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Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)

Hepatobiliary Surgery and Nutrition 2022年第2期11卷 227-252,I0011-I0014页

作者： Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Department of Medical Oncology of PLA Cancer Center Jinling HospitalNanjingChina Department of Infectious Disease Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Liver Surgery The First Affiliated Hospital of USTCHefeiChina Minimally Invasive Interventional Division Sun Yat-sen University Cancer CenterGuangzhouChina Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiation Oncology Beijing Tsinghua Changgung HospitalBeijingChina Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Pathology Fudan University Shanghai Cancer CentreShanghaiChina Department of Liver Surgery Sun Yat-sen University Cancer CentreGuangzhouChina Department of Hepatobiliary Surgery Clinical Medical CollegeYangzhou UniversityYangzhouChina Department of Hepatobiliopancreatic Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Division of Hepatobiliary Surgery Department of General SurgeryRuijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Hepatobiliary and Splenic Surgery Shengjing Hospital Affiliated to China Medical UniversityShenyangChina The Department of Hepatobiliary Oncology of Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Sarcoma CenterPeking University Cancer Hospital and InstituteBeijingChina Department of Hepatobili

Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response *** has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’***,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being *** the evidence for conversion therapy in HCC and develop consensus statements to guide clinical *** review:Many research centers in China have accumulated significant experience implementing HCC conversion *** findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related *** order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical *** consensus statements on the implementation of conversion therapy for HCC were *** statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.

关键词： Hepatocellular carcinoma(HCC) conversion therapy surgical resection systematic treatment locoregional treatment consensus China

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津藜系列藜麦芽苗期耐盐碱特性评价

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天津农业科学 2023年第7期29卷 45-48,53页

作者：黄晓帆武亚瑾孙静波赵娇娇曹高燚谢晓东天津市作物抗逆的机理及遗传改良国际联合研究中心天津农学院农学与资源环境学院天津300392 和田职业技术学院新疆和田848000

为了综合评价津藜系列品种的耐混合盐碱特性进而筛选耐盐碱性较好的品系,用于藜麦新品种选育,以津藜系列7个藜麦品种为供试材料,在T4(NaCl∶Na_(2)SO_(4)∶NaHCO_(3)∶Na_(2)CO_(3)=1∶9∶9∶1)、T5(NaCl∶Na_(2)SO_(4)∶NaHCO_(3)∶Na_... 详细信息

为了综合评价津藜系列品种的耐混合盐碱特性进而筛选耐盐碱性较好的品系,用于藜麦新品种选育,以津藜系列7个藜麦品种为供试材料,在T4(NaCl∶Na_(2)SO_(4)∶NaHCO_(3)∶Na_(2)CO_(3)=1∶9∶9∶1)、T5(NaCl∶Na_(2)SO_(4)∶NaHCO_(3)∶Na_(2)CO_(3)=1∶1∶1∶1)、T6(NaCl∶Na_(2)SO_(4)∶NaHCO_(3)∶Na_(2)CO_(3)=9∶1∶1∶9)3种不同混合盐碱胁迫处理下,测定了藜麦种子的发芽率、胚根长和幼芽鲜质量,并利用耐盐碱系数和隶属函数值对7个藜麦品种进行耐盐碱特性评价。结果表明:不同混合盐碱胁迫对藜麦种子发芽率的影响不是很大,但是对藜麦种子的胚根长以及幼芽鲜质量有较强的抑制作用。将以上述各指标的耐盐碱系数及其隶属函数值作为衡量藜麦种子耐盐碱性的依据,分析发现‘津藜1号’耐盐碱性较强,‘津藜5号’耐盐碱性较弱。

关键词：藜麦混合盐碱胁迫种子萌发耐盐碱特性

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Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis(CHESS1904):An international multicenter study

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Portal Hypertension & Cirrhosis 2022年第1期1卷 7-14页

作者： Jun‐Hui Sun He zhao Haijun Zhang Lei Li NecatiÖrmeci Zi‐Niu Yu Xun Li Shuangxi Li Xujun Yang Huaping Wei Xiaoliang Zhu Zhengcong Zhang yajin Wang Zhongwei zhao Jianting Mao Qiaohong Wu Xiaole Sun Huiling Xiang Kefeng Jia Chao Yang Wei Wu Xiuqing Lin Haixin Yao Changzeng Zuo Jitao Wang Bo Zhang Chunqing Zhang Xiaoling Wu Guangchuan Wang Shengjuan Yao Ruihang Wang Li Zhou Hui Huan Qingli Tu Xue Pu Feng Zhang Qin Yin Linpeng Zhang Ying Guo Jian Wang Kohei Kotani Sawako Uchida‐Kobayashi Norifumi Kawada He Zhu Li Li Wei Wang Guo Zhang Lei Yu Xudong Cui Qingliang Zhu Hailong Zhang Xiaoli Hu Rafael OXimenes Adriano Gonçalves de Araújo Giulliano Gardenghi Yubao Zheng Zebin Wu Mingsheng Huang Xiaoyong Chen Jun Wu Feng Xie Yang Bo Shengjuan Hu Linke Ma Xiao Li Xiaolong Qi Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineZhejiang Clinical Research Center of Hepatobiliary and Pancreatic DiseasesZhejiang Provincial Research Center for Diagnosis and Treatment of Heapatobiliary DiseasesZhejiang University Cancer CenterHangzhouZhejiangChina Department of Interventional Therapy National Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Institute of Portal Hypertension Department of General SurgeryThe First Hospital of Lanzhou UniversityLanzhouGansuChina Department of Anesthesiology and Operating Theater The First Hospital of Lanzhou UniversityLanzhouGansuChina Interventional Radiology Department The First Hospital of Lanzhou UniversityLanzhouGansuChina Department of Gastroenterology Ankara University School of MedicineAnkaraTurkey Department of Internal Medicine Istanbul Health and Technology University Medical SchoolIstanbulTurkey Department of General Surgery Key Laboratory of Biotherapy and Regenerative Medicine of Gansu ProvinceThe First Hospital of Lanzhou UniversityLanzhouGansuChina Nursing Department The First Hospital of Lanzhou UniversityLanzhouGansuChina Department of General Surgery Donggang BranchFirst Hospital of Lanzhou UniversityLanzhouGansuChina The Diagnosis and Treatment Center of Endoscopy and Interventional Radiology Department of General SurgeryDonggang BranchFirst Hospital of Lanzhou UniversityLanzhouGansuChina Department of Interventional Radiology Lishui Central HospitalLishuiZhejiangChina Department of Hepatology and Gastroenterology of The Third Central Hospital of Tianjin TianjinChina Department of Radiology of The Third Central Hospital of Tianjin TianjinChina Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Hepatobiliar

Aim:To determine the tolerance and acceptance of hepatic venous pressure gradient(HVPG)measurements in patients with liver ***:This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG measurement between October 2019 and June *** related to the tolerance and acceptance of HVPG measurements were collected using descriptive ***:HVPG measurements were technically successful in all 271 patients,with 141(52.0%)undergoing HVPG measurement *** complication rate was 0.4%.Postoperative pain was significantly lower than preoperative expected pain(p<0.001)and intraoperative pain(p<0.001),and intraoperative pain was also significantly lower than preoperative expected pain(p=0.036).No,mild,moderate,severe,and intolerable discomfort scores were reported by 36.9%,44.6%,11.1%,6.3%,and 0.4%of these patients,respectively,during HVPG measurement and by 54.6%32.5%,11.4%,1.5%,and 0%,respectively,after HVPG *** these patients,39.5%had little understanding and 10%had no understanding of the value of HVPG measurement,with 35.1%and 4.1%regarding HVPG measurements as being of little or no help,*** patients reported that they would definitely(15.5%),probably(46.9%),or possibly(29.9%)choose to undergo additional HVPG measurements again,and 62.7%regarded the cost of the procedure as ***:HVPG measurement was safe and well‐tolerated in patients with cirrhosis,but patient education and communication are warranted to improve the acceptance of this procedure.

关键词： design hypertension multicenter study portal pressure prospective study questionnaire wedge

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胆囊癌的临床分型和预后关系初步分析:多中心回顾性临床研究

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中华外科杂志 2019年第4期57卷 258-264页

作者：张东耿智敏陈晨张永杰邱应和杨宁王德盛王学智宋天强楼健颖李江涛毛先海段文斌李升平劳向明赵向前陈亚进张磊仇毓东刘建生曾永毅龚伟汤朝晖刘青光全志伟西安交通大学第一附属医院肝胆外科 710061 南京大学医学院附属鼓楼医院肝胆外科 210008 山西医科大学第一医院肝胆外科太原030001 福建医科大学孟超肝胆医院肝胆外科福州350025 上海交通大学医学院附属新华医院普通外科 200092 海军军医大学附属东方肝胆外科医院胆道外科上海200433 空军军医大学第一附属医院肝胆外科西安710032 天津医科大学附属肿瘤医院肝胆肿瘤科 300060 浙江大学医学院附属第二医院肝胆胰外科杭州310009 湖南省人民医院肝胆外科长沙410005 中山大学肿瘤防治中心肝胆科广州510060 解放军总医院第一医学中心肝胆外科北京100853 中山大学附属孙逸仙纪念医院肝胆胰外科广州510120

目的提出新的胆囊癌临床分型,探讨不同临床分型胆囊癌患者的临床病理学特征及根治性术后生存时间的差异。方法回顾性分析中国12家医学中心2013年1月至2017年12月收治的经根治性手术治疗的1059例胆囊癌患者的临床病理学资料,其中男性389... 详细信息

目的提出新的胆囊癌临床分型,探讨不同临床分型胆囊癌患者的临床病理学特征及根治性术后生存时间的差异。方法回顾性分析中国12家医学中心2013年1月至2017年12月收治的经根治性手术治疗的1059例胆囊癌患者的临床病理学资料,其中男性389例,女性670例,男女比例为1.0:1.7;年龄(62.0±10.5)岁(范围:22~88岁)。按照肿瘤生长部位和浸润方式分为腹腔型、肝脏型、肝门型和混合型,手术方式分为区域性根治切除和扩大性根治切除。分析患者整体临床病理学特征;不同分型与T分期、N分期、血管侵犯及神经浸润的相关性等。计数资料的比较采用χ^2检验,生存分析采用Kaplan-Meier法和Log-rank检验。结果1059例胆囊癌患者中,区域性根治性切除940例,其中T1期81例,T2期及以上859例;扩大性根治性切除119例。总体R0切除990例(93.5%)。总体中位生存时间为28个月。Tis^T1期患者81例,T2期及以上患者978例。T2期及以上患者腹腔型345例(35.3%)、肝脏型331例(33.8%)、肝门型122例(12.5%)、混合型180例(18.4%)。T分期(χ^2=288.60,P0.05)。结论胆囊癌不同临床分型与TNM分期、恶性生物学行为及预后均具有相关性,对术前评估、手术方案制定及预后评估具有指导作用。

关键词：胆囊肿瘤临床分型预后根治性切除

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三光气在合成二苯氯甲烷中的应用研究

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广东化工 2010年第1期37卷 42-42,47页

作者：潘亚金潘伯安曹启学李良军陈钧赵利平晏慧娟吴春雷浙江医药股份有限公司新昌制药厂浙江新昌312500 浙江国邦药业有限公司浙江上虞312369 绍兴文理学院浙江绍兴312000

以苯和三光气为主要原料,经Friedel-Crafts酰化、还原和氯化三步反应得到二苯氯甲烷。该工艺使用"绿色试剂"三光气作为酰化和氯化试剂,反应条件温和,操作方便,副产物少,后处理简单,环境污染小,三步总收率达到45.3%。

关键词：三光气二苯甲酮二苯氯甲烷氯化

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