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Natural variants and editing events provide insights into routes for spike architecture modification in common wheat

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The Crop Journal 2023年第1期11卷 148-156页

作者： Min Fan Xiaoyu Zhang Ragupathi Nagarajan Wenxuan Zhai yahya rauf Haiyan Jia Zhengqiang Ma Liuling Yan Crop Genomics and Bioinformatics Center and National Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityJiangsuNanjing 210095JiangsuChina Department of Plant and Soil Sciences Oklahoma State UniversityStillwaterOK 74078USA

Spike architecture is an indicative trait of grain yield in common wheat(Triticum aestivum).A segregating population was generated for mapping genes contributing to spike morphometric traits by crossing the two common wheat cultivars'CItr 17600'with branching spikes and'Yangmai 18'with normal spikes.A major quantitative trait locus for spike length was mapped to the Q5A region of chromosome ***18 carried a Q5Ab allele for short spikes,which harbored one SNP in the last intron,and a 1-bp InDel in the 720-bp fragment from the start codon,compared to Q5Aa in Chinese *** 17600 harbored a q5Ab allele for long spikes,which has a 6-bp deletion compared to the reported q5Aa allele that was involved in the binding site of microRNA 172(miR172).This 6-bp deletion in immediately upstream of this binding site was involved in changes of four amino *** natural q5A allele appeared to be rare in common wheat but frequent in tetraploid *** accessions with branching *** CRISPR/Cas9 technology was used to edit the upstream region involving in the miR172 binding site in Yangmai 18 and identified two independent editing events,one with a 1-bp insertion in Q5A and the other with a 2-bp deletion in Q5D,resulting in several shapes of spikes in the transgenic *** addition to the effects of natural q5A allele and the edited Q5A genes,this study indicated the regeneratability and transformability of Yangmai 18 as an elite ***,this study provides insight into future modification and engineering of spike architecture in common wheat.

关键词： Q gene Spike shape miR172 Gene editing Wheat

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Natural variants and editing events provide insights into routes for spike architecture modification in common wheat

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The Crop Journal 2023年第1期

作者： Min Fan Xiaoyu Zhang Ragupathi Nagarajan Wenxuan Zhai yahya rauf Haiyan Jia Zhengqiang Ma Liuling Yan

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Unordered rule discovery using Ant Colony Optimization

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Science China(Information Sciences) 2014年第9期57卷 189-203页

作者： KHAN Salabat BAIG Abdul rauf ALI Armughan HAIDER Bilal KHAN Farman Ali DURRANI Mehr yahya ISHTIAQ Muhammad Department of Computer Science COMSATS Institute of Information TechnologyAttock CampusPakistan Department of Computer Science National University of Computer and Emerging SciencesIslamabadPakistan Al Imam Mohammad Ibn Saud Islamic University (IMSIU) College of Computer and Information SciencesRiyadhSaudi Arabia

In this article,a novel unordered classification rule list discovery algorithm is presented based on Ant Colony Optimization(ACO).The proposed classifier is compared empirically with two other ACO-based classification techniques on 26 data sets,selected from miscellaneous domains,based on several performance *** opposed to its ancestors,our technique has the flexibility of generating a list of IF-THEN rules with unrestricted *** makes the generated classification model more comprehensible and easily *** results indicate that the performance of the proposed method is statistically significantly better as compared with previous versions of AntMiner based on predictive accuracy and comprehensibility of the classification model.

关键词： classification ant colony optimization data mining unordered rule set comprehensibility pattern recognition

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POM analysis and computational interactions of 8-hydroxydiospyrin inside active site of protein tyrosine phosphatase 1B

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BIOCELL 2021年第3期45卷 751-759页

作者： SAUD BAWAZER ASGHAR KHAN ABDUR rauf TAIBI B EN HADDA yahya SAL-AWTHAN OMAR BAHATTAB UMER RASHID INAMULLAH KHAN MUHAMMAD A SIF NAWAZ MD SAHAB UDDIN OLATUNDE AHMED MOHAMMAD A LI SHARIATI Department of Pharmaceutical Chemistry Faculty of PharmacyUmm Al-Qura UniversityMakkah21955Saudi Arabia Department of Medicine Khyber Teaching Hospital Peshawar25000Pakistan Department of Chemistry University of SwabiSwabi23430Pakistan LCM Laboratory Mohammed First UniversityFaculty of SciencesOujda60000Morocco Biology Department Faculty of SciencesUniversity of TabukTabuk1144Saudi Arabia Department of Biology Faculty of ScienceIbb UniversityIbbYemen Department of Chemistry COMSATS University IslamabadAbbottabad CampusAbbottabad22060Pakistan Department of Pharmacy University of PeshawarPeshawar25120Pakistan Department of Biotechnology Shaheed Benazir Bhutto UniversitySheringal14400Pakistan Department of Pharmacy Southeast UniversityDhaka1213Bangladesh Pharmakon Neuroscience Research Network Dhaka1207Bangladesh Department of Biochemistry Abubakar Tafawa Balewa UniversityBauchi740272Nigeria Moscow State University of Technologies and Management(The First Cossack University) Moscow119991Russian Federation

Proteintyrosine phosphatase 1B(PTP1B)inhibitionis consideredas a potentialtherapeuticfor the treatmentof cancer,type2 diabetes,*** presentwork,weinvestigatedtheanti-diabeticpotentialof8-hydroxydiospyrin(8-HDN)from *** against the PTP1B *** showed significant inhibitory activity of PTP1B with an IC 50 value of 18.37±0.02μM.A detailed molecular docking study was carried out to analyze the binding orientation,binding energy,and mechanism of inhibition.A comparative investigation of 8-HDN in the catalytic,as well as the allosteric site of PTP1B,was *** energy data showed that compound 8-HDN is more selective for the allosteric site and hence avoids the problems associated with catalytic site *** inhibition mechanism of 8-HDN can be further investigated as an active lead compound against PTP1B by using in vitro and in vivo models.

关键词： Diospyros lotus Roots 8-Hydroxydiospyrin Molecular docking Protein tyrosine phosphatase 1B

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