFT-Plus test is considered an alternative to TST and other microbiological diagnostic methods for early tuberculosis diagnosis, particularly in children and adolescents.

关键词： Interferon Gamma release Assay Children Tuberculin Test Children Latent Tuberculosis

A combo technology of autotrophic and heterotrophic denitrification processes for groundwater treatment

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Chinese Journal of Chemical Engineering 2021年第9期34卷 121-127页

作者： Cemile Seyma Arzum yapıcı Dilan Toprak müjgan yıldız Sinan Uyanık yakup Karaaslan Deniz Uçar Environmental Engineering Department Engineering FacultyHarran UniversitySanliurfa 63100Turkey Gap renewable Energy and Energy Efficiency Center Harran UniversitySanliurfa 63100Turkey General Directorate of Water management Republic of Turkey Ministry of Agriculture and Forestry Bestepe MahallesiYenimahalle 06560Turkey

In this study,a sequential process(heterotrophic up-flow column and completely mixed membrane bioreactors)was proposed combining advantages of the both *** system was operated for 249 days with simulated and real groundwater for nitrate removal at concentrations varying from 25 to 145 mg·L^(-1) NO_(3)^(-)-*** contribution of heterotrophic process to total nitrate removal in the system was controlled by dozing the ethanol considering the nitrate *** this way,sulfur based autotrophic denitrification rate was decreased and the effluent sulfate concentrations were *** alkalinity requirement in the autotrophic process was produced in the heterotrophic reactor,and the system was operated without alkalinity *** the study,the chemical oxygen demand in the heterotrophic reactor effluent was(23.7±22)mg L^(-1) and it was further decreased to(7.5±7.2)mg·L^(-1) in the system effluent,corresponding to a 70%*** the last period of the study,the real groundwater containing 145 mg·L^(-1) NO_(3)^(-)-N was completely *** was operated without chemical washing in the first 114 *** days 115-249 weekly chemical washing was required.

关键词： Nitrate removal Bioreactor Bioprocess Anaerobic process Groundwater treatment

中古中外文化交流的新探索--读《波斯锦与锁子甲:中古中国与萨珊文明》

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西域研究 2024年第1期 181-185页

作者：王平吾斯曼江·亚库甫陕西师范大学中国西部边疆研究院

人类历史文化的发展建立在交流互动和文明互鉴的基础上,人类文明史实际上是一部交流互鉴史,古代各大文明古国之间的互动关系是国际重大学术问题,其中,中古波斯与中国文化交流研究一直是学界关注的主要课题之一。“中国同古代西方诸文明... 详细信息

人类历史文化的发展建立在交流互动和文明互鉴的基础上,人类文明史实际上是一部交流互鉴史,古代各大文明古国之间的互动关系是国际重大学术问题,其中,中古波斯与中国文化交流研究一直是学界关注的主要课题之一。“中国同古代西方诸文明之间的交通与交流,源远流长,甚至可追溯到远古混沌时期。”((1))因此,“探讨中国与波斯的关系就具有重要的学术意义。”

关键词：中外文化交流交流互动人类历史文化中古中国古代西方锁子甲古波斯交流互鉴

N_(2)and Ar dilution on the premixed biogas jet flame under external acoustic enforcement

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Propulsion and Power research 2023年第4期12卷 486-504页

作者： Bugrahan Alabas Ilker yılmaz yakupÇam Department of Aeronautical Engineering Faculty of Aeronautics and AstronauticsErciyes UniversityKayseri 38039Turkey Department of Energy Systems Engineering Faculty of TechnologyGazi UniversityAnkara 06560Turkey Department of Aircraft maintenance and repair Faculty of Aeronautics and AstronauticsErciyes UniversityKayseri 38039Turkey

In this study,combustion instabilities and flue gas emission changes under different dilutions of N_(2)(nitrogen)and Ar(argon)of a promising biogas mixture(70%CH4-30%CO_(2))in the fight against greenhouse gas emissions were *** the experiments,additions were made from 0%to 50%at intervals of 10%for both *** order to detect the instability of the flame,external acoustic enforcements at different frequencies was applied through the speakers placed in the combustion chamber *** dynamic pressure fluctuation values were *** results showed that low dilution ratios were effective in reducing flame instability for both inert ***,as the dilution ratio increased,the fuel/air mixture became leaner and blowoff *** the case of comparing two different gases,it has been observed that the effect of argon gas on reducing dynamic pressure fluctuation is *** outlet temperature and brightness values of the flame decreased in both Ar and N_(2)*** and NOx emissions increased with increasing diluent volume for all dilution *** the emissions of the two diluent gases are compared,the CO emission,which was 3134 ppm in the undiluted condition,increased up to 4949 ppm in 50%Ar dilution,while it increased to 4521 ppm in 50%N_(2)dilution.

关键词： Biogas Combustion instabilities Pollutant emissions Gas turbine combustor Dilution

Potassium tert-Butoxide Catalyzed Synthesis and Characterization of Novel 3-Aryl-3-（phenylthio）-1-（thiophen-3-yl）- propan-l-one Derivatives

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Chinese Journal of Chemistry 2012年第2期30卷 341-344页

作者： Budak, yakup Department of Chemistry Faculty of Arts and Sciences Gaziosmanpasa University 60250 Tokat Turkey

A series of thiophenyl-containing 3-thiophene derivatives （4a--4i） were prepared via the reaction of chalcone-analogua compounds （3a--3i） and thiophenol in the presence of catalytic amount of KOBu-t in CH2C12 with moderate to high yields. The mechanistic pathway of the reaction was explained by the michael-type addition of thiophenol to chalcone derivatives （3a--3i）.

关键词： 1-(thiophen-3-yl)ethanone michael addition potassiumtert-butoxide chalcone catalysis

Topographic tear film trend and new parameters for noninvasive break up time test

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1932-1939页

作者： yakup Acet Department of Ophthalmology Mardin Training and Research HospitalMardin 47100Turkey

AIm:To evaluate the quantitative and qualitative results of the noninvasive tear film break-up time(NI-BUT)test and investigate the predictive ability of the new NIBUT parameter in discriminating between normal Ocular Surface Disease Index(OSDI;scores≤12)and abnormal OSDI(scores≥13).mETHODS:A total of 341 eyes of 341 volunteers who applied for routine eye outpatient control were included in the prospective *** participants'noninvasive first tear film break-up time(NIF-BUT),noninvasive average tear film break-up time(NIAvg-BUT)and average value of the first three break-up time(A3F-BUT)were analyzed.A3F-BUT,the new NI-BUT parameter,is calculated by adding the NIF-BUT value to the 2^(nd )break-up time value that has a difference of at most 1 second from the NIF-BUT value and to the 3^(rd) break-up time and then dividing the respective sum by *** operating characteristic(rOC)curve and forward logistic regression analyses were performed to determine the parameter that had the best predictive ability between the OSDI ***:The NI-BUT values of 255 eyes of 255 volunteers included in the study were analyzed *** mean NIF-BUT,NIAvg-BUT,and A3F-BUT values were calculated as 5.3±3.0,8±3.1,and 5.8±3.0 seconds,*** three parameters were found to be significantly lower in the abnormal OSDI group(P=0.014,0.034,and 0.011,respectively).The area under the curve(AUC)of the A3F-BUT to predict abnormal OSDI was AUC=0.625(0.529-0.720),P=0.011 and NIF-BUT was AUC=0.599(0.502-0.696),P=*** A3F-BUT parameter and NIF-BUT parameters were found to be significantly efficient in discriminating abnormal ***:The new parameter for the NI-BUT test has more predictive ability in the discrimination of OSDI groups.

关键词： noninvasive break-up time Ocular Surface Disease Index tear film topographic break-up time test

Urinary tract infections in neonates with jaundice in their first two weeks of life

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World Journal of Pediatrics 2014年第2期10卷 164-167页

作者： mehmet mutlu yasemin Cayır yakup Aslan Department of Neonatology Erzurum Regional Training and Research HospitalNeonatal Intensive Care UnitErzurumTurkey Department of Family Physician Erzurum Regional Training and Research HospitalNeonatal Intensive Care UnitErzurumTurkey Department of Neonatology Karadeniz Technical UniversityNeonatal Intensive Care UnitTrabzonTurkey

Background:Hyperbilirubinemia is a frequently seen condition in *** study was undertaken to determine the role of urinary tract infections(UTIs)in the etiology of indirect hyperbilirubinemia in neonates with jaundice in their fi rst two weeks of ***:The study was conducted *** subjects were neonates aged 4-14 days with hyperbilirubinemia which could not be detected by routine tests and was suffi ciently severe to necessitate ***:The study was performed in 104 neonates,of whom 18%(n=19)had *** most frequently identified micro-organism was Escherichia coli(43%).Phototherapy duration and rebound bilirubin level were higher in neonates with UTI(Pld be investigated in neonates with hyperbilirubinemia of unknown etiology in the fi rst two weeks of life.

关键词： hyperbilirubinemia neonate urinary tract infection