检索结果-南通市图书馆

miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis

Acta Pharmaceutica Sinica B 2022年第2期12卷 821-837页

作者： Tao Su Suchao Huang Yanmin Zhang yajuan guo Shuwei Zhang Jiaji Guan Mingjing Meng Linxin Liu Caiyan Wang Dihua Yu Hiu-Yee Kwan Zhiying Huang Qiuju Huang Elaine Lai-Han Leung Ming Hu Ying Wang Zhongqiu Liu Linlin Lu Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China Guangzhou University of Chinese MedicineGuangzhou 510006China Department of Molecular and Cellular Oncology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China State Key Laboratory of Quality Research in Chinese Medicine/Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao(SAR)999078China Department of Pharmacological and Pharmaceutical Sciences University of HoustonHoustonTX 77204USA

Acidosis,regardless of hypoxia involvement,is recognized as a chronic and harsh tumor microenvironment(TME)that educates malignant cells to thrive and metastasize.Although overwhelming evidence supports an acidic environment as a driver or ubiquitous hallmark of cancer progression,the unrevealed core mechanisms underlying the direct effect of acidification on tumorigenesis have hindered the discovery of novel therapeutic targets and clinical therapy.Here,chemical-induced and transgenic mouse models for colon,liver and lung cancer were established,respectively.miR-7 and TGF-β2 expressions were examined in clinical tissues(n=184).RNA-seq,miRNA-seq,proteomics,biosynthesis analyses and functional studies were performed to validate the mechanisms involved in the acidic TME-induced lung cancer metastasis.Our data show that lung cancer is sensitive to the increased acidification of TME,and acidic TME-induced lung cancer metastasis via inhibition of miR-7-5 p.TGF-β2 is a direct target of miR-7-5 p.The reduced expression of miR-7-5 p subsequently increases the expression of TGF-β2 which enhances the metastatic potential of the lung cancer.Indeed,overexpression of miR-7-5 p reduces the acidic p H-enhanced lung cancer metastasis.Furthermore,the human lung tumor samples also show a reduced miR-7-5 p expression but an elevated level of activated TGF-β2;the expressions of both miR-7-5 p and TGF-β2 are correlated with patients’survival.We are the first to identify the role of the miR-7/TGF-β2 axis in acidic p H-enhanced lung cancer metastasis.Our study not only delineates how acidification directly affects tumorigenesis,but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer(NSCLC)treatment.Our study opens an avenue to explore the p H-sensitive subcellular components as novel therapeutic targets for cancer treatment.

关键词： Acidic tumor microenvironment miR-7-5p TGF-β2 Metastasis Lung cancer pH Invasion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transceiver Optimization for Multi-Antenna Device-to-Device Communications

引用

China Communications 2016年第5期13卷 110-121页

作者： Daohua Zhu yajuan guo Lei Wei Chaoyang Zhu Biyao Huang Wei Xu Chunming Zhao Sate Grid Jiangsu Electric Power Company Electric Power Research Institute Nanjing 211103 China Sate Grid Jiangsu Electric Power Company Nanjing 210024 China Sate Grid Suzhou Power Supply Company Suzhou 215000 China Global Energy Interconnection Research Institute Beijing 102209 China National Mobile Communications Research Laboratory Southeast University Nanjing 210096 China

It has been shown that the deployment of device-to-device(D2D) communication in cellular systems can provide better support for local services. However, improper design of the hybrid system may cause severe interference between cellular and D2D links. In this paper, we consider transceiver design for the system employing multiple antennas to mitigate the interference. The precoder and decoder matrices are optimized in terms of sum mean squared error(MSE) and capacity, respectively. For the MSE minimization problem, we present an alternative transceiver optimization algorithm. While for the non-convex capacity maximization problem, we decompose the primal problem into a sequence of standard convex quadratic programs for efficient optimization. The evaluation of our proposed algorithms for performance enhancement of the entire D2D integrated cellular system is carried out through simulations.

关键词：优化算法天线设备收发信机设备通信混合系统设计蜂窝系统最小化问题最大化问题

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biodegradable metals for bone defect repair:A systematic review and meta-analysis based on animal studies

引用

Bioactive Materials 2021年第11期6卷 4027-4052页

作者： Jiazhen Zhang Yanbiao Jiang Zhizhong Shang Bing Zhao Mingyue Jiao Wenbo Liu Maobo Cheng Bao Zhai yajuan guo Bin Liu Xinli Shi Bin Ma Center for Medical Device Evaluation National Medical Products AdministrationBeijing100081PR China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou730000PR China Institute of Health Data Science Lanzhou UniversityLanzhou730000PR China

Biodegradable metals are promising candidates for bone defect repair.With an evidence-based approach,this study investigated and analyzed the performance and degradation properties of biodegradable metals in animal models for bone defect repair to explore their potential clinical translation.Animal studies on bone defect repair with biodegradable metals in comparison with other traditional biomaterials were reviewed.Data was carefully collected after identification of population,intervention,comparison,outcome,and study design(PICOS),and following the inclusion criteria of biodegradable metals in animal studies.30 publications on pure Mg,Mg alloys,pure Zn and Zn alloys were finally included after extraction from a collected database of 2543 publications.A qualitative systematic review and a quantitative meta-analysis were performed.Given the heterogeneity in animal model,anatomical site and critical size defect(CSD),biodegradable metals exhibited mixed effects on bone defect repair and degradation in animal studies in comparison with traditional non-degradable metals,biodegradable polymers,bioceramics,and autogenous bone grafts.The results indicated that there were limitations in the experimental design of the included studies,and quality of the evidence presented by the studies was very low.To enhance clinical translation of biodegradable metals,evidence-based research with data validity is needed.Future studies should adopt standardized experimental protocols in investigating the effects of biodegradable metals on bone defect repair with animal models.

关键词： Biodegradable metals Bone defect repair Animal model Systematic review and meta-analysis Regulatory science Safety and effectiveness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

机电控制系统自动控制技术与一体化设计

引用

集成电路应用 2024年第2期41卷 202-203页

作者：伦佳琪郭亚娟郑州工商学院河南451400

阐述机电控制系统中的自动控制技术与一体化设计方案,包括单片机控制芯片、A/D模数转换器、接口和电路设计,以及调节软件、智能工作软件的设计。分析机电一体化技术的应用。

关键词：机电控制系统自动控制技术一体化设计

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

海水酸化和升温对两种造礁石珊瑚生长和钙化的影响

引用

热带海洋学报 2024年第3期43卷 49-57页

作者：周伟华李颖心郭亚娟霍嘉欣宋严朱晴袁翔城刘胜黄晖中国科学院热带海洋生物资源与生态重点实验室广东省应用海洋生物学重点实验室中国科学院南海海洋研究所广东广州510301 三亚海洋科学综合(联合)实验室海南省热带海洋生物技术重点实验室海南三亚572000 海南三亚海洋生态系统国家野外科学观测研究站中国科学院海南热带海洋生物实验站海南三亚572000 中国科学院大学北京100049 中国科学院南海海洋研究所海洋环境检测中心广东广州510301

以海南岛三亚鹿回头两种常见的造礁石珊瑚(鹿角杯形珊瑚Pocillopora damicornis和丛生盔形珊瑚Galaxea fascicularis)为研究对象,通过室内培养实验探究海水酸化和升温两种联合因子对造礁石珊瑚生长和钙化的影响。结果显示:两种珊瑚受海... 详细信息

以海南岛三亚鹿回头两种常见的造礁石珊瑚(鹿角杯形珊瑚Pocillopora damicornis和丛生盔形珊瑚Galaxea fascicularis)为研究对象,通过室内培养实验探究海水酸化和升温两种联合因子对造礁石珊瑚生长和钙化的影响。结果显示:两种珊瑚受海水酸化的影响显著,丛生盔形珊瑚在pH 8.1下的生长速率显著高于pH 7.7和7.4环境,鹿角杯形珊瑚在pH 7.4下的钙化速率显著低于pH 7.7和8.1环境。且鹿角杯形珊瑚的生长速率与钙化速率显示各温度和pH因子之间均出现拮抗现象,能有效缓解珊瑚白化;相同的拮抗现象也出现在丛生盔形珊瑚的钙化速率上,但在其生长速率则表现出协同作用,加速珊瑚白化。鹿角杯形珊瑚与丛生盔形珊瑚的生长速率和钙化速率对海水升温和酸化的响应存在种间特异性。

关键词：鹿角杯形珊瑚丛生盔形珊瑚酸化升温生长钙化

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

药用辅料糊精的质量评价

引用

华西药学杂志 2024年第2期39卷 193-196页

作者：叶秀金胡淑君李艺郭雅娟胡佳哲王彩媚林嗣翔陈旻广东省药品检验所国家药品监督管理局药用辅料质量控制与评价重点实验室广东广州510663

目的考察药用辅料糊精的质量现状及存在问题。方法按现行质量标准,对18个厂家167批样品进行检验,并开展探索性试验,分析评价糊精的质量。结果按现行标准检验,1批样品不合格。产品中真菌毒素的含量较高,并存在质量不均一的情况,应重视,... 详细信息

目的考察药用辅料糊精的质量现状及存在问题。方法按现行质量标准,对18个厂家167批样品进行检验,并开展探索性试验,分析评价糊精的质量。结果按现行标准检验,1批样品不合格。产品中真菌毒素的含量较高,并存在质量不均一的情况,应重视,以免带来质量风险。结论按现行质量标准和探索性研究项目检验,糊精的合格率为85.6%。为后续制剂研究提供参考,对中药制剂的发展具重要意义。

关键词：糊精质量评价均匀性真菌毒素溶液的澄清度元素杂质还原糖农药残留

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of Fatty Acid in Biological Samples Using Liquid Chromatography–Quadrupole-Orbitrap Mass Spectrometry Under Parallel Reaction Monitoring Mode

引用

Journal of Analysis and Testing 2024年第2期8卷 210-217页

作者： Jingxuan Yang Wenjun guo Xiaohang Xu Liang Zhao yajuan Xu Yang Wang School of Pharmaceutical Sciences Changchun University of Chinese MedicineChangchun130117China Key Laboratory of Medicinal Materials Jilin Academy of Chinese Medicine SciencesChangchun130021China Jilin Ginseng Academy Changchun University of Chinese MedicineChangchun130117China

Fatty acids(FAs)are an important class of functional small molecules and participate in a variety of life biological processes.This experiment proposed a liquid chromatography–quadrupole-Qrbitrap mass spectrometry(LC–Q-Orbitrap MS)method to perform FA profiling under parallel reaction monitoring(PRM)acquisition mode.The FA was derivatized by 2-dimethylaminoethylamine(DMED)to increase the ionization e fficiency and provide the characterized fragment pattern.The mass spectra obtained from full scan,multiple ion monitoring(MIM),and PRM were compared.The results showed that the protonated ion of FA+DMED–H2O was detected and the neutral loss of 45.06 Da was observed in the tandem mass spectrum.The PRM method provided the highest selectivity and sensitivity for FA detection with the help of accurate mass weight and specific neutral loss-based fragments.The method validation was performed using the FA standards and pooled quality control serum sample,which showed that the established method had good repeatability,stability,and linearity.Finally,the developed method was successfully applied to analyze the rat serum and brain tissue samples for the drug e ffi-cacy evaluation of gross saponin of Tribulus terrestris L.fruit(GSTTF)against middle cerebral artery occlusion(MCAO)-induced ischemic stroke.This method has extensive practicability and great potential in the detection of FA,especially for the analysis of samples with complex matrices.

关键词： Fatty acid Derivatization LC-Q-Orbitrap MS Parallel reaction monitoring Biological sample

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

乏情季节应用孕酮微囊包被液态制剂对奶山羊同期发情人工授精效果对比分析

引用

中国饲料 2024年第4期 13-16页

作者：董志岷王春郭雅娟贺佳唯刘艳琴朝格吉乐图范佳乐王贵杜金娥河套学院内蒙古巴彦淖尔015000 巴彦淖尔市畜牧业服务中心内蒙古巴彦淖尔015000 巴彦淖尔市动物疫病预防控制中心内蒙古巴彦淖尔015000

奶山羊发情具有一定的季节性,每年的4~7月份属于乏情季节,为了提高种山羊的利用率,扩大种群规模,实现全年均衡生产,必须突破乏情季节奶山羊繁殖率低的瓶颈。本试验将150只适繁奶山羊随机分为3组,每组50只,第1组以全混合日粮(TMR)为载体... 详细信息

奶山羊发情具有一定的季节性,每年的4~7月份属于乏情季节,为了提高种山羊的利用率,扩大种群规模,实现全年均衡生产,必须突破乏情季节奶山羊繁殖率低的瓶颈。本试验将150只适繁奶山羊随机分为3组,每组50只,第1组以全混合日粮(TMR)为载体投放孕酮微囊包被液态制剂+PMSG+PG处理,第2组以阴道硅胶支架(CIDR)+PMSG+PG处理,第3组不做任何处理。结果表明,在相同饲养条件下,第1、2组同期发情率较高,差异不显著(P> 0.05),但显著高于第3组(P <0.05);但发情母羊人工授精后的妊娠率显示第1组和第3组显著高于第2组(P <0.05),说明在乏情季节对奶山羊应用孕酮微囊包被液态制剂可以有效减少生殖道投药的不利影响,可以有效提高种羊的利用率,为实现舍饲奶山羊快速扩繁提供技术支撑。

关键词：乏情季节孕酮微囊包被液态制剂 CIDR 同期发情

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Contract theory based incentive mechanism design for buffer resource in wireless caching networks

引用

High Technology Letters 2020年第2期26卷 152-159页

作者：刘婷婷 Tang Lei Zhu Hao Bao Yongqiang guo yajuan School of Information and Communication Engineering Nanjing Institute of TechnologyNanjing 211167P.R.China Institute of Electric Power Science Jiangsu Electric Power Co.Ltd.Nanjing 210024P.R.China

Evidences indicate that,due to the limited caching capacity or inaccurate estimation on users’preferences,the requested files may not be fully cached in the network edge.The transmissions of the un-cached files will also lead to duplicated transmissions on backhaul channels.Buffer-aided relay has been proposed to improve the transmission performance of the un-cached files.Because of the limited buffer capacity and the information asymmetric environment,how to allocate the limited buffer capacity and how to incentivize users in participating buffer-aided relay have become critical issues.In this work,an incentive scheme based on the contract theory is proposed.Specifically,the backlog violation probability,i.e.,the buffer overflow probability,is provided based on the martingale theory.Next,based on the backlog violation probability,the utility functions of the relay node and users are constructed.With the purpose to maximize the utility of the relay node,the optimal contract problem is formulated.Then,the feasibility of the contract is also demonstrated,and the optimal solution can be obtained by the interior point method.Finally,numerical results are presented to demonstrate effectiveness of the proposed contract theory scheme.

关键词： contract theory buffer resource allocation wireless caching network incentive mechanism design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于信任机制的电力无线传感网络安全簇头选举算法

引用

中国电力 2023年第8期56卷 61-67,76页

作者：韦磊徐江涛郭雅娟朱道华国网江苏省电力有限公司江苏南京210000 国网江苏省电力有限公司电力科学研究院江苏南京211103

无线传感网络(wireless sensor network,WSN)越来越多地应用于生产生活中的感知和监测场景中,但所处环境中大量的传感器节点通常面临着被攻击的安全风险。传感器节点资源受限,安全防护脆弱,在采集数据时容易遭受选择性转发、伪造篡改数... 详细信息

无线传感网络(wireless sensor network,WSN)越来越多地应用于生产生活中的感知和监测场景中,但所处环境中大量的传感器节点通常面临着被攻击的安全风险。传感器节点资源受限,安全防护脆弱,在采集数据时容易遭受选择性转发、伪造篡改数据等恶意攻击,使系统遭受不必要的损失。提出了一种基于信任机制的无线传感网络安全簇头选举算法,综合考虑节点的历史通信记录、数据一致性、簇内节点距离以及和基站之间的距离,将通信质量和能耗考虑在内,通过时间周期轮替保证簇头节点的能耗公平性,选举安全可靠的簇头作为簇群的汇聚节点。仿真结果表明,该算法能有效避免恶意节点当选簇头,提高无线传感网络的安全性。

关键词：无线传感网络信任机制安全簇头恶意节点簇头选举算法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：